Assembly and Activation of Alternative Complement Components on Endothelial Cell-Anchored Ultra-Large Von Willebrand Factor Links Complement and Hemostasis-Thrombosis

Complement activation in thrombotic microangiopathies

(2012) Shuju Feng et al.   BRITISH JOURNAL OF HAEMATOLOGY

Eculizumab in the treatment of refractory idiopathic thrombotic thrombocytopenic purpura

(2012) John Chapin et al.   BRITISH JOURNAL OF HAEMATOLOGY

Complement activation in thrombotic thrombocytopenic purpura

(2012) M. RÉTI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

STEC-HUS, atypical HUS and TTP are all diseases of complement activation

(2012) Marina Noris et al.   Nature Reviews Nephrology

Generation and Breakdown of Soluble Ultralarge von Willebrand Factor Multimers

(2012) Nancy Turner et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Alternative complement pathway assessment in patients with atypical HUS

(2011) Lubka T. Roumenina et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Atypical hemolytic uremic syndrome

(2011) Chantal Loirat et al.   Orphanet Journal of Rare Diseases

Soluble CD59 Expressed from an Adenovirus In Vivo Is a Potent Inhibitor of Complement Deposition on Murine Liver Vascular Endothelium

(2011) Jarel Gandhi et al.   PLoS One

Shiga toxin B subunits induce VWF secretion by human endothelial cells and thrombotic microangiopathy in ADAMTS13-deficient mice

(2010) J. Huang et al.   BLOOD

Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome

(2010) Tara K. Maga et al.   HUMAN MUTATION

Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage

(2009) N. A. Turner et al.   BLOOD

Mutations in Proteins of the Alternative Pathway of Complement and the Pathogenesis of Atypical Hemolytic Uremic Syndrome

(2008) Cynthia Abarrategui-Garrido et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome

(2008) V. Fremeaux-Bacchi et al.   BLOOD

ADAMTS-13 cleaves long von Willebrand factor multimeric strings anchored to endothelial cells in the absence of flow, platelets or conformation-altering chemicals

(2008) N. TURNER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Discrimination between host and pathogens by the complement system

(2008) Michael K. Pangburn et al.   VACCINE