Article
Cell Biology
Mariana O. Diniz, Anna Schurich, Senthil K. Chinnakannan, Marion Duriez, Kerstin A. Stegmann, Jessica Davies, Stephanie Kucykowicz, Kornelija Suveizdyte, Oliver E. Amin, Frances Alcock, Tamsin Cargill, Eleanor Barnes, Mala K. Maini
Summary: This study demonstrates that NK cell depletion enhances the immune response to vaccines in a mouse model of chronic HBV infection. It was found that the up-regulation of PD-L1 on liver-resident NK cells and PD-1 on intrahepatic T cells plays a negative regulatory role in the response to therapeutic vaccination. Combining cytokine activation with PD-L1 blockade can convert NK cells into efficient helpers, boosting the CD8(+) T cell response to therapeutic vaccination.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yi Feng, Shu Yao, Shan Li, Zuxiang Peng, Guoying Feng, Yan Ma, Bo Guo, Hongming Liu
Summary: Homozygous mutations in the AIRE gene lead to APECED by impairing thymic negative selection of autoreactive T cells. Moreover, the study reveals the crucial role of extrathymic Aire-expressing cells in shaping or sustaining memory T cells. These findings provide important insights into the T-cell response to infection.
Article
Multidisciplinary Sciences
Aenne Harberts, Constantin Schmidt, Joanna Schmid, Daniel Reimers, Friedrich Koch-Nolte, Hans-Willi Mittruecker, Friederike Raczkowski
Summary: IRF4 is essential for the activation and reactivation of CD8(+) memory T cells, but does not affect their overall survival. However, the formation and maintenance of CD8(+) tissue-resident memory T cells appears to depend on IRF4.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Qizhao Huang, Xia Wu, Zhiming Wang, Xiangyu Chen, Lisha Wang, Yijun Lu, Dan Xiong, Qiao Liu, Yuhan Tian, Huayu Lin, Junyi Guo, Shuqiong Wen, Wei Dong, Xiaofan Yang, Yuchen Yuan, Zhengliang Yue, Shun Lei, Qing Wu, Ling Ran, Luoyingzi Xie, Yifei Wang, Leiqiong Gao, Qin Tian, Xinyuan Zhou, Beicheng Sun, Lifan Xu, Zhonghui Tang, Lilin Ye
Summary: Blocking PD-1/PD-L1 signaling can unleash tumor-specific CD8+ T cells in the tumor draining lymph nodes and enhance anti-tumor therapeutic efficacy.
Article
Immunology
Diego von Werdt, Bilgi Gungor, Juliana Barreto de Albuquerque, Thomas Gruber, Daniel Zysset, Cheong K. C. Kwong Chung, Antonia Correa-Ferreira, Regina Berchtold, Nicolas Page, Mirjam Schenk, John H. Kehrl, Doron Merkler, Beat A. Imhof, Jens V. Stein, Jun Abe, Gleb Turchinovich, Daniela Finke, Adrian C. Hayday, Nadia Corazza, Christoph Mueller
Summary: Members of the Regulator of G-protein signaling (Rgs) family regulate G protein signaling by increasing the GTPase activity of G alpha protein subunits. Rgs1, a member of the Rgs family, preferentially deactivates G alpha q and G alpha i subunits, attenuating chemokine receptor-mediated immune cell trafficking. Its impact on tissue-resident T cells and immunosurveillance in barrier tissues is not fully understood.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Joseph S. Dolina, Joey Lee, Eugene L. Moore, Jennifer L. Hope, Donald T. Gracias, Takaji Matsutani, Ashu Chawla, Jason A. Greenbaum, Joel Linden, Stephen P. Schoenberger
Summary: During acute infection, CD4(+) regulatory T cells play a crucial role in regulating the immune response by suppressing cytotoxic CD8(+) T lymphocytes through different mechanisms. Early T cells inhibit primary CTL expansion through adenosine production, while late-phase T-regs suppress T cell proliferation through the transfer of cAMP. This study reveals the distinct roles of different T-reg lineages in fine-tuning CTL priming and contraction phases during acute infection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Romain Banchereau, Avantika S. Chitre, Alexis Scherl, Thomas D. Wu, Namrata S. Patil, Patricia de Almeida, Edward E. Kadel, Shravan Madireddi, Amelia Au-Yeung, Chikara Takahashi, Ying-Jiun Chen, Zora Modrusan, Jacqueline McBride, Rhea Nersesian, Ehab A. El-Gabry, Mark D. Robida, Jeffrey C. Hung, Marcin Kowanetz, Wei Zou, Mark McCleland, Patrick Caplazi, Shadi Toghi Eshgi, Hartmut Koeppen, Priti S. Hegde, Ira Mellman, W. Rodney Mathews, Thomas Powles, Sanjeev Mariathasan, Jane Grogan, William E. O'Gorman
Summary: CD8+ tissue-resident memory T (T-RM) cells expressing CD103 (ITGAE) are believed to actively suppress cancer progression, and their presence in tumors may predict response to immunotherapy. This study found that in inflamed tumors, CD103+ CD8+ T-RM cells exhibit a complex phenotype characterized by increased clonal expansion, expression of checkpoint regulators, and cytotoxic proteins, suggesting their involvement in antitumor response.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Julie Niogret, Helene Berger, Cedric Rebe, Romain Mary, Elise Ballot, Caroline Truntzer, Marion Thibaudin, Valentin Derangere, Christophe Hibos, Lea Hampe, David Rageot, Theo Accogli, Philippe Joubert, Bertrand Routy, James Harker, Frederique Vegran, Francois Ghiringhelli, Fanny Chalmin
Summary: Tfh cells play an important role in antitumor immune response, especially in a CD8(+)-dependent manner, by producing interleukin-21 to support the function of exhausted T cells. Their accumulation in tumor sites and draining lymph nodes is closely associated with treatment efficacy and patient survival.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Cell Biology
Sae-Hae Kim, Byeol-Hee Cho, Kwang Soon Kim, Yong-Suk Jang
Summary: C5a in the Peyer's patch enhances CD8(+) T cell responses by increasing C5/C5a levels. Single-cell RNA sequencing identifies dendritic cells expressing C5aR and lysozyme as key players in CD8(+) T cell immune induction.
Article
Oncology
Xiaoming Wang, Yan Zhang, Jian Zheng, Cuixian Yao, Xiubo Lu
Summary: In anaplastic thyroid carcinoma, the lncRNA UCA1 attenuates the killing effect of cytotoxic CD8 + T cells on cancer cells through the miR-148a/PD-L1 pathway, providing insights into the potential mechanisms of immune evasion in this type of cancer.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Maite Duhalde Vega, Daniela Olivera, Gustavo Gastao Davanzo, Mauricio Bertullo, Veronica Noya, Gabriela Fabiano de Souza, Stefanie Primon Muraro, Icaro Castro, Ana Paula Arevalo, Martina Crispo, German Galliussi, Sofia Russo, David Charbonnier, Florencia Rammauro, Mathias Jeldres, Catalina Alamon, Valentina Varela, Carlos Batthyany, Mariela Bollati-Fogolin, Pablo Oppezzo, Otto Pritsch, Jose Luiz Proenca-Modena, Helder I. Nakaya, Emiliano Trias, Luis Barbeito, Ignacio Anegon, Maria Cristina Cuturi, Pedro Moraes-Vieira, Mercedes Segovia, Marcelo Hill
Summary: This study reveals the correlation between inflammation and dysfunctional T cell responses, showing that manipulating T cells can control certain viral infections. These findings provide new insights for supporting immunotherapy targeting critical viral diseases.
Article
Immunology
Ruixuan Geng, Hui Tang, Tingting You, Xiuxiu Xu, Sijian Li, Zepeng Li, Yuan Liu, Wei Qiu, Na Zhou, Ningning Li, Yuping Ge, Fuping Guo, Yuhong Sun, Yingyi Wang, Taisheng Li, Chunmei Bai
Summary: PD-1/PD-L1 inhibitors can be effective in patients with high levels of CD8+CD28+ T cells, which can be used as a potential biomarker for predicting immunotherapy response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jiajia Qi, Tingting Ding, Tiannan Liu, Xin Xia, Shihong Wu, Jiang Liu, Qianming Chen, Dunfang Zhang, Hang Zhao
Summary: A supramolecular hydrogel called inosine-phenylenediboronic-isoguanosine (IPBisoG) has been successfully developed, which demonstrates excellent stability and self-healing properties. The hydrogel can achieve gradual and sequential release of inosine and PD-L1 blocker, enhancing the efficacy of local immunotherapy. The use of the hydrogel also triggers systemic immune responses.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Multidisciplinary Sciences
Yingxia Zheng, Li Han, Zheyi Chen, Yiyang Li, Bingqian Zhou, Rui Hu, Shiyu Chen, Haibo Xiao, Yanhui Ma, Guohua Xie, Junyao Yang, Xianting Ding, Lisong Shen
Summary: We discovered an enrichment of PD-L1(+)CD8(+) T cells in lung cancer, which were spatially localized with PD-1(+)CD8(+) T cells. These PD-L1(+)CD8(+) T cells exhibited regulatory functions that inhibited the proliferation and cytotoxic abilities of other CD8(+) T cells through the PD-L1/PD-1 axis. Tumor-derived IL-27 was found to promote the development of PD-L1(+)CD8(+) T cells through STAT1/STAT3 signaling, leading to downregulation of the adaptive immune response.
Article
Oncology
Tingting Lv, Xiaofeng Xiong, Wei Yan, Mei Liu, Hongwei Xu, Qin He
Summary: Gasdermin D (GSDMD) is found to play an important role in hepatocellular carcinoma (HCC), with increased expression associated with poor prognosis. Knockout of GSDMD reduces liver tumors, while overexpression promotes hepatocarcinogenesis. GSDMD impacts multiple signaling pathways, including cGAS and PD-L1, affecting the progression and metastasis of HCC. Targeting GSDMD may serve as a potential therapeutic strategy for HCC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Microbiology
Alayna K. Caffrey, Joshua J. Obar
CURRENT OPINION IN MICROBIOLOGY
(2016)
Review
Biochemistry & Molecular Biology
Joshua J. Obar, Tobias M. Hohl, Robert A. Cramer
Editorial Material
Cell Biology
Brian S. Sheridan, Joshua J. Obar
JOURNAL OF LEUKOCYTE BIOLOGY
(2016)
Article
Microbiology
Caitlin H. Kowalski, Sarah R. Beattie, Kevin K. Fuller, Elizabeth A. McGurk, Yi-Wei Tang, Tobias M. Hohl, Joshua J. Obar, Robert A. Cramer
Article
Microbiology
Arsa Thammahong, Alayna K. Caffrey-Card, Sourabh Dhingra, Joshua J. Obar, Robert A. Cramer
Article
Microbiology
Sarah R. Beattie, Kenneth M. K. Mark, Arsa Thammahong, Laure Nicolas Annick Ries, Sourabh Dhingra, Alayna K. Caffrey-Carr, Chao Cheng, Candice C. Black, Paul Bowyer, Michael J. Bromley, Joshua J. Obar, Gustavo H. Goldman, Robert A. Cramer
Article
Immunology
Timothy R. Borgogna, Bennett Hisey, Emily Heitmann, Joshua J. Obar, Nicole Meissner, Jovanka M. Voyich
JOURNAL OF INFECTIOUS DISEASES
(2018)
Article
Immunology
Alayna K. Caffrey-Carr, Kimberly M. Hilmer, Caitlin H. Kowalski, Kelly M. Shepardson, Rachel M. Temple, Robert A. Cramer, Joshua J. Obar
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Microbiology
Laure Nicolas Annick Ries, Jacob L. Steenwyk, Patricia Alves de Castro, Pollyne Borborema Almeida de Lima, Fausto Almeida, Leandro Jose de Assis, Adriana Oliveira Manfiolli, Azusa Takahashi-Nakaguchi, Yoko Kusuya, Daisuke Hagiwara, Hiroki Takahashi, Xi Wang, Joshua J. Obar, Antonis Rokas, Gustavo H. Goldman
FRONTIERS IN MICROBIOLOGY
(2019)
Editorial Material
Immunology
Joshua J. Obar, Agostinho Carvalho, Joana Vitte, Stephane Ranque
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Immunology
Xi Wang, Alayna K. Caffrey-Carr, Ko-Wei Liu, Vanessa Espinosa, Walburga Croteau, Sourabh Dhingra, Amariliz Rivera, Robert A. Cramer, Joshua J. Obar
JOURNAL OF IMMUNOLOGY
(2020)
Review
Microbiology
Joshua J. Obar
CURRENT OPINION IN MICROBIOLOGY
(2020)
Article
Microbiology
Jane T. Jones, Ko-Wei Liu, Xi Wang, Caitlin H. Kowalski, Brandon S. Ross, Kathleen A. M. Mills, Joshua D. Kerkaert, Tobias M. Hohl, Lotus A. Lofgren, Jason E. Stajich, Joshua J. Obar, Robert A. Cramer
Summary: This study identified a strain of A. fumigatus, W72310, resistant to leukocyte killing, that can persist in the mouse lung long-term and elicit features of ABPA-like disease.
Article
Immunology
Alayna K. Caffrey-Carr, Caitlin H. Kowalski, Sarah R. Beattie, Nathan A. Blaseg, Chanell R. Upshaw, Arsa Thammahong, Hannah E. Lust, Yi-Wei Tang, Tobias M. Hohl, Robert A. Cramer, Joshua J. Obar
INFECTION AND IMMUNITY
(2017)
Article
Immunology
Vanessa Espinosa, Orchi Dutta, Constance McElrath, Peicheng Du, Yun-Juan Chang, Bryan Cicciarelli, Amy Pitler, Ian Whitehead, Joshua J. Obar, Joan E. Durbin, Sergei V. Kotenko, Amariliz Rivera
SCIENCE IMMUNOLOGY
(2017)