Article
Cell Biology
Liang Liu, Peng Zhang, Xuchen Dong, Haoran Li, Suwen Li, Shan Cheng, Jiaqi Yuan, Xuejun Yang, Zhiyuan Qian, Jun Dong
Summary: The study reveals that circ_0001367 functions as a suppressor in glioma by targeting the miR-431/NRXN3 axis, potentially serving as a promising therapeutic target against gliomas.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Xiangdong Xu, Yang Liu, Yan Li, Huajian Chen, Yuxuan Zhang, Jie Liu, Shaokang Deng, Yaofeng Zheng, Xinlin Sun, Jihui Wang, Taoliang Chen, Min Huang, Yiquan Ke
Summary: MiR-375 expression is downregulated in gliomas, and it suppresses glioma proliferation, migration, and invasion by inhibiting the CTGF-EGFR signaling pathway. MiR-375-containing exosomes were found in human blood samples from glioma patients, with levels correlating with disease progression. Exosomal miR-375 secretion impacts the activity of the CTGF-EGFR pathway, and once secreted, exosomal miR-375 is not taken back up by glioma cells.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Chenlong Li, Xue Guan, Hanguang Jing, Xu Xiao, Hua Jin, Jinsheng Xiong, Siqi Ai, Yingjie Wang, Tianqi Su, Guiyin Sun, Tianjiao Fu, Yujie Wang, Shouli Guo, Peng Liang
Summary: The present study found that the circular RNA bifunctional apoptosis regulator (circBFAR) is highly expressed in glioblastoma multiforme (GBM) and is negatively correlated with overall survival in patients. Inhibition of circBFAR can suppress the proliferation and invasion of GBM. The study also identified that circBFAR regulates the expression of FoxM1 through interaction with miR-548b.
Article
Cell Biology
Qixiang Zhang, Zhengxin Chen, Qikai Tang, Zhangjie Wang, Jiacheng Lu, Yongping You, Huibo Wang
Summary: Recent studies have found that USP21 plays a critical role in maintaining the MES properties of GBM stem cells by stabilizing FOXD1 protein expression. Disruption of USP21 enhances degradation of FOXD1, leading to attenuation of MES identity. Additionally, overexpression of USP21 is associated with poorer patient survival in GBM.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Chaochao Wang, Hao Xue, Rongrong Zhao, Zhongzheng Sun, Xiao Gao, Yanhua Qi, Huizhi Wang, Jianye Xu, Lin Deng, Gang Li
Summary: It has been confirmed that RGS16 is upregulated in glioma tissues and its high expression is associated with poor survival. Deleting RGS16 significantly suppresses glioma cell proliferation and migration. Moreover, RGS16 has been validated as a direct target gene of miR let-7c-5p. Therefore, the inhibition of RGS16 may promote glioma progression and could potentially serve as a prognostic biomarker and therapeutic target for glioma.
FRONTIERS OF MEDICINE
(2023)
Article
Medicine, General & Internal
Yong Zhang, Qiming Xia, Jun Lin
Summary: This study found that in human glioma, the expression of Runx1 was significantly up-regulated and closely associated with tumor grade. Glioma patients with high Runx1 expression had a lower survival rate. Knockdown of Runx1 inhibited the viability, migration, invasion, and clone formation of glioma cells, activating the JAK/STAT3 signaling pathway by inhibiting the activation of the SOCS3/SOCS4 promoter.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Oncology
Danlu Yang, Xingxing Xu, Xin Wang, Wenjin Feng, Xiya Shen, Jingjing Zhang, Huitao Liu, Changnan Xie, Qian Wu, Xuemeng Miao, Yifan Guo, Hao Cai, Lihao Wu, Shuxian Zhou, Xinfei Yao, Ying Wang, Tian Xie, Zhihui Huang
Summary: The study found that low concentration of beta-elemene induces senescence in glioma cells, while high concentration leads to apoptosis, through modulation of the YAP-CDK6 signaling pathway. Overexpression of YAP and CDK6 significantly rescues beta-elemene-induced senescence in glioma cells, providing a potential novel therapeutic strategy for gliomas.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hongyu Wang, Ruiqin Han, Qiao Li, Wei Kang, Qiang Dong, Hang Yin, Liang Niu, Junqiang Dai, Yunji Yan, Yuanping Su, Xuan Yao, He Zhang, Guoqiang Yuan, Yawen Pan
Summary: In this study, we found that EEF1E1 plays a crucial role in regulating the cell cycle and cell proliferation in glioma cells. It downregulates the expression of PTEN and modulates downstream cell cycle-related proteins through the PTEN/AKT signaling pathway. Our findings demonstrate that EEF1E1 knockdown effectively inhibits glioma cell proliferation, suggesting that EEF1E1 could serve as a potential therapeutic target for glioma treatment with significant clinical implications.
MOLECULAR CARCINOGENESIS
(2023)
Article
Pharmacology & Pharmacy
Jinling Zhang, Huibin Song, Chen Chen, Lipeng Chen, Yong Dai, Ping-Hui Sun, Chang Zou, Xiaoyu Wang
Summary: The study found that METTL11A plays a promoting role in the progression of cervical cancer and has a close relationship with ELK3.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Neurosciences
Faming Wang, Le Zhang, Yao Luo, Qingyun Zhang, Yueling Zhang, Yingying Shao, Liudi Yuan
Summary: This study identified and verified a novel lncRNA RP11-279C4.1 that was upregulated in glioma tissues and cell lines, and demonstrated its role in promoting tumor progression by modulating the miR-1273g-3p/CBX3 axis.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Cell Biology
Xiaohui Zhang, Fangyuan Li, Yidong Zhou, Feng Mao, Yan Lin, Songjie Shen, Yuntao Li, Sheng Zhang, Qiang Sun
Summary: The study demonstrated the crucial role of AFAP1-AS1 in triple-negative breast cancer (TNBC), showing that silencing AFAP1-AS1 and Sp1 or upregulating miR-2110 suppressed proliferation, migration, and invasion of TNBC cells. AFAP1-AS1 acted as a miR-2110 sponge to increase Sp1 expression, modulating breast cancer cell progression and tumorigenesis.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Wentao Dong, Lude Wang, Yi Pan, Qi Tu, Ting He, Tian Zhou, Jianlie Yuan, Minfeng Tong
Summary: PLU1 is upregulated in various cancers and plays a role in glioma development and glucose metabolism. This study provides new insights into the metabolic mechanisms of PLU1 and suggests potential therapeutic strategies for glioma treatment.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2023)
Article
Biochemistry & Molecular Biology
Shikai Gui, Peng Chen, Yu Liu, Qiaorong Chen, Tianxiang Cheng, Shulong Lv, Tong Zhou, Zhen Song, Juexian Xiao, Wei He, Shengtao Yuan, Zujue Cheng
Summary: This study identified that high TUBA1C expression correlates with poor outcomes in glioma patients, and knocking down TUBA1C can suppress glioma cell proliferation via cell cycle arrest, potentially serving as a therapeutic biomarker.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Dongbao Li, Yuhong Wang, Chao Dong, Tao Chen, Anqi Dong, Jiayu Ren, Weikang Li, Gege Shu, Jiaoyang Yang, Wenhao Shen, Lei Qin, Lin Hu, Jin Zhou
Summary: This study revealed that CST1 promotes gastric cancer metastasis and progression by regulating GPX4 and inhibiting ferroptosis. High CST1 expression is associated with poor prognosis, and it inhibits ferroptosis by stabilizing GPX4 and reducing intracellular ROS levels, enhancing migration, invasion, and epithelial-mesenchymal transition of gastric cancer cells. CST1 may serve as a new oncological marker and therapeutic target for gastric cancer metastasis.
Article
Biology
Qiang Wu, Ling Liu, Yan Feng, Liqun Wang, Xin Liu, Yanan Li
Summary: This study found that UBR5 is highly expressed in human glioma and promotes the migration and invasion of glioma cells by regulating the ECRG4/NF-kappa B pathway.
JOURNAL OF BIOSCIENCES
(2022)