Article
Pathology
Caoimhe Egan, Justin Lack, Shannon Skarshaug, Thu Anh Pham, Zied Abdullaev, Liqiang Xi, Svetlana Pack, Stefania Pittaluga, Elaine S. Jaffe, Mark Raffeld
Summary: Histiocytic sarcoma and tumors with dendritic cell differentiation often exhibit mutations in the RAS/MAPK pathway, suggesting a clonal relationship with associated lymphoid malignancies. Particularly, sHDT associated with follicular lymphoma commonly shares a similar mutational profile with the associated malignancy, with frequent mutations in CREBBP and KMT2D genes.
Editorial Material
Hematology
Elias Campo, Elaine S. Jaffe
Summary: Sarkozy et al show that the genomic profiles of gray zone lymphomas (GZLs) located in the anterior mediastinum (thymic niche) or extramediastinal regions differ from each other.
Review
Pathology
Yi Xie, Elaine S. Jaffe
Summary: AITL, a subtype of peripheral T-cell lymphoma derived from T-follicular helper cells, poses diagnostic challenges due to its wide clinical and histopathologic spectrum. Diagnostic tools and molecular studies play crucial roles in aiding accurate diagnosis and differential diagnosis.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2021)
Article
Hematology
Elaine S. Jaffe, John K. C. Chan
Summary: In this study, Kemps et al provide an expanded understanding of the pathological, genomic, and clinical features of ALK-positive histiocytosis, and show the clinical efficacy of ALK inhibition in patients with central or peripheral nervous system disease, with durable responses in all cases.
Editorial Material
Hematology
Saber Tadros, Elaine S. Jaffe
Article
Hematology
Elias Campo, Elaine S. Jaffe, James R. Cook, Leticia Quintanilla-Martinez, Steven H. Swerdlow, Kenneth C. Anderson, Pierre Brousset, Lorenzo Cerroni, Laurence de Leval, Stefan Dirnhofer, Ahmet Dogan, Andrew L. Feldman, Falko Fend, Jonathan W. Friedberg, Philippe Gaulard, Paolo Ghia, Steven M. Horwitz, Rebecca L. King, Gilles Salles, Jesus San-Miguel, John F. Seymour, Steven P. Treon, Julie M. Vose, Emanuele Zucca, Ranjana Advani, Stephen Ansell, Wing-Yan Au, Carlos Barrionuevo, Leif Bergsagel, Wing C. Chan, Jeffrey I. Cohen, Francesco d'Amore, Andrew Davies, Brunangelo Falini, Irene M. Ghobrial, John R. Goodlad, John G. Gribben, Eric D. Hsi, Brad S. Kahl, Won-Seog Kim, Shaji Kumar, Ann S. LaCasce, Camille Laurent, Georg Lenz, John P. Leonard, Michael P. Link, Armando Lopez-Guillermo, Maria Victoria Mateos, Elizabeth Macintyre, Ari M. Melnick, Franck Morschhauser, Shigeo Nakamura, Marina Narbaitz, Astrid Pavlovsky, Stefano A. Pileri, Miguel Piris, Barbara Pro, Vincent Rajkumar, Steven T. Rosen, Birgitta Sander, Laurie Sehn, Margaret A. Shipp, Sonali M. Smith, Louis M. Staudt, Catherine Thieblemont, Thomas Tousseyn, Wyndham H. Wilson, Tadashi Yoshino, Pier-Luigi Zinzani, Martin Dreyling, David W. Scott, Jane N. Winter, Andrew Zelenetz
Summary: Since 1994, the classification of lymphoid neoplasms has been continuously updated through international efforts, with recent progress driven by genomic studies. This proposal presents the International Consensus Classification of mature lymphoid, histiocytic, and dendritic cell tumors, which has refined diagnostic criteria and incorporated new insights from genomics.
Editorial Material
Hematology
Neval Ozkaya, Elaine S. Jaffe
Letter
Oncology
Steven H. Swerdlow, Elias Campo, Daniel A. Arber, Mario Cazzola, James R. Cook, Hartmut Doehner, Martin Dreyling, Robert P. Hasserjian, Elaine S. Jaffe, Attilio Orazi, Leticia Quintanilla-Martinez, David W. Scott, Ayalew Tefferi, Jane N. Winter, Andrew D. Zelenetz
Editorial Material
Hematology
Elaine S. Jaffe, James R. Cook
Summary: In this article, the authors present the experience of the French Lymphopath network in using core needle biopsies and excisional lymph node biopsies as a tool for the primary diagnosis of lymphoma.
Letter
Pathology
Neval Ozkaya, Ina Lee, Terrica S. Johnson, Elaine S. Jaffe
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Letter
Hematology
Ting Zhou, Constance M. Yuan, Kathryn Lurain, Maryalice Stetler-Stevenson, Armando C. Filie, Stefania Pittaluga, Elaine S. Jaffe, Ramya Ramaswami, Robert Yarchoan, Hao-Wei Wang
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Pathology
Elaine S. Jaffe
Summary: The modern taxonomy of disease provides a framework for precision medicine that integrates traditional pathologic criteria with clinical and genomic features. Follicular lymphoma (FL) and diffuse large B-cell lymphoma are the two most common subtypes of lymphoma worldwide. Recent studies have revealed significant diversity among follicle center-derived lesions, and diffuse large B-cell lymphoma is a family of aggressive B-cell neoplasms with varied pathogenesis and clinical features. High-throughput sequencing has identified diverse mutational profiles that can guide targeted therapy and improve patient outcomes in the future.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Editorial Material
Hematology
James D. Phelan, Elaine S. Jaffe
Summary: In this study, the authors used whole genome sequencing to investigate the basis of follicular lymphoma (FL) transformation. They identified two genetically distinct subgroups of FL, dFL and cFL, which showed a significant difference in time to transformation.
Editorial Material
Hematology
Yanna Ding, Elaine S. Jaffe
Article
Hematology
Anna Keogh, Fiona Lynott, Antonios Papanicolau-Sengos, Mutaz Mohammed Nur, Aisling Spillane, Fiona Quinn, Ezzat ElHassadi, Elaine S. S. Jaffe, Richard Flavin
Summary: Nodal peripheral T cell lymphoma with T follicular helper cell phenotype is an aggressive lymphoma that responds poorly to conventional treatments. The minimum criteria for diagnosis and distinct histological features have not been well described.
HEMATOLOGY REPORTS
(2022)