Article
Endocrinology & Metabolism
Mengqi Chang, Zihao Wang, Jun Gao, Chengxian Yang, Ming Feng, Yamei Niu, Wei-Min Tong, Xinjie Bao, Renzhi Wang
Summary: This study demonstrates that m(6)A methyltransferase METTL3 promotes tumor growth and hormone secretion by increasing the expression of GNAS and GADD45 gamma in a m(6)A-dependent manner. Hence, METTL3 and the methylated RNAs may serve as suitable targets for clinical treatment of GH-PAs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Zhenye Li, Yiyuan Chen, Xiaohui Yao, Qian Liu, Haibo Zhu, Yazhuo Zhang, Jie Feng, Hua Gao
Summary: This study identified the profiling of the integrated stress response in somatotroph adenomas, highlighting the importance of EIF2 beta and its correlation with other factors. The level of EIF2 beta expression was associated with the invasiveness and immune-cell infiltration in somatotroph adenomas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pathology
Feyzanur Yildirimtepe Caldiran, Ercan Cacan
Summary: Colorectal cancer is the third most common cancer, with genetic and epigenetic changes playing major roles in its development. The expression of RGS10 is regulated by DNA methylation, and its role in colorectal carcinoma varies depending on tumor stage and microsatellite stability.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Oncology
A. J. M. Meijer, F. A. Diepstraten, T. Langer, L. Broer, I. K. Domingo, E. Clemens, A. G. Uitterlinden, A. C. H. de Vries, M. van Grotel, W. P. Vermeij, R. A. Ozinga, H. Binder, J. Byrne, E. van Dulmen-den Broeder, M. L. Garre, D. Grabow, P. Kaatsch, M. Kaiser, L. Kenborg, J. F. Winther, C. Rechnitzer, H. Hasle, T. Kepak, K. Kepakova, W. J. E. Tissing, A. L. F. van der Kooi, L. C. M. Kremer, J. Kruseova, S. M. F. Pluijm, C. E. Kuehni, H. J. H. van der Pal, R. Parfitt, C. Spix, A. Tillmanns, D. Deuster, P. Matulat, G. Calaminus, A. E. Hoetink, S. Elsner, J. Gebauer, R. Haupt, H. Lackner, C. Blattmann, S. J. C. M. M. Neggers, S. R. Rassekh, G. E. B. Wright, B. Brooks, A. P. Nagtegaal, B. I. Drogemoller, C. J. D. Ross, A. P. Bhavsar, A. G. Am Zehnhoff-Dinnesen, B. C. Carleton, O. Zolk, M. M. van den Heuvel-Eibrink
Summary: Genetic susceptibility plays a role in the occurrence of hearing loss after treatment, with the genetic variant rs893507 in the TCERG1L gene associated with ototoxicity in children with cancer. Replication studies in two independent cohorts confirmed this association. Modulating TCERG1L expression in cultured human cells altered cellular responses to cisplatin-induced cytokine secretion and toxicity, providing insights into the genetic and pathophysiological basis of cisplatin-induced ototoxicity.
NPJ PRECISION ONCOLOGY
(2021)
Article
Oncology
Hee-Jin Kim, Jong-Lyul Park, Byoung-Ha Yoon, Keeok Haam, Haejeong Heo, Jong-Hwan Kim, Seon-Young Kim, Mirang Kim, Woo-Ho Kim, Sang-Il Lee, Kyu-Sang Song, Kwang-Sung Ahn, Yong Sung Kim
Summary: This study reveals a novel mechanism in gastric carcinogenesis, where methylation and silencing of the SSTR2 promoter lead to the establishment of an inflammatory microenvironment. Loss of SSTR2 function promotes cell proliferation and tumor formation, while overexpression of SSTR2 inhibits these processes. These findings provide new insights into the initiation of gastric cancer.
Article
Endocrinology & Metabolism
Priyanka Singh, Sanjay Kumar Bhadada, Divya Dahiya, Uma Nahar Saikia, Ashutosh Kumar Arya, Naresh Sachdeva, Jyotdeep Kaur, Arunanshu Behera, Maria Luisa Brandi, Sudhaker Dhanwada Rao
Summary: The study found that the expression of GCM2 in sporadic parathyroid adenomas is suppressed by promoter hypermethylation and higher levels of H3K9me3. Treatment with DAC can restore GCM2 expression.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Immunology
Yiping Hu, Bihua Xu, Juan He, Hongying Shan, Gengmin Zhou, Deli Wang, Lu Bai, Hongxi Shang, Liping Nie, Fan Pan, Hui Yao Lan, Qingwen Wang
Summary: This study found that the expression of Smad7 was significantly decreased in CD4(+) T cells of rheumatoid arthritis (RA) patients and inversely correlated with clinical parameters of RA. DNA hypermethylation in the Smad7 promoter region was observed in CD4(+) T cells of RA patients. These findings suggest that the loss of Smad7 expression and DNA hypermethylation may contribute to the disease activity of RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Juan Rodrigo Patino-Mercau, Carlos Balinas-Gavira, Alvaro Andrades, Maria S. Benitez-Cantos, Ana Ercegovic Rot, Maria Isabel Rodriguez, Juan Carlos Alvarez-Perez, Marta Cuadros, Pedro P. Medina
Summary: Recent sequencing studies have shown that SWI/SNF complexes are frequently altered in solid tumors, but their role in acute myeloid leukemia (AML) is not well understood. This study focuses on the role of the BCL7A subunit in AML, which is recurrently mutated in lymphomas. The findings suggest that BCL7A is silenced by promoter hypermethylation in AML and its restoration suppresses tumor growth in AML cell lines and xenograft models.
BIOMARKER RESEARCH
(2023)
Article
Oncology
Hang Yin, Yingnan Zhao, Xinsheng Han, Qiao Li, Qiang Dong, Yang Liu, Xiaoqing Wang, Guoqiang Yuan, Yawen Pan
Summary: This study demonstrates that circRNA_103128 plays an important regulatory role in medulloblastoma through the sponge effect with miR-129-5p, affecting the expression of SOX4 and promoting tumor cell growth and migration.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Jing Wang, Lei Yang, Yuan Li, Xing-Bang Wang, Wei Yang, Fang Liu, Xiao-Ben Wu
Summary: The study revealed that STXBP5 and STXBP5-AS1 are downregulated in glioma and may act as novel tumor suppressors. Overexpression of these genes inhibited cell proliferation, migration, and invasion, promoted apoptosis, and suppressed tumor formation in vivo, suggesting their potential as therapeutic targets for glioma.
Article
Multidisciplinary Sciences
Ignacio Jusue-Torres, Richies Tiv, Julio C. Ricarte-Filho, Apurva Mallisetty, Leglys Contreras-Vargas, Maria Jose Godoy-Calderon, Karam Khaddour, Kathleen Kennedy, Klara Valyi-Nagy, Odile David, Martha Menchaca, Anastasia Kottorou, Angelos Koutras, Foteinos Dimitrakopoulos, Khaled M. Abdelhady, Malek Massad, Israel Rubinstein, Lawrence Feldman, John Stewart, Takeshi Shimamura, Ludmila Danilova, Alicia Hulbert
Summary: The study aimed to assess the impact of MYO1E overexpression on non-small cell lung carcinoma (NSCLC) and investigate the association between DNA methylation, RNA expression of MYO1E, and survival/mortality risk in NSCLC patients. The results show a negative correlation between DNA methylation and RNA expression of MYO1E in both LUAD and LUSC subpopulations. Late-stage LUAD patients had lower DNA methylation and higher RNA expression of MYO1E, while no significant differences were observed in LUSC patients. Low DNA methylation and high RNA expression of MYO1E were associated with shorter median survival time and increased mortality risk in LUAD, but not in LUSC. This study suggests that changes in MYO1E methylation and expression play a crucial role in the pathogenesis of lung cancer, particularly in LUAD, and highlights the potential utility of MYO1E DNA methylation and RNA expression as predictors of survival for LUAD patients. Furthermore, MYO1E DNA methylation could be used as a circulating tumor marker in liquid biopsies due to its low normal expression in blood cells.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Kohei Yagi, Hiroaki Ono, Atsushi Kudo, Yuko Kinowaki, Daisuke Asano, Shuichi Watanabe, Yoshiya Ishikawa, Hiroki Ueda, Keiichi Akahoshi, Shinji Tanaka, Minoru Tanabe
Summary: This study investigated the expression of O6-methylguanine-DNA methyltransferase (MGMT) in pancreatic neuroendocrine tumors (Pan-NET) and its association with treatment efficacy. The results showed that MGMT expression was negatively correlated with treatment outcomes, and MGMT expression was lower in NET-G2 compared to NET-G1. Therefore, MGMT may serve as a better therapeutic target for STZ treatment in NET-G2.
SCIENTIFIC REPORTS
(2023)
Article
Virology
Allison M. Tschirley, Peter A. Stockwell, Euan J. Rodger, Oliver Eltherington, Ian M. Morison, Neil Christensen, Aniruddha Chatterjee, Merilyn Hibma
Summary: Papillomaviruses can lead to DNA methylation changes in cells, potentially increasing susceptibility to ultraviolet-induced cutaneous squamous cell carcinoma.
Article
Biochemistry & Molecular Biology
Miki Bundo, Junko Ueda, Yutaka Nakachi, Kiyoto Kasai, Tadafumi Kato, Kazuya Iwamoto
Summary: Bipolar disorder is characterized by repeated mood swings and associated with genetic factors, but the underlying molecular mechanisms and the influence of environmental factors remain largely unknown. This study analyzed DNA methylation in neuronal and non-neuronal nuclei in the prefrontal cortex of BD patients, revealing decreased DNA methylation at promoters in both cell types. Gene Ontology analysis showed enrichment of molecular motor-related genes in neurons, chemokines in both cell types, and ion channel- and transporter-related genes in nonneurons.
MOLECULAR PSYCHIATRY
(2021)
Article
Oncology
Fangfang Jian, FeiMing Huang, Yu-Hang Zhang, Tao Huang, Yu-Dong Cai
Summary: This research utilized machine learning methods to analyze methylation profiles in samples of anal and cervical carcinoma, selecting methylation features that are correlated with cancer progression. The study identified methylation signals associated with the development of these cancers, both qualitatively and quantitatively.
FRONTIERS IN ONCOLOGY
(2022)