Review
Biochemistry & Molecular Biology
Jing Xu, Min Li, Xinli Jiang, Yuling Wang, Huijie Ma, Yaru Zhou, Meimei Tian, Yan Liu
Summary: This review focuses on the role of oment-1 in diabetes, including its potential signaling pathways and the correlation between circulating oment-1 levels and diabetes and its complications. Studies have shown that oment-1 may exert its effects by inhibiting the NF-κB pathway and activating the Akt and AMPK-dependent pathways. Circulating oment-1 levels are negatively correlated with the occurrence of type 2 diabetes and some complications, and can be influenced by anti-diabetic therapies. Oment-1 could be a promising marker for screening and targeted therapy for diabetes and its complications, but further research is still needed.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Medicine, General & Internal
Teresa Quattrin, Lucy D. Mastrandrea, Lucy S. K. Walker
Summary: Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic beta cells, and individuals with this disease rely on insulin for survival. Despite advancements, the burden of this disease remains high. Research shows that blocking the immune attack on beta cells holds promise in preserving endogenous insulin production.
Article
Endocrinology & Metabolism
Leena Mamilly, Lucy D. Mastrandrea, Claudia Mosquera Vasquez, Brett Klamer, Mahmoud Kallash, Ahmad Aldughiem
Summary: Diabetic nephropathy is a common microvascular complication in type 1 diabetes mellitus. Urinary markers of renal damage or oxidative stress may signal early stages of DN, but their association with blood pressure patterns and glycemic variability in children is not yet well understood. This study found that while microalbuminuria was negative, urinary NGAL/Cr and pentosidine/Cr ratios were significantly elevated in diabetic patients. Additionally, poor nocturnal systolic blood pressure dipping was found in nearly half of the cases, and urinary NGAL/Cr negatively correlated with this dipping pattern. Both NGAL/Cr and pentosidine/Cr ratios were also higher in the high glycemic variability group. Overall, this pilot study highlights the potential role of ABPM and urinary markers in the early detection of diabetic nephropathy, with glycemic variability possibly playing a role in the disease process.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Food Science & Technology
Rizliya Visvanathan, Gary Williamson
Summary: This review evaluates the mechanisms by which citrus (poly)phenols affect markers of type 2 diabetes. Animal studies suggest that long-term effects are more significant than acute effects. Citrus (poly)phenol metabolites have notable effects on hepatic glucose metabolism and insulin sensitivity, but a modest effect on digestion and sugar absorption in the gut. In vitro studies often use unrealistically high concentrations and forms of compounds, compromising physiological relevance. Future research should consider concentration and the role of gut microbiota catabolites in the action of citrus (poly)phenols.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Adriana Leandro, Marcelo Queiroz, Lara Azul, Raquel Seica, Cristina M. Sena
Summary: The study demonstrates that omentin-1 has a positive impact on endothelial function and PVAT in non-obese type 2 diabetes mellitus animals, improving vascular relaxation, reducing oxidative stress, enhancing PVAT anti-contractile action, and alleviating pro-inflammatory status.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Endocrinology & Metabolism
Josie Carmichael, Hassan Fadavi, Mitra Tavakoli
Summary: This preliminary study found that structural and functional abnormalities in the nerve fiber layer of the retina and cornea occur in patients with type 1 diabetes without retinopathy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Immunology
Erin Strachan, Xavier Clemente-Casares, Sue Tsai
Summary: Maternal influences on the immune health and development of an infant begin in utero and continue after birth, shaping and educating the child's immune system. Two important provisions from the mother include early microbial colonizers and the transfer of antibodies. These provisions help educate the developing neonatal immune system, connecting with the microbiota and influencing disease development.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Kong Yen Liew, Nurain Irdayani Kamise, Hui Ming Ong, Poi Yi Aw Yong, Fahmida Islam, Ji Wei Tan, Chau Ling Tham
Summary: Allergic diseases are a global health burden, and the current available medications have side effects, poor perceived effectiveness, and high cost. Propolis, a natural herbal medicine with antioxidant, antimicrobial, and anticancer properties, has the potential to be a prophylactic or therapeutic option for allergic diseases. Preclinical studies have shown that propolis extracts have therapeutic effects on allergic inflammation, asthma, allergic rhinitis, atopic dermatitis, and food allergy by inhibiting mast cell and basophil activation. Clinically, propolis consumption as a supplement or adjunct therapy is safe and attenuates pathological conditions in asthma. Flavonoids and cinnamic acid derivatives in propolis contribute to its anti-allergic activities, but their presence varies in different propolis samples. Future studies should focus on the relationship between propolis's anti-allergic activity and its chemical contents.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Brittany S. Bruggeman, Martha Campbell-Thompson, Stephanie L. Filipp, Matthew J. Gurka, Mark A. Atkinson, Desmond A. Schatz, Laura M. Jacobsen
Summary: Access to human pancreas samples from organ donors has greatly advanced our understanding of type 1 diabetes pathogenesis. Substance use impacts the pancreata of donors with type 1 diabetes more than controls, resulting in higher rates of acute pancreatitis, chronic pancreatitis, and chronic exocrine changes in type 1 diabetes donors. Further study of the pathophysiology of these changes is needed.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Yan Chen, Qianrong Wang, Zhiguo Xie, Gan Huang, Li Fan, Xia Li, Zhiguang Zhou
Summary: The aim of this study was to investigate the impact of family history of type 2 diabetes (T2D) on the clinical phenotypes of patients with idiopathic type 1 diabetes (T1D). The results showed that idiopathic T1D patients with a family history of T2D were more likely to have features associated with T2D and better beta-cell function. The impact of T2D family history was consistently observed in idiopathic T1D patients regardless of HLA genotypes.
DIABETES OBESITY & METABOLISM
(2023)
Review
Cardiac & Cardiovascular Systems
Jing Cui, Yanfei Liu, Yiwen Li, Fengqin Xu, Yue Liu
Summary: T2DM and its complications, particularly myocardial infarction (MI), pose significant health risks globally. It is crucial to actively treat CAD in T2DM patients to reduce the risk of MI recurrence. The latest clinical evidence-based research emphasizes the relationship between T2DM and MI, highlighting the need for further investigation in this field.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Immunology
Sefina Arif, Clara Domingo-Vila, Emily Pollock, Eleni Christakou, Evangelia Williams, Timothy I. M. Tree
Summary: The increasing number of immunotherapeutic clinical trials in type 1 diabetes highlights the need for robust immune-monitoring assays to detect and characterize islet specific immune responses. Islet-specific T cells can serve as biomarkers for drug selection and patient stratification in future clinical trials. This review focuses on commonly used immune-monitoring techniques and discusses the potential of combining these with single cell transcriptional profiling to gain a deeper understanding of the underlying mechanisms.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Environmental Sciences
Pheerasak Assavanopakun, Ratana Sapbamrer, Sirinart Kumfu, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Air pollution poses a major threat to health, affecting cellular senescence and oxidative stress. Telomere length serves as a useful biomarker for early detection of health issues related to air pollution exposure. Different factors influence the association between telomere length and air pollution, with even low levels of exposure causing alterations.
ENVIRONMENTAL POLLUTION
(2022)
Review
Immunology
S. Alice Long, Jane H. Buckner
Summary: This review examines the current understanding of the etiology of Type 1 diabetes (T1D), focusing on the role of immune cells in the progression of the disease. It also highlights how this knowledge is driving the development of immunotherapies for the prevention and treatment of T1D.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Chandan Sona, Yu-Te Yeh, Andreas Patsalos, Laszlo Halasz, Xin Yan, Natalia L. Kononenko, Laszlo Nagy, Matthew N. Poy
Summary: Through single-cell RNA sequencing analysis, this study found increased CADM1(+) cells adjacent to CD8(+) T cells in the islets of individuals with T1D and those who were autoantibody-positive, indicating that CADM1-mediated intercellular contact may facilitate the infiltration of cytotoxic T lymphocytes and could serve as a potential therapeutic target for preventing T1D pathogenesis.
Article
Endocrinology & Metabolism
Jeroen H. P. M. van der Velde, Sebastiaan C. Boone, Esther Winters-van Eekelen, Matthijs K. C. Hesselink, Vera B. Schrauwen-Hinderling, Patrick Schrauwen, Hildo J. Lamb, Frits R. Rosendaal, Renee de Mutsert
Summary: This study found that the number of breaks in sedentary time was not associated with lower liver fat content or reduced insulin resistance. However, engaging in moderate-to-vigorous physical activity in the afternoon or evening was associated with a reduction of up to 25% in insulin resistance. Further research should investigate whether the timing of physical activity also plays an important role in the occurrence of type 2 diabetes.
Editorial Material
Biotechnology & Applied Microbiology
Yingfei Xue, Payam Akhyari, Bin Duan, Hooi Hooi Ng, Zongmin Zhao
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Letter
Hematology
Nicolas Stumpe, Tuba Gueden-Silber, Rebekka Schneckmann, Katharina Wolters, Hildo Lamb, Maria Grandoch, Ulrich Floegel
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Biology
Romana Perinajova, Concepcion Borras Alvarez-Cuevas, Joe Juffermans, Jos Westenberg, Hildo Lamb, Sasa Kenjeres
Summary: There is an urgent need to establish new biomarkers for predicting the development of thoracic aortic aneurysm. In addition to hemodynamics, the roles of oxygen and nitric oxide in the pathogenesis of thoracic aortic aneurysm are potentially significant. The relationship between aneurysm presence and species distribution in both the lumen and aortic wall needs to be understood. Computational fluid dynamics can be used to explore this relationship.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Endocrinology & Metabolism
Lushun Yuan, Ruifang Li-Gao, Aswin Verhoeven, Huub J. van Eyk, Maurice B. Bizino, Patrick C. N. Rensen, Martin Giera, Ingrid M. Jazet, Hildo J. Lamb, Ton J. Rabelink, Bernard M. van den Berg
Summary: This study aimed to investigate the association between changes in HDL composition and increased microvascular risk in individuals with type 2 diabetes mellitus. Differences in HDL composition were found between Dutch South Asian and Dutch white Caucasian individuals with diabetes, and these differences were associated with the incidence of microvascular complications. These HDL compositional differences could serve as ethnicity-specific biomarkers for type 2 diabetes.
DIABETES OBESITY & METABOLISM
(2023)
Article
Engineering, Biomedical
Alicia Fernandez-Colino, Fabian Kiessling, Ioana Slabu, Laura De Laporte, Payam Akhyari, Saskia K. Nagel, Julia Stingl, Stefanie Reese, Stefan Jockenhoevel
Summary: By studying the construction rules of living organisms, it is possible to develop biomimetic materials and biomedical systems. The article highlights recent advances in transformative biohybrid systems for tissue regeneration and biomedicine, as well as the progress in computational simulations and data-driven predictions. The ongoing development of imaging methods is also essential for validating computational models and enabling longitudinal monitoring. The challenges and future prospects of lifelike biohybrid materials are discussed.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Jose L. Gerardo-Nava, Jitske Jansen, Daniel Guenther, Laura Klasen, Anja Lena Thiebes, Bastian Niessing, Cedric Bergerbit, Anna A. Meyer, John Linkhorst, Mareike Barth, Payam Akhyari, Julia Stingl, Saskia Nagel, Thomas Stiehl, Angelika Lampert, Rudolf Leube, Matthias Wessling, Francesca Santoro, Sven Ingebrandt, Stefan Jockenhoevel, Andreas Herrmann, Horst Fischer, Wolfgang Wagner, Robert H. Schmitt, Fabian Kiessling, Rafael Kramann, Laura De Laporte
Summary: Recreating human tissues and organs in the petri dish to establish models as tools in biomedical sciences has gained momentum. Transformative materials play an important role in this evolution, as they can be programmed to direct cell behavior and fate. This paper illustrates state-of-the-art developments in in vitro tissue engineering and the challenges related to the design, production, and translation of transformative materials, emphasizing the need for convergence of different technologies to generate functional human tissue models.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Cardiac & Cardiovascular Systems
Payam Akhyari, Moritz Benjamin Immohr, Florian Boenner, Petra Reinecke, Artur Lichtenberg, Udo Boeken
Summary: The incidence of SARS-CoV-2 remains high in the population, leading to an increasing number of organ donors testing positive for the virus. However, heart transplants from SARS-CoV-2 positive donors have traditionally been rejected due to potential unnoticed cardiovascular effects. This study presents three consecutive patients who underwent heart transplants from SARS-CoV-2 positive donors and showed good outcomes without rejection, viral myocarditis, or SARS-CoV-2 infection.
Article
Cardiac & Cardiovascular Systems
Joe F. Juffermans, Jos J. M. Westenberg, Pieter J. van den Boogaard, Hildo J. Lamb
Summary: This case study examines the effects of aging on aortic hemodynamics and dilation. The results show that aging has marginal effects on aortic hemodynamic parameters and diameter. Furthermore, the study suggests that the rate of aortic dilation remains constant as individuals age.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Daniel Oehler, Hannah Oehler, Dennis Sigetti, Moritz Benjamin Immohr, Charlotte Boettger, Raphael Romano Bruno, Jafer Haschemi, Hug Aubin, Patrick Horn, Ralf Westenfeld, Florian Boenner, Payam Akhyari, Malte Kelm, Artur Lichtenberg, Udo Boeken
Summary: This study aimed to investigate the association between neurologic events during hospitalization and the outcome and survival of heart transplant recipients. The results showed that neurologic events after heart transplant were strongly associated with worse postoperative outcomes and reduced survival up to 5 years after transplant.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Editorial Material
Biology
Daniel Oehler, Charlotte Boettger, Moritz Benjamin Immohr, Raphael Romano Bruno, Jafer Haschemi, Daniel Scheiber, Patrick Horn, Hug Aubin, Igor Tudorache, Ralf Westenfeld, Payam Akhyari, Malte Kelm, Artur Lichtenberg, Udo Boeken
Correction
Surgery
Moritz Benjamin Immohr, Christina Ballazs, Vincent Hettlich, Dennis Sigetti, Daniel Scheiber, Florian Boenner, Ralf Westenfeld, Hug Aubin, Igor Tudorache, Payam Akhyari, Artur Lichtenberg, Udo Boeken
CLINICAL TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Yukiharu Sugimura, Moritz Benjamin Immohr, Arash Mehdiani, Udo Boeken, Hug Aubin, Artur Lichtenberg, Payam Akhyari
Summary: The purpose of this study was to investigate the effective strategy of Impella support for patients with postcardiotomy cardiogenic shock (PCCS) in order to achieve better clinical outcomes. A retrospective observational study was conducted on 31 PCCS patients who received Impella support, and the results showed that Impella support contributed to left ventricular remodeling and early initiation of Impella support was associated with a lower in-hospital mortality rate.
ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Tjerry Hut, Arno Roest, Duco Gaillard, Mark Hazekamp, Pieter van den Boogaard, Hildo Lamb, Lucia Kroft, Monique Jongbloed, Jos Westenberg, Jolanda Wentzel, Friso Rijnberg, Sasa Kenjeres
Summary: Virtual expansion of Fontan conduits from 16 mm to 24-32 mm based on patient-specific flow significantly improves TCPC efficiency, while thrombosis risk remains low.
INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Brigit M. Aarts, Fernando M. Gomez, Marta Lopez-Yurda, Rob F. M. Bevers, Joris Herndriks, Regina G. H. Beets-Tan, Axel Bex, Elisabeth G. Klompenhouwer, Rutger W. van der Meer
Summary: This study compared the safety and efficacy of radiofrequency ablation (RFA) and microwave ablation (MWA) for the treatment of renal cell carcinoma (RCC). The results showed similar primary efficacy rates and safety between RFA and MWA.
EUROPEAN RADIOLOGY
(2023)
