Article
Cardiac & Cardiovascular Systems
Jean Jacques Noubiap, Samuel J. Tu, Mehrdad Emami, Melissa E. Middeldorp, Adrian D. Elliott, Prashanthan Sanders
Summary: This study investigated the association between respiratory function and atrial fibrillation (AF). The findings showed that reduced forced expiratory volume (FEV1), forced vital capacity (FVC), and FEV1/FVC are associated with an increased risk of AF. The risk of AF consistently increased with decreasing FEV1 percentage predicted, FEV1 z score, and FVC z score. Those with airway obstruction and known chronic obstructive pulmonary disease and asthma also had an increased risk of AF.
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Muhammad Imtiaz Ahmad, Lin Y. Chen, Sanjay Singh, T. K. Luqman-Arafath, Hooman Kamel, Elsayed Z. Soliman
Summary: This study aimed to examine the joint associations of albuminuria and electrocardiographic left atrial abnormality (ECG-LAA) with incident atrial fibrillation (AF) and explore the racial differences in this relationship. The results showed that the concomitant presence of ECG-LAA and albuminuria was associated with a higher risk of AF, with a stronger association observed in black participants.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Su Nam Lee, Seung-Hyun Ko, Sung-Ho Her, Kyungdo Han, Donggyu Moon, Sung Kyoung Kim, Ki-Dong Yoo, Yu-Bae Ahn
Summary: This study investigated the association between lung function and atrial fibrillation. The results showed that reduced lung function was significantly associated with an increased risk of atrial fibrillation.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Kristin M. D'Silva, Sara Jane Cromer, Elaine W. Yu, Michael Fischer, Seoyoung C. Kim
Summary: This study found that compared to denosumab, treatment with zoledronic acid for osteoporosis and possibly malignancy-related bone disease is associated with a modestly increased risk of incident atrial fibrillation in the first year of treatment.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Jason D. Roberts, Eric Vittinghoff, Ake T. Lu, Alvaro Alonso, Biqi Wang, Colleen M. Sitlani, Pedrum Mohammadi-Shemirani, Myriam Fornage, Jelena Kornej, Jennifer A. Brody, Dan E. Arking, Honghuang Lin, Susan R. Heckbert, Ivana Prokic, Mohsen Ghanbari, Allan C. Skanes, Traci M. Bartz, Marco Perez, Kent D. Taylor, Steven A. Lubitz, Patrick T. Ellinor, Kathryn L. Lunetta, James S. Pankow, Guillaume Pare, Nona Sotoodehnia, Emelia J. Benjamin, Steve Horvath, Gregory M. Marcus
Summary: The study identified associations between epigenetic age acceleration measures and incident atrial fibrillation, indicating the importance of biological aging independent of chronological age. However, the potential underlying causal relationship remains unclear. These aging processes may be modifiable and not constrained by the immutable factor of time.
Article
Public, Environmental & Occupational Health
Ahmed Arafa, Yoshihiro Kokubo, Keiko Shimamoto, Rena Kashima, Emi Watanabe, Yukie Sakai, Jiaqi Li, Masayuki Teramoto, Haytham A. Sheerah, Kengo Kusano
Summary: This study investigated the association between stair climbing and the risk of atrial fibrillation (AF) in a Japanese population. The results showed that frequent stair climbing was associated with a reduced risk of AF, providing a simple way to reduce the risk of AF at the population level.
ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
(2022)
Article
Urology & Nephrology
Nisha Bansal, Leila R. Zelnick, Elsayed Z. Soliman, Amanda Anderson, Robert Christenson, Christopher DeFilippi, Rajat Deo, Harold Feldman, Jiang He, Bonnie Ky, John Kusek, James Lash, Stephen Seliger, Tariq Shafi, Myles Wolf, Alan S. Go, Michael G. Shlipak
Summary: In chronic kidney disease (CKD), increases in NT-proBNP were significantly associated with greater risk of incident HF and AF, and increases in sST2 were associated with HF. Further studies should investigate whether these markers of subclinical cardiovascular disease can be modified to reduce the risk of cardiovascular disease in CKD.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
So-Ryoung Lee, Eue-Keun Choi, Jin-Hyung Jung, Kyung-Do Han, Seil Oh, Gregory Y. H. Lip
Summary: This study found that patients with newly diagnosed atrial fibrillation who abstained from alcohol or were non-drinkers had a lower risk of ischemic stroke compared to current drinkers.
EUROPEAN HEART JOURNAL
(2021)
Article
Health Care Sciences & Services
Marina Shapkina, Andrey Ryabikov, Ekaterina Mazdorova, Anastasia Titarenko, Ekaterina Avdeeva, Elena Mazurenko, Lilia Shcherbakova, Hynek Pikhart, Martin Bobak, Sofia Malyutina
Summary: This study analyzed the determinants of the 13-year risk of incident atrial fibrillation (AF) in a Russian population cohort and found that the risk is positively associated with male sex, age, body mass index (BMI), and systolic blood pressure (SBP), and negatively associated with total cholesterol (TC). In women, the risk of AF is more strongly associated with hypertension (HT) and negatively related to total cholesterol (TC) level.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Utibe R. Essien, Megan E. McCabe, Kiarri N. Kershaw, Quentin R. Youmans, Michael J. Fine, Clyde W. Yancy, Sadiya S. Khan
Summary: The study found that individuals living in high poverty areas were more likely to develop atrial fibrillation, and those in intermediate poverty areas had a higher risk of AF compared to those in low poverty areas. This research helps understand the neighborhood-level drivers of AF disparities and works towards achieving equitable care.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Medicine, General & Internal
Ankit Maheshwari, Faye L. Norby, Riccardo M. Inciardi, Wendy Wang, Michael J. Zhang, Elsayed Z. Soliman, Alvaro Alonso, Michelle C. Johansen, Rebecca F. Gottesman, Scott D. Solomon, Amil M. Shah, Lin Yee Chen
Summary: This study evaluated the association between left atrial function and size and ischemic stroke, and determined whether these measures could improve the accuracy of stroke prediction using CHA(2)DS(2)-VASc score variables. The results showed that left atrial size and function were associated with ischemic stroke, and the cumulative incidence rates of severe left atrial enlargement were 2.99%, 3.18%, and 1.99% for left atrial reservoir, conduit, and contractile strain, respectively. Adding left atrial function measures to CHA(2)DS(2)-VASc score variables improved stroke prediction accuracy.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Zakaria Almuwaqqat, J. 'Neka S. Claxton, Faye L. Norby, Pamela L. Lutsey, Jingkai Wei, Elsayed Z. Soliman, Lin Y. Chen, Kunihiro Matsushita, Gerardo Heiss, Alvaro Alonso
Summary: In a study of community-dwelling older adults, central arterial stiffness, as measured by carotid femoral pulse wave velocity, was found to have a U-shaped association with the risk of atrial fibrillation.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Junguo Zhang, Anping Cai, Ge Chen, Xiaojie Wang, Miao Cai, Haitao Li, Steven E. Nissen, Gregory Y. H. Lip, Hualiang Lin
Summary: The effects of fish oil supplementation on the risk of atrial fibrillation (AF) are mixed, with no association found with genetic AF risk or background oily fish consumption. However, the supplementation is associated with an increased risk of incident AF in individuals without baseline cardiovascular disease (CVD).
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Gen-Min Lin, Donald M. Lloyd-Jones, Laura A. Colangelo, Moyses Szklo, Susan R. Heckbert, Lin Yee Chen, Joao A. C. Lima, Kiang Liu
Summary: The study found that higher levels of urine cotinine, a marker of secondhand tobacco smoke exposure, were associated with a 1.6-fold higher risk of incident atrial fibrillation in never smokers.
PROGRESS IN CARDIOVASCULAR DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Anthony L. Lin, Gregory Nah, Janet J. Tang, Eric Vittinghoff, Thomas A. Dewland, Gregory M. Marcus
Summary: The study conducted a longitudinal analysis of over 23 million patients in California, finding that the use of methamphetamine, cocaine, opiates, and cannabis were each associated with an increased risk of developing incident atrial fibrillation.
EUROPEAN HEART JOURNAL
(2022)
Article
Medicine, General & Internal
Ankit Maheshwari, Faye L. Norby, Riccardo M. Inciardi, Wendy Wang, Michael J. Zhang, Elsayed Z. Soliman, Alvaro Alonso, Michelle C. Johansen, Rebecca F. Gottesman, Scott D. Solomon, Amil M. Shah, Lin Yee Chen
Summary: This study evaluated the association between left atrial function and size and ischemic stroke, and determined whether these measures could improve the accuracy of stroke prediction using CHA(2)DS(2)-VASc score variables. The results showed that left atrial size and function were associated with ischemic stroke, and the cumulative incidence rates of severe left atrial enlargement were 2.99%, 3.18%, and 1.99% for left atrial reservoir, conduit, and contractile strain, respectively. Adding left atrial function measures to CHA(2)DS(2)-VASc score variables improved stroke prediction accuracy.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Hematology
Brian T. Steffen, James S. Pankow, Faye L. Norby, Pamela L. Lutsey, Ryan T. Demmer, Weihua Guan, Nathan Pankratz, Aixin Li, Guning Liu, Kunihiro Matsushita, Adrienne Tin, Weihong Tang
Summary: This study identified proteomic signatures and pathways related to 23 gene loci associated with abdominal aortic aneurysm (AAA). The results suggest that low levels of neogenin and kit ligand may be novel risk factors for AAA development.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Emilie K. Frimodt-Moller, John S. Gottdiener, Elsayed Z. Soliman, Jorge R. Kizer, Eric Vittinghoff, Bruce M. Psaty, Tor Biering-Sorensen, Gregory M. Marcus
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Xiaoming Jia, Mahmoud Al Rifai, Chiadi E. Ndumele, Salim S. Virani, James A. de Lemos, Emmanuel Lee, Amil M. Shah, Justin B. Echouffo-Tcheugui, Biykem Bozkurt, Ron Hoogeveen, Elizabeth Selvin, Christie M. Ballantyne, Vijay Nambi
Summary: This study evaluated the impact of incorporating cardiac biomarkers in reclassifying heart failure (HF) and assessed the prognosis of HF using these biomarkers. The results showed that approximately 1 in 5 older adults without prevalent HF were reclassified as Stage B HF, and the measurement of cardiac biomarkers can help identify individuals at higher HF risk.
JACC-HEART FAILURE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Rob F. Walker, Neil A. Zakai, Richard F. Maclehose, Faye L. Norby, Wendy Wang, Alvaro Alonso, Pamela L. Lutsey
Meeting Abstract
Cardiac & Cardiovascular Systems
Wendy Wang, Lin Y. Chen, Rob F. Walker, Alvaro Alonso, Faye L. Norby, Kamakshi Lakshminarayan, Pamela L. Lutsey
Article
Cardiac & Cardiovascular Systems
Harpriya S. Chugh, Arayik Sargsyan, Kotoka Nakamura, Audrey Uy-Evanado, Bernadine Dizon, Faye L. Norby, Christopher Young, Katy Hadduck, Jonathan Jui, Daniel Shepherd, Angelo Salvucci, Sumeet S. Chugh, Kyndaron Reinier
Summary: This study assessed the impact of COVID-19 on sudden cardiac arrest (SCA) and found that during the pandemic, SCA incidence increased significantly and survival rates decreased. Hispanics faced more difficulties in bystander CPR and resuscitation compared to non-Hispanics. Therefore, it is necessary to urgently evaluate and intervene in the acute care of SCA, especially among specific ethnic groups.
Article
Cardiac & Cardiovascular Systems
Muhammad Imtiaz Ahmad, Mai Z. Soliman, Elsayed Z. Soliman
Summary: The presence of premature ventricular complexes (PVCs) is associated with an increased risk of stroke mortality, particularly in individuals with coronary heart disease (CHD). Prospective studies are needed to investigate whether improved hospital care or modification of PVCs could improve outcomes.
JOURNAL OF ELECTROCARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jorge L. Reyes, Faye L. Norby, Yuekai Ji, Wendy Wang, Romil Parikh, Michael J. Zhang, Niki C. Oldenburg, Pamela L. Lutsey, Clifford R. Jack, Michelle Johansen, Rebecca F. Gottesman, Josef Coresh, Thomas Mosley, Elsayed Z. Soliman, Alvaro Alonso, Lin Yee Chen
Summary: Recent evidence suggests that abnormal P-wave parameters, which are electrocardiogram markers of atrial myopathy, are associated with incident dementia, independent of atrial fibrillation and clinical ischemic stroke. This study found that these abnormal P-wave parameters were associated with a higher prevalence of brain infarcts and microhemorrhage, indicating subclinical vascular brain injury as a possible mechanism underlying the association of atrial myopathy with dementia.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2023)
Article
Nutrition & Dietetics
Linzi Li, Pamela L. Lutsey, Lin Yee Chen, Elsayed Z. Soliman, Mary R. Rooney, Alvaro Alonso
Summary: Higher serum magnesium is associated with a lower risk of cardiovascular events, especially myocardial infarction, in patients with atrial fibrillation.
Article
Cardiac & Cardiovascular Systems
Lena Mathews, Xiao Hu, Ning Ding, Junichi Ishigami, Mahmoud Al Rifai, Ron C. C. Hoogeveen, Josef Coresh, Christie M. M. Ballantyne, Elizabeth Selvin, Kunihiro Matsushita
Summary: A study on 9205 participants from the ARIC study found that higher levels of GDF15 protein were associated with bleeding events and improved the prediction of bleeding risk in individuals without cardiovascular disease.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Biochemistry & Molecular Biology
Amir S. Heravi, Di Zhao, Erin D. Michos, Henrique Doria De Vasconcellos, Bharath Ambale-Venkatesh, Donald Lloyd-Jones, Pamela J. Schreiner, Jared P. Reis, James M. Shikany, Cora E. Lewis, Chiadi E. Ndumele, Eliseo Guallar, Pamela Ouyang, Ron C. Hoogeveen, Joao A. C. Lima, Wendy S. Post, Dhananjay Vaidya
Summary: This study investigated the association between oxidative stress and cardiovascular diseases, finding that female individuals had higher levels of oxidative stress. Furthermore, factors such as higher body mass index, lipid levels, smoking, and lack of physical activity were also associated with higher oxidative stress. This suggests that oxidative stress may play an important role in cardiovascular diseases.
Article
Public, Environmental & Occupational Health
Emily A. Groene, Faye L. Norby, Anne A. Eaton, Susan M. Mason, Eva A. Enns, Shalini Kulasingam, David M. Vock
Summary: Gonorrhea diagnosis is associated with pelvic inflammatory disease, ectopic pregnancy, and tubal factor infertility in women, and this association has not changed in recent years.
JOURNAL OF WOMENS HEALTH
(2023)
Article
Medicine, General & Internal
Wendy Wang, Lin Yee Chen, Rob F. Walker, Lisa S. Chow, Faye L. Norby, Alvaro Alonso, James S. Pankow, Pamela L. Lutsey
Summary: The objective of this study was to assess the association between SGLT2 inhibitors and other second-line diabetes therapies with the risk of cardiovascular disease (CVD) and conduct head-to-head comparisons between SGLT2 inhibitors. Using data from the MarketScan databases, SGLT2 inhibitor users were matched with other second-line therapy users. The results showed that SGLT2 inhibitors were associated with a lower risk of CVD compared to other second-line therapies. No significant differences were found when comparing individual SGLT2 inhibitors.
MAYO CLINIC PROCEEDINGS
(2023)