Article
Biochemistry & Molecular Biology
Jae-Sung Kim, Euni Cho, Seok-Jun Mun, Sojin Kim, Sun-Young Kim, Dong-Gyu Kim, Wooic Son, Hye-In Jeon, Hyo-Keun Kim, Young-Jin Jeong, Sein Jang, Hyun-Sung Kim, Chul-Su Yang
Summary: The study showed that rMPT can interact with important host proteins, regulate the immune system, and combat Mycobacterium tuberculosis, making it a potential effective vaccine or therapeutic agent.
Article
Pharmacology & Pharmacy
Eri Wakai, Kenji Ikemura, Toshiro Mizuno, Kazuhiko Takeuchi, Satoshi Tamaru, Masahiro Okuda, Yuhei Nishimura
Summary: The proton pump inhibitor lansoprazole (LPZ) has been found to reduce the ototoxicity caused by cisplatin (CDDP) by inhibiting the organic cation transporter OCT2. In vivo fluorescence imaging of zebrafish hair cells confirmed this hypothesis, and retrospective studies on human patients showed a significant decrease in ototoxicity incidence in those co-treated with LPZ. These findings suggest that LPZ may protect against CDDP-induced ototoxicity.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Haru Yamamoto, Yusuke Ichikawa, Shin-ichi Hirano, Bunpei Sato, Yoshiyasu Takefuji, Fumitake Satoh
Summary: Mibyou refers to pre-symptomatic diseases where a disease is slowly developing within the body yet the symptoms are not apparent. Molecular hydrogen (H-2) has been shown to treat chronic inflammation by eliminating oxidative stress, showing potential as a protective agent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Endeshaw Chekol Abebe, Tadesse Asmamaw Dejenie
Summary: Neutralizing antibodies (NAbs) play a central role in the immune response against SARS-CoV-2 by neutralizing viral antigens and collaborating with immune cells to combat the virus. They have various clinical applications, including COVID-19 diagnosis, severity evaluation, prognosis assessment, and identification of suitable plasma donors. However, their use in clinical settings can present challenges. This review discusses the functions, mechanisms, and clinical applications of NAbs, as well as the challenges and solutions associated with antibody-based prophylaxis, therapy, and vaccination in COVID-19.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rumyana Simeonova, Dimitrina Zheleva, Iva Valkova, Georgi Stavrakov, Irena Philipova, Mariyana Atanasova, Irini Doytchinova
Summary: The study introduces a novel hybrid compound, a non-toxic AChE inhibitor with high antioxidant activity, which shows promising potential as a prospective drug candidate for the treatment of neurodegenerative disorders in mouse models.
Article
Environmental Sciences
Nidhi Kandhol, Bharti Aggarwal, Ruchi Bansal, Nishat Parveen, Vijay Pratap Singh, Devendra Kumar Chauhan, Humira Sonah, Shivendra Sahi, Renato Grillo, Jose Peralta-Videa, Rupesh Deshmukh, Durgesh Kumar Tripathi
Summary: Technological and industrial advancements in the past decades have led to a significant decline in environmental and ecosystem quality due to the continuous release of pollutants. Arsenic is a hazardous metal that contaminates the environment and can cause critical diseases in humans and toxicity in plants even in small quantities. Recent studies suggest that nanoparticles can effectively mitigate arsenic-induced phytotoxicity by promoting plant growth through various physiological, biochemical, and molecular alterations.
ENVIRONMENTAL POLLUTION
(2022)
Review
Integrative & Complementary Medicine
Danijela Paunovic, Jovana Rajkovic, Radmila Novakovic, Jelica Grujic-Milanovic, Reham Hassan Mekky, Dragos Popa, Daniela Calina, Javad Sharifi-Rad
Summary: Gossypol, derived from cottonseed plants, has shifted from a male contraceptive to a potential cancer therapy. It inhibits Bcl-2 family of anti-apoptotic proteins, promoting apoptosis in tumor cells. Clinical trials have shown its promise as an anticancer agent, but further research is needed to enhance its efficacy.
Review
Environmental Sciences
Jae Hyeon Park, Byung Mu Lee, Hyung Sik Kim
Summary: Curcumin, a compound found in turmeric, has beneficial effects against heavy metal-induced organ toxicity by targeting biological pathways involved in anti-oxidation, anti-inflammation, and anti-tumorigenesis. It scavenges ROS and inhibits oxidative damage, providing potential therapeutic properties.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS
(2021)
Article
Spectroscopy
Xiaodi Kou, Xingying Li, Chengting Hu, Juanjuan Liu, Yuhong Chen, Yang Zhang, Aihong Yang, Rui Shen
Summary: Metal ions play a crucial role in the pathogenesis of Alzheimer's disease. A highly selective and sensitive multifunctional fluorescence sensor has been synthesized, which has the potential to regulate metal ion homeostasis, reduce Aβ accumulation, and eliminate oxidative stress, showing promise as a theranostic agent.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Medicine, Research & Experimental
Emanuel Paula Magalhaes, Brenna Pinheiro Silva, Natalia Luna Aires, Lyanna Rodrigues Ribeiro, Arif Ali, Mariana Maciel Cavalcanti, Joao Victor Serra Nunes, Tiago Lima Sampaio, Ramon Roseo Paula Pessoa Bezerra de Menezes, Alice Maria Costa Martins
Summary: This study evaluated the protective effect of α-bisabolol (BIS) against amphotericin B (AmB)-induced nephrotoxicity. BIS pretreatment increased cell viability, inhibited cell death, reduced reactive oxygen species (ROS) accumulation, improved mitochondrial function, and prevented kidney injury molecule-1 (KIM-1) release. These findings suggest that BIS has potential as a nephroprotective agent.
Article
Biochemistry & Molecular Biology
Malathi Balasubramaniyan, Mona Santhanam, Vimalraj Vinayagam, Kaliraj Perumal
Summary: This study aimed to enhance the immune efficacy of filarial antigens using chitosan nanoparticles (CN) through oral immunization. The results showed that oral immunization could produce enhanced humoral response and balanced antibody isotype response, and increase the immune efficacy of the antigens in mice.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Lin Yue, Zhouping Wang, Meihong Zheng, Min Wang, Imran Mahmood Khan, Xiaowei Ding, Yin Zhang
Summary: In this study, Hydroxypropyl chitosan was used as a carrier of the photosensitizer chlorin e6 to develop a photodynamic antibacterial agent with good water solubility, high biocompatibility, and antibacterial activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Food Science & Technology
Rebeca Andre, Rita Pacheco, Mafalda Bourbon, Maria Luisa Serralheiro
Summary: Brown algae have been a part of human diet for centuries, but in recent years, there has been increased commercial and scientific interest in them due to the growing demand for healthier diets globally. Brown algae and their metabolites have been linked to various beneficial health effects, including cardiovascular diseases, which are a major cause of death in Europe, as high blood cholesterol levels are a major cardiovascular risk factor.
Article
Biochemistry & Molecular Biology
Dingwu Qu, Fengting Sun, Saisai Feng, Leilei Yu, Fengwei Tian, Hao Zhang, Wei Chen, Qixiao Zhai
Summary: The study compared the anti-inflammatory effects of six Bacteroides fragilis strains on systemic inflammation, finding strain-specific in vitro anti-inflammatory effects with certain strains inducing higher colon SCFAs in vivo and IL-10 production in vitro. Comparative genomic analysis revealed that SCFA-inducing strains possess genes related to carbohydrate metabolism and transportation, while IL-10-inducing strains share a highly similar gene structure.
Article
Chemistry, Multidisciplinary
Farhang Aliakbari, Hossein Mohammad-Beigi, Shahsanam Abbasi, Nasrollah Rezaei-Ghaleh, Frederik Lermyte, Soha Parsafar, Stefan Becker, Azita Parvaneh Tafreshi, Peter B. O'Connor, Joanna F. Collingwood, Gunna Christiansen, Duncan S. Sutherland, Poul Henning Jensen, Dina Morshedi, Daniel E. Otzen
Summary: Incorporation of baicalein into zwitterionic nanoliposomes successfully addresses the stability and solubility issues, making NLP-Ba effective in inhibiting alpha-synuclein fibrillation associated with Parkinson's disease. This nanosystem shows potential neuroprotective effects and could be a promising therapeutic option against PD.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Applied
Gaurav Rajauria, Rajeev Ravindran, Marco Garcia-Vaquero, Dilip K. Rai, Torres Sweeney, John O'Doherty
Summary: This study aimed to determine the effect of hydrothermal-assisted extraction and a multi-step purification process on the molecular characteristics and antioxidant activity of laminarin extracts from brown seaweed. The optimized extraction conditions were found to be effective in recovering biologically active laminarin, while the purification process reduced the antioxidant activity compared to crude extract.
FOOD HYDROCOLLOIDS
(2021)
Article
Chemistry, Medicinal
Stafford Vigors, John O'Doherty, Ruth Rattigan, Torres Sweeney
Summary: Supplementation with laminarin and fucoidan enriched seaweed extracts did not have significant effects on animal performance, but had positive influences on intestinal health through alterations in the gastrointestinal microbiome and increased butyrate production.
Article
Chemistry, Medicinal
Marco Garcia-Vaquero, Gaurav Rajauria, Marta Miranda, Torres Sweeney, Marta Lopez-Alonso, John O'Doherty
Summary: The study aimed to determine the chemical, phytochemical, fatty acid and mineral profiles of three commercially relevant brown macroalgae collected off the west coast of Ireland over two years. Results showed significant variations in these profiles depending on the macroalgal species, season and year of collection. The findings indicate that protein content in the macroalgae was negatively correlated with carbohydrate content, with protein levels peaking in winter and/or spring and decreasing in summer and/or autumn.
Article
Agriculture, Dairy & Animal Science
B. Venardou, J. O'Doherty, S. Vigors, C. J. O'Shea, E. J. Burton, M. T. Ryan, T. Sweeney
Summary: The study showed that supplementing broiler chicken feed with 300 ppm laminarin significantly increased final body weight, average daily weight gain, and daily feed intake, while also promoting the relative and absolute abundance of Bifidobacterium in the caecum.
Review
Agriculture, Dairy & Animal Science
Eadaoin Conway, Torres Sweeney, Alison Dowley, Shane Maher, Gaurav Rajauria, Supriya Yadav, Jude Wilson, William Gabrielli, John V. O'Doherty
Summary: The study found that supplementing weaned pigs with mushroom powder and vitamin D-2 enriched mushroom powder had no significant impact on growth performance and fecal scores within 35 days post-weaning. However, supplementation of mushroom powder and MPD2 resulted in reduced feed intake, while zinc oxide supplementation increased growth rate and feed intake.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2022)
Article
Chemistry, Analytical
Jamie Cafferky, Raquel Cama-Moncunill, Torres Sweeney, Paul Allen, Andrew Cromie, Ruth M. Hamill
Summary: The objective of this study was to investigate the application of Raman spectroscopy in predicting sensory quality in beef. The study found that Raman spectra can accurately predict sensory traits such as tenderness, metallic flavor, fatty after-effect, and juiciness. Mathematical spectral pre-treatments improve the predictive accuracy of the models. This study provides a non-destructive method to calibrate valuable quality traits in beef using Raman spectra collected at a specific time point compatible with meat management systems.
Article
Agriculture, Dairy & Animal Science
Eadaoin Conway, Torres Sweeney, Alison Dowley, Stafford Vigors, Marion Ryan, Supriya Yadav, Jude Wilson, John O'Doherty
Summary: This study aimed to investigate the effects of different selenium inclusion levels on post-weaning growth performance, intestinal health, and antioxidant capacity in pigs. The results showed that supplementation with 0.3 SeMP had positive effects on faecal scores and pig performance in Period 1, while the addition of 0.3 ppm selenite to 0.3 SeMP (0.6 SeMP/Sel) in Period 2 led to enhanced pig performance and gastrointestinal health.
Article
Genetics & Heredity
Qiaowei Li, Liyuan Wang, Kai Xing, Yalan Yang, Adeyinka Abiola Adetula, Yuwen Liu, Guoqiang Yi, Hongfu Zhang, Torres Sweeney, Zhonglin Tang
Summary: This study compared the spatio-temporal expression pattern of circRNAs between different adipose deposition breeds in pigs. It identified circRNAs involved in the regulation of adipogenesis and analyzed the interaction between circRNAs and miRNAs. The study revealed important circRNAs and their target genes enriched in fatty acid biosynthesis, fatty acid metabolism, and Wnt/TGF-beta signaling pathways. These findings provide valuable insights into the molecular mechanism of circRNAs in pig adipose biology.
Article
Food Science & Technology
Aidan P. Moloney, Shane McGettrick, Peter G. Dunne, Kevin J. Shingfield, Robert Ian Richardson, Frank J. Monahan, Finbar J. Mulligan, Marion Ryan, Torres Sweeney
Summary: Beef contains conjugated linoleic acid (CLA) isomers with positive effects on human health. Developing a CLA-enriched beef production system and adding CLA to the diet can increase the CLA concentration in beef without negatively affecting its quality and sensory characteristics.
Review
Agriculture, Dairy & Animal Science
Dillon P. Kiernan, John V. O'Doherty, Torres Sweeney
Summary: The gastrointestinal tract microbiota plays a crucial role in animal health and performance. Modulating the maternal microbiota by supplementing probiotics or synbiotics in the diet can improve the health and development of the offspring. This review discusses the importance and mechanisms of action for maternal probiotic and synbiotic supplementation and summarizes key findings from studies in pigs.
Review
Agriculture, Dairy & Animal Science
Dillon P. Kiernan, John V. O'Doherty, Torres Sweeney
Summary: Establishing a balanced and diverse microbiota in the gastrointestinal tract (GIT) is crucial for optimizing health and performance in pigs throughout the production cycle. The post-weaning period is a critical phase associated with dysbiosis, intestinal dysfunction, and poor performance. Prebiotics, as a class of bioactive compounds, can be utilized by beneficial microbes in the GIT to enhance their proliferation and production of health-promoting metabolites, while suppressing the growth of pathogenic bacteria. There are various types of prebiotics, including carbohydrates such as non-digestible oligosaccharides, beta-glucans, resistant starch, and inulin. This review aims to characterize different prebiotics, discuss the concept of stimbiotics, and outline how supplementation of prebiotics at different stages of pig development and production can modulate the GIT microbiota and improve animal health and performance.
Article
Veterinary Sciences
Dillon P. Kiernan, John V. O'Doherty, Kathryn Ruth Connolly, Marion Ryan, Torres Sweeney
Summary: This experiment explored the differential expression of key genes within the three glandular regions of the stomach in weaned pigs. Unique gene expression signatures were identified in each region, with a transition region between the cardiac and fundic region clearly identifiable.
VETERINARY SCIENCES
(2023)