Article
Immunology
Xiao Wu, Runfeng Li, Yunceng Weng, Hongxia Zhou, Haiming Jiang, Jin Zhao, Bin Liu, Ruifeng Chen, Xinxin Chen, Weimin Yang, Zifeng Yang, Xinhua Wang
Summary: Primary influenza virus infection can predispose hosts to secondary infection with Haemophilus influenzae, which increases disease severity and mortality. Sequential infection with influenza A virus and Haemophilus influenzae induced lethal synergy in a mouse model, possibly due to increased bacterial loads and lung damage. Analysis showed a correlation between specific adhesion molecules and bacterial growth in secondary pneumonia following primary viral infection.
MICROBES AND INFECTION
(2021)
Article
Multidisciplinary Sciences
Seol Hwa Seo, Dasung Lee, Soung-Hoon Lee, Kang-Yell Choi
Summary: Obesity is closely associated with metabolic diseases, and the Wnt/beta-catenin signaling pathway plays a crucial role in adipogenesis and obesity. Inhibiting the interaction of CXXC5 and Dvl to activate this pathway may be a potential therapeutic approach for treating obesity and insulin resistance.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Christopher Mendoza, Dario Mizrachi
Summary: Decades of evidence suggest that alterations in cell adhesion properties contribute to the invasive and migratory phenotype of neoplastic cells. The role of tight junction proteins in the tumor microenvironment is crucial. Reprogramming immune cells using CAR-T cells to target and eliminate tumors has been approved as a therapy. Researchers have developed a new biologic that specifically targets cancer cells and reduces proliferation and metastasis.
Article
Medicine, Research & Experimental
Qian Wu, Rui Li, Qing-Xiang Wang, Meng-Yu Zhang, Ting-Ting Liu, Yi-Qing Qu
Summary: Our study revealed the oncogenic role of JAML in LUAD, showing that elevated JAML expression is positively correlated with pT and pTNM. Silencing JAML significantly inhibited malignant behaviors of LUAD cells, induced cell cycle arrest at G(0)/G(1) phase, and promoted apoptosis, possibly through inactivation of the Wnt/beta-catenin pathway in LUAD cells. Rescue experiments confirmed the effects of JAML could be reversed by Wnt/beta-catenin pathway activator in A549 cells. This suggests that JAML may serve as a predictive biomarker and potential therapeutic target for LUAD.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Mate Kiss, Els Lebegge, Aleksandar Murgaski, Helena Van Damme, Daliya Kancheva, Jan Brughmans, Isabelle Scheyltjens, Ali Talebi, Robin Maximilian Awad, Yvon Elkrim, Pauline M. R. Bardet, Sana M. Arnouk, Cleo Goyvaerts, Johan Swinnen, Frank Aboubakar Nana, Jo A. Van Ginderachter, Damya Laoui
Summary: This study found that cancer-associated inflammation can enhance the expression of JAM-A on circulating monocytes, but the function of JAM-A in tumor-infiltrating myeloid cells is little understood. Through gene knockout mouse experiments and RNA sequencing, we found that JAM-A is dispensable for the recruitment and transcriptional reprogramming of myeloid cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Integrative & Complementary Medicine
Qian Wu, Yong-bin Wang, Xiao-wen Che, Hui Wang, Wei Wang
Summary: JAML protein is an oncogenic protein in lung adenocarcinoma (LUAD) and may serve as a novel therapeutic target. The flavonoid kaempferol inhibits JAML, leading to suppression of proliferation, migration, and invasion of LUAD cells, and partially inhibits epithelial-mesenchymal transition (EMT) through the PI3K/AKT/mTOR pathway. These findings suggest that JAML is a new target for kaempferol in LUAD cells.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2023)
Article
Oncology
Miki Yamaguchi, Sachie Hirai, Masashi Idogawa, Toshiyuki Sumi, Hiroaki Uchida, Naoki Fujitani, Motoko Takahashi, Yuji Sakuma
Summary: There is a need for novel and effective treatments for small cell lung carcinoma (SCLC). This study investigated the use of an antibody-drug conjugate (ADC) targeting junctional adhesion molecule 3 (JAM3) as a potential therapy for SCLC. The results showed that JAM3 mRNA was expressed at higher levels in SCLC cell lines and tissues compared to lung adenocarcinoma. The ADC specifically targeting JAM3 exhibited dose- and time-dependent antitumor effects on SCLC cells. Silencing JAM3 alone suppressed the growth of SCLC cells. These findings suggest that targeting JAM3 with an ADC could be a promising approach for treating SCLC.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Reproductive Biology
Chie-Pein Chen, Liang-Kai Wang, Chen-Yu Chen, Chia-Yu Chen, Yi-Hsiu Kuo, Yi-Hsin Wu
Summary: The protein JAM3 is involved in the structure and regulation of placental cells, affecting their fusion, differentiation, proliferation, apoptosis, and motility. Dysregulation of JAM3 expression is crucial in the development of preeclampsia.
BIOLOGY OF REPRODUCTION
(2022)
Article
Biochemistry & Molecular Biology
Yuki Shimba, Rena Senda, Keigo Katayama, Akihito Morita, Masahiko Ikeda, Yasutomi Kamei, Shinji Miura
Summary: The research demonstrates that inducing the expression of FOXO-1 in skeletal muscle can suppress the progression of atherosclerosis in ApoE-KO mice, reducing vascular cell adhesion molecule-1 and macrophage infiltration.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Yuying Fang, Jianmin Yang, Guohong Zu, Changsheng Cong, Shuai Liu, Fei Xue, Shuzhen Ma, Jie Liu, Yuping Sun, Meili Sun
Summary: JAML, a newly discovered junctional adhesion molecule, plays a critical role in promoting gastric cancer cell migration and proliferation, potentially serving as a novel diagnostic biomarker and therapeutic target for gastric cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Catherine M. Davis, Wenri H. Zhang, Elyse M. Allen, Thierno M. Bah, Robert E. Shangraw, Nabil J. Alkayed
Summary: This study found that tAUCB administered after ischemic stroke onset provides brain protection in non-diabetic mice but not in diabetic mice, and the neuroprotection seems to be independent of changes in gross CBF. Furthermore, DM2-induced hyperglycemia abolishes t-AUCB-mediated neuroprotection after stroke onset.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Miguel S. Marques, Ana C. Costa, Hugo Osorio, Marta L. Pinto, Sandra Relvas, Mario Dinis-Ribeiro, Fatima Carneiro, Marina Leite, Ceu Figueiredo
Summary: Helicobacter pylori infects approximately half of the world's population and is a major risk factor for peptic ulcer disease and gastric cancer. It disrupts epithelial integrity by targeting the junctional adhesion molecule-A (JAM-A) and uses a unique strategy to do so. This study identified PqqE (HP1012) as the virulence factor responsible for cleaving JAM-A, providing new insights into the pathogenesis of this infection.
Article
Neurosciences
Jonathan D. Drake, Alison B. Chambers, Brian R. Ott, Lori A. Daiello
Summary: The study found that plasma-based vascular biomarkers, particularly VCAM-1 and ICAM-1, were associated with Alzheimer's disease (AD) and clinical impairment. VCAM-1 was linked with clinical dementia rating sum-of-boxes (CDR-SB) scores, with the APOE epsilon 4 genotype modifying this relationship. Additionally, combining VCAM-1 and cerebrospinal fluid (CSF) biomarkers showed independent associations with AD-related clinical impairment.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Cell Biology
Marlon R. Schneider, Silja Zettler, Birgit Rathkolb, Maik Dahlhoff
Summary: TXNIP deficiency promotes beta cell survival, while overexpression of TXNIP can lead to increased blood glucose levels, impaired glucose tolerance, and worsen the severity of type 1 diabetes.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Wei Gu, Xing Wang, Huanfen Zhao, Jianlin Geng, Xiaolong Li, Kunjie Zheng, Yunpeng Guan, Xiaoyu Hou, Chao Wang, Guangyao Song
Summary: Diabetic kidney disease is a common complication of diabetes, and lipid deposits in the kidneys contribute to kidney damage. This study found that abnormal lipid metabolism is closely related to diabetic kidney disease in patients. Additionally, the administration of resveratrol in mice with high-fat diet-induced renal abnormalities reduced lipid deposition, improved renal function, and regulated lipid synthesis pathways.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sarah Garrido-Urbani, Alain Vonlaufen, Jimmy Stalin, Maria De Grandis, Patricia Ropraz, Stephane Jemelin, Florence Bardin, Holger Scheib, Michel Aurrand-Lions, Beat A. Imhof
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2018)
Article
Immunology
Silvia Tietz, Therese Perinat, Gretchen Greene, Gaby Enzmann, Urban Deutsch, Ralf Adams, Beat Imhof, Michel Aurrand-Lions, Britta Engelhardt
BRAIN BEHAVIOR AND IMMUNITY
(2018)
Article
Immunology
Edith Hintermann, Monika Bayer, Clara Benedetta Conti, Sina Fuchs, Michel Fausther, Patrick S. Leung, Michel Aurrand-Lions, Richard Taubert, Josef M. Pfeilschifter, Mireen Friedrich-Rust, Detlef Schuppan, Jonathan A. Dranoff, M. Eric Gershwin, Michael P. Manns, Beat A. Imhof, Urs Christen
JOURNAL OF AUTOIMMUNITY
(2018)
Article
Biochemistry & Molecular Biology
Madalina Viviana Nastase, Jinyang Zeng-Brouwers, Janet Beckmann, Claudia Tredup, Urs Christen, Heinfried H. Radeke, Malgorzata Wygrecka, Liliana Schaefer
Article
Biochemistry & Molecular Biology
Itamar Goren, Urs Christen, Josef Pfeilschifter, Stefan Frank
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2018)
Review
Biochemistry & Molecular Biology
Michel Aurrand-Lions, Stephane J. C. Mancini
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Editorial Material
Biochemistry & Molecular Biology
Geoffrey Brown, Rhodri Ceredig
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Letter
Oncology
Maria De Grandis, Stephane J. C. Mancini, Norbert Vey, Michel Aurrand-Lions
Editorial Material
Immunology
U. Christen
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2019)
Article
Immunology
Wenyan He, Stephan Holtkamp, Sophia Martina Hergenhan, Kerstin Kraus, Alba de Juan, Jasmin Weber, Paul Bradfield, Julien Martin Pierre Grenier, Jeoffrey Pelletier, David Druzd, Chien-Sin Chen, Louise Madeleine Ince, Susanne Bierschenk, Robert Pick, Markus Sperandio, Michel Aurrand-Lions, Christoph Scheiermann
Article
Cardiac & Cardiovascular Systems
Muriel G. Blin, Richard Bachelier, Karim Fallague, Karima Moussouni, Michel Aurrand-Lions, Samantha Fernandez, Benjamin Guillet, Stephane Robert, Alexandrine Foucault-Bertaud, Nathalie Bardin, Marcel Blot-Chabaud, Francoise Dignat-George, Aurelie S. Leroyer
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2019)
Article
Cell Biology
Marielle Balzano, Maria De Grandis, Thien-Phong Vu Manh, Lionel Chasson, Florence Bardin, Anne Farina, Arnauld Serge, Ghislain Bidaut, Pierre Charbord, Leonard Herault, Anne-Laure Bailly, Amandine Cartier-Michaud, Annie Boned, Marc Dalod, Estelle Duprez, Paul Genever, Mark Coles, Marc Bajenoff, Luc Xerri, Michel Aurrand-Lions, Claudine Schiff, Stephane J. C. Mancini
Review
Cell Biology
Edith Hintermann, Urs Christen
Article
Biochemistry & Molecular Biology
Katja B. Kostelnik, Amy Barker, Christopher Schultz, Tom P. Mitchell, Vinothini Rajeeve, Ian J. White, Michel Aurrand-Lions, Sussan Nourshargh, Pedro Cutillas, Thomas D. Nightingale
Article
Medicine, Research & Experimental
Channakeshava Sokke Umeshappa, Jacques Mbongue, Santiswarup Singha, Saswat Mohapatra, Jun Yamanouchi, Justin A. Lee, Roopa Hebbandi Nanjundappa, Kun Shao, Urs Christen, Yang Yang, Kristofor K. Ellestad, Pere Santamaria
JOURNAL OF CLINICAL INVESTIGATION
(2020)