Article
Nutrition & Dietetics
Matthew Stefan, Matthew Sharp, Raad Gheith, Ryan Lowery, Charlie Ottinger, Jacob Wilson, Shane Durkee, Aouatef Bellamine
Summary: The study indicates that L-carnitine tartrate supplementation can improve short-term recovery among athletes, while longer-term effects in the general population need further research. The experiment found that L-carnitine tartrate supplementation for 5 weeks could enhance perceived recovery and reduce soreness, as well as lower serum creatine kinase levels.
Article
Psychiatry
Yuichi Inoue, Makoto Uchiyama, Hideo Umeuchi, Koichi Onishi, Hiroki Ogo, Iwao Kitajima, Isao Matsushita, Izumi Nishino, Naohisa Uchimura
Summary: The optimal dose of Enserisant for narcolepsy treatment could not be determined in these two studies. Although there were some indications of efficacy, the doses were not well tolerated and adverse events were reported.
Article
Pediatrics
Manish Narang, Dheeraj Shah
Summary: This study confirms that oral lactase can effectively alleviate symptoms of infantile colic, reduce crying time, and improve parental satisfaction.
Article
Clinical Neurology
Ahmad Shamabadi, Farnaz Kafi, Melika Arab Bafrani, Hassan Asadigandomani, Fatemeh A. Basti, Shahin Akhondzadeh
Summary: This study found that adjunctive L-theanine, when combined with sertraline, showed better efficacy in treating major depressive disorder (MDD) compared to placebo. The L-theanine group demonstrated significant improvement in depression symptoms and a greater reduction in depression scores compared to the placebo group at weeks 2, 4, and 6. Furthermore, the L-theanine group had higher remission and response rates at week 6. These findings suggest that L-theanine is a safe and effective adjunctive therapy for MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Pharmacology & Pharmacy
Priyam Singh, Khushtar Anwar Salman, Mohammad Shameem, Mohd Sharib Warsi
Summary: This study demonstrated the clinical efficacy of Withania somnifera (WS) root as an add-on therapy for COPD patients, significantly improving lung function, quality of life, exercise tolerance, and reducing inflammation. Withanolides found in WS root showed inhibitory activity against the SARS-CoV-2 receptor and proteins associated with inflammation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Maxwell J. Roeske, Maureen Mchugo, Baxter Rogers, Kristan Armstrong, Suzanne Avery, Manus Donahue, Stephan Heckers
Summary: This study found that patients with schizophrenia have hippocampal hyperactivity and the drug levetiracetam may be able to regulate hippocampal activity. Neuroimaging methods can be used to study the regulation of hippocampal hyperactivity, but not all methods are suitable. Further research is needed to establish levetiracetam as a treatment for schizophrenia.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Steven T. Szabo, Seth C. Hopkins, Robert Lew, Antony Loebel, Thomas Roth, Kenneth S. Koblan
Summary: This study evaluated the acute and sustained effects of Ulotaront on REM sleep and symptoms in subjects with narcolepsy-cataplexy. The results showed that Ulotaront can reduce nighttime REM duration and the number of short-onset REM periods during the day, but the efficacy in narcolepsy-cataplexy patients was not significant.
Article
Endocrinology & Metabolism
Chao-Hsu Lin, Chien-Yu Lin, Yi-Hsiang Sung, Sung-Tse Li, Bi-Wen Cheng, Shun-Long Weng, Shing-Jyh Chang, Hung-Chang Lee, Yann-Jinn Lee, Wei-Hsin Ting, Hung-Yang Chang, Yi-Lei Wu, Chih-Sheng Lin
Summary: Breastfed infants are at risk of vitamin D deficiency, and oral supplementation of vitamin D can increase vitamin D levels but does not significantly affect bone mineral density.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Integrative & Complementary Medicine
Xuedong An, Bo Peng, Xiaodong Huang, Hongmei Jiang, Zhang'e Xiong, Hong Zhang, Fengmei Lian, Yuanming Ba, Xiaolin Tong
Summary: The study suggests that Ludangshen oral liquid treatment for two weeks may have certain effects on improving digestive and respiratory symptoms in convalescent COVID-19 patients, including fatigue, anorexia, loose stools, and shortness of breath.
Article
Biochemistry & Molecular Biology
Stephen A. Harrison, Federico Perez Manghi, William B. Smith, Diana Alpenidze, Diego Aizenberg, Naomi Klarenbeek, Chi-Yi Chen, Eli Zuckerman, Eric Ravussin, Phunchai Charatcharoenwitthaya, Pin-Nan Cheng, Helena Katchman, Samuel Klein, Ziv Ben-Ari, Anisha E. Mendonza, Yiming Zhang, Miljen Martic, Shenglin Ma, Sheena Kao, Sandra Tanner, Alok Pachori, Michael K. Badman, YanLing He, Chinweike Ukomadu, Eric Sicard
Summary: In patients with nonalcoholic steatohepatitis (NASH), the use of licogliflozin led to reductions in serum alanine aminotransferase levels, suggesting it could be a potential therapeutic option. However, further studies are needed to validate these findings and evaluate its combination with other drugs.
Article
Medicine, General & Internal
Raymond Hang Wun Li, Sue Seen Tsing Lo, Kristina Gemzell-Danielsson, Carol Ho Yi Fong, Pak Chung Ho, Ernest Hung Yu Ng
Summary: This study found that co-administration of oral piroxicam 40 mg with levonorgestrel improved the efficacy of emergency contraception. The use of piroxicam could be considered in clinical settings where levonorgestrel emergency contraception is the chosen option.
Article
Medicine, Research & Experimental
Saman Tauqir, Momina Israr, Bushra Rauf, Muhammad Omar Malik, Syed Hamid Habib, Fawad Ali Shah, Muhammad Usman, Muhammad Asif Raza, Inayat Shah, Haroon Badshah, Ehtesham Ehtesham, Mohsin Shah
Summary: The study indicates that addition of ALC therapy is superior to metformin plus pioglitazone in ameliorating insulin resistance, polycystic ovaries, menstrual irregularities, and hypoadiponectinemia in women with PCOS.
ADVANCES IN THERAPY
(2021)
Article
Endocrinology & Metabolism
Franziska Plessow, Dean A. Marengi, Sylvia K. Perry, Elizabeth A. Lawson
Summary: The study explores the potential of oxytocin to improve cognitive control over behavior in humans. Findings suggest that oxytocin enhances proactive control over behavior by improving the ability to suppress behavioral impulses, which may have implications for its anorexigenic effects in human obesity. Future research is needed to further investigate the impact of oxytocin on cognitive control and its role in weight loss treatment.
Article
Biotechnology & Applied Microbiology
Irfan A. Rather, Byung-Chun Kim, Lee-Ching Lew, Seong-Kwan Cha, Jong Hwan Lee, Gyeong-Jun Nam, Rajib Majumder, Jeongheui Lim, Seul-Ki Lim, Young-Joon Seo, Yong-Ha Park
Summary: The study indicates that oral administration of L. sakeiproBio65 in both viable and non-viable forms may lead to positive improvements in alleviating symptoms of atopic dermatitis, improving skin barrier function, and reducing skin inflammation.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Article
Gastroenterology & Hepatology
B. D. Wilkie, R. Chandra, J. Chua, D. C. S. Lam, E. D. Paratz, V An, J. O. Keck
Summary: The study found that oral metronidazole did not significantly reduce posthaemorrhoidectomy pain, suggesting it should not be routinely used as an adjunct to analgesia.
COLORECTAL DISEASE
(2021)