Discovery of a hapE Mutation That Causes Azole Resistance in Aspergillus fumigatus through Whole Genome Sequencing and Sexual Crossing

Interrogation of Related Clinical Pan-Azole-Resistant Aspergillus fumigatus Strains: G138C, Y431C, and G434C Single Nucleotide Polymorphisms incyp51A, Upregulation ofcyp51A, and Integration and Activation of TransposonAtf1in thecyp51APromoter

(2011) Ahmed M. Albarrag et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Failure of Posaconazole Therapy in a Renal Transplant Patient with Invasive Aspergillosis Due to Aspergillus fumigatus with Attenuated Susceptibility to Posaconazole

(2011) Saskia Kuipers et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Regulation of Efflux Pump Expression and Drug Resistance by the Transcription Factors Mrr1, Upc2, and Cap1 in Candida albicans

(2011) Sabrina Schubert et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Differential Requirement of the Transcription Factor Mcm1 for Activation of the Candida albicans Multidrug Efflux PumpMDR1by Its Regulators Mrr1 and Cap1

(2011) Selene Mogavero et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Rapid Induction of Multiple Resistance Mechanisms in Aspergillus fumigatus during Azole Therapy: a Case Study and Review of the Literature

(2011) Simone M. T. Camps et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

SREBP-Dependent Triazole Susceptibility in Aspergillus fumigatus Is Mediated through Direct Transcriptional Regulation oferg11A(cyp51A)

(2011) Sara J. Blosser et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Azole Resistance of Aspergillus fumigatus Biofilms Is Partly Associated with Efflux Pump Activity

(2011) Ranjith Rajendran et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Azole Resistance in Aspergillus fumigatus Isolates from the ARTEMIS Global Surveillance Study Is Primarily Due to the TR/L98H Mutation in thecyp51AGene

(2011) Shawn R. Lockhart et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

High-frequency Triazole Resistance Found In Nonculturable Aspergillus fumigatus from Lungs of Patients with Chronic Fungal Disease

(2011) David W. Denning et al.   CLINICAL INFECTIOUS DISEASES

NF-Y and the transcriptional activation of CCAAT promoters

(2011) Diletta Dolfini et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The structure–function relationship of the Aspergillus fumigatus cyp51A L98H conversion by site-directed mutagenesis: The mechanism of L98H azole resistance

(2011) Eveline Snelders et al.   FUNGAL GENETICS AND BIOLOGY

Azole resistance inAspergillus fumigatus: a new challenge in the management of invasive aspergillosis?

(2011) Eveline Snelders et al.   Future Microbiology

CADRE: the Central Aspergillus Data REpository 2012

(2011) J. Mabey Gilsenan et al.   NUCLEIC ACIDS RESEARCH

SREBP Coordinates Iron and Ergosterol Homeostasis to Mediate Triazole Drug and Hypoxia Responses in the Human Fungal Pathogen Aspergillus fumigatus

(2011) Michael Blatzer et al.   PLoS Genetics

An A643V Amino Acid Substitution in Upc2p Contributes to Azole Resistance in Well-Characterized Clinical Isolates ofCandida albicans

(2010) Samantha J. Hoot et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

T-2307 Shows Efficacy in a Murine Model of Candida glabrata Infection despite In Vitro Trailing Growth Phenomena

(2010) E. Yamada et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: new substitutions and a review of the literature

(2010) Florent Morio et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

AfMkk2 is required for cell wall integrity signaling, adhesion, and full virulence of the human pathogen Aspergillus fumigatus

(2010) Franziska Dirr et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Azole antifungal resistance in Aspergillus fumigatus: 2008 and 2009

(2010) A. Bueid et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Truncated Afyap1 Attenuates Antifungal Susceptibility of Aspergillus fumigatus to Voriconazole and Confers Adaptation of the Fungus to Oxidative Stress

(2010) Jianjun Qiao et al.   MYCOPATHOLOGIA

Development of Azole Resistance in Aspergillus fumigatus during Azole Therapy Associated with Change in Virulence

(2010) Maiken Cavling Arendrup et al.   PLoS One

HapX-Mediated Adaption to Iron Starvation Is Crucial for Virulence of Aspergillus fumigatus

(2010) Markus Schrettl et al.   PLoS Pathogens

Possible Environmental Origin of Resistance of Aspergillus fumigatus to Medical Triazoles

(2009) E. Snelders et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Azole‐Resistant Central Nervous System Aspergillosis

(2009) Jan W. M. van der Linden et al.   CLINICAL INFECTIOUS DISEASES

Azole resistance in allergic bronchopulmonary aspergillosis and Aspergillus bronchitis

(2009) S.J. Howard et al.   CLINICAL MICROBIOLOGY AND INFECTION

Efflux-Mediated Antifungal Drug Resistance

(2009) R. D. Cannon et al.   CLINICAL MICROBIOLOGY REVIEWS

Azole-resistance in Aspergillus: Proposed nomenclature and breakpoints

(2009) Paul E. Verweij et al.   DRUG RESISTANCE UPDATES

A Role for the Unfolded Protein Response (UPR) in Virulence and Antifungal Susceptibility in Aspergillus fumigatus

(2009) Daryl L. Richie et al.   PLoS Pathogens

Treatment of Aspergillosis: Clinical Practice Guidelines of the Infectious Diseases Society of America

(2008) Thomas J. Walsh et al.   CLINICAL INFECTIOUS DISEASES

EUCAST Technical Note on the method for the determination of broth dilution minimum inhibitory concentrations of antifungal agents for conidia–forming moulds

(2008)   CLINICAL MICROBIOLOGY AND INFECTION

A Gain-of-Function Mutation in the Transcription Factor Upc2p Causes Upregulation of Ergosterol Biosynthesis Genes and Increased Fluconazole Resistance in a ClinicalCandida albicansIsolate

(2008) Nico Dunkel et al.   EUKARYOTIC CELL

Mapping short DNA sequencing reads and calling variants using mapping quality scores

(2008) H. Li et al.   GENOME RESEARCH

Multiple-azole-resistantAspergillus fumigatusosteomyelitis in a patient with chronic granulomatous disease successfully treated with long-term oral posaconazole and surgery

(2008) Caspar J. Hodiamont et al.   MEDICAL MYCOLOGY

Mutations in the multi-drug resistance regulatorMRR1, followed by loss of heterozygosity, are the main cause ofMDR1overexpression in fluconazole-resistantCandida albicansstrains

(2008) Nico Dunkel et al.   MOLECULAR MICROBIOLOGY

Discovery of a sexual cycle in the opportunistic fungal pathogen Aspergillus fumigatus

(2008) Céline M. O’Gorman et al.   NATURE

Genomic Islands in the Pathogenic Filamentous Fungus Aspergillus fumigatus

(2008) Natalie D. Fedorova et al.   PLoS Genetics

Emergence of Azole Resistance in Aspergillus fumigatus and Spread of a Single Resistance Mechanism

(2008) Eveline Snelders et al.   PLOS MEDICINE

A Sterol-Regulatory Element Binding Protein Is Required for Cell Polarity, Hypoxia Adaptation, Azole Drug Resistance, and Virulence in Aspergillus fumigatus

(2008) Sven D. Willger et al.   PLoS Pathogens