Article
Multidisciplinary Sciences
Erin R. Hascup, Lindsey N. Sime, Mackenzie R. Peck, Kevin N. Hascup
Summary: Lactate utilization may play a critical role in maintaining central bioenergetics in Alzheimer's disease (AD) patients. Previous studies have shown that soluble amyloid-beta (A beta)(42) can stimulate glutamate release and elevate glutamate levels in the hippocampus of AD model mice. This study found that A beta(42) stimulates lactate release, possibly through the activation of the astrocyte neuron lactate shuttle (ANLS), leading to elevated extracellular lactate levels.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Priya Prakash, Krupal P. Jethava, Nils Korte, Pablo Izquierdo, Emilia Favuzzi, Indigo V. L. Rose, Kevin A. Guttenplan, Palak Manchanda, Sayan Dutta, Jean-Christophe Rochet, Gord Fishell, Shane A. Liddelow, David Attwell, Gaurav Chopra
Summary: Phagocytosis by glial cells plays a crucial role in regulating brain function, especially in the pathogenesis and progression of Alzheimer's disease. The newly developed Aβ(pH) analogue provides a tool to study the mechanisms of glial cell clearance of Aβ, offering potential insights into Aβ clearance at different stages of AD.
Editorial Material
Cell Biology
Eduardo R. Zimmer, Tharick A. Pascoal, Pedro Rosa-Neto, Agneta Nordberg, Luc Pellerin
Summary: This statement suggests that astrocytes play a major role in the microglia-dependent modulation of FDG-PET.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Neurosciences
Jiamei Guo, Tian Qiu, Lixia Wang, Lei Shi, Ming Ai, Zhu Xia, Zhiping Peng, Anhai Zheng, Xiao Li, Li Kuang
Summary: In this study, the role of glial cells in stress-induced depression was investigated. The findings suggest that changes in glial cells may contribute to the development and symptoms of depression.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Polymer Science
Roni Mina Hendler, Orly Eva Weiss, Tzachy Morad, Guy Sion, Michael Kirby, Zvy Dubinsky, Ayan Barbora, Refael Minnes, Danny Baranes
Summary: Our study demonstrates that culturing neural precursor cells (NPCs) on coralline-derived calcium carbonate coated with poly-D-lysine (PDL-CS) promotes their differentiation into reactive astrocytes, potentially accelerating the repair of neural tissue.
Article
Multidisciplinary Sciences
Ren Y. Sato, Koki Kotake, Yumin Zhang, Hiraku Onishi, Futaba Matsui, Hiroaki Norimoto, Zhiwen Zhou
Summary: The study revealed that MVK impairs spatial memory in mice and activates glial cells in subregions of the hippocampus, indicating a potential link between MVK exposure, memory deficits, and neural inflammation in the brain.
Article
Biochemistry & Molecular Biology
Fernando Cruz-Mendoza, Sonia Luquin, Joaquin Garcia-Estrada, David Fernandez-Quezada, Fernando Jauregui-Huerta
Summary: This study investigated the effects of acoustic stress on hippocampal proliferation and glial cytoarchitecture in adult male rats using environmental noise as a stress model. The results showed abnormal cellular proliferation in the hippocampus after 21 days of noise exposure, with an inverse effect on the proliferation ratios of astrocytes and microglia. Both cell lineages also displayed atrophic morphologies with fewer processes and lower densities in the noise-stressed animals. These findings suggest that stress not only affects neurogenesis and neuronal death in the hippocampus, but also the proliferation ratio, cell density, and morphology of glial cells, potentially triggering an inflammatory-like response that compromises their homeostatic and repair functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lamis Chamas, Isabelle Seugnet, Roseline Poirier, Marie-Stephanie Clerget-Froidevaux, Valerie Enderlin
Summary: This study investigated the protective mechanisms linking hypothyroidism and neuroinflammation. Hypothyroid WSB/EiJ mice showed no neuroinflammatory response and maintained hippocampal thyroid signaling despite low circulating thyroid hormone levels, while C57BL/6J mice exhibited disturbed thyroid signaling, accompanied by neuroinflammation and memory impairment. The results highlight the importance of the hippocampal thyroid regulatory system in glial reactivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Franziska E. Mueller, Sophie K. Schade, Volodymyr Cherkas, Laura Stopper, Bjoern Breithausen, Daniel Minge, Hristo Varbanov, Christian Wahl-Schott, Svitlana Antoniuk, Catia Domingos, Valerie Compan, Frank Kirchhoff, Christian Henneberger, Evgeni Ponimaskin, Andre Zeug
Summary: Recent research has shown that the serotonin receptor 4 (5-HT4R) is expressed in hippocampal astrocytes, where its activation triggers RhoA activity via G alpha(13)-mediated signaling, leading to morphological changes. This signaling pathway can alter glutamatergic synaptic transmission, affecting the functional regulation of neuronal networks.
Article
Clinical Neurology
Fenghua Chen, Jibrin Danladi, Maryam Ardalan, Jens R. Nyengaard, Connie Sanchez, Gregers Wegener
Summary: Vortioxetine has early effects on hippocampal neurons and the vascular system in rats, increasing the number of astrocytes and microglia cells with elevated VEGF levels. Fluoxetine, on the other hand, did not have an impact on these measures after 7 days of treatment. These findings suggest that astrocytes and microglia may play a role in mediating the pharmacological effects of vortioxetine.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Cell Biology
Yantao Ma, Handan Xie, Xiaomin Du, Lipeng Wang, Xueqin Jin, Qianqian Zhang, Yawen Han, Shicheng Sun, Longteng Wang, Xiang Li, Changjiang Zhang, Mengdi Wang, Cheng Li, Jun Xu, Zhuo Huang, Xiaoqun Wang, Zhen Chai, Hongkui Deng
Summary: This study demonstrates that small molecules can reprogram astrocytes into neurons in the adult mouse brain. The in situ chemically induced neurons show similarities to endogenous neurons in terms of marker expression, electrophysiological properties, and synaptic connectivity, providing a potential approach for developing neuronal replacement therapies.
Article
Neurosciences
Lulu Xie, Jiaxin Qin, Tingting Wang, Shuai Zhang, Mingcui Luo, Xuelei Cheng, Xinrui Cao, Hui Wang, Baozhen Yao, Dan Xu, Biwen Peng
Summary: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used analgesic agents and can be found in the environment. Prenatal exposure to acetaminophen (PAcE) can cause damage to the developing hippocampus, but the underlying molecular mechanisms are unclear. This study shows an increased risk of adverse neurodevelopmental outcomes in offspring following exposure to acetaminophen during pregnancy in mice. Different doses, timings, and duration of exposure to acetaminophen during pregnancy were associated with dose-dependent changes in the offspring's hippocampus.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Environmental Sciences
Sandra Willkommen, Jens Lange, Uta Ulrich, Matthias Pfannerstill, Nicola Fohrer
Summary: The study found that preferential flow was an important transport pathway for Flufenacet in dry soil, while Flufenacet ESA was detected in all groundwater samples. The absence of TP510 formation in the immediate topsoil during the dry period was also observed.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Multidisciplinary Sciences
Airi Watanabe, Connie Guo, Per Jesper Sjostrom
Summary: We studied the maturation process of astrocytes in the layer 5 mouse visual cortex from postnatal days 3-50. We observed an increase in resting membrane potential, a decrease in input resistance, and a transition towards more passive membrane responses as the astrocytes matured. Gap-junction coupling increased starting around postnatal day 7. Morphological reconstructions showed increased branch density but shorter branches after postnatal day 20, indicating branch pruning during tiling establishment. Additionally, spontaneous Ca2+ transients became decorrelated, more frequent, and briefer with age, suggesting a shift from cell-wide, synchronous waves to local transients as astrocytes matured. Some astrocyte properties were stably mature by postnatal day 15, coinciding with eye opening, while morphology continued to develop. Our findings provide a descriptive foundation for astrocyte maturation and its impact on visual cortex critical period plasticity.
Article
Cell Biology
Fei Liu, Yijie Zhang, Fuliang Chen, Jiacheng Yuan, Sanlan Li, Sue Han, Dengyu Lu, Junlan Geng, Zhiping Rao, Li Sun, Jianhua Xu, Yuhan Shi, Xiaojing Wang, Yueguang Liu
Summary: The study utilized the AAV(2/8) delivery system to overexpress Neurog2 into astrocytes, successfully converting them into neurons with mature electrophysiological properties, glutamatergic identity, and synapse-like configuration. Furthermore, evidence also proved that Neurog2-iNs in the intact spinal cord are capable of responding to diverse afferent inputs.
CELL DEATH & DISEASE
(2021)
Article
Physiology
T. E. Dick, M. Dutschmann, J. L. Feldman, A. Y. Fong, S. Hulsmann, K. M. Morris, J. M. Ramirez, J. C. Smith
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2018)
Article
Physiology
Guillaume Mesuret, Julia Dannenberg, Mauricio Arnoldt, Anja-Annett Gruetzner, Marcus Niebert, Swen Huelsmann
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2018)
Article
Neurosciences
Swen Huelsmann, Yoshihiko Oke, Guillaume Mesuret, A. Tobias Latal, Michal G. Fortuna, Marcus Niebert, Johannes Hirrlinger, Julia Fischer, Kurt Hammerschmidt
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Article
Physiology
Michal G. Fortuna, Sebastian Kuegler, Swen Huelsmann
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2019)
Article
Neurosciences
Johannes Hirrlinger, Grit Marx, Stefanie Besser, Marit Sicker, Susanne Koehler, Petra G. Hirrlinger, Sonja M. Wojcik, Volker Eulenburg, Ulrike Winkler, Swen Huelsmann
FRONTIERS IN CELLULAR NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Maria A. Eichel, Vasiliki-Ilya Gargareta, Elisa D'Este, Robert Fledrich, Theresa Kungl, Tobias J. Buscham, Katja A. Lueders, Cristina Miracle, Ramona B. Jung, Ute Distler, Kathrin Kusch, Wiebke Moebius, Swen Huelsmann, Stefan Tenzer, Klaus-Armin Nave, Hauke B. Werner
NATURE COMMUNICATIONS
(2020)
Letter
Neurosciences
Swen Huelsmann
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Physiology
Swen Hulsmann, Sepideh Khabbazzadeh, Konrad Meissner, Michael Quintel
Summary: ARDS is characterized by acute inflammation of the lungs triggered by various causes, leading to pulmonary edema and hypoxemia. Respiratory drive in ARDS patients may become dysregulated and detached from blood gas status. This dysregulation may be related to alterations in the renin-angiotensin system.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Swen Huelsmann, Liya Hagos, Volker Eulenburg, Johannes Hirrlinger
Summary: The role of inhibitory neurons in the respiratory network remains controversial, with recent studies indicating that their activation in vivo can significantly impact respiratory rate by potentially inhibiting excitatory rhythmogenic neurons within the preBotzinger complex. This suggests that inhibitory neurons may play a crucial role in mediating phase-switching in the respiratory rhythm.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Amara Khan, Andrea Markus, Thomas Rittmann, Jonas Albers, Frauke Alves, Swen Huelsmann, Christian Dullin
Summary: The study developed a new X-ray lung function evaluation method, which shows superior sensitivity and precision in measuring lung volumes compared to micro-CT and whole-body plethysmography.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Swen Huelsmann, Amara Khan, Liya Hagos, Martin Hindermann, Torsten Naegel, Christian Dullin
Summary: Whole-body plethysmography is a method for determining physiological parameters and breathing pathophysiological changes in animals and disease models. Debate continues about what exactly is measured by whole-body plethysmography and the reliability of the data. An artificial lung model was designed to evaluate predictions about WBP, revealing pressure changes due to conditioning and airway resistance. Measurement of breathing volume is hindered by factors including unknown contributions of components, and the expiratory negative pressure peak does not directly measure airway resistance but reflects the animal's response to it.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Volker Eulenburg, Swen Huelsmann
Summary: Glycine plays a crucial role in protein biosynthesis and metabolism, and also serves as an important inhibitory neurotransmitter in the caudal regions of the brain. To maintain its functions, tight regulation of glycine concentration is required in both synaptic clefts and intracellular/extracellular compartments. This regulation is achieved by confining glycine synthesis and degradation to mitochondria, and through the action of high-affinity, large-capacity glycine transporters.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Angelika Svetlove, Jonas Albers, Swen Huelsmann, Marietta Andrea Markus, Jana Zschuentzsch, Frauke Alves, Christian Dullin
Summary: This study aimed to establish a sensitive and reliable method for assessing respiratory muscle weakness and irregular breathing patterns. Optical respiratory dynamics tracking (ORDT) was developed and successfully distinguished mice with Duchenne muscular dystrophy (DMD) from healthy controls by measuring expiration constants. ORDT was able to distinguish fast and slow expiratory phases, which could not be observed using X-ray based lung function measurements. The simplicity and reliability of ORDT were further validated using smartphone acquisition.
Article
Physiology
Behnam Vafadari, Yoshitaka Oku, Charlotte Tacke, Ali Harb, Swen Huelsmann
Summary: The preBo·tzinger Complex (preBo·tC) in the brainstem plays a critical role in generating respiratory rhythm. This study aimed to investigate the activity of inhibitory glycinergic neurons in the preBo·tC of anesthetized mice. Using juxtacellular recordings and optogenetic activation, the researchers were able to identify and characterize the activity pattern of these inhibitory neurons in relation to the breathing rhythm.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Meeting Abstract
Neurosciences
M. Eichel, V-I. Gargareta, E. D'Este, R. Fledrich, T. Kungl, T. J. Buscham, K. A. Lueders, C. Miracle, R. B. Jung, U. Distler, K. Kusch, W. Moebius, S. Huelsmann, S. Tenzer, K-A. Nave, H. B. Werner