Article
Cell Biology
Tamara Casteels, Simon Bajew, Jiri Reinis, Lennart Enders, Michael Schuster, Frederic Fontaine, Andre C. Mueller, Bridget K. Wagner, Christoph Bock, Stefan Kubicek
Summary: The study identifies the key factor Smndc1 connecting splicing and chromatin remodeling to the control of insulin expression in human and mouse islet cells, demonstrating its repressive role on insulin expression and regulation of the β-cell transcription factor Pdx1.
Article
Biotechnology & Applied Microbiology
Dandan Jia, Jun Zhang, Jia Nie, John-Paul Andersen, Samantha Rendon, Yue Zheng, Xueling Liu, Zhenjun Tian, Yuguang Shi
Summary: Cardiolipin is crucial for maintaining cardiac health, and the loss of TLCL is linked to the pathogenesis of CHD. ALCAT1 acts as a key link between hypoxia and CHD, promoting mitochondrial dysfunction in the process. Ablation or inhibition of ALCAT1 could effectively mitigate CHD and its associated pathologies.
Article
Biochemistry & Molecular Biology
Zhuqing Liang, Michael W. Schmidtke, Miriam L. Greenberg
Summary: Barth syndrome is a genetic disorder caused by variants of the TAFAZZIN gene, leading to cardio- and skeletal myopathy, exercise intolerance, and neutropenia. CL oxidation may play a key role in the pathogenesis of Barth syndrome.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Cell Biology
Katherine Labbe, Shona Mookerjee, Maxence Le Vasseur, Eddy Gibbs, Chad Lerner, Jodi Nunnari
Summary: The study reveals that MTCH2 plays a role in regulating lipid metabolism through controlling mitochondrial fusion and division, and acts as a protective factor for mitochondria under starvation conditions.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shiv K. Sah-Teli, Matyas Pinkas, Mikko J. Hynonen, Sarah J. Butcher, Rik K. Wierenga, Jiri Novacek, Rajaram Venkatesan
Summary: This study investigated the structure of two enzymes (TFE) in facultative anaerobic bacteria Escherichia coli, which are closely related to the human mitochondrial TFE. The study found that the membrane-binding properties of the two enzymes differ, with the anaerobic TFE having stronger membrane interaction. These findings provide important insights into bacterial oxidation cycle and fatty acid metabolism.
Article
Materials Science, Biomaterials
Ketav Kulkarni, Jenisi Kelderman, Harold Coleman, Marie-Isabel Aguilar, Helena Parkington, Mark Del Borgo
Summary: Researchers have successfully synthesized a novel beta-amino acid to allow for the self-assembly of a trifunctional beta-tripeptide, which acts as a bioactive neuronal scaffold, showing promise for studies involving neuronal cell growth and development.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Ying Huang, Sandra Hoefgen, Fabio Gherlone, Vito Valiante
Summary: Enzymes in Escherichia coli can synthesize styrylpyrones with phenylpropionic acids through a non-decarboxylative Claisen condensation, making the reaction more efficient. Different styrylpyrones can also be synthesized in vitro using a cell-free approach. Targeted feeding experiments demonstrate the ability to synthesize these molecules in bacteria.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Plant Sciences
Linhui Yu, Jilian Fan, Chao Zhou, Changcheng Xu
Summary: The study reveals that plants adjust the rates of fatty acid and glycerolipid biosynthesis under different light conditions to meet cellular metabolic needs, highlighting the importance of lipid metabolism in light acclimation.
Article
Multidisciplinary Sciences
Jargalsaikhan Dagvadorj, Karolina Mikulska-Ruminska, Gantsetseg Tumurkhuu, Rojo A. Ratsimandresy, Jessica Carriere, Allen M. Andres, Stefanie Marek-Iannucci, Yang Song, Shuang Chen, Malcolm Lane, Andrea Dorfleutner, Roberta A. Gottlieb, Christian Stehlik, Suzanne Cassel, Fayyaz S. Sutterwala, Ivet Bahar, Timothy R. Crother, Moshe Arditi
Summary: The balance between NLRP3 inflammasome activation and mitophagy is crucial for cellular homeostasis, with IL-1 alpha playing a key role in regulating this balance. IL-1 alpha deficiency can lead to altered cellular functions and health by affecting mitochondrial damage and NLRP3 inflammasome activation. The interaction between IL-1 alpha and mitochondrial cardiolipin disrupts mitophagy and enhances NLRP3 inflammasome activation, highlighting the importance of this regulatory mechanism in cellular health.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Hematology
Moua Yang, Joyce Chiu, Christina Scartelli, Nathan Ponzar, Sachin Patel, Anika Patel, Renan B. Ferreira, Robert F. Keyes, Kate S. Carroll, Nicola Pozzi, Philip J. Hogg, Brian C. Smith, Robert Flaumenhaft
Summary: Oxidative stress leads to protein damage and inactivation. PDI is disrupted during oxidative stress, resulting in thrombus formation. Inhibiting PDI disruption can reduce thrombus formation.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Biochemistry & Molecular Biology
Shinichiro Toyoda, Jihoon Shin, Atsunori Fukuhara, Michio Otsuki, Iichiro Shimomura
Summary: The study reveals that TGF-beta 1 plays a crucial role in promoting lipogenesis in adipose tissue by regulating ECM remodeling and the lipogenic pathway, allowing adipocytes to adapt to physiological feeding events.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Food Science & Technology
Jason R. Bush, Jun Han, Edward C. Deehan, Scott Harding, Madhura Maiya, Joshua Baisley, David Schibli, David R. Goodlett
Summary: This study found that resistant potato starch (RPS) can reduce histamine levels and decrease the quantity of bacteria secreting histamine, while enhancing gut barrier function.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Chemistry, Medicinal
Shuai Wang, Xiaopeng Zhu, Manqi Zhangsun, Yong Wu, Jinpeng Yu, Peta J. Harvey, Quentin Kaas, Dongting Zhangsun, David J. Craik, Sulan Luo
Summary: The study identified that amidated [Q1G, Delta R14]LvIB is a potent blocker of rat alpha 7 nAChRs and can differentiate between human and rat alpha 7 nAChRs. Substitutions at key mutation sites between rat and human alpha 7 nAChRs revealed that the combined influence of Gln141, Asn184, and Lys186 determines the alpha 7 nAChR species specificity of this peptide.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jun H. Heo, Sang R. Lee, Seong Lae Jo, Hyun Yang, Hye Won Lee, Eui-Ju Hong
Summary: Letrozole, an aromatase inhibitor used in breast cancer treatment, has been reported to cause metabolic changes and structural remodeling in the heart. Our study found that letrozole exposure in female rats resulted in decreased fatty acid oxidation, increased glycolysis, and left ventricular hypertrophy. This shift in cardiac metabolism may lead to reduced energy supply and increased risk of heart failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Applied
Yukun Zhao, Jingwen Xu, Hongbing Chen, Yi Xia, Lin Hu
Summary: A first iron-catalyzed oxophosphorylation reaction of styrene derivatives with dialkyl H-phosphonates under open air conditions is developed, leading to the formation of a range of previously underexplored α-substituted β-ketophosphonates. Additionally, a convenient one-pot procedure for the direct conversion of styrenes to α,β-unsaturated ketones is demonstrated, providing access to valuable products from simple starting materials.
ADVANCED SYNTHESIS & CATALYSIS
(2023)