Article
Biology
Xin Hua, Wei Song, Kangzong Wang, Xue Yin, Changqi Hao, Baozhong Duan, Zhichao Xu, Tongbing Su, Zheyong Xue
Summary: Xin Hua, Wei Song, and ZheYong Xue et al. report an effective method to predict key genes involved in polyphyllin biosynthesis in plants. Their results provide further insight into biosynthesis pathways in Paris polyphylla, and the approach may be relevant to other medicinal plants.
COMMUNICATIONS BIOLOGY
(2022)
Article
Oncology
Zhenjian Zhuo, Lei Miao, Wenfeng Hua, Huitong Chen, Zhonghua Yang, Yong Li, Jiao Zhang, Suhong Li, Jiwen Cheng, Li Li, Huimin Xia, Jing He
Summary: Through genotype analysis of Chinese children diagnosed with hepatoblastoma and controls, two SNPs in the XPC gene were found to be associated with increased or decreased risk of hepatoblastoma, suggesting XPC gene as a potential biomarker for hepatoblastoma risk.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Endocrinology & Metabolism
Ellen G. Wall, Reena Desai, Zin Khant Aung, Shel Hwa Yeo, David R. Grattan, David J. Handelsman, Allan E. Herbison
Summary: Using liquid chromatography-mass spectrometry, the study provides a detailed profile of gonadal steroid levels across the estrous cycle of C57BL/6J mice. The results show that the levels of estradiol, luteinizing hormone (LH), and prolactin vary at different stages of the estrous cycle, indicating species differences between mice and other ovulating species. These findings have important implications for understanding reproductive physiology in mice.
Article
Agronomy
Yunsong Gu, Shichen Han, Lin Chen, Junyi Mu, Luning Duan, Yaxuan Li, Yueming Yan, Xiaohui Li
Summary: This study identified key proteins and genes involved in wheat reserve starch biosynthesis through RNA-Seq libraries and expression analyses. The transcription factor TaMYB44 was found to potentially regulate the pathway. These findings provide insights for increasing starch content in wheat endosperm.
Article
Genetics & Heredity
Yifei Cheng, Yixuan Meng, Shuwei Li, Dongliang Cao, Shuai Ben, Chao Qin, Lixin Hua, Gong Cheng
Summary: This study systematically evaluated the association of SNPs in 21 cholesterol biosynthesis pathway genes with the risk of prostate cancer (PCa) and found that the T allele of rs67415672 in HMGCS1 is a significant protective allele of PCa. The expression of HMGCS1 was significantly decreased in PCa primary tumors compared to normal tissues, indicating that rs67415672 might be a possible functional susceptibility loci for PCa.
Review
Biotechnology & Applied Microbiology
L. Sunil, Nandini P. Shetty
Summary: Anthocyanins are pigments responsible for coloring fruits and vegetables, and they offer a wide range of health benefits. In recent years, research on anthocyanins has focused on their stability and concentration, in order to find novel approaches for the food industry. One promising option is the biosynthesis of anthocyanins using engineered microorganisms.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
Mengxue Zheng, Claus Yding Andersen, Frida Roikjer Rasmussen, Jesus Cadenas, Soren Tvorup Christensen, Linn Salto Mamsen
Summary: This study investigates the expression patterns of key enzymes involved in human ovarian steroidogenesis during follicle development. The results show that steroidogenesis-related enzymes have low expression levels during early follicle development, but HSD3B2 is upregulated in granulosa cells (GCs) as follicles progress to the antral/preovulatory stage. Immunohistochemistry analysis confirms the expression of HSD3B2 in GCs and its co-localization with CYP17A1 in a subset of theca cells (TCs) surrounding small antral follicles. Additionally, the expression of CYB5A is significantly upregulated during follicle transition from the antral stage to the pre-ovulatory stage, indicating an enhanced progesterone production. The increased expression of DHCR24, LDLR, and HMGCR suggests an increased substrate availability for ovarian steroidogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Zhenjian Zhuo, Ao Lin, Jiao Zhang, Huitong Chen, Yong Li, Zhonghua Yang, Li Li, Suhong Li, Jiwen Cheng, Jing He
Summary: This study found that the SNP rs293795 in the hOGG1 gene significantly increases hepatoblastoma risk under the recessive model. Stratified analysis showed that other SNPs might have different effects on risk in male and different clinical stage subgroups. Further research is needed to confirm these findings and understand the biological pathways involved.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jose Avila-Mendoza, Karen Delgado-Rueda, Valeria A. Urban-Sosa, Martha Carranza, Maricela Luna, Carlos G. Martinez-Moreno, Carlos Aramburo
Summary: KLF13 is an important transcription factor involved in essential processes of the central nervous system. It acts as a transcriptional repressor, influencing the activity of several signaling pathways, including the JAK/STAT pathway. KLF13 directly regulates the expression of several genes in this pathway and its deficiency dysregulates the expression of key genes in hippocampus-derived cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Muhammad Jawaad Atif, Bakht Amin, Muhammad Imran Ghani, Muhammad Ali, Somia Khursheed, Zhihui Cheng
Summary: The study found that garlic plants exhibit different responses to long day and short day in terms of plant hormone levels, with differential gene expression enriching various pathways, particularly those related to plant hormone signaling and photoperiod. The outcomes provide valuable insights into the response mechanisms of garlic to photoperiod.
Article
Medicine, Research & Experimental
Huizhen Nie, Pei-Qi Huang, Shu-Heng Jiang, Qin Yang, Li-Peng Hu, Xiao-Mei Yang, Jun Li, Ya-Hui Wang, Qing Li, Yi-Fan Zhang, Lei Zhu, Yan-Li Zhang, Yanqiu Yu, Gary Guishan Xiao, Yong-Wei Sun, Jianguang Ji, Zhi-Gang Zhang
Summary: This study reveals that PRLR-SF is highly expressed in PDAC tissues and can inhibit the proliferation of PDAC cells by activating the Hippo signaling pathway, thereby slowing tumor growth. PRLR-SF affects metabolic reprogramming and PDAC progression by reducing the expression of genes involved in the Pentose Phosphate Pathway (PPP) and nucleotide biosynthesis.
Article
Biochemistry & Molecular Biology
Xiaodong Chen, Hao Sun, Bin Zhao, Rui Wang, Changhao Ji, Bin Zhu
Summary: RNA-Seq was used to identify 13,172 differentially expressed genes (DEGs) in barley tissues, with more up-regulated DEGs observed in leaf vs spike and stem vs spike comparisons, while down-regulated DEGs were dominant in stem vs leaf comparison. 47 DEGs were annotated to the monolignol pathway, of which six were candidate genes regulating lignin biosynthesis. qRT-PCR assay validated the expression profiles of the six candidate genes, with four genes potentially positively regulating lignin biosynthesis, and the other two genes possibly having reverse effects. These findings provide target genes for further investigations on molecular regulatory mechanisms of lignin biosynthesis and genetic resources for improvement of forage quality in barley breeding.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Cell Biology
Wenlong Liu, Qingxiang Zeng, Yinhui Zeng, Yiquan Tang, Renzhong Luo
Summary: The study found that genetic variations in the ERCC1 and XPC genes may affect the risk of allergic rhinitis, providing new insights into the genetics of allergic rhinitis from the perspective of DNA damage repair.
MEDIATORS OF INFLAMMATION
(2022)
Article
Immunology
Julia A. Gomes, Eduarda Sgarioni, Igor A. Vieira, Lucas R. Fraga, Patricia Ashton-Prolla, Ana Claudia P. Tercas-Tretell, Juliana H. da Silva, Bethania F. R. Ribeiro, Marcial F. Galera, Thalita M. de Oliveira, Maria Denise F. Carvalho de Andrade, Isabella F. Carvalho, Lavinia Schuler-Faccini, Fernanda S. L. Vianna
Summary: Our study found that children with CZS were mainly exposed to ZIKV in the first trimester, while controls were mainly exposed in the third trimester; additionally, children with CZS were more likely to come from families with a lower socioeconomic level. Although no statistically significant association was found between the investigated polymorphisms and CZS development, a significant difference in allelic frequencies of TP53 rs1042522 was observed when comparing individuals with CZS and lissencephaly. This suggests that TP53 rs1042522 polymorphism should be further investigated as a genetic risk factor for lissencephaly development in children with CZS.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Endocrinology & Metabolism
Lovlesh Thakur, Sunil Thakur
Summary: This review summarizes the role of miRNAs in endometrial cancer regulated by sex steroid hormone pathways. Dysregulation of miRNAs has been linked to abnormal sex steroid hormone signaling and the development of endometrial cancer. Various miRNAs have been identified as modulators of estrogen and progesterone receptor expression, and the miRNA expression profile has been shown to be a predictor of response to hormone therapy. Future studies should focus on elucidating the functional roles of specific miRNAs in sex steroid hormone signaling and identifying novel miRNA targets for hormone therapy in endometrial cancer management.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jun-young Kim, Joel Cramer, Kyujoon Lee, Dong-Soo Han, Dongwook Go, Pavel Salev, Pavel N. Lapa, Nicolas M. Vargas, Ivan K. Schuller, Yuriy Mokrousov, Gerhard Jakob, Mathias Klaeui
Summary: This study investigates current-induced spin-orbit torques in VO2/NiFe heterostructures and reveals that the change in spin absorption across the VO2 phase transition leads to a twofold increase in the Gilbert damping parameter alpha with temperature. Furthermore, a significant modulation and sign change of the current-induced spin-orbit torque across the VO2 phase transition suggest the existence of two competing spin-orbit torque generating mechanisms.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Gastroenterology & Hepatology
Seung Wook Hong, Byong Duk Ye, Jae Hee Cheon, Ji Hyun Lee, Ja Seol Koo, Byung Ik Jang, Kang-Moon Lee, You Sun Kim, Tae Oh Kim, Jong Pil Im, Geun Am Song, Sung-Ae Jung, Hyun Soo Kim, Dong Il Park, Hyun-Soo Kim, Kyu Chan Huh, Young-Ho Kim, Jae Myung Cha, Geom Seog Seo, Chang Hwan Choi, Hyun Joo Song, Gwang Ho Baik, Ji Won Kim, Sung Jae Shin, Young Sook Park, Chang Kyun Lee, Jun Lee, Sung Hee Jung, Yunho Jung, Sung Chul Park, Young-Eun Joo, Yoon Tae Jeen, Dong Soo Han, Suk-Kyun Yang, Hyo Jong Kim, Won Ho Kim, Joo Sung Kim
Article
Biochemistry & Molecular Biology
Jae Gon Lee, Jiyoung Lee, A-reum Lee, Su Vin Jo, Chan Hyuk Park, Dong Soo Han, Chang Soo Eun
Summary: Supplementation of SCFAs did not lead to a significant reduction in colon inflammation, but it did increase the expression of regulatory T cells and IL-17-producing T cells, as well as promote both protective and aggressive gut microbiota.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Nutrition & Dietetics
Sang Young Kim, Jung Hyun Kwak, Chang Soo Eun, Dong Soo Han, Yong Sung Kim, Kyu Sang Song, Bo Youl Choi, Hyun Ja Kim
Summary: Dietary factors, such as high meal frequency, overeating, and preference for spicy or salty foods, significantly increase the risk of gastric cancer.
Article
Nutrition & Dietetics
Sang Young Kim, Chang Soo Eun, Dong Soo Han, Yong Sung Kim, Kyu Sang Song, Bo Youl Choi, Hyun Ja Kim
Summary: This study found a significant association between high glycemic index and glycemic load and an increased risk of gastric cancer, especially among males, older individuals, smokers, drinkers, and people with Helicobacter pylori infection.
NUTRITION RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Jae Hee Cheon, Hyun-Soo Kim, Dong Soo Han, Sung Kook Kim, Sung Jae Shin, Joo Sung Kim, Byong Duk Ye, Geun Am Song, YoungJa Lee, Youngdoe Kim, Yoosun Lee, Won Ho Kim
Summary: This study provides evidence that infliximab is effective and well-tolerated in patients with moderate-to-severe active intestinal Behcet's disease.
Article
Nutrition & Dietetics
Jung Hyun Kwak, Chang Soo Eun, Dong Soo Han, Yong Sung Kim, Kyu Sang Song, Bo Youl Choi, Hyun Ja Kim
Summary: This study evaluated the association of individual or a combination of protective foods on the incidence of gastric cancer in H. pylori-positive subjects. Results showed that a higher intake of soy products and fruits was associated with a lower risk of gastric cancer. Additionally, the combination of soy products or fruits with dairy products also reduced the risk of gastric cancer.
NUTRITION RESEARCH AND PRACTICE
(2023)
Article
Oncology
Hyuntak Na, Jeeyoo Lee, Sooyoung Cho, Woo-Kyoung Shin, Ji-Yeob Choi, Daehee Kang, Aesun Shin
Summary: This study conducted a large-scale prospective cohort study in Korea and found no significant association between coffee and green tea consumption and the risk of colorectal cancer. However, among women, the consumption of black coffee was significantly associated with an increased risk of colon cancer.
JOURNAL OF CANCER PREVENTION
(2022)
Article
Oncology
Jaesung Choi, JooYong Park, Ji-Eun Kim, Miyoung Lee, Daehee Kang, Aesun Shin, Ji-Yeob Choi
Summary: This study assessed the association between physical activity characteristics and cancer incidence in Koreans, specifically examining the differences in association among overweight individuals. The findings indicate that physical activity has a protective effect against cancer in overweight males, particularly for colorectal cancer. These results suggest the importance of promoting physical activity among overweight Asian males to reduce their cancer risk.
CANCER PREVENTION RESEARCH
(2023)
Article
Oncology
Jaesung Choi, Joo-Yong Park, Ji-Eun Kim, Miyoung Lee, Kyuwan Lee, Jong-Koo Lee, Daehee Kang, Aesun Shin, Ji-Yeob Choi
Summary: This study investigated the associations between different types, intensities, durations, and quantities of physical activities and mortality in Korean cancer patients. The results showed that patients who participated in vigorous-intensity activities, walking, climbing, sports, and more than two activities had significantly lower overall mortality, especially for colorectal cancer patients participating in vigorous-intensity activities. Post-diagnosis, only patients who performed more than two activities had significantly lower all-cause mortality.
Article
Oncology
Tung Hoang, Sooyoung Cho, Ji-Yeob Choi, Daehee Kang, Aesun Shin
Summary: This study aimed to explore the potential interaction between dietary intake and genetics on the incidence of colorectal cancer (CRC), and whether adherence to healthy dietary habits could attenuate CRC risk in individuals at high genetic risk.
Article
Public, Environmental & Occupational Health
Dong-Wook Lee, Sooyoung Cho, Aesun Shin
Summary: Based on job positions, the study examined the mortality rate of lymphohematopoietic cancer in workers at a semiconductor manufacturing company in South Korea. The findings revealed that female operators had a higher risk of mortality from lymphohematopoietic cancer among the semiconductor manufacturing workers.
Review
Oncology
Yu Rim Kim, Ji Yoon Baek, Seung Hee Seo, Hyeree Park, Sooyoung Cho, Aesun Shin
Summary: This study aimed to review the operational definitions of liver cancer used in studies based on the NHIS database and suggest the most appropriate one. After screening 90 articles, it was found that most studies did not specify whether the codes for the operational definition were from the main diagnosis or both the main and sub-diagnosis. The most frequently used operational definition was C22, and using C22.0 or C22.9 for men and C22.0 for women as the main diagnosis was suggested based on comparison with KCCR data.
JOURNAL OF CANCER PREVENTION
(2023)
Article
Public, Environmental & Occupational Health
Sukhong Min, Woo-Kyoung Shin, Katherine De la Torre, Dan Huang, Hyung-Suk Yoon, Aesun Shin, Ji-Yeob Choi, Daehee Kang
Summary: Long sleep duration is associated with all-cause mortality among Koreans, even after adjusting for comorbidities. Further studies are needed to explore the mechanism underlying the association between sleep duration and major causes of mortality.
JOURNAL OF PREVENTIVE MEDICINE & PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Seung Hee Seo, Sooyoung Cho, Shin Hye Yoo, Bhumsuk Keam, Aesun Shin
Summary: The first year of the COVID-19 pandemic in Korea led to changes in healthcare service utilization. This study aimed to report the changes in healthcare service utilization among cancer patients during the first year of the COVID-19 pandemic in Korea.
YONSEI MEDICAL JOURNAL
(2023)
