Article
Urology & Nephrology
Yin-Ching Chen, Philip A. A. Waghorn, Ivy A. A. Rosales, Gunisha Arora, Derek J. J. Erstad, Nicholas J. J. Rotile, Chloe M. M. Jones, Diego S. S. Ferreira, Lan Wei, Robert V. P. Martinez, Franklin J. J. Schlerman, Jeremy Wellen, Bryan C. C. Fuchs, Robert B. B. Colvin, Ilknur Ay, Peter Caravan
Summary: The study shows that magnetic resonance imaging combined with the Gd-OA probe can noninvasively detect and stage renal fibrosis, which is of great significance for accurately assessing disease progression and developing new antifibrotic therapies.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Immunology
Yuyuan Liu, Yanzhe Wang, Sijia Chen, Linnan Bai, Xinmiao Xie, Ling Zhang, Xiaoxia Wang
Summary: Dapagliflozin has been shown to improve renal function and reduce renal interstitial fibrosis (RIF) in a mouse model, independent of blood glucose control. Transcriptome analysis and molecular biology methods suggest that dapagliflozin's therapeutic effect on RIF may be achieved through multiple pathways regulation. Network pharmacology analysis also revealed potential targets of dapagliflozin against RIF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Shang Guo Piao, Jun Ding, Xue Jing Lin, Qi Yan Nan, Mei Ying Xuan, Yu Ji Jiang, Hai Lan Zheng, Ji Zhe Jin, Can Li
Summary: This study found that RIP1-RIP3-mediated necroptosis is involved in the development of renal fibrosis via the Wnt3 alpha/beta-catenin/GSK-3 beta signaling pathway. RIP inhibitors and ICG-001 can inhibit renal fibrosis and improve cell viability in both a rat model and in vitro cell experiments.
Review
Biochemistry & Molecular Biology
Yanxia Li, Jing Zhao, Yuan Yin, Ke Li, Chenchen Zhang, Yajuan Zheng
Summary: Fibrosis is a detrimental outcome of most chronic inflammatory disorders, and IL-6 plays a significant role in these diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Savino Sciascia, Martina Cozzi, Alice Barinotti, Massimo Radin, Irene Cecchi, Roberta Fenoglio, Daniele Mancardi, Georgia Wilson Jones, Daniela Rossi, Dario Roccatello
Summary: Fibrosis is a pathological process that can affect the kidney, leading to persistent inflammation or long-term injury. Recently, there has been increasing attention on interstitial fibrosis and tubular atrophy as markers of injury severity, predictors of treatment response, and prognostic factors for renal outcome in lupus nephritis (LN). This review explores the mechanisms of fibrogenesis in LN and the importance of the chronicity index in predicting treatment response and renal prognosis. Understanding the cellular and molecular pathways involved in fibrosis in LN could help identify individuals at higher risk of chronic kidney disease and develop new therapeutic strategies for lupus patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Chao Bi, Xiao-Lan Han, Xue-Zhu Li, Jian-Yong Sun, Yan Liu, Sheng-Zhong Duan, Hai-Xia Lu
Summary: This study found that periodontitis increased renal inflammatory response in the UUO mouse model, but did not have a significant effect on renal interstitial fibrosis or renal function.
Article
Cell & Tissue Engineering
Shulin Li, Yanping Wang, Zhuojun Wang, Lu Chen, Bangjie Zuo, Caixia Liu, Dong Sun
Summary: The study demonstrated that GDNF-modified AMSCs enhance the protective effect on renal fibrosis by promoting angiogenesis and repairing damaged endothelial cell function.
STEM CELL RESEARCH & THERAPY
(2021)
Editorial Material
Respiratory System
Shakti D. Shukla, Steven L. Taylor, Peter G. Gibson, Daniel Barker, John W. Upham, Ian A. Yang, Paul N. Reynolds, Sandra Hodge, Alan L. James, Geraint B. Rogers, Jodie L. Simpson
Summary: Add-on azithromycin significantly reduces exacerbations in poorly controlled asthma, especially in non-eosinophilic asthma, by reducing key sputum inflammatory proteins and Haemophilus influenzae load. Further prospective studies are needed to identify patients who would benefit most from AZM add-on therapy.
Article
Medicine, Research & Experimental
Kai Ai, Xiaozhou Li, Pan Zhang, Jian Pan, Huiling Li, Zhibiao He, Hongliang Zhang, Lei Yi, Ye Kang, Yinhuai Wang, Junxiang Chen, Yijian Li, Xudong Xiang, Xiangping Chai, Dongshan Zhang
Summary: This study reveals the role and mechanism of MBD2 in renal fibrosis. MBD2 promotes ECM production by regulating the activity of EGR1. Inhibition of MBD2 reduces renal fibrosis, suggesting it as a potential target for the treatment of fibrotic kidney disease.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Biochemistry & Molecular Biology
Tessa Gerrits, Isabella J. Brouwer, Kyra L. Dijkstra, Ron Wolterbeek, Jan A. Bruijn, Marion Scharpfenecker, Hans J. Baelde
Summary: Chronic kidney disease (CKD) involves progressive deterioration of renal function, characterized by glomerular sclerosis, tubular atrophy, and interstitial fibrosis. Endoglin, expressed in endothelial cells and fibroblasts, may function as a co-receptor of TGF signaling and potentially play a role in the progression of CKD. The study found that endoglin was upregulated in patients with CKD, particularly those with chronic allograft dysfunction and diabetic nephropathy. The overexpression of endoglin in human kidney fibroblasts also resulted in increased mRNA and protein upregulation of ECM components, suggesting its significance as a therapeutic target for the prevention of end-stage renal disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hao Yuan, Xuelian Wu, Xiaomin Wang, Chengfu Yuan
Summary: This study utilized network pharmacology and experimental verification to investigate the therapeutic effects and potential mechanism of Astragalus and Angelica decoction (A&A) on renal interstitial fibrosis (RIF). The results showed that A&A had significant effects on RIF by regulating the cell cycle, limiting apoptosis, and inhibiting inflammation.
Article
Peripheral Vascular Disease
Jordyn M. Thomas, Yeong H. Ling, Brooke Huuskes, Maria Jelinic, Prerna Sharma, Narbada Saini, Dorota M. Ferens, Henry Diep, Shalini M. Krishnan, Barbara K. Kemp-Harper, Paul M. O'Connor, Eicke Latz, Thiruma V. Arumugam, Tomasz J. Guzik, Michael J. Hickey, Ashley Mansell, Christopher G. Sobey, Antony Vinh, Grant R. Drummond
Summary: IL-18 is elevated in hypertensive patients, and its production by tubular epithelial cells contributes to elevated blood pressure, renal inflammation, and fibrosis in a low-renin hypertension mouse model. This suggests IL-18 as a promising therapeutic target for hypertension and kidney disease.
Article
Biochemistry & Molecular Biology
Anca Cardoneanu, Alexandra Maria Burlui, Luana Andreea Macovei, Ioana Bratoiu, Patricia Richter, Elena Rezus
Summary: Systemic sclerosis (SS) is a chronic autoimmune disorder characterized by cutaneous and systemic clinical manifestations. Interleukin-6 (IL-6) plays a critical role in the development of vascular damage and fibrosis in SS. Tocilizumab, an anti-IL-6 therapy, shows promising results in improving skin and lung damage in SS patients.
Article
Urology & Nephrology
Taoxia Wang, Shubei Cui, Xiaoli Liu, Li Han, Xiaoting Duan, Shuning Feng, Sen Zhang, Guiying Li
Summary: This study explores the role of long noncoding RNA taurine-up-regulated gene 1 (TUG1) in tubular fibrosis caused by high glucose and its target genes. Results show that downregulation of TUG1 contributes to renal injury and fibrosis, while overexpression of TUG1 alleviates these effects through the miR-145-5p/DUSP6 axis. These findings provide insights into the mechanism of diabetic nephropathy and potential therapeutic targets.
Article
Dermatology
Hiromichi Hara, Hanae Miyagawa, Jun Araya, Shunsuke Minagawa, Takanori Numata, Yoshinori Umezawa, Akihiko Asahina, Hidemi Nakagawa, Kazuyoshi Kuwano
Summary: This study aimed to investigate the effects of anti-IL-17 biologics on KL-6 levels in psoriasis patients, and found that they decreased KL-6 levels in the high baseline KL-6 group. However, the decrease in KL-6 levels was not associated with radiographic improvement of interstitial pneumonia. Future studies with larger sample sizes and long-term observations are needed to further explore this relationship.
JOURNAL OF DERMATOLOGY
(2021)