Article
Cell Biology
Valentina Castillo, Pamela Diaz-Astudillo, Rocio Corrales-Orovio, Sebastian San Martin, Jose Tomas Egana
Summary: Throughout an organism's lifespan, tissue regeneration capabilities vary significantly. We conducted a comparative analysis of skin derived from mice at regenerative and reparative stages, and found differences in molecular composition, structure, and functionality between the two types of skin. This study provides valuable insights for developing new biomaterials and strategies for tissue engineering and regeneration.
Article
Multidisciplinary Sciences
Jing Mao, Jiexiong Liu, Mei Zhou, Guiqiang Wang, Xia Xiong, Yongqiong Deng
Summary: This research systematically investigates the effects of hypoxia-induced endothelial mesenchymal transition (EndMT) on skin microvascular remodeling in systemic sclerosis (SSc) and its underlying mechanism. The results suggest that the HIF-1α/VEGF signaling pathway plays a critical role in mediating the effect of hypoxia-induced EndMT on skin microvascular remodeling in SSc.
Article
Immunology
Min-Jung You, Chan Rim, Youn-Jung Kang, Min-Soo Kwon
Summary: This study developed a new method to obtain mature microglia from mouse NEL at E13.5, which exhibited microglial functions and maintained characteristics in passage culture. Transcriptome analysis showed NEL-MG had better conservation of microglia signature genes compared to neonatal microglia.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Cell Biology
Sangbum Park
Summary: Wound repair is a crucial process for restoring tissue function, and it shares many similarities with embryonic tissue development. However, there are fundamental differences in terms of cellular components, neighboring tissues, and the surrounding environment. Recent studies have revealed subpopulations, long-term cell fates, and dynamic cellular behaviors in live animals that were previously unknown.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Robin Puellen, Jens Konrad, Rudolf Merkel, Bernd Hoffmann
Summary: The epidermis forms a protective barrier against external damage, chemical factors, and pathogens, with mechanoprotective functions changing dramatically during development and aging. Comparative analysis shows significant differences in viscoelastic and plastic deformation behavior between embryonic and adult skin. Skin equivalents exhibit similar mechanical properties to adult tissue, especially after preconditioning, making them valuable model systems for studying cellular interactions in natural tissues.
Article
Biochemistry & Molecular Biology
Nadia Nascimento da Rosa, Julia Maurer Appel, Ana Carolina Irioda, Bassam Felipe Mogharbel, Nathalia Barth de Oliveira, Maiara Carolina Perussolo, Priscila Elias Ferreira Stricker, Livia Rosa-Fernandes, Claudio Romero Farias Marinho, Katherine Athayde Teixeira de Carvalho
Summary: A 3D lung model was developed using Wharton's jelly mesenchymal stem cells (WJ-MSC) for pulmonary differentiation and bioprinting. The differentiation of WJ-MSC into lung cells and bioprinting in a 3D structure were successfully achieved, providing a promising alternative for in vitro drug testing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Young-Bum Son, Yeon Ik Jeong, Yeon Woo Jeong, Mohammad Shamim Hossein, Alex Tinson, Kuhad Kuldip Singh, Woo Suk Hwang
Summary: This study evaluated the biological characteristics of mesenchymal stem cells (MSCs) derived from skeletal muscle, dermal skin, and adipose tissue from a single donor Camelus dromedarius, demonstrating differences in proliferation and differentiation abilities. The adipogenic differentiation capacity of adipose tissue-derived MSCs was significantly higher, while the osteoblast differentiation capacity was lower compared to skeletal muscle and dermal skin-derived MSCs. Further comparative analysis revealed variations in pluripotent marker expression and alkaline phosphatase activity among the different tissue-derived MSCs.
Article
Respiratory System
Dennis Kruk, Anna C. Y. Yeung, Alen Faiz, Nick H. T. ten Hacken, Wim Timens, Toin H. van Kuppevelt, Willeke Daamen, Danique Hof, Martin C. Harmsen, Mauricio Rojas, Irene H. Heijink
Summary: This study evaluated the transcriptome differences between lung-derived MSCs (LMSCs), bone marrow-derived MSCs (BM-MSC), and adipose-derived MSCs (AD-MSCs) from COPD patients and non-COPD controls. The results showed strong gene signature differences between MSCs from different sources. LMSCs predominantly expressed FGF10 and HGF growth factors. MSCs from all sources displayed altered gene expression in COPD, with the most significant changes observed in AD-MSCs, particularly in genes involved in extracellular matrix binding and expression. The gene CSGALNACT1 showed the strongest difference between COPD and control in LMSCs, which is a gene involved in extracellular matrix modulation.
RESPIRATORY RESEARCH
(2023)
Article
Plant Sciences
Sami Hannachi, Stefaan Werbrouck, Insaf Bahrini, Abdelmuhsin Abdelgadir, Hira Affan Siddiqui, Marie Christine Van Labeke
Summary: An efficient regeneration protocol was applied to regenerate shoots on salt stress-tolerant calli lines of aubergine. Two different methods were used to obtain NaCl-tolerant cell lines, resulting in calli with different growth and biochemical properties.
Article
Materials Science, Multidisciplinary
Mahnaz Aghaleh, Azade Rafiee, Mohammad Hossein Morowvat, Younes Ghasemi
Summary: This study successfully differentiated undifferentiated mesenchymal stem cell lines from amniotic membrane into human chondrocyte stem cell precursors and evaluated the cytotoxicity of different carbon nanotubes. Response surface methodology was used to optimize operational conditions and ensure the highest viability of human chondrocyte stem cell precursors on the CNT scaffold.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Raphael Nogueira do Amaral, Ana Cristina Aoun Tannuri, Junia Marielle Teixeira Rodrigues Neri, Hugo de Souza Reis, Josiane Oliveira Goncalves, Suellen Sera, Uenis Tannuri
Summary: Incisional hernias are less common in children compared to adults, and this could be explained by the more efficient healing process in pediatric patients, which includes differences in neovascularization, inflammation, collagen levels, fibroblast proliferation, and gene expression.
Article
Multidisciplinary Sciences
Fatma Z. Gharbia, Ahmed S. Abouhashem, Yomna A. Moqidem, Ahmed A. Elbaz, Ahmed Abdellatif, Kanhaiya Singh, Chandan K. Sen, Hassan M. E. Azzazy
Summary: Wound healing is a dynamic process involving several phases and fibroblasts play important roles in this process. Researchers analyzed single-cell RNA sequencing datasets of normal and wounded skin in mice during the proliferative phase of wound healing. They identified a specific subset of fibroblasts that increased in wounded skin and were associated with gene signatures related to epithelial mesenchymal transition (EMT) and angiogenesis. By comparing the differential gene expression profile of these fibroblasts with drug signatures in a database, potential drugs that could induce the necessary gene expression changes for wound healing were identified. The study suggests the importance of this subset of fibroblasts and potential candidates for inducing wound closure.
SCIENTIFIC REPORTS
(2023)
Review
Cell Biology
Giuliana Mannino, Cristina Russo, Grazia Maugeri, Giuseppe Musumeci, Nunzio Vicario, Daniele Tibullo, Rosario Giuffrida, Rosalba Parenti, Debora Lo Furno
Summary: Adult stem cells are essential for tissue homeostasis, growth, and regeneration, residing in specialized environments called niches. Interactions within the niche, including intrinsic factors, supporting cells, extracellular matrix, and signaling pathways, govern cell fate and regulate proliferation and differentiation. Tissues can be classified based on their turnover rate and repair abilities, with stem cell niches playing a crucial role in tissue maintenance and response to injury or disease.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biology
Amy Reilein, Helen Kogan, Rachel Misner, Karen Sophia Park, Daniel Kalderon
Summary: In adult Drosophila ovaries, the development of follicle stem cells and niche cells is regulated by signals from both anterior and posterior sources, leading to appropriate spatial organization through controlled proliferative expansion and establishment of signaling cues.
Article
Medicine, Research & Experimental
Meiqi Liu, Jingwei Feng
Summary: Facial aging has a causal relationship with adiposity and its three major indicators, including body mass index, body fat percentage, and waist circumference. This relationship was found through a two-sample Mendelian randomization study and was statistically strong and significant. Waist circumference showed a stronger causal association with facial aging compared to the other two indicators.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Laura M. Perez, Beatriz de Lucas, Aurora Bernal, Beatriz G. Galvez
INTERNATIONAL JOURNAL OF OBESITY
(2020)
Article
Cell Biology
Alejandro Santos-Lozano, Pedro L. Valenzuela, Francisco Llavero, Simone Lista, Pedro Carrera-Bastos, Harald Hampel, Helios Pareja-Galeano, Beatriz G. Galvez, Juan Antonio Lopez, Jesus Vazquez, Enzo Emanuele, Jose L. Zugaza, Alejandro Lucia
Article
Cell Biology
Laura M. Perez, Beatriz de Lucas, Beatriz G. Galvez
Summary: This study revealed functional differences in pericardial adipose stem cells (PSCs) from obese and ex-obese mice, with alterations in apoptosis and migratory capacity accompanied by changes in gene expression profiles. BMP endothelial cell precursor-derived regulator (BMPER) was identified as an important regulator in PSCs, impacting cardiac cell function. Dysregulation of BMPER may be associated with obesity and affect cardiac cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Pedro L. Valenzuela, Pedro Carrera-Bastos, Beatriz G. Galvez, Gema Ruiz-Hurtado, Jose M. Ordovas, Luis M. Ruilope, Alejandro Lucia
Summary: This Review discusses the epidemiological evidence and physiological mechanisms supporting the benefits of major lifestyle interventions in hypertension prevention and adjuvant treatment. Lifestyle interventions, including regular physical exercise, body weight management, healthy diet, adequate sleep patterns, circadian entrainment, and stress management, are increasingly supported as effective approaches in combating hypertension.
NATURE REVIEWS CARDIOLOGY
(2021)
Review
Genetics & Heredity
Beatriz de Lucas, Laura M. Perez, Aurora Bernal, Beatriz G. Galvez
Article
Multidisciplinary Sciences
Beatriz de Lucas, Laura M. Perez, Aurora Bernal, Beatriz G. Galvez
Summary: Ultrasound has been used in regenerative medicine for more than twenty years and has shown positive effects on bone healing and cell processes. However, in this study, low-intensity ultrasound stimulation did not affect the proliferation or migration ability of skin mesenchymal precursors, as observed through various cell and gene expression analyses. Further investigations are needed to optimize ultrasound parameters for stimulating cell populations.
Review
Biochemistry & Molecular Biology
Aurora Bernal, Claudia Calcagno, Willem J. M. Mulder, Carlos Perez-Medina
Summary: Nanomedicine research is prolific but clinical translation lags behind. Understanding the in vivo behavior of nanomedicines is a major challenge for efficient clinical translation. Noninvasive imaging provides valuable information about biodistribution, pharmacokinetics, stability, and therapeutic efficacy of nanomedicines.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Beatriz G. Galvez, Clara Martinez-Perez, Cesar Villa-Collar, Cristina Alvarez-Peregrina, Miguel Angel Sanchez-Tena
Summary: This study used citation networks to analyze the relationship between different publications on the impact of cytokines at an ocular level and their authors. The main research areas were identified and the most cited publications were determined.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Alicia Villatoro, Vincent Cuminetti, Aurora Bernal, Carlos Torroja, Itziar Cossio, Alberto Benguria, Marc Ferre, Joanna Konieczny, Enrique Vazquez, Andrea Rubio, Peter Utnes, Xiaona You, Christopher G. Fenton, Ruth H. Paulssen, Jing Zhang, Fatima Sanchez-Cabo, Ana Dopazo, Anders Vik, Endre Anderssen, Andres Hidalgo, Lorena Arranz
Summary: The balance between IL-1rn and IL-1 beta levels regulates HSC differentiation, and repression of IL-1 beta signaling by IL-1rn protects against pre-leukemic myelopoiesis.
NATURE COMMUNICATIONS
(2023)
Review
Genetics & Heredity
Giulio Cossu, Rossana Tonlorenzi, Silvia Brunelli, Maurilio Sampaolesi, Graziella Messina, Emanuele Azzoni, Sara Benedetti, Stefano Biressi, Chiara Bonfanti, Laricia Bragg, Jordi Camps, Ornella Cappellari, Marco Cassano, Fabio Ciceri, Marcello Coletta, Diego Covarello, Stefania Crippa, M. Gabriella Cusella-De Angelis, Luciana De Angelis, Arianna Dellavalle, Jordi Diaz-Manera, Daniela Galli, Francesco Galli, Cesare Gargioli, Mattia F. M. Gerli, Giorgia Giacomazzi, Beatriz G. Galvez, Hidetoshi Hoshiya, Maria Guttinger, Anna Innocenzi, M. Giulia Minasi, Laura Perani, Stefano C. Previtali, Mattia Quattrocelli, Martina Ragazzi, Urmas Roostalu, Giuliana Rossi, Raffaella Scardigli, Dario Sirabella, Francesco Saverio Tedesco, Yvan Torrente, Gonzalo Ugarte
Summary: In 2002, we discovered a group of vessel-associated progenitors called mesoangioblasts (MABs). Studies over the past decade have shown that muscle development and regeneration are more complex than previously thought. We identified the origin of MABs as partly from the embryonic aorta and later from the microvasculature of skeletal muscle. MABs could be expanded in vitro and cross the vessel wall, making them a potential choice for cell therapy of muscular dystrophies.
FRONTIERS IN GENETICS
(2023)
Article
Microbiology
Miguel Angel Sanchez-Tena, Beatriz G. Galvez, Clara Martinez-Perez, Cristina Alvarez-Peregrina
Summary: This study conducted a citation network analysis to analyze the relevance of different publications and authors in the field of microbiota on ocular diseases. A bibliographic search was conducted using the Web of Science database, resulting in 705 publications and 1014 citation networks. The main research areas were identified as microbiology and ophthalmology, and the main research topics included the composition and diversity of bacterial communities on the ocular surface of patients with various pathologies.
MICROBIOLOGY RESEARCH
(2023)
Article
Immunology
Carmen Fiuza-Luces, Pedro L. Valenzuela, Beatriz G. Galvez, Manuel Ramirez, Alejandro Lopez-Soto, Richard J. Simpson, Alejandro Lucia
Summary: Regular physical activity is associated with a lower incidence and mortality of cancer, including aggressive malignancies. It improves cancer immunosurveillance, stimulates immune cell infiltration into tumors, and has potential clinical implications for adoptive cell therapy. Exercise has a positive effect on anticancer immunity.
NATURE REVIEWS IMMUNOLOGY
(2023)
Review
Immunology
Asuncion Martin-Ruiz, Carmen Fiuza-Luces, Cecilia Rincon-Castanedo, David Fernandez-Moreno, Beatriz G. Galvez, Esther Martinez-Martinez, Paloma Martin-Acosta, Maria Jose Coronado, Lidia Franco-Luzon, Africa Gonzalez-Murillo, Manuel Ramirez, Mariano Provencio, Alejandro Lucia
EXERCISE IMMUNOLOGY REVIEW
(2020)
