Article
Cell Biology
Yu Zhang, Moises Hernandez, Jonathan Gower, Nolan Winicki, Xena Morataya, Sebastian Alvarez, Jason X-J Yuan, John Shyy, Patricia A. Thistlethwaite
Summary: This study found that the NOTCH3 pathway plays a crucial role in controlling vascular smooth muscle cell proliferation and differentiation in the pulmonary arterial tree. In pulmonary arterial hypertension (PAH) patients, JAGGED-1 is overexpressed in small pulmonary artery smooth muscle cells and selectively activates NOTCH3 signaling, leading to increased cellular proliferation. On the other hand, DELTA-LIKE 4 inhibits NOTCH3 signaling and retards smooth muscle cell proliferation. A new monoclonal antibody was developed to block JAGGED-1-induced cleavage of NOTCH3 and successfully reversed pulmonary hypertension in animal models without toxic side effects. Targeting JAGGED-1 activation of NOTCH3 may be an effective and safe strategy for treating PAH.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Qin Fang, Yang Bai, Shuiqing Hu, Jie Ding, Lei Liu, Meiyan Dai, Jie Qiu, Lujin Wu, Xiaoquan Rao, Yan Wang
Summary: This review article explores the role and mechanism of Nrf2 in pulmonary vascular remodeling associated with PH, as well as summarizes the therapeutic potential of Nrf2 inducers.
Article
Pharmacology & Pharmacy
Cunlin Gu, Zhanting Yang, Shanshan Su, Ke Ma, Xingmei Nan, Zhanqiang Li, Dianxiang Lu
Summary: 4-Terpineol attenuates pulmonary arterial remodeling and pulmonary arterial hypertension by inhibiting the proliferation of pulmonary arterial smooth muscle cells through the suppression of the PI3K/Akt signaling pathway.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Review
Health Care Sciences & Services
Zhuangzhuang Jia, Shuai Wang, Haifeng Yan, Yawen Cao, Xuan Zhang, Lin Wang, Zeyu Zhang, Shanshan Lin, Xianliang Wang, Jingyuan Mao
Summary: Pulmonary vascular remodeling, involving changes in the intima, media and adventitia, is a critical structural alteration and pathological feature in pulmonary hypertension. It includes the proliferation and phenotypic transformation of pulmonary artery endothelial cells (PAECs) and pulmonary artery smooth muscle cells (PASMCs), as well as interactions with pulmonary artery fibroblasts (PAFs) and extracellular matrix (ECM). Inflammatory mechanisms, apoptosis, and other factors are influenced by different mechanisms that contribute to disease progression. This article reviews these pathological changes and discusses the underlying mechanisms in the remodeling process.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, Research & Experimental
Weiquan Zeng, Xiuli Zhang, Yao Lu, Ying Wen, Qiurong Xie, Xuan Yang, Shuyu He, Zhi Guo, Jiapeng Li, Aling Shen, Jun Peng
Summary: This study investigates the effect of neferine on hypertensive vascular remodeling and its underlying mechanisms. The results demonstrate that neferine can effectively reduce blood pressure, pulse wave velocity, and abdominal aortic thickening in hypertensive rats. It also suppresses the abnormal activation of PI3K/AKT and TGF-beta/Smad2/3 signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Plant Sciences
Tingting Chen, Shanshan Su, Zhanting Yang, Dejun Zhang, Zhanqiang Li, Dianxiang Lu
Summary: This study aimed to investigate the role of SBT in attenuating pulmonary arterial pressure and vascular remodeling caused by MCT and hypoxia. The study found that SBT reduces pulmonary arterial pressure, vascular remodeling, and levels of inflammatory cytokines in rats. Furthermore, SBT significantly suppresses the MAPK/NF-Kappa B signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ting Wang, Yan Duan, Dong Liu, Gang Li, Bin Liu
Summary: The study found that the expression of TG2 is significantly altered in PAH, and that a TG2 inhibitor can decrease pulmonary vascular remodeling in rats with PAH, thus preventing the formation of PAH. This effect may be achieved through the inhibition of TG2 activity, 5-HTT expression, and possibly the inhibition of RhoA/ROCK signaling pathway activation.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Biochemistry & Molecular Biology
Xiaoyu Fang, Min Xie, Xiansheng Liu, Yuanzhou He
Summary: High expression of CENPE is observed in PH patients and hypoxia-induced PH animals, and its deficiency inhibits pulmonary vascular remodeling and right ventricular hypertrophy. CENPE may exert its biological effect by targeting the transcription of CDK1 proteins.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Jiamei Yao, Xia Fang, Cui Zhang, Yushu Yang, Dongsheng Wang, Qiong Chen, Guangwei Zhong
Summary: The study investigated the protective effects and mechanisms underlying AS-IV on hypoxia-induced PASMC proliferation and pulmonary vascular remodeling in PAH model rats. AS-IV treatment inhibited hypoxia-induced PASMC proliferation by downregulating PCNA expression and effectively alleviated PAH symptoms by suppressing Notch signaling pathway activity.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Critical Care Medicine
Bradley A. Maron, David E. Kleiner, Elena Arons, Bradley M. Wertheim, Nirmal S. Sharma, Kathleen J. Haley, Andriy O. Samokhin, Ethan J. Rowin, Martin S. Maron, Douglas R. Rosing, Barry J. Maron
Summary: This study found that in patients with hypertrophic cardiomyopathy (HCM), the interpretation of pulmonary hypertension (PH) pathophysiological features may be confounded by dynamic left ventricular outflow tract obstruction. By comparing multiple HCM patients and control tissue specimens, the study found that HCM patients exhibited pulmonary arterial hypertrophy and fibrosis, which correlated with myocardial thickness and left ventricular outflow tract gradient. These findings have important implications for understanding the PH pathophysiological features in HCM patients.
Article
Biochemistry & Molecular Biology
Xiaowei Nie, Chenyou Shen, Jianxin Tan, Xusheng Yang, Wei Wang, Youai Dai, Haijian Sun, Zhiyuan Wu, Jingyu Chen
Summary: The study demonstrated that Andrographolide (ANDRO) may reverse pulmonary vascular remodeling through modulation of NOX/Nrf2-mediated oxidative stress and NF-kappa B-mediated inflammation, suggesting therapeutic potential in the treatment of pulmonary hypertension.
Review
Cell Biology
Qiang Zhao, Ping Song, Ming-Hui Zou
Summary: Pulmonary hypertension is a debilitating disease characterized by increased blood pressure in the pulmonary arteries. The role of AMPK in PH is controversial as both inhibition and activation of AMPK can potentially prevent the development of PH. Clinical studies suggest that metformin, an AMPK activator, is effective in treating early-stage PH and particularly beneficial for patients with PH associated with heart failure.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Luckika Panthiya, Jiraporn Tocharus, Amnart Onsa-ard, Waraluck Chaichompoo, Apichart Suksamrarn, Chainarong Tocharus
Summary: The study found that HHC can improve vascular function and attenuate vascular remodeling in hypertensive rats. Its potential mechanisms of action may involve antioxidant and anti-inflammatory effects.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Pharmacology & Pharmacy
Xiaonan Zhang, Zhanting Yang, Shanshan Su, Xingmei Nan, Xin Xie, Zhanqiang Li, Dianxiang Lu
Summary: This study found that the flavonoid compound kaempferol can reduce pulmonary artery pressure and pulmonary vascular remodeling, and alleviate right ventricular hypertrophy in rats with high altitude pulmonary hypertension. Mechanistic analysis demonstrated that kaempferol inhibits smooth muscle cell proliferation and promotes apoptosis via modulation of the Akt/GSK38/CyclinD axis.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Charifa Awada, Alice Bourgeois, Sarah-Eve Lemay, Yann Grobs, Tetsuro Yokokawa, Sandra Breuils-Bonnet, Sandra Martineau, Vinod Krishna, Francois Potus, Jey Jeyaseelan, Steeve Provencher, Sebastien Bonnet, Olivier Boucherat
Summary: Pulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling, and the inhibition of the histone methyltransferase G9a/GLP may represent a new therapeutic approach for PAH.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Engineering, Industrial
Xiaoping Xu, Yujing Chen, Ping He, Yugang Yu, Gongbing Bi
Summary: This paper investigates the cooperating mode selection problem of a manufacturer selling products through offline and online channels. The study finds that demand disruptions and cross-channel effects significantly influence the manufacturer's optimal operational decisions and platform mode selection. The presence of demand disruptions complicates the manufacturer's mode selection, and higher cross-channel effects can lead to increased production. Furthermore, demand disruptions have a significant impact on the profits of both the manufacturer and the platform.
INTERNATIONAL JOURNAL OF PRODUCTION RESEARCH
(2023)
Article
Environmental Sciences
Ce Liu, Bin Luo, Bo Wang, Li He, Huanmei Wu, Lifang Hou, Kai Zhang
Summary: With climate change, the burden of cardiovascular diseases attributed to high temperatures is continuously increasing, especially in tropical regions and regions with lower socio-demographic levels. The burden of CVD attributed to low temperatures and non-optimal temperatures is decreasing.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Fisheries
Yan Chen, Yucen Bai, Xiaolu Hu, Xiaofei Yang, Shaogang Xu, Bo Cheng
Summary: This study investigated the mechanism of gill remodeling in early life stages of fish due to predicted increases in carbon dioxide (CO2). The findings suggest that high CO2 exposure disrupts cellular redox homeostasis in the gill and triggers stress responses to mitigate oxidative stress and prevent protein aggregation.
ICHTHYOLOGICAL RESEARCH
(2023)
Article
Engineering, Multidisciplinary
Yuru Hu, Feng Zhang, Xiangpeng Xin, Hanze Liu
Summary: In this article, the Date-Jimbo-Kashiwara-Miwa equation is extended to a new variable-coefficients equation with respect to the time variable. The infinitesimal generators and optimal system are obtained through Lie symmetry analysis. The reduced partial differential equations are transformed into ordinary differential equations using traveling wave transform, and the exact solutions are found using the extended tanh-function method. The structural features of exact solutions at different times are illustrated with images.
INTERNATIONAL JOURNAL OF NONLINEAR SCIENCES AND NUMERICAL SIMULATION
(2023)
Article
Medicine, General & Internal
Yuerong Yan, Xiaoyi Wang, Hongshi Wu, Caixia Chen, Xiaohui Li, Rongxue Yang, Feng Li, Li Yan, Muchao Mu, Mingtong Xu
Summary: This study aimed to explore the association between sleep status and thyroid nodules. The results showed that individuals who slept less than 5 hours per night had a significantly higher percentage of thyroid nodules compared to those who slept 5-8 hours or more than 8 hours per night. Therefore, screening for thyroid nodules is recommended in this population.
POSTGRADUATE MEDICINE
(2023)
Article
Psychiatry
Cuicui Wang, Dawn L. DeMeo, Eric S. Kim, Andres Cardenas, Kelvin C. Fong, Lewina O. Lee, Avron Spiro, Eric A. Whitsel, Steve Horvath, Lifang Hou, Andrea A. Baccarelli, Yun Li, James D. Stewart, JoAnn E. Manson, Francine Grodstein, Laura D. Kubzansky, Joel D. Schwartz
Summary: Optimism is associated with reduced mortality and lower risk of age-related chronic diseases. DNA methylation provides insight into mechanisms underlying these relationships. Cross-sectional data from two population-based cohorts of women and men revealed that optimism is associated with epigenome-wide leukocyte DNA methylation, providing new insights into the possible mechanisms underlying optimism and health.
PSYCHOSOMATIC MEDICINE
(2023)
Article
Engineering, Geological
Jianting Feng, Yang Shen, Hanlong Liu, Wen Shi
Summary: In this study, an improved analytical solution for excess pore water pressure is proposed based on the analysis and verification of experimental results. The modified electroosmotic consolidation theory provides a closer approximation to the measured values and better matches the actual situation compared to Esrig's theory.
Article
Environmental Sciences
Cuicui Wang, Zongli Xu, Xinye Qiu, Yaguang Wei, Adjani A. Peralta, Mahdieh Danesh Yazdi, Tingfan Jin, Wenyuan Li, Allan Just, Jonathan Heiss, Lifang Hou, Yinan Zheng, Brent A. Coull, Anna Kosheleva, David Sparrow, Chitra Amarasiriwardena, Robert O. Wright, Andrea A. Baccarelli, Joel D. Schwartz
Summary: This study investigated the relationship between toenail metals and adverse health outcomes, such as cancer and cardiovascular disease, in elderly men. The researchers analyzed DNA methylation and found significant associations with metal mixtures and CpG sites related to cancer and cardiovascular disease.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Jian Wang, Ran Ma, Zheng Jiang
Summary: In this study, the DTAB/TiO2 composite material was successfully prepared and applied for uranium adsorption from water. The DTAB/TiO2 showed excellent chemical stability and rough surface, enabling the removal of U(VI) in a monolayer adsorption form. The surface oxygen-containing functional groups played a crucial role in the removal of U(VI).
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Yinsheng Xie, Dawen Liu, Haijun Pan, Wangping Wu, Xiaoyan Li, Yi Zhang, Peng Jiang
Summary: The effect of different roll speed ratios on microstructures and mechanical properties of V-Ti-Ni alloys was investigated through experiments of asynchronous rolling. The results show that the roll speed ratios have a significant influence on the reduction rates and hardness of the alloys, and can also lead to the formation of fiber structures. The rolled microstructures of the alloys exhibit irregular deformation.
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
(2023)
Article
Respiratory System
Yuyang Gao, Wenli Xu, Wenyan Li, Zhiyu Chen, Qi Li, Zhen Liu, Hanmin Liu, Li Dai
Summary: This study characterized the epidemiology of pulmonary sequestration (PS) in the Chinese population over the past decade, showing an increasing prevalence and poor perinatal outcomes. The prevalence rates varied by maternal age, residence area, geographical region, and infant sex. Non-isolated PS cases were more likely to have accompanying respiratory and circulatory system malformations. This study provides important insights into the prevalence and outcomes of PS in the Chinese population, highlighting the need for improved perinatal management.
BMC PULMONARY MEDICINE
(2023)
Article
Computer Science, Artificial Intelligence
Hangkai Hu, Gao Huang, Xiang Li, Shiji Song
Summary: This article introduces an off-policy meta-RL algorithm that allows meta-learners to adapt their exploration strategy and balance task-agnostic and task-related information through latent context reorganization.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)
Article
Microbiology
Linqing Zhao, Xiaoyan Dong, Ling Cao, Yongmei Jiang, Hong Zhang, Ran Mo, Hanmin Liu
Summary: This study evaluated the performance of Acaruiter Respiratory Panel (fluorescent PCR) in detecting respiratory tract infection pathogens in children. The results showed that it has good consistency, high accuracy, and high positive and negative agreement percentages.
MICROBIOLOGY SPECTRUM
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qiurong Wei, Zeli Chen, Yehuan Tang, Weicui Chen, Liming Zhong, Liting Mao, Shaowei Hu, Yuankui Wu, Kan Deng, Wei Yang, Xian Liu
Summary: This study developed a machine learning model to predict the pathological complete response (pCR) in rectal cancer patients after neoadjuvant chemoradiotherapy, and compared the performance of different classifiers. The results showed that the random forest algorithm performed well in predicting pCR.
EUROPEAN RADIOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Xiaoli Ye, Yuxia Guo, Peng Wang, Yonghui Zhao, Wenshuo Xie, Guorui Feng
Summary: This study investigates the effect of barium hydroxide on the performance of cemented gangue backfill material (CGBM) in acid mine water with sulfate ions. The results show that adding barium hydroxide promotes the formation of barium sulfate precipitation and inhibits corrosion products, delaying the progress of corrosion reactions and improving the performance of the CGBM specimens.
JOURNAL OF RENEWABLE MATERIALS
(2023)
