Sensitivity to Lysosome-Dependent Cell Death Is Directly Regulated by Lysosomal Cholesterol Content

Neurodegenerative lysosomal disorders: A continuum from development to late age

(2014) Ralph A. Nixon et al.   Autophagy

Attenuation of the Lysosomal Death Pathway by Lysosomal Cholesterol Accumulation

(2011) Hanna Appelqvist et al.   AMERICAN JOURNAL OF PATHOLOGY

Lysosomes and lysosomal cathepsins in cell death

(2011) Urška Repnik et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Regulation of apoptosis-associated lysosomal membrane permeabilization

(2010) Ann-Charlotte Johansson et al.   APOPTOSIS

Lysosomal membrane proteins: life between acid and neutral conditions: Figure 1

(2010) Paul Saftig et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Myriocin-mediated up-regulation of hepatocyte apoA-I synthesis is associated with ERK inhibition

(2010) Elias N. Glaros et al.   CLINICAL SCIENCE

Nonesterified cholesterol content of lysosomes modulates susceptibility to oxidant-induced permeabilization

(2010) John J. Reiners et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pathophysiology of neuropathic lysosomal storage disorders

(2010) Cinzia Maria Bellettato et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells

(2010) A. I. Rosenbaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective cell death in neurodegeneration: Why are some neurons spared in vulnerable regions?

(2010) K.L. Double et al.   PROGRESS IN NEUROBIOLOGY

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Lipids on Trial: The Search for the Offending Metabolite in Niemann-Pick type C Disease

(2010) Emyr Lloyd-Evans et al.   TRAFFIC

Improvement in Lipid and Protein Trafficking in Niemann-Pick C1 Cells by Correction of a Secondary Enzyme Defect

(2010) Cecilia Devlin et al.   TRAFFIC

Increased Activity and Altered Subcellular Distribution of Lysosomal Enzymes Determine Neuronal Vulnerability in Niemann-Pick Type C1-Deficient Mice

(2009) Asha Amritraj et al.   AMERICAN JOURNAL OF PATHOLOGY

Niemann-Pick C1 Functions Independently of Niemann-Pick C2 in the Initial Stage of Retrograde Transport of Membrane-impermeable Lysosomal Cargo

(2009) Stephen D. B. Goldman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role for LAMP-2 in endosomal cholesterol transport

(2009) Alexander Schneede et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cyclodextrin overcomes the transport defect in nearly every organ of NPC1 mice leading to excretion of sequestered cholesterol as bile acid

(2009) Benny Liu et al.   JOURNAL OF LIPID RESEARCH

Adaptation of neuronal cells to chronic oxidative stress is associated with altered cholesterol and sphingolipid homeostasis and lysosomal function

(2009) Angela B. Clement et al.   JOURNAL OF NEUROCHEMISTRY

Chronic Cyclodextrin Treatment of Murine Niemann-Pick C Disease Ameliorates Neuronal Cholesterol and Glycosphingolipid Storage and Disease Progression

(2009) Cristin D. Davidson et al.   PLoS One

Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells

(2009) L. Abi-Mosleh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensitization to the Lysosomal Cell Death Pathway by Oncogene-Induced Down-regulation of Lysosome-Associated Membrane Proteins 1 and 2

(2008) N. Fehrenbacher et al.   CANCER RESEARCH

Niemann-Pick C1 Functions in Regulating Lysosomal Amine Content

(2008) Allyn M. Kaufmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysobisphosphatidic Acid Controls Endosomal Cholesterol Levels

(2008) Julien Chevallier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

(2008) Emyr Lloyd-Evans et al.   NATURE MEDICINE