Article
Multidisciplinary Sciences
Huiling Li, Yangao Huo, Xi He, Liping Yao, Hao Zhang, Yiqiang Cui, Huijuan Xiao, Wenxiu Xie, Dejiu Zhang, Yue Wang, Shu Zhang, Haixia Tu, Yiwei Cheng, Yueshuai Guo, Xintao Cao, Yunfei Zhu, Tao Jiang, Xuejiang Guo, Yan Qin, Jiahao Sha
Summary: A sperm-specific ribosome with a specialized nascent polypeptide exit tunnel has been identified in mice, which plays a crucial role in regulating protein folding during sperm formation.
Review
Biology
Aivars Cirulis, Bengt Hansson, Jessica K. Abbott
Summary: This article provides an overview of the effects of sex-limited chromosomes on non-reproductive traits and discusses the evolutionary processes maintaining variation at sex-limited chromosomes and the molecular mechanisms affecting non-reproductive traits.
Article
Biochemistry & Molecular Biology
Alice S. Naftaly, Shana Pau, Michael A. White
Summary: Long-read sequencing technology, such as Pacific Biosciences (PacBio) Iso-Seq, allows for the accurate detection of full-length alternative transcripts, improving genomic resources and enhancing our understanding of transcriptome complexity in threespine stickleback fish.
Article
Multidisciplinary Sciences
Miho Terao, Yuya Ogawa, Shuji Takada, Rei Kajitani, Miki Okuno, Yuta Mochimaru, Kentaro Matsuoka, Takehiko Itoh, Atsushi Toyoda, Tomohiro Kono, Takamichi Jogahara, Shusei Mizushima, Asato Kuroiwa
Summary: Mammalian sex chromosomes are highly conserved, but two exceptional rodent groups have provided insights into how novel sex genes can arise and replace Sry. A male-specific duplication of an enhancer of Sox9 has been discovered in the Amami spiny rat, which lacks a Y chromosome and Sry. This duplication acts as a substitute for Sry and defines a novel Y chromosome in the spiny rat.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Saffron A. G. Willis-Owen, Clara Domingo-Sabugo, Elizabeth Starren, Liming Liang, Maxim B. Freidin, Madeleine Arseneault, Youming Zhang, Shir Kiong Lu, Sanjay Popat, Eric Lim, Andrew G. Nicholson, Yasser Riazalhosseini, Mark Lathrop, William O. C. Cookson, Miriam F. Moffatt
Summary: Lung cancer disproportionately affects men with KDM5D deficiency associated with a higher risk of death. The study identifies KDM5D deficiency as a prognostic marker for male lung cancer patients, explaining the sex disparity in lung cancer outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Peiwei Chen, Alexei A. Aravin
Summary: This study revealed that the sexual dimorphism in piRNA program in Drosophila is mainly determined by germ cells rather than somatic cells. The presence of Y chromosome can partially replicate the male piRNA program in a female cellular environment, while sexual identity controls sexually divergent piRNA production by regulating Sxl, Phf7 and Kipferl. This work delineates the genetic control of sex-specific piRNA program.
Article
Biochemistry & Molecular Biology
Shuqing Zheng, Wenjing Tao, Hongyan Tao, Haowen Yang, Limin Wu, Feng Shao, Zhijian Wang, Li Jin, Zuogang Peng, Deshou Wang, Yaoguang Zhang
Summary: The genomes of female and male Amur catfish were assembled using nanopore and Hi-C technologies, with sizes of 757.15 and 755.44 Mb, respectively. Comparative analysis revealed the presence of an XX/XY sex determination system in Amur catfish, with Chr5 as the sex chromosome containing a Y-specific region (MSY). The male-specific duplicate of amhr2, amhr2y, was found in the MSY and expressed only in the testes. These findings provide valuable genomic resources and identify amhr2y as the candidate sex determination gene in Amur catfish.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Matthew B. Couger, Scott W. Roy, Noelle Anderson, Landen Gozashti, Stacy Pirro, Lindsay S. Millward, Michelle Kim, Duncan Kilburn, Kelvin J. Liu, Todd M. Wilson, Clinton W. Epps, Laurie Dizney, Luis A. Ruedas, Polly Campbell
Summary: The sex chromosome system of the creeping vole is unique, with females having an unpaired X chromosome (X0) and the sex chromosome being one of the two X chromosomes, both carrying fragments of the ancestral Y chromosome. The consequences of this transformed sex chromosome system in this species include Y-like degeneration, expression of Y-linked genes in females, and X inactivation of the male-specific chromosome in male somatic cells.
Article
Fisheries
Thitipong Panthum, Pish Wattanadilokchatkun, Kitipong Jaisamut, Worapong Singchat, Syed Farhan Ahmad, Narongrit Muangmai, Prateep Duengkae, Agostinho Antunes, Kornsorn Srikulnath
Summary: In this study, the male-linked region of the jade perch was identified on chromosome 19, and a remnant of the amh gene was found in this region, which is considered a candidate gene for sex determination in teleosts.
Article
Fisheries
Hui Luo, Yu Li, Shuqing Zheng, Jian Zhou, Xinxi Zou, Chuangju Li, Huan Ye, Zhe Li, Chaowei Zhou, Guangjun Lv, Shijun Xiao, Hua Ye
Summary: Sex-specific DNA markers were developed to accelerate the development of sex control techniques for the Chinese longsnout catfish. The markers showed a high accuracy in predicting the sex of individuals from different local populations. The ACAP1 gene was identified as a potential candidate involved in sex determination or differentiation in L. longirostris.
Article
Geriatrics & Gerontology
Natasha L. Pacheco, Nicole Noren Hooten, Yongqing Zhang, Calais S. Prince, Nicolle A. Mode, Ngozi Ezike, Kevin G. Becker, Alan B. Zonderman, Michele K. Evans
Summary: The study revealed sex-specific transcriptional changes in middle-aged frailty, aiding in the understanding of frailty progression and providing potential therapeutic targets for preventing frailty.
Article
Biotechnology & Applied Microbiology
Jiao Wang, Yue Lan, Lewei He, Ruixiang Tang, Yuhui Li, Yuan Huang, Shan Liang, Zhan Gao, Megan Price, Bisong Yue, Miao He, Tao Guo, Zhenxin Fan
Summary: The study revealed sex-specific gene expression differences in the blood tissues of four primates, with 31 sex-specific differentially expressed genes identified in humans. Most XY gene pairs had similar expression levels between species, except for one pair (EIF1AY/EIF1AX). Humans had significant XY-biased and XX-biased X-Y gene pairs, while rhesus and Tibetan macaques did not show significant differential expression levels in their X-Y gene pairs.
Article
Biochemistry & Molecular Biology
Elena Makarova, Antonina Kazantseva, Anastasia Dubinina, Tatiana Jakovleva, Natalia Balybina, Konstantin Baranov, Nadezhda Bazhan
Summary: The study compared the effects of FGF21 on male and female mice with diet-induced obesity, showing that despite sex differences in metabolic characteristics, FGF21 beneficially affected mice of both sexes and induced female-specific activation of gene expression in WAT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ecology
Benjamin A. Sandkam, Pedro Almeida, Iulia Darolti, Benjamin L. S. Furman, Wouter van der Bijl, Jake Morris, Godfrey R. Bourne, Felix Breden, Judith E. Mank
Summary: Males of the freshwater fish Poecilia parae occur as one of five morphs with different reproductive strategies that are controlled by five Y haplotypes. Analysis of Y chromosomes of the five morphs shows extreme diversity in the three major morphs despite constraints imposed by lack of recombination of sex chromosomes.
NATURE ECOLOGY & EVOLUTION
(2021)
Article
Agronomy
Naveed Ahmad, Ruizheng Tian, Guanghui Li, Chuanzhi Zhao, Shoujin Fan, Jie Sun, Shuzhen Zhao, Xingjun Wang
Summary: This study discovered male-specific sequence-tagged site (STS) markers in garden asparagus and established an efficient molecular method for sex identification, enabling the rapid selection of male parental lines in future breeding programmes.
Article
Biochemistry & Molecular Biology
Molly A. Bogue, Vivek M. Philip, David O. Walton, Stephen C. Grubb, Matthew H. Dunn, Georgi Kolishovski, Jake Emerson, Gaurab Mukherjee, Timothy Stearns, Hao He, Vinita Sinha, Beena Kadakkuzha, Govindarajan Kunde-Ramamoorthy, Elissa J. Chesler
NUCLEIC ACIDS RESEARCH
(2020)
Article
Genetics & Heredity
Harriet M. Jackson, Kate E. Foley, Rita O'Rourke, Timothy M. Stearns, Dina Fathalla, B. Paul Morgan, Gareth R. Howell
Article
Biology
Kelsey Yetsko, Jessica A. Farrell, Nicholas B. Blackburn, Liam Whitmore, Maximilian R. Stammnitz, Jenny Whilde, Catherine B. Eastman, Devon Rollinson Ramia, Rachel Thomas, Aleksandar Krstic, Paul Linser, Simon Creer, Gary Carvalho, Mariana A. Devlin, Nina Nahvi, Ana Cristina Leandro, Thomas W. DeMaar, Brooke Burkhalter, Elizabeth P. Murchison, Christine Schnitzler, David J. Duffy
Summary: Sea turtle populations are threatened by fibropapillomatosis, an animal epidemic. Researchers have found that internal tumors in turtles with this disease are molecularly distinct from external tumors, though they share common oncogenic signaling pathways that could be targeted for treatment.
COMMUNICATIONS BIOLOGY
(2021)
Article
Cell Biology
David E. Harrison, Randy Strong, Peter Reifsnyder, Navasuja Kumar, Elizabeth Fernandez, Kevin Flurkey, Martin A. Javors, Marisa Lopez-Cruzan, Francesca Macchiarini, James F. Nelson, Adrian Markewych, Alessandro Bitto, Amy L. Sindler, Gino Cortopassi, Kylie Kavanagh, Lin Leng, Richard Bucala, Nadia Rosenthal, Adam Salmon, Timothy M. Stearns, Molly Bogue, Richard A. Miller
Summary: In genetically heterogeneous mice, the non-feminizing estrogen 17aE2 significantly extended the lifespan of male mice when fed at doses starting at 16 or 20 months, without affecting the lifespan of female mice.
Article
Cell & Tissue Engineering
Kira Young, Elizabeth Eudy, Rebecca Bell, Matthew A. Loberg, Tim Stearns, Devyani Sharma, Lars Velten, Simon Haas, Marie-Dominique Filippi, Jennifer J. Trowbridge
Summary: As individuals age, the function of hematopoietic stem cells (HSCs) declines, leading to limited health span of the blood and immune systems. Research indicates that the hallmarks of aging in HSCs and hematopoiesis start accumulating by middle age, with decreased levels of the longevity-associated molecule IGF1 in the bone marrow microenvironment playing a key role in causing HSC aging. By directly stimulating middle-aged HSCs with IGF1, molecular and functional hallmarks of aging can be rescued, highlighting the complex relationship between IGF1 levels, longevity, and HSC function.
Article
Cell Biology
Leslie A. Sepaniac, Whitney Martin, Louise A. Dionne, Timothy M. Stearns, Laura G. Reinholdt, Jason Stumpff
Summary: Micronuclei are associated with tumorigenesis, but not all micronuclei actively promote tumor formation. Loss of Kif18a results in stable nuclear envelopes around micronuclei, potentially enhancing chromatin expansion.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Plant Sciences
Junaldo A. Mantiquilla, Merlene E. Elumba, Meng-Shin Shiao, Yu-Chung Chiang
Summary: Microsatellites markers are promising tools for assessing genetic diversity in Nipa populations, providing valuable insights for characterizing the species within its distribution range.
PLANT GENETIC RESOURCES-CHARACTERIZATION AND UTILIZATION
(2021)
Article
Oncology
Chien-Feng Li, Ti-Chun Chan, Cheng-Tang Pan, Pichpisith Pierre Vejvisithsakul, Jia-Chen Lai, Szu-Yu Chen, Ya-Wen Hsu, Meng-Shin Shiao, Yow-Ling Shiue
Summary: The study identified that EMP2 induces cytostasis through the TGF beta/SMAD/SP1 axis and recruits P2RX7 to enhance apoptosis in UBUC. These findings provide new insights for the design of UBUC targeting therapies.
Article
Biochemistry & Molecular Biology
Tiraput Poonpanichakul, Meng-Shin Shiao, Natnicha Jiravejchakul, Ponpan Matangkasombut, Ekaphop Sirachainan, Varodom Charoensawan, Natini Jinawath
Summary: This study employed single-cell RNA-sequencing to explore ascites-derived cells from a colorectal cancer patient, revealing highly heterogeneous cancer subpopulations that respond differently to treatment, with the majority of ascites-derived cells showing resistance to therapy.
BIOSCIENCE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Emma Westermann-Clark, Ramani Soundararajan, Jutaro Fukumoto, Sahebgowda Sidramagowda Patil, Timothy M. Stearns, Smita Saji, Alexander Czachor, Helena Hernandez-Cuervo, Mason Breitzig, Sudarshan Krishnamurthy, Richard F. Lockey, Narasaiah Kolliputi
Summary: Abnormalities in airway epithelia and lung parenchyma are found in Atp8b1 mutant mice. MMP7 expression is significantly upregulated in these mice, suggesting potential involvement in the pathogenesis of pulmonary fibrosis.
Review
Biochemistry & Molecular Biology
Meng-Shin Shiao, Jia-Ming Chang, Arb-Aroon Lertkhachonsuk, Naparat Rermluk, Natini Jinawath
Summary: Early detection of EOC is crucial for improving survival rates. Exosomal miRNAs show promise as non-invasive biomarkers for early cancer detection, but stability, sensitivity, and selection of endogenous reference miRNAs are important considerations. Current clinical trials using miRNAs for EOC detection suggest their potential utility in the future.
Article
Oncology
Jennifer M. SanMiguel, Elizabeth Eudy, Matthew A. Loberg, Kira A. Young, Jayna J. Mistry, Kristina D. Mujica, Logan S. Schwartz, Timothy M. Stearns, Grant A. Challen, Jennifer J. Trowbridge
Summary: Clonal hematopoiesis resulting from enhanced fitness of mutant hematopoietic stem cells can lead to both favorable and unfavorable health outcomes. This study found that aging-induced TNF alpha signaling promotes the selective advantage of mutant HSCs and stimulates the production of mutant B lymphoid cells. The loss of TNFR1 abolishes the advantage of mutant HSCs, while the loss of TNFR2 results in overproduction of mutant myeloid cells without affecting HSC fitness.
Article
Plant Sciences
Junaldo A. Mantiquilla, Meng-Shin Shiao, Hsueh-Yu Lu, Kitichate Sridith, Siti Nordahliawate M. Sidique, Wasantha Kumara Liyanage, Ya-Ling Chu, Huie-Chuan Shih, Yu-Chung Chiang
Summary: This study assessed genetic variations of the mangrove palm Nipa using microsatellite markers and found genetic differentiation among different populations. The Malacca Strait was identified as a genetic and geographic barrier. The study also revealed strong contemporary genetic connectivity from west to east.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Junaldo A. Mantiquilla, Hsueh-Yu Lu, Huei-Chuan Shih, Li-Ping Ju, Meng-Shin Shiao, Yu-Chung Chiang
Summary: In this study, the genetic structures of the critically endangered species, Yellow water lily, in Taiwan were examined. It was found that the species exhibited significant genetic structuring and there was genetic exchange and migration between different populations. It is suggested to consider certain populations as separate conservation units due to their geographical distance from other populations.
Article
Microbiology
Ya-Zhu Ko, Wasantha Kumara Liyanage, Huei-Chuan Shih, Min-Nan Tseng, Meng-Shin Shiao, Yu-Chung Chiang
Summary: This study investigated the diversity and genetic variation of Lasiodiplodia species in Taiwan and identified several new infection records. The study found that the diversity of Lasiodiplodia in Taiwan had been underestimated, and L. theobromae exhibited high genetic diversity and low gene flow. The high genetic diversity and host-associated differentiation of Lasiodiplodia species indicate their powerful evolutionary potential in Taiwan.