Article
Multidisciplinary Sciences
Wooi F. Lim, Mitra Forouhan, Thomas C. Roberts, Jesse Dabney, Ruth Ellerington, Alfina A. Speciale, Raquel Manzano, Maria Lieto, Gavinda Sangha, Subhashis Banerjee, Mariana Conceicao, Lara Cravo, Annabelle Biscans, Loic Roux, Naemeh Pourshafie, Christopher Grunseich, Stephanie Duguez, Anastasia Khvorova, Maria Pennuto, Constanza J. Cortes, Albert R. La Spada, Kenneth H. Fischbeck, Matthew J. A. Wood, Carlo Rinaldi
Summary: SBMA is a neuromuscular disease caused by a polyQ expansion in AR protein, with recent studies highlighting the importance of mutant AR-altered transcriptional activity. Targeting AR isoform 2 can ameliorate the disease phenotype in SBMA mice by restoring dysregulated transcriptional activity of polyQ AR protein.
Article
Multidisciplinary Sciences
Sakshi Goel, Vipul Bhatia, Sushmita Kundu, Tanay Biswas, Shannon Carskadon, Nilesh Gupta, Mohammad Asim, Colm Morrissey, Nallasivam Palanisamy, Bushra Ateeq
Summary: DLX1 serves as a crucial factor in prostate cancer, and its high levels are associated with aggressive disease and poor prognosis. Through regulating the transcriptional activity of DLX1, ERG and AR contribute to tumorigenesis and metastasis. Inhibiting ERG/AR-mediated transcription of DLX1 using BET inhibitors and anti-androgens can reduce its expression and downstream oncogenic effects.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Meixia Che, Aashi Chaturvedi, Sarah A. Munro, Samuel P. Pitzen, Alex Ling, Weijie Zhang, Josh Mentzer, Sheng-Yu Ku, Loredana Puca, Yanyun Zhu, Andries M. Bergman, Tesa M. Severson, Colleen Forster, Yuzhen Liu, Jacob Hildebrand, Mark Daniel, Ting-You Wang, Luke A. Selth, Theresa Hickey, Amina Zoubeidi, Martin Gleave, Rohan Bareja, Andrea Sboner, Wayne Tilley, Jason S. Carroll, Winston Tan, Manish Kohli, Rendong Yang, Andrew C. Hsieh, Paari Murugan, Wilbert Zwart, Himisha Beltran, R. Stephanie Huang, Scott M. Dehm
Summary: Endocrine therapies for prostate cancer often lead to the reactivation of the androgen receptor, promoting disease progression. This study shows that the transcription factor KLF5 is induced during treatment, promoting cellular migration and the development of a basal epithelial cell phenotype.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Deng Wang, Chaping Cheng, Xinyu Chen, Jinming Wang, Kaiyuan Liu, Na Jing, Penghui Xu, Xialian Xi, Yujiao Sun, Zhongzhong Ji, Huifang Zhao, Yuman He, Kai Zhang, Xinxing Du, Baijun Dong, Yuxiang Fang, Pengcheng Zhang, Xueming Qian, Wei Xue, Wei-Qiang Gao, Helen He Zhu
Summary: The activation of androgen receptor (AR) signaling pathway in tumor-associated macrophages (TAMs) promotes the overexpression and secretion of IL-1 beta, inhibiting cytotoxic T cells activation and leading to an immune suppressive microenvironment in advanced prostate cancer (PCa). Combined treatment of androgen deprivation therapy (ADT) with anti-IL-1 beta antibody and immune checkpoint inhibitor anti-PD-1 antibody shows a stronger anticancer effect on castration-resistant PCa.
Article
Biology
Yali Lu, Xuechao Wan, Wenhua Huang, Lu Zhang, Jun Luo, Dujian Li, Yan Huang, Yao Li, Yaoting Xu
Summary: The study elucidated the role of lncRNA AC016745.3 in prostate cancer, showing its ability to inhibit the pro-oncogenic functions of NONO by binding to it, thereby affecting the proliferation and migration of tumor cells.
Article
Hematology
Yun Tan, Xiaoling Wang, Huan Song, Yi Zhang, Rongsheng Zhang, Shufen Li, Wen Jin, Saijuan Chen, Hai Fang, Zhu Chen, Kankan Wang
Summary: The activation function of PML/RAR alpha through recruiting P300 and HDAC1 and forming super-enhancers, and its synergistic effects with all-trans retinoic acid and arsenic trioxide in controlling super-enhancer-associated PML/RAR alpha-regulated targets in APL cells are highlighted. The study demonstrated the necessity of the PML/RAR alpha-activated target gene GFI1 for maintaining APL cells and the interplay between GFI1 and PML/RAR alpha in coregulating target genes on chromatin. Genomic insight into the dual role of fusion transcription factors in transcriptional deregulation to drive leukemia development is provided, emphasizing the importance of globally dissecting regulatory circuits.
Article
Engineering, Electrical & Electronic
Qinlei Li, Liping Song, Yongquan Zhang
Summary: Data association is crucial in target tracking systems, especially with clutter measurements. A tractable algorithm based on Gaussian process measurement model and truncated joint probabilistic data association technique is proposed for tracking multiple extended targets, showing higher accuracy compared to other algorithms.
IET SIGNAL PROCESSING
(2021)
Article
Endocrinology & Metabolism
Zhengyang Han, Ujjwal Rimal, Prabesh Khatiwada, Jacob Brandman, Jun Zhou, Muhammad Hussain, Ronald E. Viola, Lirim Shemshedini
Summary: Researchers have developed novel peptide inhibitors that target the SUZ12 protein component to inhibit the functions of PRC2, showing promise in the treatment of mCRPC.
Article
Oncology
Iris Simon, Sonia Perales, Laura Casado-Medina, Alba Rodriguez-Martinez, Maria del Carmen Garrido-Navas, Ignacio Puche-Sanz, Juan J. Diaz-Mochon, Clara Alaminos, Pablo Lupianez, Jose A. Lorente, Maria J. Serrano, Pedro J. Real
Summary: The combination therapy of Abiraterone plus Enzalutamide reduces cell growth and survival in hormonal sensitive human prostate cancer cells, and cellular models of resistance generated from prostate cancer cell lines show restoration of Androgen Receptor functionality and cross-resistance to each other. This suggests the potential benefit of testing this combination therapy as first-line treatment in hormone-sensitive prostate cancer patients before they develop hormonal resistance.
Article
Andrology
Mohammad Hassan Jafari Najaf Abadi, Mohsen Khorashadizadeh, Hossein Zarei Jaliani, Khadigeh Jamialahmadi, Seyed Hamid Aghaee-Bakhtiari
Summary: This study aimed to identify miRNAs targeting AR coregulators and experimentally validate their effects on prostate cancer cell lines. The results showed that miR-27a-3p and miR-124 decreased cell viability and gene expression, with different cell cycle changes in different cell lines. These findings suggest the potential of using miR-124 and miR-27a-3p as therapeutic agents for prostate cancer treatment.
Article
Oncology
Salah Boudjadi, Puspa Raj Pandey, Bishwanath Chatterjee, Thanh Hung Nguyen, Wenyue Sun, Frederic G. Barr
Summary: In a model of cancer initiated by a fusion transcription factor, constitutive activation of a downstream transcriptional target leads to fusion oncoprotein-independent recurrences, thereby highlighting a novel progression mechanism and therapeutic target.
Article
Immunology
Jing Yang, Edith A. Perez, Changchun Hou, Pin Zhang, Michelle Van Scoyk, Robert A. Winn, Lijun Rong, Jing Liu
Summary: Multiple lines of evidence demonstrate that cigarette smoke or Chronic Obstructive Pulmonary Disease upregulates angiotensin-converting enzyme 2, predisposing individuals to severe Coronavirus disease 2019. Researchers found that loss of function of Miz1 in lung epithelium leads to COPD-like phenotype and upregulation of ACE2, while the binding of Miz1 to ACE2 promoter suppresses its activity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Giusy Ferraro, Raffaella Belvedere, Antonello Petrella, Alessandra Tosco, Bjoern Stork, Stefano Salamone, Alberto Minassi, Federica Pollastro, Elva Morretta, Maria Chiara Monti
Summary: Artemetin interacts directly with filamins A and B in HeLa cells, leading to the disruption of the cell cytoskeleton and actin filaments, and ultimately blocking cell migration. This compound has potential anti-cancer and anti-inflammatory effects.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Multidisciplinary Sciences
Bo Feng, Andiara E. Freitas, Lilach Gorodetski, Jingyi Wang, Runyi Tian, Yeo Rang Lee, Akumbir S. Grewal, Yimin Zou
Summary: The PCP signaling pathway plays a crucial role in maintaining adult glutamatergic synapses, and Aβ pathology may induce synapse loss through regulating PCP signaling components. Intervening in the PCP signaling pathway may help protect synapses and preserve cognitive function.
Article
Chemistry, Multidisciplinary
Yudai Tabuchi, Takahito Watanabe, Riku Katsuki, Yuji Ito, Masumi Taki
Summary: A covalent binder for a target protein was obtained by screening a peptide library on the T7 phage, with activation of the warhead only in the specific microenvironment created between the target protein and an appropriate peptide during the selection process.
CHEMICAL COMMUNICATIONS
(2021)