Article
Cardiac & Cardiovascular Systems
Lorenzo Da Dalt, Annalisa Moregola, Monika Svecla, Silvia Pedretti, Francesca Fantini, Mirko Ronzio, Patrizia Uboldi, Diletta Dolfini, Elena Donetti, Andrea Baragetti, Nico Mitro, Luca Scorrano, Giuseppe Danilo Norata
Summary: Impairment of mitochondrial fusion affects the development of liver steatosis and obesity. Mice lacking OPA1 are protected from high-fat diet-induced metabolic dysfunction due to reduced lipid absorption.
CARDIOVASCULAR RESEARCH
(2023)
Review
Nutrition & Dietetics
Frans Stellaard
Summary: Dietary cholesterol plays a significant role in the endogenous cholesterol pool and affects the serum concentration of total cholesterol, particularly LDL cholesterol. Maintaining a balance in hepatic cholesterol metabolism is crucial for preventing the risk of atherosclerosis and cardiovascular diseases.
Article
Endocrinology & Metabolism
Yanyong Xu, Yingdong Zhu, Shuwei Hu, Xiaoli Pan, Fathima Cassim Bawa, Helen H. Wang, David Q. -H. Wang, Liya Yin, Yanqiao Zhang
Summary: Hepatocyte miR-34a plays a crucial role in the development and progression of NAFLD by regulating lipid absorption, lipogenesis, inflammation, and apoptosis, while inhibiting fatty acid oxidation. Pharmacological inhibition of miR-34a shows potential in reversing NASH induced by a high-fat diet.
MOLECULAR METABOLISM
(2021)
Article
Multidisciplinary Sciences
Mei Lan Chen, Xiangsheng Huang, Hongtao Wang, Courtney Hegner, Yujin Liu, Jinsai Shang, Amber Eliason, Huitian Diao, HaJeung Park, Blake Frey, Guohui Wang, Sarah A. Mosure, Laura A. Solt, Douglas J. Kojetin, Alex Rodriguez-Palacios, Deborah A. Schady, Casey T. Weaver, Matthew E. Pipkin, David D. Moore, Mark S. Sundrud
Summary: The study identified the nuclear xenobiotic receptor CAR as a regulator of MDR1 expression in T cells, protecting the small intestine from bile acid toxicity and inflammation. Activation of CAR in T-eff cells infiltrating the small intestine induced large-scale transcriptional reprogramming and promoted the expression of the anti-inflammatory cytokine IL-10.
Review
Gastroenterology & Hepatology
Junwei Xiang, Zhengyan Zhang, Hongyi Xie, Chengcheng Zhang, Yan Bai, Hua Cao, Qishi Che, Jiao Guo, Zhengquan Su
Summary: FXR, a nuclear receptor for bile acids, plays a key role in regulating metabolic pathways and improving various diseases. Bile acids link the intestine with the liver through the enterohepatic circulation, with different types of bile acids having diverse effects on the intestines, providing a foundation for new treatment methods.
Article
Multidisciplinary Sciences
Lili Ding, Eryun Zhang, Qiaoling Yang, Lihua Jin, Kyle M. Sousa, Bingning Dong, Yangmeng Wang, Jui Tu, Xiaoxiao Ma, Jingyan Tian, Hongli Zhang, Zhipeng Fang, Ana Guan, Yixin Zhang, Zhengtao Wang, David D. Moore, Li Yang, Wendong Huang
Summary: The study suggests that vertical sleeve gastrectomy (VSG) achieves its metabolic benefits by reducing intestinal bile acids and fat absorption levels.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Nirajan Shrestha, Nathan Rout-Pitt, Alexandra McCarron, Courtney A. A. Jackson, Andrew C. C. Bulmer, Andrew J. J. McAinch, Martin Donnelley, David W. W. Parsons, Deanne H. H. Hryciw
Summary: This study aimed to investigate the characteristics of essential fatty acid deficiency caused by cystic fibrosis (CF), which is the result of mutations in the CF transmembrane conductance regulator (CFTR). Two rodent models of CF were studied: one strain with a loss of phenylalanine at position 508 (Phe508del) in CFTR and the other lacking functional CFTR (510X). Fatty acid concentrations were measured in the serum, and the expression of genes related to fatty acid transport and metabolism was quantified. Histological assessment of the ileal tissue was also performed. The results showed genotype- and age-dependent alterations in fatty acid concentration, as well as changes in gene expression and tissue morphology. These findings suggest that CF rat models exhibit abnormalities in the handling of fatty acids, possibly due to altered transport and metabolism, as well as fibrosis and structural changes in the ileum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Andras Gregor, Sandra Auernigg-Haselmaier, Manuel Malleier, Stefan Bruckberger, Joana Seneca, Petra Pjevac, Marc Pignitter, Kalina Duszka
Summary: Previously, we found that caloric restriction (CR) led to increased levels of taurine and taurine-conjugated bile acids (BA) in the gut. In this study, we discovered that restrictive diets, such as intermittent fasting and fasting-mimicking diet, had a similar effect as CR. The type of cage bedding affected the levels of BAs and taurine, and removal of cage bedding reversed the CR phenotype. Microbiota transplant from CR mice increased BAs deconjugation. Inhibition of bile salt hydrolase (BSH) prevented the increase in free taurine while increasing taurine-conjugated BA levels. Consuming high fiber diets increased taurine conjugates without elevating BAs levels.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Nutrition & Dietetics
Hung N. Luu, Chi Thi-Du Tran, Renwei Wang, Mai Vu-Tuyet Nguyen, Mo Thi Tran, Thuy Thi-Van Tuong, Quang Hong Tran, Linh Cu Le, Huong Thi-Thu Pham, Hien Huy Vu, Nam Chi Bui, Hien Thi-Thu Ha, Dung Tuan Trinh, Claire E. Thomas, Jennifer Adams-Haduch, Liudmilla Velikokhatnaya, Robert E. Schoen, Guoxiang Xie, Wei Jia, Paolo Boffetta, Jose C. Clemente, Jian-Min Yuan
Summary: The study found that colorectal advanced adenoma is associated with alterations in ileal juice bile acids. The concentrations of hyodeoxycholic acid (HCA) species in ileal juice were significantly higher in advanced adenoma patients compared to controls. The relative abundance of ursodeoxycholic acid (UDCA) in total bile acids was significantly reduced in cases than controls.
Article
Biochemistry & Molecular Biology
Andras Gregor, Marc Pignitter, Christine Fahrngruber, Sebastian Bayer, Veronika Somoza, Juergen Koenig, Kalina Duszka
Summary: In the study, it was found that caloric restriction led to increased levels of free taurine and taurine conjugates in the intestine, along with increased GST enzymatic activity and gene expression in the gastrointestinal tract. Additionally, the levels of free GSH were decreased in the intestine of caloric restriction mice compared to ad libitum fed mice, while levels of oxidized GSH were not affected.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Gastroenterology & Hepatology
Andras Gregor, Marc Pignitter, Slave Trajanoski, Sandra Auernigg-Haselmaier, Veronika Somoza, Juergen Koenig, Kalina Duszka
Summary: The study revealed that microbiota plays a critical role in the intestinal response to caloric restriction-induced changes in taurine, bile acids, and GST levels. Antibiotics treatment that depleted gut bacteria diminished the specific increase in these levels, highlighting the importance of microbiota in modulating metabolic responses to caloric restriction. Transplant of microbiota from caloric restriction mice induced similar changes in gene expression and metabolite levels in ad libitum fed mice, further emphasizing the influence of microbiota on metabolic pathways.
Article
Biochemistry & Molecular Biology
Gergo Horvath, Bence Balterer, Andras Micsonai, Jozsef Kardos, Orsolya Toke
Summary: The study investigates the role of dynamics in ligand binding of hI-BABP by introducing functionally impairing single-residue mutations. Results show that mutations in key regions of the protein lead to redistribution of motional freedom and affect site-selectivity of bile salts, as well as binding cooperativity. MD simulations suggest structural differences and changes in dynamics induced by mutations in different regions of the protein.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Geriatrics & Gerontology
Qiwen Wang, Yadong Qi, Weiyi Shen, Jilei Xu, Lan Wang, Shujie Chen, Tongyao Hou, Jianmin Si
Summary: Due to the growing elderly population, age-related problems are receiving more attention from the scientific community. The aging intestine undergoes changes that may be the causes of overall aging, making it important to identify aged intestines and search for novel strategies to rescue them. While progress has been made in some areas of research, a comprehensive understanding of intestinal aging is still limited.
Article
Pharmacology & Pharmacy
Shaoxiong Huang, Shiliang Dong, Lizhen Lin, Qiming Ma, Mengping Xu, Limei Ni, Qitong Fan
Summary: Inulin, a natural plant extract, improves metabolic syndrome by modulating the gut microbiota and inducing bile acid excretion.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Fisheries
Peng Chen, Dong Huang, Xinxin Li, Mingzhu Pan, Zhenhua Wu, Wanxiu Rao, Chang Liu, Zhengyi Cui, Kangsen Mai, Wenbing Zhang
Summary: A 105-day feeding trial was conducted to investigate the effects of dietary lipid and bile acids on the growth, digestion, and lipid metabolism in abalone. The results showed that 6.3% dietary lipid decreased the weight gain rate, while increasing dietary bile acids level enhanced the weight gain rate. The expression of genes involved in lipid transport, lipolysis, and lipogenesis was influenced by dietary lipid and bile acids. In conclusion, excessive dietary lipid content negatively impacted abalone growth, while appropriate levels of dietary bile acids significantly improved growth and digestion.
AQUACULTURE REPORTS
(2023)
Article
Biology
Kent Riemondy, Xiao-jing Wang, Enrique C. Torchia, Dennis R. Roop, Rui Yi
Article
Oncology
Anna E. Baron, Nancy L. Asdigian, Victoria Gonzalez, Jenny Aalborg, Tamara Terzian, Regan A. Stiegmann, Enrique C. Torchia, Marianne Berwick, Robert P. Dellavalle, Joseph G. Morelli, Stefan T. Mokrohisky, Lori A. Crane, Neil F. Box
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2014)
Article
Oncology
Enrique C. Torchia, Yiyun Chen, Hong Sheng, Hiroshi Katayama, James Fitzpatrick, William R. Brinkley, Carlos Caulin, Subrata Sen, Dennis R. Roop
Article
Biochemistry & Molecular Biology
Weston Kenneth Ryan, Josiah Fernandez, Mikayla Katherine Peterson, David William Sheneman, Brendan Keefe Podell, Subhajyoti De, Enrique Carlo Torchia
CELL DEATH AND DIFFERENTIATION
(2019)
Article
Dermatology
Enrique C. Torchia, Lei Zhang, Aaron J. Huebner, Subrata Sen, Dennis R. Roop
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2013)
Article
Biochemistry & Molecular Biology
E. C. Torchia, C. Caulin, S. Acin, T. Terzian, B. J. Kubick, N. F. Box, D. R. Roop
Editorial Material
Oncology
Neil F. Box, Enrique C. Torchia, Dennis R. Roop
PIGMENT CELL & MELANOMA RESEARCH
(2010)
Article
Oncology
Tamara Terzian, Enrique C. Torchia, Daisy Dai, Steven E. Robinson, Kazutoshi Murao, Regan A. Stiegmann, Victoria Gonzalez, Glen M. Boyle, Marianne B. Powell, Pamela M. Pollock, Guillermina Lozano, William A. Robinson, Dennis R. Roop, Neil F. Box
PIGMENT CELL & MELANOMA RESEARCH
(2010)
News Item
Oncology
Enrique C. Torchia, Dennis R. Roop
PIGMENT CELL & MELANOMA RESEARCH
(2012)
Article
Multidisciplinary Sciences
Lei Zhang, Michael Ferreyros, Weiguo Feng, Melanie Hupe, Debra A. Crumrine, Jiang Chen, Peter M. Elias, Walter M. Holleran, Lee Niswander, Daniel Hohl, Trevor Williams, Enrique C. Torchia, Dennis R. Roop
Article
Cell & Tissue Engineering
Ganna Bilousova, Du Hyun Jun, Karen B. King, Stijn De Langhe, Wallace S. Chick, Enrique C. Torchia, Kelsey S. Chow, Dwight J. Klemm, Dennis R. Roop, Susan M. Majka
Article
Cell & Tissue Engineering
Du Jun, Chrystelle Garat, James West, Nathalie Thorn, Kelsey Chow, Timothy Cleaver, Timothy Sullivan, Enrique C. Torchia, Christine Childs, Theodore Shade, Mehrdad Tadjali, Abigail Lara, Eva Nozik-Grayck, Stephen Malkoski, Brian Sorrentino, Barbara Meyrick, Dwight Klemm, Mauricio Rojas, David H. Wagner, Susan M. Majka
Article
Multidisciplinary Sciences
Josiah Fernandez, Enrique C. Torchia
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Letter
Dermatology
Sukhinder K. Cheema, Peter O. Isesele, Sydney Marchando, Michael G. Edwards, Enrique C. Torchia
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2020)