Article
Biochemistry & Molecular Biology
Sonia Turrini, Naomi Bevacqua, Antonio Cataneo, Emilio Chiappini, Francesca Fiori, Simone Battaglia, Vincenzo Romei, Alessio Avenanti
Summary: Aging is associated with a decline in motor control and neural plasticity. The plasticity in premotor-motor circuits predicts hand motor abilities in young and elderly humans. Physiological indices of PMv-M1 plasticity could provide a neurophysiological marker of fine motor control across age-groups.
Article
Neurosciences
Corey G. Wadsley, John Cirillo, Arne Nieuwenhuys, Winston D. Byblow
Summary: This study aimed to investigate the role of interhemispheric primary motor cortex (M1-M1) influences during selective stopping with proactive cueing. The results showed that increased stopping uncertainty led to slower response times and reduced stopping interference. Proactive response inhibition was characterized by a slower rate of rise and faster cancel time in electromyographical bursts during stopping. There was a reduction in muscle excitability when the left hand was cued to stop, but there was no reinstatement of interhemispheric inhibition between the motor cortices.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Psychology, Biological
Nicola Loi, Francesca Ginatempo, Miriam Carta, Francesco Melis, Andrea Manca, Franca Deriu
Summary: The processing of face expressions is crucial for social interactions. This study investigated the influence of face emotional expressions on the excitability of the hand primary motor cortex (M1) and found that passive viewing of negative face expressions can reduce interhemispheric inhibition.
Article
Neurosciences
Dongting Tian, Shin-Ichi Izumi
Summary: Results of this study suggest that 20Hz rTMS induces a reliable interhemispheric facilitatory effect, with a significant increase in single-pulse MEP and paired-pulse intracortical facilitation (ICF) in the non-stimulated hemisphere after rTMS intervention. Intracortical inhibition in the unstimulated hemisphere also increased following rTMS.
Article
Geriatrics & Gerontology
Daniel Boari Coelho, Paulo Rodrigo Bazan, Guilherme Augusto Zimeo Morais, Joana Bisol Balardin, Alana Xavier Batista, Claudia Eunice Neves de Oliveira, Emanuele Los Angeles, Claudionor Bernardo, Joao Ricardo Sato, Andrea C. de Lima-Pardini
Summary: Aging impairs inhibitory control and hemodynamic responses in areas controlling gait initiation under cognitive conflict, leading to worse APA performance in the older group compared to the young group.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
Katharina M. Schnitzspahn, Franziska Plessow, Clemens Kirschbaum, Yu Ho Wong, Matthias Kliegel
Summary: The study found that acute psychosocial stress negatively affects memory and cognitive control in young adults, while older adults show resilience to stress effects on performance. Young adults under stress were more likely to fail in the prospective memory task, while older adults remained unaffected.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Neurosciences
Takuya Morishita, Jan E. Timmermann, Robert Schulz, Friedhelm C. Hummel
Summary: This study examined the behavioral relevance of interhemispheric inhibition (IHI) for bimanual movement control in different age groups. The results showed that individuals with better bimanual movement control in the young group had larger short-latency IHI, while this association was not observed in the older group. This suggests that short-latency IHI may serve as a neurophysiological marker for the ability to suppress activity of the contralateral side in efficient bimanual movement control.
EXPERIMENTAL BRAIN RESEARCH
(2022)
Article
Geriatrics & Gerontology
Patricia Izbicki, Tessa Mendoza, Andrew Zaman, Elizabeth L. Stegemoller
Summary: Despite lower resting SICI MEP and higher inhibition percentage in older adults compared to young adults, musicians showed lower inhibition percentage than non-musicians when controlling for background EMG activity. This suggests that motor inhibitory circuitry remains intact and functional in both young and older musicians and non-musicians.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Federica Bencivenga, Maria Giulia Tullo, Valentina Sulpizio, Gaspare Galati
Summary: By using dynamic causal modelling and Parametric Empirical Bayes analyses applied to fMRI data, this study found that the connectivity patterns between bilateral regions in the grasping network are similar during executed grasping movements. However, during pantomimed grasping, interhemispheric crosstalk is mainly driven by premotor areas, with inhibitory influences from the right PMd towards the left premotor and motor areas and excitatory couplings between homologous ventral premotor and supplementary motor regions. Overall, the results suggest that unilateral grasping execution involves a non-lateralized set of brain areas complexly intertwined by interhemispheric dynamics, while motor imagery follows different principles.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Kozue Takada, Takuya Yamaguchi, Yuko Hyuga, Yuto Mitsuno, Satoshi Horiguchi, Masako Kinoshita, Takeshi Satow
Summary: This study evaluated the clinical features of bimanual movement impairment in a patient following surgery for a frontal lobe tumor. The results showed that resection of the frontal lobe can cause transient impairment of in-phase bimanual movement, and auditory cueing can improve bimanual movement performance.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Nutrition & Dietetics
Ryan J. Benson, Evan J. Lockyer, Chris T. Compton, Kevin E. Power
Summary: This study demonstrates the activation of interhemispheric inhibition during arm cycling for the first time, quantifying it through assessing the depth of the ipsilateral silent period. Significant reduction in electromyography amplitude of the iSP during cycling was observed.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Article
Multidisciplinary Sciences
Alberto Lazari, Piergiorgio Salvan, Lennart Verhagen, Michiel Cottaar, Daniel Papp, Olof Jens van der Werf, Bronwyn Gavine, James Kolasinski, Matthew Webster, Charlotte J. Stagg, Matthew F. S. Rushworth, Heidi Johansen-Berg
Summary: Myelination levels in white matter tracts may influence the cortico-cortical interactions during tasks, and there is a link between the physiology of the motor network and the myelination of tracts connecting its components. Myelination plays a key role in brain function and can affect motor network physiology.
NATURE COMMUNICATIONS
(2022)
Article
Clinical Neurology
Jasmine L. Mirdamadi, Jing Xu, Karla M. Arevalo-Alas, Liana K. Kam, Michael R. Borich
Summary: This study aimed to investigate state-dependent interhemispheric inhibition (IHI) in chronic stroke survivors compared to neurotypical older adult controls and examined its association with upper extremity motor behavior. The results showed that stroke survivors had reduced IHI at rest and less modulation of IHI during activity compared to controls. Individual differences in IHI modulation were related to motor behavior differences, where greater modulation was associated with greater motor impairment and more mirroring. The findings suggest that abnormal state-dependent interhemispheric circuit activity may be more sensitive to post-stroke motor deficits. Characterizing state-dependent changes in neural circuitry could enhance stroke recovery models and inform rehabilitation interventions.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Neurosciences
Margherita Giamundo, Franco Giarrocco, Emiliano Brunamonti, Francesco Fabbrini, Pierpaolo Pani, Stefano Ferraina
Summary: Reward prospect influences motor decisions, with animals adopting different strategies based on reward information and PMd neuronal activity correlating with behavior.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Wei-Yeh Liao, George M. Opie, Ulf Ziemann, John G. Semmler
Summary: Previous research has shown that the connectivity between dorsal premotor cortex (PMd) and motor cortex (M1) weakens with age. However, the influence of PMd on specific indirect wave circuits within M1 and its effect on age are unclear. This study investigates the influence of PMd on early and late I-wave excitability in M1 of young and older adults.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Geriatrics & Gerontology
Hakuei Fujiyama, Mark R. Hinder, Azadeh Barzideh, Charis Van de Vijver, Andreea C. Badache, Maria Nathalya Manrique-C, Paola Reissig, Xue Zhang, Oron Levin, Jeffery J. Summers, Stephan P. Swinnen
NEUROBIOLOGY OF AGING
(2017)
Article
Behavioral Sciences
Mark R. Hinder, Rohan Puri, Sarah Kemp, Sara Waitzer, Paola Reissig, Tino Stoeckel, Hakuei Fujiyama
Article
Multidisciplinary Sciences
Alexander D. Tang, William Bennett, Claire Hadrill, Jessica Collins, Barbora Fulopova, Karen Wills, Aidan Bindoff, Rohan Puri, Michael I. Garry, Mark R. Hinder, Jeffery J. Summers, Jennifer Rodger, Alison J. Canty
SCIENTIFIC REPORTS
(2018)
Review
Neurosciences
Jane Tan, Kartik K. Iyer, Alexander D. Tang, Asif Jamil, Ralph N. Martins, Hamid R. Sohrabi, Michael A. Nitsche, Mark R. Hinder, Hakuei Fujiyama
Article
Multidisciplinary Sciences
Ann-Maree Vallence, Mark R. Hinder, Hakuei Fujiyama
Article
Neurosciences
Rebecca J. St George, Mark R. Hinder, Rohan Puri, Eliza Walker, Michele L. Callisaya
Summary: The study found that older adults exhibit a limit to PFC activity and increased postural sway at higher levels of balance task demand, while younger adults perform better under similar conditions. This suggests that PFC activity compensates for sensorimotor deficits in older adults to maintain stability, but reaches a cognitive resource limit in easier balance tasks compared to younger adults. Increasing cortical capacity in older people may improve their balance.
Article
Geriatrics & Gerontology
Hakuei Fujiyama, Jane Tan, Rohan Puri, Mark R. Hinder
Summary: Research suggests that transcranial direct current stimulation can improve executive function in healthy older adults, including decision-making speed and inhibitory control. Anodal tDCS appears to enhance perceptual decision-making and inhibitory control performance in both younger and older adults.
NEUROBIOLOGY OF AGING
(2022)
Article
Behavioral Sciences
Jeremy Cosgrove, Mark R. Hinder, Rebecca J. St George, Chiara Picardi, Stephen L. Smith, Michael A. Lones, Stuart Jamieson, Jane E. Alty
Summary: In Parkinson's disease, individuals exhibit increased reliance on visual feedback during upper limb reaching movements, especially in the presence of cognitive decline, indicating a greater need for visual guidance in motor planning and execution.
Article
Clinical Neurology
Alexander D. Tang, William Bennett, Aidan D. Bindoff, Samuel Bolland, Jessica Collins, Ross C. Langley, Michael Garry, Jeffery J. Summers, Mark R. Hinder, Jennifer Rodger, Alison J. Canty
Summary: The study examined the effects of subthreshold rTMS on structural synaptic plasticity in the mouse motor cortex of young and aged mice. The results showed that subthreshold rTMS can alter the rate of dendritic spine losses and gains, and effectively drive structural synaptic plasticity in both young adult and aged mice.
Article
Behavioral Sciences
Rohan Puri, Rebecca J. St George, Mark R. Hinder
Summary: The study investigates the features of stopping interference through a multicomponent stop-signal task. The results indicate that stopping interference can be attenuated by foreknowledge and reveal a novel role of interhemispheric inhibition in facilitating continuing action components.
COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
(2023)
Article
Psychology, Multidisciplinary
Melanie Krueger, Mark R. Hinder, Rohan Puri, Jeffery J. Summers
FRONTIERS IN PSYCHOLOGY
(2017)
Letter
Clinical Neurology
Mark R. Hinder, Hakuei Fujiyama, Ann-Maree Vallence