Review
Immunology
Ryosuke Nakano, Lillian M. Tran, David A. Geller, Camila Macedo, Diana M. Metes, Angus W. Thomson
Summary: Liver allograft recipients are more likely to develop transplantation tolerance, with liver interstitial dendritic cells playing pivotal roles. Interstitial liver DCs, recruited in situ or derived from circulating precursors, are involved in regulating ischemia/reperfusion injury and anti-donor immunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Fernando Lucas-Ruiz, Alejandro Penin-Franch, Jose Antonio Pons, Pablo Ramirez, Pablo Pelegrin, Santiago Cuevas, Alberto Baroja-Mazo
Summary: The NLRP3 inflammasome and pyroptosis play important roles in liver transplantation, affecting the progression of liver disease and treatment outcomes. Studying this pathway may lead to new strategies for the future treatment of LT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Degong Jia, Shanshan Guo, Zhixing Jia, Zhengjie Gao, Kun You, Jianping Gong, Shengwei Li
Summary: A systematic review and meta-analysis found that N-acetylcysteine (NAC) is effective in treating ischemia-reperfusion injury in transplanted livers, reducing the incidence of primary graft non-function, postoperative complications, and peak enzyme levels. However, NAC increases the requirements for cryoprecipitate and red blood cells during surgery.
Article
Cell Biology
Hanyi Liu, Jinglin Wang, Yitao Ding, Xiaolei Shi, Haozhen Ren
Summary: Our study demonstrates that prophylactic antibiotic pretreatment can attenuate liver ischemia-reperfusion injury by reshaping the gut microbiota and altering bile acid composition. This beneficial effect is mediated through the activation of the farnesoid X receptor (FXR) pathway, which suppresses inflammatory responses and cell apoptosis in the liver. These findings suggest that targeting FXR activation may be a potential therapeutic strategy for liver injury.
CELL DEATH & DISEASE
(2022)
Review
Immunology
Victor Lopez-Lopez, Fernando Perez-Sanz, Carlos de Torre-Minguela, Josefa Marco-Abenza, Ricardo Robles-Campos, Francisco Sanchez-Bueno, Jose A. Pons, Pablo Ramirez, Alberto Baroja-Mazo
Summary: Proteomics has been used in liver transplantation research to study outcomes such as ischemia-reperfusion injury (IRI) and rejection, showing a higher number of shared proteins between these two conditions. Metabolism was found to be the most enriched pathway in liver biopsy samples, IRI, and rejection, while cytokine-cytokine receptor interactions were predominant in tolerance studies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Yanyao Liu, Zilun Lei, Hao Chai, Quan Kang, Xiaoyan Qin
Summary: Salidroside alleviates hepatic ischemia-reperfusion injury by modulating the TLR-4/NF-κB/NLRP3 inflammatory pathway.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Anna Radajewska, Jakub Szyller, Anna Krzywonos-Zawadzka, Agnieszka Olejnik, Grzegorz Sawicki, Iwona Bil-Lula
Summary: Transplanted organs are exposed to harmful conditions before and after surgery. Adding the antioxidant MitoQ to the hypothermic machine perfusion system can mitigate kidney injury and improve transplantation success rate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Fayez T. Hammad, Suhail Al-Salam, Rahaf Ahmad, Javed Yasin, Awwab F. Hammad, Jasmine Abdul Rasheed, Loay Lubbad
Summary: It has been found that nerolidol has a protective effect on renal ischemia-reperfusion injury, improving renal function and reducing tissue damage.
Article
Biochemistry & Molecular Biology
Anxiong Liu, Wei Wang, Zhongshan Lu, Zhongzhong Liu, Wei Zhou, Zibiao Zhong, Qifa Ye
Summary: Liver ischemia-reperfusion injury is an unavoidable pathological process in transplantation, and there is currently no clear therapeutic measure. Research suggests that mild hypothermia therapy can protect the liver from IR injury by regulating autophagy flux. This finding provides a potential theoretical basis for the further application of mild hypothermia in related clinical diseases.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Abolfazl Badripour, Mohamad Behzadi, Amin Hassanipour, Pasha Reza Shams Azar, Alireza Rahbar, Zhaleh Abbaslou, Elnaz Ehghaghi, Ashkan Piranviseh, Mohammad Mahdi Khavandi, Seyed Mohsen Ahmadi-Tafti, Mohammad Ashouri, Zahra Ebrahim Soltani, Ahmadreza Dehpour
Summary: This study aimed to evaluate the effects of Albendazole pretreatment on mesenteric ischemia reperfusion (MIR) injury. The findings demonstrated that Albendazole could ameliorate the inflammatory response and enhance the ischemia threshold following MIR injury.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, General & Internal
Nader Abraham, Min Zhang, Paul Cray, Qimeng Gao, Kannan P. Samy, Ryan Neill, Greta Cywinska, JonCarlo Migaly, Riley Kahan, Arya Pontula, Samantha E. Halpern, Caroline Rush, Jude Penaflor, Samuel J. Kesseli, Madison Krischak, Mingqing Song, Matthew G. Hartwig, Justin J. Pollara, Andrew S. Barbas
Summary: Based on a rat model, this study shows that during SNMP, the biliary compartment is more sensitive in detecting graft injury compared to the perfusate compartment. Additionally, using acRTMP provides better graft preservation in DCD liver transplantation compared to SCS.
FRONTIERS IN MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Omar Abdulhameed Almazroo, Imam H. Shaik, Christopher B. Hughes, Abhinav Humar, Raman Venkataramanan
Summary: Treprostinil treatment reduces ischemia-reperfusion injury and alters the expression of drug transporters in the liver. This is of great significance for improving the outcomes of deceased donor liver transplantation.
PHARMACEUTICAL RESEARCH
(2022)
Article
Veterinary Sciences
Jennifer Davis, Anthea L. Raisis, Claire R. Sharp, Rachel E. Cianciolo, Steven C. Wallis, Kwok M. Ho
Summary: Oral administration of resveratrol for seven days improved hemodynamic response to hemorrhage in dogs without inducing coagulopathy, but did not show renal protective effects against acute kidney injury.
VETERINARY SCIENCES
(2021)
Article
Oncology
Zhiyong Guo, Jinghong Xu, Shanzhou Huang, Meixian Yin, Qiang Zhao, Weiqiang Ju, Dongping Wang, Ningxin Gao, Changjun Huang, Lu Yang, Maogen Chen, Zhiheng Zhang, Zebin Zhu, Linhe Wang, Caihui Zhu, Yixi Zhang, Yunhua Tang, Haitian Chen, Kunpeng Liu, Yuting Lu, Yi Ma, Anbin Hu, Yinghua Chen, Xiaofeng Zhu, Xiaoshun He
Summary: Ischemia-free liver transplantation can avoid graft ischemia-reperfusion injury and has the potential to improve transplant outcomes and organ utilization.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Eliano Bonaccorsi-Riani, Andrew R. Gillooly, Samuele Iesari, Isabel M. A. Bruggenwirth, Chantal M. Ferguson, Mina Komuta, Daela Xhema, Aurelie Daumerie, Louis Maistriaux, Henri Leuvenink, Jerzy Kupiec-Weglinski, Robert J. Porte, Anastasia Khvorova, David R. Cave, Pierre Gianello, Paulo N. Martins
Summary: The study showed that inhibition of the FAS gene through siRNA therapy can reduce the severity of ischemia-reperfusion injury after liver transplantation in a static cold storage protocol. However, using siRNA therapy in combination with a HOPE perfusion model presents challenges and requires further research with better designed compounds and appropriate dosages to prove its effectiveness.
Article
Surgery
Raffaele Brustia, Alexis Laurent, Claire Goumard, Serena Langella, Daniel Cherqui, Takayuki Kawai, Olivier Soubrane, Francois Cauchy, Olivier Farges, Benjamin Menahem, Christian Hobeika, Rami Rhaiem, Daniele Sommacale, Shinya Okumura, Stefan Hofmeyr, Alessandro Ferrero, Francois-Rene Pruvot, Jean-Marc Regimbeau, David Fuks, Eric Vibert, Olivier Scatton
Summary: This study compared the overall survival of patients with intrahepatic cholangiocarcinoma who underwent open or laparoscopic liver resection. The results showed that laparoscopic liver resection was associated with better overall survival compared to open liver resection. Severe postoperative complications and steatosis were identified as predictors of death, while transfusion and severe postoperative complications were predictors of recurrence.
Article
Gastroenterology & Hepatology
Maria Conticchio, Antonella Delvecchio, Francesca Ratti, Maximiliano Gelli, Ferdinando M. Anelli, Alexis Laurent, Giulio C. Vitali, Paolo Magistri, Giacomo Assirati, Emanuele Felli, Taiga Wakabayashi, Patrick Pessaux, Tullio Piardi, Fabrizio Di Benedetto, Nicola de'Angelis, Delgado F. Javier Briceno, Antonio G. Rampoldi, Rene Adam, Daniel Cherqui, Luca Aldrighetti, Riccardo Memeo
Summary: This study compared the effectiveness of LLR and RFA in elderly patients with single HCC smaller than 3 cm. The results showed that despite the longer length of hospital stay and operative time, LLR had a comparable postoperative course and better overall and disease-free survival in patients with HCC located in the anterolateral segments.
Article
Gastroenterology & Hepatology
Laurence Chiche, Maxime Guieu, Philippe Bachellier, Bertrand Suc, Olivier Soubrane, Karim Boudjema, Francis Navarro, Rene Adam, Jean-Christophe Vaillant, Ephrem Salame, Bruno Heyd, Stephanie Truant, Jean-Philippe Adam, Christophe Laurent
Summary: This study investigated liver transplantations performed in France for major bile duct injuries (BDI) following cholecystectomy. The findings show that iatrogenic BDI remains a serious concern, often requiring treatment in expert centers. The post-transplant morbidity rate is high and the results are not optimal. Therefore, early referral to expert centers is necessary for all major BDI patients to prevent severe outcomes.
Article
Surgery
Melina Heinemann, Timur Liwinski, Rene Adam, Marina Berenguer, Darius Mirza, Seyed Ali Malek-Hosseini, Michael A. Heneghan, Peter Lodge, Johann Pratschke, Karim Boudjema, Andreas Paul, Krzysztof Zieniewicz, Jiri Fronek, Arianeb Mehrabi, Koray Acarli, Yaman Tokat, Ahmet Coker, Sezai Yilmaz, Vincent Karam, Christophe Duvoux, Ansgar W. Lohse, Christoph Schramm
Summary: The study analyzed survival outcomes of living donor liver transplantation (LDLT) for autoimmune liver diseases, particularly focusing on primary sclerosing cholangitis (PSC) patients. It found that adult PSC patients had lower survival rates and increased mortality risk, with male donors and biliary complications identified as important risk factors for death after LDLT in PSC patients.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Review
Biochemistry & Molecular Biology
Julie Massart, Karima Begriche, Anne Corlu, Bernard Fromenty
Summary: Metabolic-associated fatty liver disease (MAFLD), often associated with obesity, is a disease that encompasses a range of liver lesions. In addition to nutritional and genetic factors, pharmaceuticals and environmental toxicants are suspected to worsen MAFLD in obese individuals. The mechanisms by which xenobiotics can aggravate MAFLD are still poorly understood, but previous studies have indicated the involvement of different metabolic pathways and cellular events associated with reactive oxygen species overproduction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Qinghe Zeng, Christophe Klein, Stefano Caruso, Pascale Maille, Narmin Ghaffari Laleh, Daniele Sommacale, Alexis Laurent, Giuliana Amaddeo, David Gentien, Audrey Rapinat, Helene Regnault, Cecile Charpy, Cong Trung Nguyen, Christophe Tournigand, Raffaele Brustia, Jean Michel Pawlotsky, Jakob Nikolas Kather, Maria Chiara Maiuri, Nicolas Lomenie, Julien Calderaro
Summary: Researchers developed artificial intelligence-based pathology models to predict the activation of immune gene signatures in hepatocellular carcinoma patients. The models showed good predictive performance and provided insights into the morphological features of tumor tissues.
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Antonella Delvecchio, Maria Conticchio, Umberto Riccelli, Valentina Ferraro, Francesca Ratti, Maximiliano Gelli, Ferdinando M. Anelli, Alexis Laurent, Giulio C. Vitali, Paolo Magistri, Giacomo Assirati, Emanuele Felli, Taiga Wakabayashi, Patrick Pessaux, Tullio Piardi, Fabrizio Di Benedetto, Nicola De'Angelis, Javier Briceno-Delgado, Rene Adam, Daniel Cherqui, Luca Aldrighetti, Riccardo Memeo
Summary: The study found that laparoscopic liver resection in elderly patients with hepatocellular carcinoma has good short-term outcomes compared to open liver resection, with no significant differences in long-term survival rates between the two groups.
Article
Multidisciplinary Sciences
Lise Desquilles, Luis Cano, Gevorg Ghukasyan, Nicolas Mouchet, Clemence Landreau, Anne Corlu, Bruno Clement, Bruno Turlin, Romain Desert, Orlando Musso
Summary: The study analyzed the expression and localization of ACE2 and TMPRSS2 in human liver cancers and non-tumor livers. The results showed that ACE2 and TMPRSS2 were mainly located at the biliary pole of tumor hepatocytes in liver cancers. In normal liver samples, ACE2 was distributed in hepatocyte's bile canaliculi, biliary epithelium, sinusoidal, and capillary endothelial cells. Additionally, tumors carrying mutated beta-catenin showed upregulated ACE2 expression, consistent with the predicted response sites in the ACE2 promoter. These findings reveal a potential link between liver cancer, liver diseases, and SARS-CoV-2 infection.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
Elise Lelou, Anne Corlu, Nicolas Nesseler, Claudine Rauch, Yannick Malledant, Philippe Seguin, Caroline Aninat
Summary: In recent years, there has been an increasing number of research publications on the role of catecholamines in liver diseases. However, the mechanisms behind these effects are not well understood. This review focuses on the interaction between the liver and catecholamines, the expression of adrenergic and dopaminergic receptors in liver cells, and the involvement of catecholamines in physiological and pathophysiological processes. The importance of understanding these mechanisms for potential therapeutic use of adrenergic and dopaminergic antagonists is highlighted.
Article
Gastroenterology & Hepatology
Emanuele Felli, Emmanuel Boleslawski, Daniele Sommacale, Olivier Scatton, Raffaele Brustia, Lilian Schwarz, Daniel Cherqui, Thomas Zacharias, Alexis Laurent, Jean-Yves Mabrut, Catherine Schuster, Benoit Gallix, Patrick Pessaux
Summary: This study analyzed the role of preoperative 3D reconstruction models in selecting the surgical approach and modifying the established plan for hepatocellular carcinoma patients. The results showed that 3D imaging had a better prediction of the actual surgical procedure compared to conventional 2D imaging.
Article
Medicine, General & Internal
Alexandre Thobie, Fabien Robin, Benjamin Menahem, Jean Lubrano, Karim Boudjema, Arnaud Alves, Olivier Dejardin, Laurent Sulpice
Summary: This retrospective study focused on the impact of post-pancreatectomy hemorrhage (PPH) on long-term survival after pancreatoduodenectomy (PD) for cancer. The results showed that PPH significantly increased mortality rate and severe postoperative complication rate, but after 6 months, PPH had no impact on mortality.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Francois Villeret, Sebastien Dharancy, Domitille Erard, Armand Abergel, Louise Barbier, Camille Besch, Olivier Boillot, Karim Boudjema, Audrey Coilly, Filomena Conti, Christophe Corpechot, Christophe Duvoux, Francois Faitot, Stephanie Faure, Claire Francoz, Emiliano Giostra, Jean Gugenheim, Jean Hardwigsen, Marie-Noelle Hilleret, Jean-Baptiste Hiriart, Pauline Houssel-Debry, Nassim Kamar, Guillaume Lassailly, Marianne Latournerie, Georges-Philippe Pageaux, Didier Samuel, Claire Vanlemmens, Faouzi Saliba, Jerome Dumortier
Summary: This study evaluated the risk of disease recurrence after liver transplantation for non-alcoholic fatty liver disease (NAFLD) and identified several factors influencing recurrence. The study found a high cumulative recurrence rate of steatosis, steatohepatitis, and fibrosis after transplantation for NAFLD. Age at transplantation, post-transplant high-density lipoprotein-cholesterol level, and steatosis grade were significant risk factors for recurrence. The study highlights the need for further evaluation of preventive measures for disease recurrence after transplantation for NAFLD.
Article
Biochemistry & Molecular Biology
Annaig Lan, Thomas Guerbette, Mireille Andriamihaja, Benjamin Magnin, Martin Bordet, Pierre-Jean Ferron, Agnes Burel, Roselyne Viel, Bernard Fromenty, Anne Corlu, Francois Blachier, Guillaume Bouguen
Summary: Mucosal healing is important in the treatment of ulcerative colitis, and the involvement of mitochondrial activity in epithelial repair after colitis induction in mouse colonic crypts has been explored. The results show adaptations of colonocyte metabolism to ensure maximal ATP production, despite decreased mitochondrial biogenesis, during inflammation and recovery phases.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Julien Edeline, John Bridgewater, Boris Campillo-Gimenez, Estelle Neveu, Jean-Marc Phelip, Cindy Neuzillet, Karim Boudjema, Yan Rolland, Juan W. Valle, Etienne Garin, David Malka, Angela Lamarca
Summary: The study suggests that SIRT combined with chemotherapy may improve outcomes over chemotherapy alone for patients with advanced, liver-only intrahepatic cholangiocarcinoma (iCCA). Further randomized controlled trials are needed to confirm these findings.
Meeting Abstract
Gastroenterology & Hepatology
Lise Desquilles, Romain Desert, Valerie Monbet, Joyce Madison Giacofci, Luis Cano, Clemence Landreau, Natalia Nieto, Anne Corlu, Christelle Reynes, Orlando Musso
JOURNAL OF HEPATOLOGY
(2022)