Article
Biochemistry & Molecular Biology
Elena Cesaro, Arianna Pastore, Alessia Polverino, Lorenzo Manna, Giuseppina Divisato, Cristina Quintavalle, Maddalena Di Sanzo, Maria Concetta Faniello, Michela Grosso, Paola Costanzo
Summary: The zinc finger protein ZNF224 has been found to play a role in promoting tumorigenic properties in melanoma, including cell proliferation and invasiveness. ZNF224 modulates the expression of TGF-beta itself and its receptors, possibly enhancing endogenous TGF beta/Smad signaling and promoting epithelial-mesenchymal transition and tumor metastasis.
HUMAN MOLECULAR GENETICS
(2021)
Article
Plant Sciences
Saddam Hussain, Yuxin Cheng, Yingying Li, Wei Wang, Hainan Tian, Na Zhang, Yating Wang, Yuan Yuan, Hadia Hussain, Rao Lin, Chen Wang, Tianya Wang, Shucai Wang
Summary: The transcription factor AtbZIP62 is involved in regulating plant responses to abiotic stresses and has a role in ABA responses. Overexpression and gene editing experiments showed that AtbZIP62 positively regulates ABA responses in seed germination and cotyledon greening by controlling the expression of ABA-responsive genes.
Article
Plant Sciences
Lei Shen, Xin Xia, Longhao Zhang, Shixin Yang, Xu Yang
Summary: Salt stress seriously affects plant growth and yield, and the mechanisms of plant response to salt stress are still unclear. This study found that SmWRKY11, a transcription factor, acts as a positive regulator in eggplant response to salt stress and indirectly regulates salt stress response through forming a positive feedback loop with SmERF1.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Neurosciences
Thomas J. LaRocca, Alyssa N. Cavalier, Christine M. Roberts, Maddie R. Lemieux, Pooja Ramesh, Micklaus A. Garcia, Christopher D. Link
Summary: The amyloid beta (A beta) peptide is believed to have a central role in Alzheimer's disease by synergistically promoting pro-inflammatory activation in primary human astrocytes with known cytokines. By directly substituting for the complement component C1q in a cytokine cocktail, A beta activates astrocytes similarly to neurotoxic astrocytes found in brain aging and AD. The biological action of A beta at low concentrations is distinct from that of high doses typically used in in vitro studies.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Mingfei Zhang, Yanfei Zhu, Hongbin Yang, Xin Li, Rangwei Xu, Feng Zhu, Yunjiang Cheng
Summary: This study investigates the role of a citrus NOD26-like intrinsic protein, CsNIP5;1, in regulating water permeability. The results show that CsNIP5;1 reduces water loss in plant leaves and promotes seed germination under hyperosmotic stress. Overexpression of CsNIP5;1 also alleviates water loss in citrus fruit and callus during storage. The study further reveals that CsNIP5;1 may regulate water loss by influencing the accumulation of osmotic adjustment substances and the expression of other aquaporins. Additionally, CsWRKY4 and CsWRKY28 are identified as regulators of CsNIP5;1 during the postharvest period.
Article
Biochemistry & Molecular Biology
Zhuoyun Wei, Haoyong Zhang, Meng Fang, Shuyuan Lin, Mingsong Zhu, Yuxiu Li, Limin Jiang, Tianliang Cui, Yanwei Cui, Hong Kui, Liang Peng, Xiaoping Gou, Jia Li
Summary: Photosynthetic efficiency is crucial for crop yield. In this study, a gain-of-function mutant cogwheel1-3D, overexpressing a transcription factor COG1, showed increased biomass in Arabidopsis. Knocking out COG1 and its paralogs reduced biomass. COG1 was found to regulate genes involved in photosynthesis and directly bind to their promoter regions, enhancing photosynthetic capacity. Manipulating COG1 could improve crop yield.
Article
Developmental Biology
Annika Missel, Lena Walenta, Katja Eubler, Nadine Mundt, Hanna Heikela, Ulrich Pickl, Matthias Trottmann, Bastian Popper, Matti Poutanen, Leena Strauss, Frank-Michael Koehn, Lars Kunz, Marc Spehr, Artur Mayerhofer
Summary: The presence of ATP metabolites and adenosine receptors in human testicular peritubular cells suggests their involvement in cytokine production and potential impact on fertility and male infertility.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Developmental Biology
Annika Missel, Lena Walenta, Katja Eubler, Nadine Mundt, Hanna Heikela, Ulrich Pickl, Matthias Trottmann, Bastian Popper, Matti Poutanen, Leena Strauss, Frank-Michael Koehn, Lars Kunz, Marc Spehr, Artur Mayerhofer
Summary: Extracellular ATP has been found to play a role in cytokine production in human testicular cells, with adenosine possibly involved as a metabolite. Pharmacological inhibition of ENTPD1 reduced pro-inflammatory cytokines, suggesting a link to ATP metabolites like adenosine. Targeting ATP metabolites or adenosine receptors could potentially reduce inflammatory events in the testis, offering novel therapeutic avenues for male infertility treatment.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Multidisciplinary Sciences
Katherine M. Almasy, Jonathan P. Davies, Samantha M. Lisy, Reyhaneh Tirgar, Sirena C. Tran, Lars Plate
Summary: Compound 147 has been shown to be an effective host-centered antiviral agent against flaviviruses by reducing infection without causing toxicity in host cells. It acts by attenuating the infectivity of secreted virions and is a preferential activator of the ATF6 pathway of the ER unfolded protein response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, Research & Experimental
Farah Hasan, Yulun Chiu, Rebecca M. Shaw, Junmei Wang, Cassian Yee
Summary: The combination of hypoxia and TGF-beta(1) can induce the development of a T-RM phenotype in human CD8(+) T cells, leading to specific phenotypic features and enrichment of human T-RM gene signatures. This finding suggests a previously unreported cue for the T-RM differentiation program, offering potential applications in adoptive cellular therapy and basic research.
Article
Plant Sciences
Yan Mao, Jie Xu, Qi Wang, Guobang Li, Xin Tang, Tianhong Liu, Xuanjun Feng, Fengkai Wu, Menglu Li, Wubing Xie, Yanli Lu
Summary: In this study, it was discovered that 51 NAC genes in Gramineae contain cis-NATs, with ZmNAC48 and cis-NATZmNAC48 both playing a role in plant response to drought stress through a double-stranded RNA-dependent mechanism.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Plant Sciences
Mei Zheng, Jingchen Lin, Xingbei Liu, Wei Chu, Jinpeng Li, Yujiao Gao, Kexin An, Wanjun Song, Mingming Xin, Yingyin Yao, Huiru Peng, Zhongfu Ni, Qixin Sun, Zhaorong Hu
Summary: The study reveals the critical role of the histone acetyltransferase TaHAG1 in salt tolerance of wheat, enhancing tolerance by modulating reactive oxygen species production and signal transduction. TaHAG1 also directly targets a subset of hydrogen peroxide production genes, increasing their acetylation and transcriptional upregulation under salt stress. In wheat accessions with different ploidy levels, the salinity-induced TaHAG1-mediated ROS production pathway contributes to salt tolerance differences.
Article
Biology
Choco Michael Gorospe, Gustavo Carvalho, Alicia Herrera Curbelo, Lisa Marchhart, Isabela C. Mendes, Katarzyna Niedzwiecka, Paulina H. Wanrooij
Summary: Mitochondrial dysfunction has a profound impact on cells and can lead to diseases. The interaction between mitochondria and the rest of the cell can slow down the cell cycle progression. Decreased mitochondrial membrane potential serves as the initial signal to delay the G1-to-S phase transition in cells.
LIFE SCIENCE ALLIANCE
(2023)
Article
Plant Sciences
Lei Shen, Enpeng Zhao, Ruie Liu, Xu Yang
Summary: Salt stress inhibits plant growth and decreases crop yield. This study identified enriched pathways and genes affected during salt treatment using mRNA sequencing. The AP2/ERF transcription factor SmERF1 was found to be significantly upregulated by salt stress and played a crucial role in the response to salt stress in eggplant. Silencing SmERF1 increased plant susceptibility to salt stress and reduced the expression of defense-related genes.
Article
Multidisciplinary Sciences
Pattapon Kunadirek, Chaiyaboot Ariyachet, Supachaya Sriphoosanaphan, Nutcha Pinjaroen, Pongserath Sirichindakul, Intawat Nookaew, Natthaya Chuaypen, Pisit Tangkijvanich
Summary: Novel and sensitive biomarkers are crucial for early detection and prognosis prediction of hepatocellular carcinoma (HCC). Through RNA-Sequencing, BHLHE40 in PBMCs was identified as a potential diagnostic and prognostic biomarker for HBV-related HCC, showing better diagnostic performance and high sensitivity for early-stage HCC.
SCIENTIFIC REPORTS
(2021)