Article
Environmental Sciences
Carly Colville, Alper James Alcaraz, Derek Green, Bradley Park, Jianguo Xia, Othman Soufan, Pavel Hruska, David Potesil, Zbynek Zdrahal, Doug Crump, Niladri Basu, Natacha Hogan, Markus Hecker
Summary: This study investigated the mechanistic toxicity of fluoxetine (FLX) in adult fathead minnows using new approach methodologies (NAMs). The results revealed that high concentrations of FLX caused molecular toxicity changes in the liver and brain, leading to lipid-type vacuolation in liver hepatocytes and alterations in serotonin-related signaling processes and reproductive behavior in the brain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Multidisciplinary Sciences
Rubab Fatima, Robert Briggs, William A. Dew
Summary: Fish can detect and respond to various cations in their environment, including copper. The response of fish to copper can vary, with some fish avoiding it and others showing attraction, depending on the concentration. This study found that an intact olfactory system is necessary for fish to sense copper.
Article
Engineering, Environmental
Alper James G. Alcaraz, David Potesil, Kamil Mikulasek, Derek Green, Bradley Park, Connor Burbridge, Kerstin Bluhm, Othman Soufan, Taylor Lane, Marek Pipal, Markus Brinkmann, Jianguo Xia, Zbynek Zdrahal, David Schneider, Doug Crump, Niladri Basu, Natacha Hogan, Markus Hecker
Summary: This study aimed to develop a comprehensive early life stage toxicity pathway model for fish exposed to estrogenic chemicals, rooted in mechanistic toxicology. The integration of omics data improved the interpretation of perturbations in early life stage fish, showing promise as a replacement for standard adult live animal tests. The study provided evidence of conservation of toxicity pathways across levels of biological organization.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Environmental Sciences
Russell J. Erickson, David R. Mount, Terry L. Highland, J. Russell Hockett, Dale J. Hoff, Correne T. Jenson, Teresa J. Norberg-King, Brandy Forsman
Summary: Mathematical models for acute median lethal concentrations of major geochemical ions to fathead minnows were presented based on extensive experiments. Six independent toxicity mechanisms were identified and evaluated. The models were compared to previous models and their application to risk assessments was discussed.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2022)
Article
Environmental Sciences
Susari Malala Irugal Bandaralage, Juan Ignacio Bertucci, Brad Park, Derek Green, Markus Brinkmann, Anita Masse, Doug Crump, Niladri Basu, Natacha Hogan, Markus Hecker
Summary: This study investigated the effects of dietary HBCD on adult fathead minnows and the accumulation and maternal transfer dynamics of HBCD in adult tissue and eggs. The results showed that exposed adults had significantly increased egg production in the medium treatment group. The study also found a correlation between HBCD accumulation in eggs and exposure time.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Article
Fisheries
Joseph M. Leese, Julia McMahon, Joseph C. Colosi
Summary: In a natural setting, wastewater treatment plant effluents containing EDCs may impact reproductive behavior in fish, with even short-term exposure leading to changes in male fish behavior.
Article
Environmental Sciences
Russell J. Erickson, David R. Mount, Terry L. Highland, J. Russell Hockett, Dale J. Hoff, Correne T. Jenson, Teresa J. Norberg-King, Brandy Forsman
Summary: The results of experiments on the acute toxicity of major geochemical ions to fathead minnows are reported. The toxicities of Na, Mg, and K salts decrease as the overall ion content of the dilution water increases. Multiple independent mechanisms of action were identified, including K-specific toxicity and Ca/Mg-specific toxicity.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2022)
Article
Ecology
Madisen C. Strand, Isabel G. DeVriendt, Alex R. Seigel, Christopher L. Merkord, Brian D. Wisenden
Summary: This study examines the impact of hypoxia on the antipredator responses of fathead minnows. The findings reveal that under low dissolved oxygen levels, the minnows' responses are truncated, leading them to stay near the surface where they are more vulnerable to predation.
ENVIRONMENTAL BIOLOGY OF FISHES
(2022)
Article
Environmental Sciences
J. G. Suski, C. J. Salice, M. K. Chanov, J. Ayers, J. Rewerts, J. Field
Summary: This study investigated the effects of PFOS and PFHxS on fathead minnows and found that PFOS had negative impacts on juvenile fish growth, while PFHxS did not exhibit toxicity on adult or juvenile fish at concentrations up to 1200 μg/L.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2021)
Article
Engineering, Environmental
Kristin M. Nielsen, Lily DeCamp, Mona Birgisson, Vince P. Palace, Karen A. Kidd, Joanne L. Parrott, Mark E. McMaster, Mehran Alaee, Nicholas Blandford, Erin J. Ussery
Summary: Metformin, commonly used for treating Type 2 diabetes, is frequently detected in aquatic ecosystems. Laboratory studies have shown that exposure to environmental concentrations of metformin can affect metabolic pathways and impact the growth of early life stage fish. It is unknown if these effects occur in wild populations. This study evaluates the representativeness of laboratory studies and compares the sensitivities of wild and lab-spawned fish. The results indicate that developmental metformin exposure affects the growth and morphology of both cohorts, with wild-spawned fish being more affected. The study also confirms the bioavailability of metformin in natural systems and suggests that current exposure scenarios may negatively impact developing fish.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Environmental Sciences
M. Lefebvre-Raine, N. Paquet, G. Triffault-Bouchet, V. S. Langlois
Summary: The study found that the five cytostatics did not show significant toxicity to fathead minnow larvae at environmental concentrations. However, exposure to ifosfamide led to an increased proportion of complete swim bladders, suggesting an interaction with the thyroid axis. Further research should investigate endpoints such as behavioral changes, reproductive success, and transgenerational effects.
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2021)
Article
Environmental Sciences
Brett R. Blackwell, Gerald T. Ankley, Adam D. Biales, Jenna E. Cavallin, Alexander R. Cole, Timothy W. Collette, Drew R. Ekman, Rachel N. Hofer, Weichun Huang, Kathleen M. Jensen, Michael D. Kahl, Ashley R. Kittelson, Shannon N. Romano, Mary Jean See, Quincy Teng, Charlene B. Tilton, Daniel L. Villeneuve
Summary: Multiple experiments were conducted to investigate the reproductive toxicity of metformin and guanylurea to adult fathead minnows. The results showed that both compounds did not have significant effects on steroidogenesis, gene transcription, hormone concentrations, or fecundity. The impacts on the hepatic transcriptome and metabolome were time-dependent, with the greatest effect observed after 23 days of exposure to 100 μg/L guanylurea.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2022)
Article
Environmental Sciences
Abigail DeBofsky, Yuwei Xie, Jonathan K. Challis, Niteesh Jain, Markus Brinkmann, Paul D. Jones, John P. Giesy
Summary: The study showed that environmentally-relevant concentrations of BaP can alter the diversity of the gut microbiome and community network connectivity. Exposure to BaP reduced alpha diversity at the greatest exposure concentrations, but also altered community composition and reduced network complexity of the microbial community.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Yolina Yu Lin Wang, Ping Li, Okugbe Ebiotubo Ohore, Yuwen Wang, Dainan Zhang, Yunfei Bai, Tenghui Su, Jing You, Xiaowei Jin, Wenhua Liu, Zhen Wang
Summary: The Fish Embryo Acute Toxicity (FET) test was proposed as an alternative to traditional test methods, but the suitability of fathead minnow (Pimephales promelas) embryos for FET remains uncertain. This study used probabilistic ecological risk assessment (PERA) to determine ecological threshold of toxicological concern (ecoTTC) values and uncertainty factors (UFs). The results showed that embryos were less sensitive compared to larvae or adults for certain categories, and non-classified chemicals, especially inorganic compounds, were most toxic to P. promelas embryos.
ENVIRONMENTAL POLLUTION
(2021)
Article
Marine & Freshwater Biology
Angelo J. Cozzola, Gavin K. Dehnert, Amber M. White, William H. Karasov
Summary: Fluridone used in aquatic plant management has sublethal effects on fathead minnows, causing endocrine disruption and negative impacts on behavior.
AQUATIC TOXICOLOGY
(2022)
Letter
Engineering, Environmental
David C. Podgorski, Phoebe Zito, Jennifer T. McGuire, Dalma Martinovic-Weigelt, Isabelle M. Cozzarelli, Barbara A. Bekins, Robert G. M. Spencer
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2018)
Article
Engineering, Environmental
Huajun Zhen, Drew R. Ekman, Timothy W. Collette, Susan T. Glassmeyer, Marc A. Mills, Edward T. Furlong, Dana W. Kolpin, Quincy Teng
Article
Chemistry, Organic
Nicholas C. Pflug, Christopher J. Knutson, Dalma Martinovic-Weigelt, Dale C. Swenson, Kristine H. Wammer, David M. Cwiertny, James B. Gloer
Article
Engineering, Environmental
Timothy W. Collette, Drew R. Ekman, Huajun Zhen, Ha Nguyen, Paul M. Bradley, Quincy Teng
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2019)
Article
Chemistry, Organic
Nicholas C. Pflug, Eric V. Patterson, Dalma Martinovic-Weigelt, Edward P. Kolodziej, James B. Gloer, Kristopher McNeill, David M. Cwiertny, Kristine H. Wammer
JOURNAL OF ORGANIC CHEMISTRY
(2019)
Article
Engineering, Environmental
Barbara A. Bekins, Jennifer C. Brennan, Donald E. Tillitt, Isabelle M. Cozzarelli, Jennifer McGuire Illig, Dalma Martinovic-Weigelt
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2020)
Article
Environmental Sciences
G. T. Ankley, J. P. Berninger, B. R. Blackwell, J. E. Cavallin, T. W. Collette, D. R. Ekman, K. A. Fay, D. J. Feifarek, K. M. Jensen, M. D. Kahl, J. D. Mosley, S. T. Poole, E. C. Randolph, D. Rearick, A. L. Schroeder, J. Swintek, D. L. Villeneuve
Summary: The study demonstrates the application of integrated measurements for understanding the effects of complex chemical mixtures in the environment. By using pathway-based chemical and biological approaches to assess risks in the Maumee River, the research reveals the potential perturbations of biological pathways by different compounds in the environment and the direct effects of chemicals on fish.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2021)
Article
Engineering, Environmental
Huajun Zhen, Quincy Teng, Jonathan D. Mosley, Timothy W. Collette, Yang Yue, Paul M. Bradley, Drew R. Ekman
Summary: This study utilized a zebrafish liver cell-based lipidomics approach to assess the ecotoxicological effects of complex contaminant mixtures in impacted stream waters, revealing lipid changes as potential indicators for environmental monitoring and risk assessments.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Environmental Sciences
Stefan Scholz, John W. Nichols, Beate Escher, Gerald T. Ankley, Rolf Altenburger, Brett Blackwell, Werner Brack, Lawrence Burkhard, Timothy W. Collette, Jon A. Doering, Drew Ekman, Kellie Fay, Fabian Fischer, Joerg Hackermueller, Joel C. Hoffman, Chih Lai, David Leuthold, Dalma Martinovic-Weigelt, Thorsten Reemtsma, Nathan Pollesch, Anthony Schroeder, Gerrit Schueuermann, Martin von Bergen
Summary: The concept of the eco-exposome, analogous to the human exposome, aims to describe the totality of internal exposure over the lifetime of ecologically relevant organisms and explore linking exposure to adverse effects. The study discusses methods and technologies using targeted and nontargeted chemical analyses and bioassays to characterize eco-exposome exposure.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2022)
Article
Environmental Sciences
Brett R. Blackwell, Gerald T. Ankley, Adam D. Biales, Jenna E. Cavallin, Alexander R. Cole, Timothy W. Collette, Drew R. Ekman, Rachel N. Hofer, Weichun Huang, Kathleen M. Jensen, Michael D. Kahl, Ashley R. Kittelson, Shannon N. Romano, Mary Jean See, Quincy Teng, Charlene B. Tilton, Daniel L. Villeneuve
Summary: Multiple experiments were conducted to investigate the reproductive toxicity of metformin and guanylurea to adult fathead minnows. The results showed that both compounds did not have significant effects on steroidogenesis, gene transcription, hormone concentrations, or fecundity. The impacts on the hepatic transcriptome and metabolome were time-dependent, with the greatest effect observed after 23 days of exposure to 100 μg/L guanylurea.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2022)
Article
Fisheries
Drew R. Ekman, Marina G. Evich, Jonathan D. Mosley, Jon A. Doering, Kellie A. Fay, Gerald T. Ankley, Timothy W. Collette
Summary: There is a need for more comprehensive approaches to fisheries assessments and reducing the health impacts of sample collections. Metabolomic tools provide high-throughput, untargeted biochemical information without the need for a sequenced genome, making them ideal for monitoring fish species, especially those under protected status.
JOURNAL OF FISH BIOLOGY
(2023)
Article
Environmental Sciences
David W. Bertolatus, Larry B. Barber, Christopher J. Martyniuk, Huajun Zhen, Timothy W. Collette, Drew R. Ekman, Aaron Jastrow, Jennifer L. Rapp, Alan M. Vajda
Summary: In order to evaluate the relationships between anthropogenic impacts, contaminant occurrence, and fish health, fish exposures were conducted across different land use sites in the Shenandoah River watershed. The study found adverse reproductive outcomes and increased mortality in fish exposed to wastewater treatment plant effluent and agricultural impacts. Molecular biomarkers and hepatic metabolomic and transcriptomic profiles indicated variations in land use and contaminant profiles. This study demonstrated the linkages between human impacts, contaminant occurrence, and exposure effects, highlighting the increased risk of adverse outcomes in fish exposed to complex mixtures.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Marina G. Evich, Jonathan D. Mosley, Ioanna Ntai, Jenna E. Cavallin, Daniel L. Villeneuve, Gerald T. Ankley, Timothy W. Collette, Drew R. Ekman
Summary: The complexity of contaminant mixtures in surface waters presents challenges to assessing risks to human health and the environment. Novel strategies are needed to identify non-targeted contaminants and prioritize detected compounds based on their biological relevance.
Article
Environmental Sciences
Olga Malev, Mario Lovric, Drazenka Stipanicev, Sinisa Repec, Dalma Martinovic-Weigelt, Davor Zanella, Tomislav Ivankovic, Valnea Sindicic Duretec, Josip Barisic, Mei Li, Goran Klobucar
ENVIRONMENTAL POLLUTION
(2020)
Proceedings Paper
Engineering, Industrial
Yuyu He, Chih Lai, Dalma Martinovic-Weigelt, Zezheng Long
2019 14TH ANNUAL CONFERENCE SYSTEM OF SYSTEMS ENGINEERING (SOSE)
(2019)