Review
Oncology
Ryota Masuzaki, Tatsuo Kanda, Reina Sasaki, Naoki Matsumoto, Kazushige Nirei, Masahiro Ogawa, Seth J. Karp, Mitsuhiko Moriyama, Hirofumi Kogure
Summary: Hepatocellular carcinoma (HCC) is a common malignancy worldwide and the SOCS family proteins play an important role in HCC development and liver regeneration. By negatively regulating cytokine signaling, SOCS proteins can modulate cellular growth, differentiation, and immune response. In HCC treatment, SOCS proteins may be potential targets for controlling cell proliferation and immune response.
Article
Biochemistry & Molecular Biology
Yanxia Li, Jing Zhao, Yuan Yin, Chenchen Zhang, Zhaoying Zhang, Yajuan Zheng
Summary: In this study, STAT3 activation was found to be involved in fibrosis induced by IL-6 and TGF-β1. Inhibiting STAT3 reversed the fibrotic responses, and overexpressing SOCS3 rescued the fibrotic effects of IL-6 and TGF-β1 by inactivating STAT3. Furthermore, treatment with S3I-201 inhibited profibrotic gene expression and fibrosis in a rat model of GFS. These findings suggest that STAT3 is a potential target for antifibrotic therapies following GFS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Chuanfeng Lv, Hui Li, Hongxia Cui, Qianyu Bi, Meng Wang
Summary: The study formulated rhynchophylline-solid lipid nanoparticles to treat allergic asthma in mice model, showing better therapeutic effects in inhibiting airway inflammation and oxidative stress. The nanoparticles relieved allergic asthma by upregulating suppressor of cytokine signaling 1 and repressing the p38 signaling pathway.
Article
Immunology
Beate J. Muller, Arne Westheider, Katharina Birkner, Birte Seelig, Susanne Kirschnek, Christian Bogdan, Friederike D. von Loewenich
Summary: Research shows that TLR, rather than NLR or CLR, is crucial for the detection of A. phagocytophilum, and defective TLR signaling may be compensated for by the redundancy of the immune system in vivo.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Medicine, Research & Experimental
Sibo Liu, Hongfeng Bi, Meiling Jiang, Yuanli Chen, Meixiu Jiang
Summary: This review summarizes the relationship between atherosclerosis and NLRP3 inflammasome, and explores the regulatory role of the TRIM family in mediating inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Genetics & Heredity
Asuman Gedikbasi, Gokhan Adas, Nilgun Isiksacan, Kadriye Kart Yasar, Esra Canbolat Unlu, Rabia Yilmaz, Gulsum Oya Hergunsel, Zafer Cukurova
Summary: This study found that the miRNA miR-155-5p was significantly upregulated in COVID-19 patients and was associated with disease severity. Overexpression of miR-155-5p increased inflammatory cytokine production and promoted COVID-19 progression. The study suggests that miR-155 may facilitate immune inflammation by targeting SOCS1 and is associated with disease prognosis.
Article
Multidisciplinary Sciences
Martin Liu, Anastasios Nikolaos Panagopoulos, Usama M. Oguz, Saurabhi Samant, Charu Hasini Vasa, Devendra K. Agrawal, Yiannis S. Chatzizisis
Summary: This study investigated the role of TREM-1 in the signaling pathways linking low shear stress to inflammation. The results showed that low shear stress increased TREM-1 expression and led to increased production of inflammatory mediators and matrix-degrading enzymes. Inhibition of TREM-1 reduced the production of inflammatory mediators and enzymes under low shear stress conditions. This study provides important insights into the pathophysiological association and molecular pathways of low shear stress, TREM-1, and inflammation.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Martin Liu, Anastasios Nikolaos Panagopoulos, Usama M. M. Oguz, Saurabhi Samant, Charu Hasini Vasa, Devendra K. K. Agrawal, Yiannis S. S. Chatzizisis
Summary: Low shear stress induces TREM-1 expression and increases production of inflammatory mediators and matrix-degrading enzymes, while high shear stress does not significantly affect TREM-1 and inflammatory mediators. Inhibition of TREM-1 transcription can reduce the production of vascular inflammatory mediators and matrix-degrading enzymes under low shear stress conditions.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Antigona Ulndreaj, Angela Li, Yonghong Chen, Rickvinder Besla, Shaun Pacheco, Marwan G. Althagafi, Myron I. Cybulsky, Thomas Lindsay, Clinton S. Robbins, John S. Byrne
Summary: The study found that aortic macrophage accumulation in abdominal aortic aneurysm (AAA) is primarily caused by adventitial recruitment of Lyve-1(-) macrophages, with a relative depletion of Lyve-1(+) macrophages. Selective targeting of macrophage subtypes may represent a potential novel therapeutic avenue for the medical treatment of AAA.
Article
Cardiac & Cardiovascular Systems
Yoshihiko Saito
Summary: This review article focuses on the roles of the placental growth factor (PlGF) signaling pathway and its receptor, fms-like tyrosine kinase-1 (Flt-1), in the development of the cardiorenal connection. The upregulation of PlGF and downregulation of its antagonist, soluble Flt-1, in the presence of renal dysfunction contribute to the activation of the PlGF/Flt-1 signaling pathway, leading to worsening atherosclerosis and heart failure commonly seen in patients with kidney problems. Furthermore, the plasma levels of soluble Flt-1 are correlated with the severity of renal dysfunction and incidence of cardiovascular events, suggesting a potential role of noninfectious inflammation via PlGF/Flt-1 signaling in the development of renal dysfunction-related cardiovascular complications.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
KyoungJoo Cho, Sejeong Kim, Seung Ho Choi
Summary: SOCS2 is upregulated in Huntington's disease and substantially induced in extended polyglutamine-expressing striatal cells. The induced level is augmented under aging conditions. In extended polyglutamine-expressing cells, downregulated SOCS2 improves autophagic dysfunction rather than altered inflammatory conditions.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Xiangyu Zhang, Trent D. Evans, Sunny Chen, Ismail Sergin, Jeremiah Stitham, Se-Jin Jeong, Astrid Rodriguez-Velez, Yu-Sheng Yeh, Arick Park, In-Hyuk Jung, Abhinav Diwan, Joel D. Schilling, Oren Rom, Arif Yurdagul, Slava Epelman, Jaehyung Cho, Irfan J. Lodhi, Bettina Mittendorfer, Babak Razani
Summary: The mTOR pathway plays a significant role in atherosclerosis, with mTORC1 promoting lesion formation and mTORC2 inhibiting inflammatory response and regulating plaque complexity. The balanced and opposing roles of these two arms of mTOR signaling have important implications for plaque size and complexity.
CIRCULATION RESEARCH
(2023)
Article
Health Care Sciences & Services
Nobuyuki Kobayashi, Shunichiro Shinagawa, Tomoyuki Nagata, Masahiro Shigeta, Kazuhiro Kondo
Summary: There is evidence suggesting the association between major depressive disorder (MDD) and inflammation, but the mechanism behind the lack of increase in inflammatory cytokines in MDD patients is unknown. This study found that while the levels of inflammatory cytokines and negative regulators of cytokine signaling were not significantly elevated in the blood of MDD patients, there were significant decreases in certain mRNA levels, indicating that these genes might play a role in depressive symptoms. Remission from MDD was associated with a decrease in SOCS3 mRNA levels, suggesting its potential as a trait marker for depressive symptoms.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Pathology
Samy Y. Elkhawaga, Ahmed Elshafei, Mohamed A. Elkady, Amr Mohamed Yehia, Ahmed I. Abulsoud, Nourhan M. Abdelmaksoud, Elsayed G. E. Elsakka, Ahmed Ismail, Mahmoud Mohamed Mokhtar, Hesham A. El-Mahdy, Maghawry Hegazy, Mohammed S. Elballal, Osama A. Mohammed, Mustafa Ahmed Abdel-Reheim, Walaa A. El-Dakroury, Sherif S. Abdel Mageed, Mahmoud A. Elrebehy, Reem K. Shahin, Mohamed Bakr Zaki, Ahmed S. Doghish
Summary: This study investigates the potential role of miRNAs in the development of PCC and explores their association with survival rates and treatment options.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Microbiology
Nele Zoellner, Noemi Coesfeld, Frederik Henry De Vos, Jennifer Denter, Haifeng C. Xu, Elena Zimmer, Birgit Knebel, Hadi Al-Hasani, Sofie Mossner, Philipp A. Lang, Doreen M. Floss, Juergen Scheller
Summary: Researchers found that synthetic type I interferon signaling mainly originates from IFNAR2, rather than IFNAR1, by reformatting the structure of IFNAR1 and IFNAR2.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Surgery
Verena Buchecker, Ines Koska, Claudia Pace, Steven R. Talbot, Rupert Palme, Andre Bleich, Heidrun Potschka
Summary: Chronic epilepsy models require neurosurgical procedures including depth electrode implants. The intrahippocampal kainate model is a frequently used chronic paradigm, which is based on chemoconvulsant administration and status epilepticus induction during the surgical procedure. This experimental approach raises the question of the extent to which this approach affects postsurgical recovery.
EUROPEAN SURGICAL RESEARCH
(2023)
Article
Emergency Medicine
T. Gruebl, D. Nauheimer, H. Wolff, G. Gehret, N. Rott, W. Schmidbauer, B. Schieffer, B. Gliwitzky
Summary: The treatment of patients with cardiac arrest is complex, and establishing cardiac arrest centers can improve patient outcomes. The certification and re-certification process for these centers is multi-stage and takes about a year. These centers require infrastructure, evidence-based treatment algorithms, structured training, and regular evaluations for process optimization. The goal is to provide focused and standardized care for patients with cardiac arrest. Multidisciplinary cooperation, accurate procedures, high standards for patient safety, and detailed documentation are necessary. These measures optimize treatment and improve outcomes for cardiac arrest patients. The updated international resuscitation guidelines strongly recommend the establishment of cardiac arrest centers.
NOTFALL & RETTUNGSMEDIZIN
(2023)
Article
Cardiac & Cardiovascular Systems
Julian Kreutz, Amar Mardini, Ann-Christin Schaefer, Bernhard Schieffer, Birgit Markus
Summary: This article presents a case of severe cardiogenic-septic shock and introduces a method of treating accompanying complications using an experimental arterio-venous shunt, which achieved good therapeutic effects.
Article
Surgery
Eva Zentrich, Laura Wassermann, Birgitta Struve, Kristin Selke, Manuela Buettner, Lydia Maria Keubler, Janin Reifenrath, Nina Angrisani, Merle Kempfert, Annika Krause, Olaf Bellmann, Marcin Kopaczka, Dorit Merhof, Marion Bankstahl, Andre Bleich, Christine Haeger
Summary: In this study, telemetry and the Sheep Grimace Scale (SGS) were used to assess pain severity in sheep after surgical interventions. The results showed that SGS and telemetry data were able to detect postoperative pain in sheep, contributing to the improvement of individual pain recognition and postoperative management, and therefore enhancing the scientific validity of the study.
EUROPEAN SURGICAL RESEARCH
(2023)
Article
Engineering, Biomedical
Julian Kreutz, Maryana Choukeir, Georgios Chatzis, Bernhard Schieffer, Birgit Markus
Summary: This case report highlights the recognition of severe Capnocytophaga infection in immunocompetent patients, which can lead to critical conditions. Combined therapeutic measures, including broad spectrum antibiotic therapy, mass transfusions, continuous renal replacement therapy, and hemoadsorption therapy, resulted in control of the critical situation.
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
(2023)
Article
Gastroenterology & Hepatology
Yuhan Yin, Anna Sichler, Josef Ecker, Melanie Laschinger, Gerhard Liebisch, Marcus Hoering, Marijana Basic, Andre Bleich, Xue-Jun Zhang, Ludwig Kuebelsbeck, Johannes Plagge, Emely Scherer, Dirk Wohlleber, Jianye Wang, Yang Wang, Marcella Steffani, Pavel Stupakov, Yasmin Gaertner, Fabian Lohoefer, Carolin Mogler, Helmut Friess, Daniel Hartmann, Bernhard Holzmann, Norbert Hueser, Klaus-Peter Janssen
Summary: Hepatocyte growth and proliferation depend on membrane phospholipid biosynthesis, which is significantly influenced by short-chain fatty acids (SCFAs) generated through bacterial fermentation. Antibiotic treatment and dysbiosis not only affect gut microbiota, but also impair hepatic lipid synthesis and liver regeneration.
JOURNAL OF HEPATOLOGY
(2023)
Article
Nutrition & Dietetics
Silvia Bolsega, Anna Smoczek, Chen Meng, Karin Kleigrewe, Tim Scheele, Sebastian Meller, Silke Glage, Holger A. Volk, Andre Bleich, Marijana Basic
Summary: The size of the cecum in germ-free mice is influenced by their genetic background. Mice on B6 background have the largest cecum, while those on C3H background have the smallest cecum. The cecal size of NMRI and BALBc mice is intermediate. The genetic background affects cecal enlargement through regulation of water transport, production of acidic mucins, and metabolic profiles.
Article
Medicine, General & Internal
Nikolaos Patsalis, Julian Kreutz, Georgios Chatzis, Styliani Syntila, Sebastian Griewing, Carly Pirlet-Grant, Malte Schlegel, Bernhard Schieffer, Birgit Markus
Summary: Impella (R) support can improve hemodynamics and renal organ perfusion in patients with myocardial infarction complicating cardiogenic shock. Targeted control of the renal resistive index (RRI) by the Impella (R) pump may contribute to renal organ protection.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Steven R. Talbot, Simone Kumstel, Benjamin Schulz, Guanglin Tang, Ahmed Abdelrahman, Nico Seume, Edgar H. U. Wendt, Johanna Eichberg, Christine Haeger, Andre Bleich, Brigitte Vollmar, Dietmar Zechner
Summary: This study analyzed the reliability of four parameters in four gastrointestinal animal models and found that the performance of the parameters varied depending on the model. Burrowing and nesting were more robust, while body weight was also robust in certain models. The Relative Severity Assessment (RELSA) procedure was used to address the complexity of severity.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Daniel Segelcke, Steven R. Talbot, Rupert Palme, Carmen La Porta, Esther Pogatzki-Zahn, Andre Bleich, Anke Tappe-Theodor
Summary: Rodent behavior is influenced by environmental conditions, including housing conditions and familiarization with the experimenter. This study aimed to investigate the effects of different housing conditions and experimenter familiarization on pain-related behavior in male mice with peripheral neuropathy. The results showed that housing conditions and experimenter familiarization had an impact on mechanical sensitivity, gait pattern, anxiety-like behavior, and stress levels in the mice. These findings highlight the importance of considering environmental conditions in preclinical pain studies.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Tobias Braun, Alina Pruene, Milita Darguzyte, Alexander F. vom Stein, Phuong-Hien Nguyen, Dimitrios L. Wagner, Jonas Kath, Alicia Roig-Merino, Michael Heuser, Lucas L. Riehm, Andreas Schneider, Sabine Awerkiew, Steven R. Talbot, Andre Bleich, Constanca Figueiredo, Martin Bornhaeuser, Renata Stripecke
Summary: This study evaluated the feasibility of using gene-edited CAR-T cell therapies for treating Burkitt lymphoma. The results showed that both edited CAR-T cells exhibited cytotoxic effects against Burkitt lymphoma cells in vitro, and CD19(KI)CAR-T cells delayed lymphoma dissemination in vivo while gp350(KI)CAR-T cells reduced EBV DNA load. However, the two types of CAR-T cells showed differences in therapeutic effects and in vivo dynamics, reflecting the complexity of EBV immune escape mechanisms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Amira Metwaly, Jelena Jovic, Nadine Waldschmitt, Sevana Khaloian, Helena Heimes, Deborah Haecker, Mohamed Ahmed, Nassim Hammoudi, Lionel Le Bourhis, Aida Mayorgas, Kolja Siebert, Marijana Basic, Tobias Schwerd, Matthieu Allez, Julian Panes, Azucena Salas, Andre Bleich, Sebastian Zeissig, Pamela Schnupf, Fabio Cominelli, Dirk Haller
Summary: This study found that segmented filamentous bacteria (SFB) are associated with Crohn's disease (CD) and can induce ileo-colonic inflammation in mouse models. The severity of CD-like inflammation strongly correlates with the abundance of SFB. SFB colonization can be prevented by a purified diet, which also prevents disease development.
Review
Behavioral Sciences
Lydia M. Keubler, Steven R. Talbot, Andre Bleich, Erin C. Boyle
Summary: This systematic review assessed the impact of fecal microbiota transplantation (FMT) on animal behavior. The results showed that FMT can alter animal behavior, thereby confirming evidence for the gut microbiota-brain axis. However, the study also emphasized the urgent need for methodological safeguards to reduce bias and improve the internal validity of future studies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
J. M. Schubart, M. K. H. Schaefer, G. A. Bonaterra, L. Mey, U. Luesebrink, B. Schieffer, L. E. Eiden, R. Kinscherf, E. Weihe, C. Waechter
EUROPEAN HEART JOURNAL
(2022)
Article
Biotechnology & Applied Microbiology
Niels Oppel, Malena Ezzat, Philipp Krueger, Katharina Schmitt, Alexandra Napp, Friederike Pohl, Andre Bleich, Thomas Lenarz, Tobias Stein, Gerrit Paasche, Robert Schuon
Summary: This study successfully developed a method to reproducibly induce Eustachian tube dysfunction by injecting hyaluronic acid near the Eustachian tube. The established model can be used to test novel treatment options for Eustachian tube functionality.
BIOENGINEERING-BASEL
(2022)
