Article
Neurosciences
Amrita Benoy, Mohammad Zaki Bin Ibrahim, Thomas Behnisch, Sreedharan Sajikumar
Summary: Research shows that activation of cholinergic receptors in the hippocampal CA2 area regulates synaptic plasticity, with muscarinic acetylcholine receptors playing a role in early facilitation and nicotinic acetylcholine receptors involved in late maintenance. Furthermore, priming with cholinergic stimulation lowers the threshold for subsequent long-term potentiation induction and demonstrates a metaplastic regulation of CA2 synaptic learning rules.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Zi-Fan Mai, Zhi-Ping Cao, Shu-Yi Huang, Wen-Wen Yan, Jun-Ni Huang, Bao-Yan Wu, Chu-Hua Li
Summary: Cordycepin may modulate metaplasticity in the hippocampal CA1 area of rats through adenosine A(1) receptors, affecting the induction of LTP and LTD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Sami I. Hassan, Shivani Bigler, Steven A. Siegelbaum
Summary: This study investigated the mechanisms for social sensory information processing in the hippocampus using two-photon calcium imaging. The findings showed that CA2 pyramidal neurons represent social odors of individual conspecifics and that these representations are refined during associative social odor-reward learning.
Article
Neurosciences
Daniel Radzicki, Sarah Chong, Serena M. Dudek
Summary: Hippocampal area CA2 is a distinct region of the hippocampus that can be defined by molecular markers. Some commonly used markers are better suited for defining the border between CA2/3 and CA2/1. In addition, there are fewer complex spines in CA2 compared to CA3.
Article
Geriatrics & Gerontology
Antonio M. Carvalho da Silva, Cristina Lemos, Henrique B. Silva, Ildete L. Ferreira, Angelo R. Tome, A. Cristina Rego, Rodrigo A. Cunha
Summary: This multidimensional study demonstrates that the circadian oscillation in brain behavior, synaptic plasticity, and synaptic mitochondria function are impaired in 3xTg-AD mice, highlighting the effects of circadian misalignment in AD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Alen Eapen, Diego Fernandez-Fernandez, John Georgiou, Zuner A. Bortolotto, Stafford Lightman, David E. Jane, Arturas Volianskis, Graham L. Collingridge
Summary: The study demonstrates the involvement of GluN2D-containing NMDARs in both short-term potentiation (STP) and long-term potentiation (LTP) in the mouse hippocampus, highlighting the important role of GluN2D subunits in synaptic plasticity.
Article
Neurosciences
Mahsa Samadi, Claire A. Hales, Daniel J. Lustberg, Shannon Farris, Madeleine R. Ross, Meilan Zhao, John R. Hepler, Nicholas H. Harbin, Emma S. J. Robinson, Paul J. Banks, Zafar I. Bashir, Serena M. Dudek
Summary: Pyramidal cells in hippocampal area CA2 have distinct synaptic properties, including a lack of typical long-term potentiation. This study investigated the role of metabotropic glutamate receptor (mGluR)-dependent signaling regulators in CA2 synaptic plasticity. The results showed that mGluR agonist-induced long-term depression (mGluR-LTD) is more pronounced in CA2 compared to CA1, and that this process depends on protein synthesis and the presence of STEP and RGS14 proteins. Additionally, RGS14 was found to play a crucial role in CA2 mGluR-LTD. Furthermore, RGS14 knockout mice showed impaired social recognition memory, suggesting a role for CA2 synaptic plasticity in social cognition.
Article
Neurosciences
Madeleine Kyrke-Smith, Lenora J. Volk, Samuel F. Cooke, Mark F. Bear, Richard L. Huganir, Jason D. Shepherd
Summary: Research shows that mice lacking the Arc gene do not exhibit deficits in hippocampal long-term potentiation (LTP), indicating that Arc is not necessary for LTP in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Christophe Clement Rey, Vincent Robert, Guillaume Bouisset, Maithe Loisy, Sebastien Lopez, Vanessa Cattaud, Camille Lejards, Rebecca Ann Piskorowski, Claire Rampon, Vivien Chevaleyre, Laure Verret
Summary: The study found that decreased presence of PNN around PV cells in Alzheimer's disease mouse models is associated with social memory deficits. Single local injection of the growth factor NRG1 can restore both PV/PNN levels and social memory performance of these mice.
Article
Neurosciences
Sylvie L. Lesuis, Paul J. Lucassen, Harm J. Krugers
Summary: This study investigates the effects of early life stress (ELS) on fear learning and hippocampal synaptic potentiation in AD mice. The results indicate that ELS increases fear memory in both familiar and novel contexts, accompanied by aberrant hippocampal synaptic potentiation.
Review
Neurosciences
Rebecca A. Piskorowski, Vivien Chevaleyre
Summary: The hippocampal area CA2 plays a crucial role in social recognition memory and has unique cellular and molecular properties. It has a high density of interneurons and displays two distinct forms of long-term synaptic plasticity. Recent studies have revealed changes in inhibitory transmission and plasticity of CA2 in mouse models of neurological disorders such as multiple sclerosis, autism spectrum disorder, Alzheimer's disease, schizophrenia, and the 22q11.2 deletion syndrome. These findings suggest that these changes in CA2 could contribute to the social cognitive deficits observed in these disorders.
FRONTIERS IN NEURAL CIRCUITS
(2023)
Review
Neurosciences
Hugo Balleza-Tapia, Luis Enrique Arroyo-Garcia, Arturo G. Isla, Raul Loera-Valencia, Andre Fisahn
Summary: Gamma oscillations in the hippocampal area CA3 are crucial for memory function. Recent studies have found that pyramidal cells (PCs) in CA3 are organized into different functional subpopulations, which play important roles in cognition-related network dynamics.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Kelly E. Carstens, Daniel J. Lustberg, Emma K. Shaughnessy, Katharine E. McCann, Georgia M. Alexander, Serena M. Dudek
Summary: The study reveals that Perineuronal nets (PNNs) are abnormal in the brains of individuals with Rett syndrome (RTT) and RTT mouse models, leading to compromised plasticity in the CA2 region of the hippocampus. Degradation of PNNs in Mecp2-null mice rescues the premature disruption of plasticity in CA2 synapses.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Neurosciences
Mara Yone D. Fernandes, Joao Pedro Lopes, Henrique B. Silva, Geanne M. Andrade, Rodrigo A. Cunha, Angelo R. Tome
Summary: Caffeic acid, a polyphenolic compound found in many dietary components, has been shown to reduce brain ischemia and attenuate various brain diseases. This study investigated whether caffeic acid directly affects synaptic transmission and plasticity, and found that it does not have a direct effect but can indirectly correct synaptic dysfunction.
NEUROSCIENCE LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Jiandong Sun, Yan Liu, Xiaoning Hao, Weiju Lin, Wenyue Su, Emerald Chiang, Michel Baudry, Xiaoning Bi
Summary: This study reveals that LAMTOR1 restricts lysosomal trafficking in dendrites of hippocampal neurons by inhibiting TRPML1 activity independently of mTORC1. Deletion of LAMTOR1 or disrupting LAMTOR1-TRPML1 binding enhances TRPML1-mediated calcium ion release and facilitates dendritic lysosomal trafficking. Moreover, LAMTOR1 deletion in adult mice results in altered synaptic plasticity, impaired learning, and memory.