Article
Biochemistry & Molecular Biology
Jinzhao Xu, Mengqi Tang, Xinyu Wu, Xiangli Kong, Yini Liu, Xiaoxi Xu
Summary: Lactobacillus rhamnosus (L. rhamnosus) zz-1 has been found to prevent and alleviate depression caused by chronic stress by regulating the gut microbiota and improving intestinal environment. This study provides new evidence for the mental benefits of probiotics.
Article
Immunology
Mingfei Liu, Shirong Li, Ningning Cao, Qingguo Wang, Yuhao Liu, Qianqian Xu, Lin Zhang, Chenghong Sun, Xuefeng Xiao, Jingchun Yao
Summary: This study investigates the relationship between intestinal flora, metabolism, and immunity, and reveals the significant changes in intestinal flora and reduced immune cell abundance in RA mice. The findings provide new therapeutic strategies for RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Xu Yan, Yuanyuan Zhai, Wenling Zhou, Yuan Qiao, Lingling Guan, Hao Liu, Jizhi Jiang, Liang Peng
Summary: Rutin supplementation can alleviate obesity and metabolic disorders induced by high-fat diet through modulating the composition of intestinal flora. Rutin supplementation reduces body-weight gain, improves insulin resistance, and acts favorably on intestinal barrier, reducing endotoxemia and systemic inflammation. Antibiotic treatment and fecal microbiota transplantation demonstrate the importance of intestinal flora in the beneficial effects of rutin on obesity control.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Linlin Wang, Mao Chai, Jialiang Wang, Qiangqing Yu, Gang Wang, Hao Zhang, Jianxin Zhao, Wei Chen
Summary: This study found that Bifidobacterium longum can relieve constipation by regulating the intestinal barrier, enhancing intestinal motility, improving water and electrolyte metabolism, inhibiting inflammation, and preventing loperamide-induced intestinal barrier damage.
Article
Microbiology
Irina Efremova, Roman Maslennikov, Aliya Alieva, Elena Poluektova, Vladimir Ivashkin
Summary: The aim of this study was to determine whether the presence of small intestinal bacterial overgrowth (SIBO) affects the prognosis in cirrhosis. A total of 50 patients were included in this prospective cohort study and underwent lactulose hydrogen breath test for SIBO. The results showed that SIBO is associated with poor prognosis in cirrhosis.
Article
Urology & Nephrology
Hoang Thuy Linh, Yasunori Iwata, Yasuko Senda, Yukiko Sakai-Takemori, Yusuke Nakade, Megumi Oshima, Shiori Nakagawa-Yoneda, Hisayuki Ogura, Koichi Sato, Taichiro Minami, Shinji Kitajima, Tadashi Toyama, Yuta Yamamura, Taro Miyagawa, Akinori Hara, Miho Shimizu, Kengo Furuichi, Norihiko Sakai, Hiroyuki Yamada, Katsuhiko Asanuma, Kouji Matsushima, Takashi Wada
Summary: Impairment of intestinal barrier function is associated with the progression of diabetic kidney disease, and abnormal MAVS signaling in the kidney and intestine contributes to disrupted intestinal homeostasis. Controlling intestinal homeostasis may offer a novel therapeutic approach for diabetic kidney disease.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Neurosciences
Zhongci Hang, Shanglin Cai, Tong Lei, Xiaoshuang Zhang, Zhuangzhuang Xiao, Donghui Wang, Yingxian Li, Wangyu Bi, Yanjie Yang, Shiwen Deng, Li Wang, Quanhai Li, Hongwu Du
Summary: Intestinal flora transplantation from tumor-bearing mice can ameliorate cognitive impairment in AD mice, showing better efficacy compared to the control group. FMT treatment has positive effects on inflammatory factors, A beta plaques, and microbiota composition in AD mice.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Immunology
Dongyue Li, Lanrong Cui, Yanhong Gao, Yang Li, Xin Tan, Hongyu Xu
Summary: Ulcerative colitis is a chronic inflammatory disease of the intestine, and its pathogenesis is associated with environmental factors, genetic susceptibility, dysbiosis of the intestinal flora, and autoimmunity. Fecal microbiota transplantation has been found to be a potential new strategy for the treatment of ulcerative colitis.
MICROBIAL PATHOGENESIS
(2022)
Article
Immunology
Yangyang Yuan, Shaohua Liu, Xianfei Ding, Ying Li, Xiaojuan Zhang, Heng Song, Xueyan Qi, Zihao Zhang, Kaiyuan Guo, Tongwen Sun
Summary: The study found significant differences in the abundance and structure of the gut microbiota between aged and adult sepsis mice. Aged sepsis mice had more severe gut microbiota destruction and liver tissue inflammation compared to adult sepsis mice.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Liying Ding, Xiuting Chen, K. Qian, Z. Jiang
Summary: Inflammatory bowel disease is becoming more common in China due to dietary changes, prompting research on the efficacy of probiotics like Lactobacillus plantarum in modifying intestinal flora of mice.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Ecology
Ruina Liu, Qi Wang, Kai Zhang, Hao Wu, Gongji Wang, Wumin Cai, Kai Yu, Qinru Sun, Shuanliang Fan, Zhenyuan Wang
Summary: The study investigated microbial succession patterns during decomposition, identified seven different succession patterns, and developed a random forest regression model to predict postmortem intervals. Lactobacillus, Dubosiella, Enterococcus, and the Lachnospiraceae NK4A136 group were considered significant biomarkers for the model.
Article
Multidisciplinary Sciences
Junfeng Shi, Hongyan Qiu, Qian Xu, Yuting Ma, Tongtong Ye, Zengguang Kuang, Na Qu, Chengxia Kan, Ningning Hou, Fang Han, Xiaodong Sun
Summary: Obesity is a global epidemic that causes various chronic complications. This study demonstrates that empagliflozin, a sodium-glucose cotransporter 2 inhibitor, can regulate metabolism in obese hosts through modulating the intestinal microbiota. Empagliflozin treatment increases species diversity of gut microbiota and affects metabolites involved in amino acid metabolism. It also activates immune pathways in the intestinal network. These findings provide insights into developing obesity therapies based on host-microbe interactions.
Article
Immunology
Yahui Peng, Jieling Wei, Xiaonan Jia, Feiyu Luan, Mingyin Man, Xiaohui Ma, Yinghao Luo, Yue Li, Nana Li, Qian Wang, Xibo Wang, Yang Zhou, Yuanyuan Ji, Wenjing Mu, Jun Wang, Chunying Wang, Qianqian Zhang, Kaijiang Yu, Mingyan Zhao, Changsong Wang
Summary: This study observed the changes in gut microbiota in septic mice and found that the gut microbiota in the colon changed most significantly after infection, while the changes in the small intestine were less pronounced. It suggests that protective gut microbiota and mucin-degrading microbes should be focused on. These findings may help inform sepsis treatment in the future.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tobias Hasler, Leticia Tavares-Gomes, Sereina Gut, Meghna Swayambhu, Mario Gysi, Martin Hausmann, Natasha Arora, Thierry Hennet
Summary: The availability of carbohydrates in the gastrointestinal tract influences the gut microbiota composition. Bacterial glycoside hydrolases play a role in carbohydrate foraging and can alter the properties of host glycans. Increased sialidase activity exacerbates acute colitis severity by remodeling surface sialylation.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yuan Zhang, Waleed A. S. Aldamarany, Liling Deng, Geng Zhong
Summary: Bacterial translocation (BT) induced by antibiotics is associated with increased risk of inflammatory disorders, and intestinal barrier integrity plays a vital role in this process. In this study, the prebiotic effects of deacetylated konjac glucomannan (DKGM) and konjac oligo-glucomannan (KOGM) were investigated in a mouse model. The results showed that these derivatives showed potential in inhibiting BT and alleviating colon tissue lesions. Additionally, they improved short-chain fatty acid production and reduced inflammation response.
Article
Radiology, Nuclear Medicine & Medical Imaging
Rolf Reiter, Florian N. Loch, Carsten Kamphues, Christian Bayerl, Stephan R. Marticorena Garcia, Britta Siegmund, Anja A. Kuehl, Bernd Hamm, Juergen Braun, Ingolf Sack, Patrick Asbach
Summary: This study tested the feasibility of MR elastography of the gut in healthy volunteers and IBD patients, showing excellent diagnostic performance in predicting IBD.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Cell Biology
Svetlana Saveljeva, Gavin W. Sewell, Katharina Ramshorn, M. Zaeem Cader, James A. West, Simon Clare, Lea-Maxie Haag, Rodrigo Pereira de Almeida Rodrigues, Lukas W. Unger, Ana Belen Iglesias-Romero, Lorraine M. Holland, Christophe Bourges, Muhammad N. Md-Ibrahim, James O. Jones, Richard S. Blumberg, James C. Lee, Nicole C. Kaneider, Trevor D. Lawley, Allan Bradley, Gordon Dougan, Arthur Kaser
Summary: FAMIN plays a crucial role in regulating immune responses, protecting against excessive T cell activation and autoimmune reactions.
Article
Gastroenterology & Hepatology
Moritz Leppkes, Aylin Lindemann, Stefanie Goesswein, Susanne Paulus, Dominik Roth, Anne Hartung, Eva Liebing, Sebastian Zundler, Miguel Gonzalez-Acera, Jay Patankar, Fabrizio Mascia, Kristina Scheibe, Markus Hoffmann, Stefan Uderhardt, Christine Schauer, Sebastian Foersch, Clemens Neufert, Michael Vieth, Georg Schett, Raja Atreya, Anja A. Kuehl, Andre Bleich, Christoph Becker, Martin Herrmann, Markus F. Neurath
Summary: Bleeding ulcers and erosions are common in active ulcerative colitis, with fibrin layers correlated with rectal bleeding. Neutrophils induce secondary immunothrombosis through PAD4-dependent mechanisms, protecting against acute colitis and rectal bleeding. Deficiency in immunothrombosis can lead to exacerbated colitis and increased bleeding.
Review
Gastroenterology & Hepatology
Laura Golusda, Anja A. Kuehl, Britta Siegmund, Daniela Paclik
Summary: This review discusses the influence of pain medication on inflammatory bowel disease research in colitis models, arguing that the current administration of pain medication impacts results and reproducibility, leading to misconceptions.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Immunology
Jonas Ahlers, Andrej Mantei, Laura Lozza, Manuela Staeber, Frederik Heinrich, Petra Bacher, Thordis Hohnstein, Lutz Menzel, Simge G. Yuez, Daniel Alvarez-Simon, Anne Rieke Bickenbach, Carl Weidinger, Nadine Mockel-Tenbrinck, Anja A. Kuehl, Britta Siegmund, Jochen Maul, Christian Neumann, Alexander Scheffold
Summary: We identified a Notch/STAT3-Blimp-1/c-Maf axis as a common anti-inflammatory pathway in human CD4(+) T cells and found that this pathway is defective in inflammatory bowel disease.
MUCOSAL IMMUNOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Lea-Maxie Haag, Britta Siegmund
Article
Neurosciences
Gidon Karmon, Shlomo Sragovich, Gal Hacohen-Kleiman, Inbar Ben-Horin-Hazak, Petr Kasparek, Bjorn Schuster, Radislav Sedlacek, Metsada Pasmanik-Chor, Paschalis Theotokis, Olga Touloumi, Sofia Zoidou, Linxuan Huang, Pei You Wu, Roy Shi, Oxana Kapitansky, Alexandra Lobyntseva, Eliezer Giladi, Guy Shapira, Noam Shomron, Stefan Bereswill, Markus M. Heimesaat, Nikolaos Grigoriadis, R. Anne McKinney, Moran Rubinstein, Illana Gozes
Summary: The study used CRISPR-Cas9 editing to create mice with a mutation similar to the most common ADNP syndrome mutation. NAP was found to correct the abnormal gene expression and has potential as a drug target for ADNP syndrome. This research provides valuable insights into the pathology and potential treatment options for ADNP syndrome.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Immunology
Ping Shen, Madlen Rother, Ulrik Stervbo, Vicky Lampropoulou, Elisabeth Calderon-Gomez, Toralf Roch, Ellen Hilgenberg, Steffi Ries, Anja A. Kuehl, Luc Jouneau, Pierre Boudinot, Simon Fillatreau
Summary: This study demonstrates the critical role of neutrophils in the regulation of antigen-specific CD4(+) T cell expansion in lymph nodes, and the counter-regulatory role of TLR signaling in this process.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Immunology
Caio Andreeta Figueiredo, Henning Peter Duesedau, Johannes Steffen, Stefanie Ehrentraut, Miklos P. Dunay, Gabor Toth, Dora Regloedi, Markus M. Heimesaat, Ildiko Rita Dunay
Summary: The study demonstrates that administration of PACAP can alleviate brain tissue inflammation and cell apoptosis induced by T. gondii infection, inhibit the activation of microglia and recruitment of monocytes. Additionally, PACAP also reduces the expression of inflammatory mediators and promotes neuronal health by increasing the expression of neurotrophin BDNF and reducing p75(NTR) receptor associated with neuronal cell death.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Immunology
Kristina Koop, Karin Enderle, Miriam Hillmann, Laura Ruspeckhofer, Michael Vieth, Gregor Sturm, Zlatko Trajanoski, Anja A. Kuehl, Raja Atreya, Moritz Leppkes, Patrick Baum, Janine Roy, Andrea Martin, Markus F. Neurath, Clemens Neufert
Summary: Fibrostenotic disease is a common complication in Crohn's disease characterized by ECM accumulation. This study found that MMP13 expression is regulated by IL36R signaling during intestinal fibrosis, and the loss of MMP13 can alleviate intestinal fibrosis in mice. Targeting IL36R-inducible MMP13 could be a promising approach to interfere with the development and progression of intestinal fibrosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Gastroenterology & Hepatology
Mathias K. -M. Herzog, Monica Cazzaniga, Audrey Peters, Nizar Shayya, Luca Beldi, Siegfried Hapfelmeier, Markus M. M. Heimesaat, Stefan Bereswill, Gad Frankel, Cormac G. M. Gahan, Wolf-Dietrich Hardt
Summary: Enteropathogenic bacteria are a major global cause of disease and death, but not all individuals naturally exposed to these bacteria develop disease. The gut microbiota and various barriers contribute to resistance against gastrointestinal infection. However, the mechanisms underlying inter-individual differences in resistance are still not fully understood.
Review
Biochemistry & Molecular Biology
Markus M. Heimesaat, Steffen Backert, Thomas Alter, Stefan Bereswill
Summary: Human campylobacteriosis is a foodborne infection caused by Campylobacter bacteria, which are responsible for bacterial gastroenteritis. Contaminated poultry meat is the main source of transmission to humans, causing abdominal pain and diarrhea. Prevention strategies focus on reducing pathogenic food contamination through hygiene measures.
Article
Biochemistry & Molecular Biology
Minnja S. S. Foote, Ke Du, Soraya Mousavi, Stefan Bereswill, Markus M. M. Heimesaat
Summary: Human Campylobacter jejuni infections are increasing globally and alternative intervention measures are needed. This study investigated the therapeutic effects of carvacrol, a phenolic compound with antimicrobial and immune-modulatory properties, in mice with acute campylobacteriosis. Treatment with carvacrol reduced pathogen loads in the small intestines, alleviated symptoms and histopathological changes in the colon, and decreased immune cell numbers. Carvacrol also dampened pro-inflammatory mediator secretion and induced shifts in the fecal microbiota composition. Overall, these findings suggest that carvacrol application could be a promising option to alleviate campylobacteriosis in infected vertebrate hosts.
Article
Nutrition & Dietetics
Janine Buettner, Elisabeth Bluethner, Sophie Greif, Anja Kuehl, Sefer Elezkurtaj, Jan Ulrich, Sebastian Maasberg, Christoph Jochum, Frank Tacke, Ulrich-Frank Pape
Summary: This study investigated biomarkers for the regulation mechanisms in the intestinal barrier during adaptive response or treatment with the glucagon-like peptide-2 analog in short bowel syndrome patients. Gene expression analyses and intestinal permeability testing were conducted. The results showed altered gene expression in nutrient transport genes and the usefulness of mannitol recovery in describing gut absorptive capacity.
Article
Biochemistry & Molecular Biology
Leonie Wittner, Lukas Wagener, Jakob J. Wiese, Iris Stolzer, Susanne M. Krug, Elisabeth Naschberger, Rene Jackstadt, Rudi Beyaert, Raja Atreya, Anja A. Kuehl, Gregor Sturm, Miguel Gonzalez-Acera, Jay V. Patankar, Christoph Becker, Britta Siegmund, Zlatko Trajanoski, Beate Winner, Markus F. Neurath, Michael Schumann, Claudia Guenther
Summary: The paracaspase MALT1 plays a crucial role in mucosal inflammation. It is highly expressed in colonic epithelial cells of UC patients and experimental colitis. Mechanistically, MALT1 protease function inhibits ferroptosis and contributes to NF-kappa B signaling and STAT3 signaling, which are involved in inflammation and tissue healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)