Article
Cell Biology
Shengbo Chen, Hongbin Liu, Zhijun Li, Jingyi Tang, Bing Huang, Fachao Zhi, Xinmei Zhao
Summary: PBLD plays a crucial role in UC, as its deficiency leads to impaired intestinal barrier function and dysregulated immune responses, exacerbating colonic inflammation.
CELL DEATH & DISEASE
(2021)
Article
Pharmacology & Pharmacy
Yu Gu, Chen Wang, Xiali Qin, Bingqian Zhou, Xiang Liu, Tianyu Liu, Runxiang Xie, Jinghua Liu, Bangmao Wang, Hailong Cao
Summary: The study found that the supernatant of Saccharomyces boulardii can upregulate serotonin transporter expression by activating the epidermal growth factor receptor, and it can also modulate gut microbiota to inhibit gut motility.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ke Gu, Guangmang Liu, Caimei Wu, Gang Jia, Hua Zhao, Xiaoling Chen, Gang Tian, Jingyi Cai, Ruinan Zhang, Jing Wang
Summary: This study demonstrated that tryptophan enhances cell migration in porcine intestine epithelial cells (IPEC-J2) through the CaSR/Rac1/PLC-γ1 signaling pathway.
Article
Biochemistry & Molecular Biology
Mingrui Zhang, Ruixia Mo, Mingtan Li, Yuankai Qu, Haotian Wang, Tianyi Liu, Pan Liu, Yi Wu
Summary: This study compared the effects of dietary supplementation with enzymolysis seaweed powder and Saccharomyces boulardii on the intestinal health of kittens. The results showed that enzymolysis seaweed powder can improve immune and antioxidant capacity, reduce intestinal permeability and inflammation levels in kittens, and have a positive impact on the composition of the gut microbiota. This study provides new perspectives on the application of enzymolysis seaweed powder.
Article
Immunology
Jingxia Gao, Guanzhong Song, Haibo Shen, Yiming Wu, Chongqi Zhao, Zhuo Zhang, Qian Jiang, Xilong Li, Xiaokang Ma, Bie Tan, Yulong Yin
Summary: This study found that allicin improves intestinal barrier function and prevents damage caused by bacteria. It increases cell viability and enhances the integrity of cell monolayers.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Amira Seltana, Gabriel Cloutier, Vilcy Reyes Nicolas, Taoufik Khalfaoui, Inga C. Teller, Nathalie Perreault, Jean-Francois Beaulieu
Summary: Fibrinogen plays an important role in wound healing and tissue inflammation, acting as a substrate in the basement membrane of intestinal cells. It has a promoting effect on cell healing, especially under pathological conditions that require rapid epithelial repair.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Anrong Wang, Xinyi Liang, Wanxia Chen, Yiting Liu, Yiping Zhu, Dong Zhang, Ling Hu, Ruliu Li
Summary: The study investigated the potential effects of total ginsenosides (TG) in intestinal mucosal restitution. TG reversed cell growth inhibition caused by DFMO and promoted cell proliferation by affecting the translation of c-Myc. Furthermore, Panax ginseng aqueous extract (PGE) prevented intestinal mucosal injury and promoted mucosal restitution through enhancing HuR and c-Myc levels.
Article
Pharmacology & Pharmacy
Vanessa D'Antongiovanni, Luca Antonioli, Laura Benvenuti, Carolina Pellegrini, Clelia Di Salvo, Marco Calvigioni, Adelaide Panattoni, Larisa Ryskalin, Gianfranco Natale, Sebastiano Banni, Gianfranca Carta, Emilia Ghelardi, Matteo Fornai
Summary: Treatment with Saccharomyces boulardii CNCM I-745 prevents diclofenac-induced enteropathy through anti-inflammatory and antioxidant activities, likely by improving butyrate uptake by the enteric mucosa.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jolanta Mierzejewska, Patrycja Kowalska, Klaudia Marlicka, Sara Dworakowska, Ewa Sitkiewicz, Maciej Trzaskowski, Agata Gluchowska, Grazyna Mosieniak, Malgorzata Milner-Krawczyk
Summary: This study investigated the ability of extracellular vesicles (EVs) produced by the probiotic yeast Saccharomyces boulardii to transfer and internalize bioactive molecules in human intestinal cells. The results showed that these EVs successfully delivered the anticancer drug doxorubicin to the cells without significant negative effects. Proteomic analysis also identified 541 proteins, providing important information for exploring yeast EVs as a drug delivery system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Debra T. Linfield, Nannan Gao, Andjela Raduka, Terri J. Harford, Giovanni Piedimonte, Fariba Rezaee
Summary: The study revealed that RSV infection delays the airway epithelium wound repair process by attenuating epithelial cell migration and affecting the internal structure of cells.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Shelley R. Wang, Navneeta Rathor, Min S. Kwon, Lan Xiao, Hee Kyoung Chung, Douglas J. Turner, Jian-Ying Wang, Jaladanki N. Rao
Summary: miR-195 plays a regulatory role in early intestinal epithelial restitution by altering the expression of ARP-2. Cellular polyamines decrease miR-195 abundance and enhance ARP-2 translation. Overexpression of miR-195 disrupts F-actin cytoskeleton organization, which can be prevented by ARP2 overexpression.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Nutrition & Dietetics
Xinge Xu, Jingwei Wu, Yuxin Jin, Kunlun Huang, Yuanyuan Zhang, Zhihong Liang
Summary: This study investigated the effect of S. boulardii and its postbiotics on DSS-induced ulcerative colitis in mice. The results showed that S. boulardii and postbiotics intervention improved colonic shortening and tissue damage, increased the expression of intestinal tight junction protein, reduced the secretion of pro-inflammatory factors, increased the secretion of anti-inflammatory factors, and maintained the homeostasis of intestinal microorganisms. Postbiotics intervention was more effective than probiotics. In conclusion, S. boulardii and its postbiotics effectively alleviate DSS-induced colitis in mice by modulating host immunity and maintaining intestinal homeostasis. Postbiotics are promising next-generation biotherapeutics for ulcerative colitis treatment.
Article
Immunology
Gunnar Andreas Walaas, Shreya Gopalakrishnan, Ingunn Bakke, Helene Kolstad Skovdahl, Arnar Flatberg, Ann Elisabet ostvik, Arne Kristian Sandvik, Torunn Bruland
Summary: The study investigates the effects of different oxygen levels on the growth, differentiation, and immunological responses of human colonoids. It shows that colonoids cultured in a 2% oxygen environment have larger cell mass and a tendency towards lower pro-inflammatory response compared to those cultured in a 20% oxygen environment. The results suggest that studying colonoids in a physioxia environment is important for better resemblance to in vivo conditions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Liang Wang, Baohui Song, Yan Hu, Jun Chen, Shuaishuai Zhang, Dapeng Chen, Jingyu Wang
Summary: This study demonstrates the protective effects of puerarin in 5-fluorouracil-induced intestinal mucositis by inhibiting the activation of JAK, which suppresses inflammation, oxidative reactions, cell apoptosis, and protects intestinal barrier functions. Puerarin may serve as a potential natural JAK inhibitor in the treatment of 5-FU-induced intestinal mucositis.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2021)
Article
Agriculture, Dairy & Animal Science
Wenwen Gao, Keying An, Peng Li, Lei Li, Zhaofei Xia
Summary: This study aimed to investigate the effects of dietary Saccharomyces cerevisiae (SC) on the intestinal flora structure and barrier function of Pekin duck. The results showed that dietary SC supplementation improved feed conversion efficiency, increased ileum length, improved bacterial diversity and abundance, and up-regulated the expression of certain genes related to intestinal barrier function.
Article
Oncology
Carole Siret, Chloe Terciolo, Aurelie Dobric, Marie-Christine Habib, Sebastien Germain, Renate Bonnier, Dominique Lombardo, Veronique Rigot, Frederic Andre
BRITISH JOURNAL OF CANCER
(2015)
Article
Gastroenterology & Hepatology
Chloe Terciolo, Aurelie Dobric, Mehdi Ouaissi, Carole Siret, Gilles Breuzard, Francoise Silvy, Bastien Marchiori, Sebastien Germain, Renate Bonier, Adel Hama, Roisin Owens, Dominique Lombardo, Veronique Rigot, Frederic Andre
JOURNAL OF CROHNS & COLITIS
(2017)
Review
Food Science & Technology
Chloe Terciolo, Marc Maresca, Philippe Pinton, Isabelle P. Oswald
FOOD AND CHEMICAL TOXICOLOGY
(2018)
Article
Multidisciplinary Sciences
Rodolphe Pontier-Bres, Patrick Munro, Laurent Boyer, Rodolphe Anty, Veronique Imbert, Chloe Terciolo, Federic Andre, Patrick Rampal, Emmanuel Lemichez, Jean-Francois Peyron, Dorota Czerucka
Article
Food Science & Technology
Chloe Terciolo, Ana Paula Bracarense, Pollyana C. M. C. Souto, Anne-Marie Cossalter, Leonie Dopavogui, Nicolas Loiseau, Carlos A. F. Oliveira, Philippe Pinton, Isabelle P. Oswald
Article
Environmental Sciences
Su Luo, Chloe Terciolo, Ana Paula F. L. Bracarense, Delphine Payros, Philippe Pinton, Isabelle P. Oswald
ENVIRONMENT INTERNATIONAL
(2019)
Article
Environmental Sciences
Su Luo, Chloe Terciolo, Manon Neves, Sylvie Puel, Claire Naylies, Yannick Lippi, Philippe Pinton, Isabelle P. Oswald
Summary: This study demonstrated that proliferative intestinal epithelial cells are more susceptible to the mycotoxin deoxynivalenol (DON) compared to differentiated cells. DON was also found to delay the differentiation process in the intestinal epithelium. The differential gene expression analysis revealed the involvement of various pathways in the response to DON and the differentiation process.
ENVIRONMENTAL POLLUTION
(2021)
Article
Medicine, Research & Experimental
Emilie Bersuder, Chloe Terciolo, Mathilde Lechevrel, Elisabeth Martin, Celine Quesnelle, Jean-Noel Freund, Jean-Marie Reimund, Isabelle Gross
Summary: Mesalazine may promote intestinal mucosal healing and resistance against colorectal cancer by increasing the expression levels of genes like MUCDHL, with its efficacy potentially dependent on the cellular and molecular context.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Food Science & Technology
Leonie Dopavogui, Arnaud Polizzi, Anne Fougerat, Pascal Gourbeyre, Chloe Terciolo, Wendy Klement, Philippe Pinton, Joelle Laffite, Anne-Marie Cossalter, Jean-Denis Bailly, Olivier Puel, Yannick Lippi, Claire Naylies, Herve Guillou, Isabelle P. Oswald, Nicolas Loiseau
Summary: Fumonisin B1 (FB1) is a widespread mycotoxin produced mainly in maize, and pigs and horses are most susceptible to it. FB1 exposure can cause diverse clinical symptoms. By analyzing the transcriptomes of four organs, common biological processes and tissue-specific processes related to lipid outcomes were identified in response to FB1 exposure.
Article
Medicine, Research & Experimental
Jean-Baptiste Delhorme, Emilie Bersuder, Chloe Terciolo, Ourania Vlami, Marie-Pierrette Chenard, Elisabeth Martin, Serge Rohr, Cecile Brigand, Isabelle Duluc, Jean-Noel Freund, Isabelle Gross
Summary: This study demonstrates the role of CDX2 in chemoresistance of CRC, showing that CDX2 expression enhances resistance of colon cancer cells towards 5-FU by regulating ABCC11 and DPYD genes. The findings suggest the therapeutic potential of targeting CDX2/ABCC11/DPYD pathway to improve systemic chemotherapy in CRC.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Toxicology
Laura Soler, Ingrid Miller, Chloe Terciolo, Karin Hummel, Katharina Noebauer, Manon Neves, Isabelle P. Oswald
Summary: We compared the protein composition of pig intestinal explants exposed to DON or NX and found that the changes in the extracellular proteome were different between the two toxins. DON decreased cell viability and caused cell destruction, while NX led to an enrichment of mitochondrial proteins in the secretome, which may be related to its ability to induce intestinal inflammation.
ARCHIVES OF TOXICOLOGY
(2022)
Review
Gastroenterology & Hepatology
Chloe Terciolo, Michel Dapoigny, Frederic Andre
CLINICAL AND EXPERIMENTAL GASTROENTEROLOGY
(2019)
Article
Oncology
Carole Siret, Aurelie Dobric, Anna Martirosyan, Chloe Terciolo, Sebastien Germain, Renate Bonier, Thassadite Dirami, Nelson Dusetti, Richard Tomasini, Marion Rubis, Stephane Garcia, Juan Iovanna, Dominique Lombardo, Veronique Rigot, Frederic Andre
BRITISH JOURNAL OF CANCER
(2018)