Article
Environmental Sciences
Wenxuan Dong, Lianqi Yan, Yun Tan, Shufang Chen, Kanglei Zhang, Zhonggui Gong, Wenjing Liu, Hui Zou, Ruilong Song, Jiaqiao Zhu, Gang Liu, Zongping Liu
Summary: This study explores the protective effects of melatonin against cadmium-induced nephrotoxicity and the underlying mechanism. The findings suggest that melatonin inhibits mitochondrial fission mediated by dynamin-related protein 1 and mitochondrial fission protein 1, leading to the attenuation of cytotoxicity and oxidative stress induced by cadmium.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Huan Liu, Siyu Zhu, Wenna Han, Yueqi Cai, Chunhong Liu
Summary: DMEP induces mitochondrial damage and cellular oxidative stress in HepG2 cells, impacting the Nrf2 pathway and mitochondrial biogenesis, leading to autophagy and apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Pharmacology & Pharmacy
Qunwei Huang, Hongbo Chen, Kai Yin, Yilan Shen, Kanghong Lin, Xieyi Guo, Xiang Zhang, Niansong Wang, Wenfeng Xin, Youhua Xu, Dingkun Gui
Summary: Formononetin (FMN) may alleviate renal tubular injury and mitochondrial damage in diabetic nephropathy (DN) partly by regulating the Sirt1/PGC-1 alpha pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Weili Li, Jing Cao, Xiaoping Wang, Yawen Zhang, Qianbin Sun, Yanyan Jiang, Junkai Yao, Chun Li, Yong Wang, Wei Wang
Summary: The study demonstrated that Ferruginol (FGL) exerts cardioprotective effects by enhancing mitochondrial biogenesis and fatty acid oxidation through stimulating the SIRT1-PGC-1 alpha axis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Food Science & Technology
Huan Liu, Wenna Han, Siyu Zhu, Zhongyi Li, Chunhong Liu
Summary: DEHP and DnOP, commonly used plasticizers, induce oxidative stress and mitochondrial damage in HepG2 cells by inhibiting the Nrf2 pathway and mitochondrial biogenesis, leading to excessive autophagy and cell death. The two plasticizers differ in their effects on the Nrf2 pathway, autophagic pathway, and MAPK pathway, possibly due to structural differences.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ying Jiang, Da Li, Zhiqiang Du, Jie Li, Rongrong Lu, Qin Zhou, Qi Wang, Haohao Zhu
Summary: The study investigated the protective effects of Perampanel on mitochondrial biogenesis and bioenergetics in human neuronal cells. Results showed that Perampanel stimulated mitochondrial biogenesis and improved mitochondrial bioenergetics.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yahong Cheng, Xin Zeng, Qianting Mai, Xinying Bai, Yuan Jiang, Jinjin Li, Shiqi Fan, Hong Ding
Summary: Insulin has significant neuroprotective effects against epilepsy seizures, including improving mitochondrial dysfunction and reducing oxidative stress. Its pretreatment also helps regulate relevant proteins to resist hippocampal neuron apoptosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Neurosciences
Yu Chen, Yuhui Jiang, Yinuo Yang, Xinzhong Huang, Cheng Sun
Summary: The study revealed that SIRT1 has neuroprotective effects on dopaminergic neurons by promoting cell survival, maintaining mitochondrial function, and reducing cell apoptosis. These effects are dependent on SIRT1-mediated mitochondrial biogenesis via PGC-1α, suggesting great therapeutic potential of SIRT1 for disorders associated with dopaminergic neuron loss such as PD.
NEUROTOXICITY RESEARCH
(2021)
Article
Psychiatry
Jin Wang, Jing Tang, Xin Liang, Yanmin Luo, Peilin Zhu, Yue Li, Kai Xiao, Lin Jiang, Hao Yang, Yuhan Xie, Lei Zhang, Yuhui Deng, Jing Li, Yong Tang
Summary: Running exercise has been shown to positively impact depressive-like symptoms, with PGC-1 alpha playing a key role in regulating PV+ interneurons in the hippocampus. Lack of PGC-1 alpha impairs the effectiveness of running exercise in improving depressive-like behaviors and influencing PV+ interneurons, highlighting the importance of hippocampal PGC-1 alpha in the antidepressant effects of exercise.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Neurosciences
L. J. McMeekin, K. L. Joyce, L. M. Jenkins, B. M. Bohannon, K. D. Patel, A. S. Bohannon, A. Patel, S. N. Fox, M. S. Simmons, J. J. Day, A. Kralli, D. K. Crossman, R. M. Cowell
Summary: This study identified ERRa as necessary for normal expression of PGC-1a-dependent genes in neurons, with a strong correlation in expression between ERRa and PGC-1a in the brain. In ERRa null mice, PGC-1a-dependent genes were reduced in multiple brain regions, leading to behavioral abnormalities without severe motor impairments seen in PGC-1a null mice.
Article
Biochemistry & Molecular Biology
Xiaoming Chai, Mengyue Pan, Jingjie Wang, Mingmei Feng, Yupeng Wang, Qi Zhang, Yang Sun
Summary: Cordycepin has a beneficial effect on physical fatigue and can relieve fatigue by regulating energy metabolism and the pentose phosphate pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Jian- Lee, Shang-Chuan Ng, Jia-Yun Hsu, Hsun Liu, Chih-Jung Chen, Chih-Yang Huang, Wei-Wen Kuo
Summary: UV radiation and H2O2 are the primary factors that cause skin aging, and galangin may exert anti-photoaging and antioxidant effects by promoting SIRT1/PGC-1 alpha/Nrf2 signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Peng Ye, Wei Li, Xin Huang, Sheng Zhao, Wu Chen, Yuqi Xia, Weimin Yu, Ting Rao, Jinzhuo Ning, Xiangjun Zhou, Yuan Ruan, Fan Cheng
Summary: This study aimed to investigate the role and mechanism of BMAL1 in renal ischemia-reperfusion injury (IRI). The results showed that BMAL1 mediates mitochondrial homeostasis in renal IRI through the SIRT1/PGC-1 alpha axis, providing a new direction for targeted therapy for renal IRI.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Neurosciences
Yuta Kashiwagi, Hyun Yi, Shue Liu, Keiya Takahashi, Kentaro Hayashi, Daigo Ikegami, Xun Zhu, Jun Gu, Shuanglin Hao
Summary: Opioid use disorders (OUDs) have become epidemic in the United States, involving illicit use, prescription drugs, and counterfeit opioids. This study shows that spinal PGC-1 alpha can reduce morphine tolerance by decreasing mitochondria-targeted superoxide in the spinal cord dorsal horn.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jin-Ho Koh, Jong-Yeon Kim
Summary: Mitochondria are essential for cellular functions, with NAD(+) playing a crucial role in metabolism. PGC-1 alpha is key in orchestrating mitochondrial biogenesis and regulating the NAD(+) pool.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Correction
Multidisciplinary Sciences
Lucia Lichvarova, Walter Blum, Beat Schwaller, Viktoria Szabolcsi
SCIENTIFIC REPORTS
(2020)
Article
Genetics & Heredity
Lucia Janickova, Karin Farah Rechberger, Lucas Wey, Beat Schwaller
Article
Neurosciences
Lucia Janickova, Beat Schwaller
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Correction
Genetics & Heredity
Lucia Janickova, Karin Farah Rechberger, Lucas Wey, Beat Schwaller
Summary: The amended version of this paper has been published and can be accessed through the original article.
Article
Cell Biology
Benjamin Chatei, Sylvie Ducreux, Zeina Harhous, Nadia Bendridi, Isabelle Varlet, Augustin C. Ogier, Monique Bernard, Julien Gondin, Jennifer Rieusset, Hakan Westerblad, David Bendahan, Charlotte Gineste
Summary: Mitochondrial diseases are genetic disorders that impair mitochondrial function and lead to muscle weakness and exercise intolerance. In the Tfam KO mouse model, impaired mitochondrial energy production and premature fatigue occur before muscle weakness and early death.
DISEASE MODELS & MECHANISMS
(2021)
Article
Biochemistry & Molecular Biology
Thomas Henzi, Kim-Long Diep, Anne Oberson, Valerie Salicio, Christian G. Bochet, Beat Schwaller
Summary: Malignant mesothelioma (MM) is an aggressive cancer derived from mesothelial cells, often caused by asbestos exposure. The current treatment options are limited in effectiveness, hence the search for novel therapies. Recent research has identified septins as a potential target for treatment. Some FCF analogs have been found to inhibit the growth of MM cells in vitro, but at concentrations too high for clinical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Clotilde Raynard, Xingjie Ma, Anda Huna, Nolwenn Tessier, Amelie Massemin, Kexin Zhu, Jean-Michel Flaman, Florentin Moulin, Delphine Goehrig, Jean-Jacques Medard, David Vindrieux, Isabelle Treilleux, Hector Hernandez-Vargas, Sylvie Ducreux, Nadine Martin, David Bernard
Summary: Cellular senescence is characterized by stable proliferation arrest and the acquisition of a senescence-associated secretory phenotype (SASP). The SASP affects the environment of senescent cells and can induce different phenotypic changes. This study reveals that the SASP can promote the neuroendocrine transdifferentiation (NED) of some epithelial cancer cells, providing insights into the functional link between senescent cell accumulation, NED, and clinical patient outcome.
Article
Biochemistry & Molecular Biology
Clotilde Raynard, Nolwenn Tessier, Anda Huna, Marine Warnier, Jean-Michel Flaman, Fabien Van Coppenolle, Sylvie Ducreux, Nadine Martin, David Bernard
Summary: The regulation of calcium ion (Ca2+) levels during cellular senescence is not well understood. This study found that several senescence inducers increased intracellular Ca2+ content in human mammary epithelial cells (HMECs), and the expression of the Ca2+-binding protein CALB1 was upregulated through the Ca2+-dependent calcineurin/NFAT pathway. Overexpression of CALB1 buffered the rise in intracellular Ca2+ levels observed in senescent cells. Additionally, increased expression of Ca2+-binding proteins calbindins was found to be a common marker of senescent cells. These findings suggest that Ca2+ and Ca2+-binding proteins play a crucial role in regulating cellular senescence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Fabrice Gonnot, Maya Dia, Yves Gouriou, Gabriel Bidaux, Christophe Chouabe, Claire Crola da Silva, Sylvie Ducreux, Bruno Pillot, Christelle Leon, Coralie Perret, Franck Sciandra, Fadi Faraht, Laurent Sebbag, Thomas Bochaton, Helene Thibault, Michel Ovize, Melanie Paillard, Ludovic Gomez
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Multidisciplinary Sciences
Fabrice Gonnot, Laura Boulogne, Camille Brun, Maya Dia, Yves Gouriou, Gabriel Bidaux, Christophe Chouabe, Claire Crola Da Silva, Sylvie Ducreux, Bruno Pillot, Andrea Kaczmarczyk, Christelle Leon, Stephanie Chanon, Coralie Perret, Franck Sciandra, Tanushri Dargar, Vincent Gache, Fadi Farhat, Laurent Sebbag, Thomas Bochaton, Helene Thibault, Michel Ovize, Melanie Paillard, Ludovic Gomez
Summary: Despite advancements in cardioprotection, novel therapeutic approaches are still required to prevent ischemia-reperfusion injury in patients. This study reveals that phosphorylation of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA2) at serine 663 is a clinical and pathophysiological event affecting cardiac function. Inhibition of serine 663 phosphorylation enhances SERCA2 activity, mitigates cell death, and counteracts cytosolic and mitochondrial Ca2+ overload. These findings enhance our understanding of excitation/contraction coupling in cardiomyocytes and highlight the therapeutic potential of SERCA2 modulation in acute myocardial infarction.
NATURE COMMUNICATIONS
(2023)
Review
Immunology
Camille Brun, Lucie Chalet, Florentin Moulin, Thomas Bochaton, Sylvie Ducreux, Melanie Paillard, Claire Crola Da Silva
Summary: This review explores the field of inflammation and Ca2+ signaling in PBMCs, highlighting the structure and evolution in a physio-pathological context. Flow cytometry analysis of Ca2+ fluxes in PBMCs is the focus, revealing remaining knowledge gaps and the potential of flow cytometry as a solid option for studying Ca2+ signaling.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Nolwenn Tessier, Mallory Ducrozet, Maya Dia, Sally Badawi, Christophe Chouabe, Claire Crola Da Silva, Michel Ovize, Gabriel Bidaux, Fabien Van Coppenolle, Sylvie Ducreux
Summary: This study provides the first evidence that TRPV1 channels contribute to Ca2+ exchanges in MAMs.
Article
Geriatrics & Gerontology
Lisa S. Martin, Audrey Josset-Lamaugarny, Thomas El Jammal, Sylvie Ducreux, Fabien P. Chevalier, Berengere Fromy
Summary: In this study, it was found that heat-induced vasodilation was reduced in old mice, associated with decreased expression of TRPV3 channels. Additionally, expression and activity of TRPV3 channel were found to decrease in human primary keratinocytes from old donors. This suggests that aging affects the ability of the skin to detect changes in temperature.
Meeting Abstract
Cardiac & Cardiovascular Systems
Simon Leboube, Camille Brun, Florentin Moulin, Ahmad Hayek, Iyad Abousaleh, Alexandre Paccalet, Gilles Rioufol, Cyril Prieur, Eric Bonnefoy-Cudraz, Nathan O. Mewton, Gabriel Bidaux, Melanie Paillard, Claire Crola Da Silva, Sylvie Ducreux, Thomas Bochaton
Meeting Abstract
Cardiac & Cardiovascular Systems
Fabrice Gonnot, Maya Dia, Yves Gouriou, Gabriel Bidaux, Christophe Chouabe, Claire Crola Da Silva, Sylvie Ducreux, Bruno Pillot, Andrea Kaczmarczyk, Christelle Leon, Coralie Perret, Franck Sciandra, Fadi Farhat, Laurent Sebbag, Thomas Bochaton, Helene Thibault, Michel Ovize, Melanie Paillard, Ludovic Gomez