Article
Multidisciplinary Sciences
Toru Hachisuga, Midori Murakami, Hiroshi Harada, Taeko Ueda, Tomoko Kurita, Seiji Kagami, Kiyoshi Yoshino, Ryosuke Tajiri, Masanori Hisaoka
Summary: Intra-tumoral budding (ITB) has been demonstrated to be a risk factor for adverse outcomes in colorectal carcinoma, and this study found its prognostic significance in high-grade serous ovarian carcinomas (HGSOC). ITB was correlated with a higher level of CA125, advanced stage, lymph node metastasis, and lymphovascular space invasion (LVSI). Patients with HGSOC with ITB had shorter progression-free survival (PFS) compared to those without ITB, but ITB was not an independent prognostic factor. ITB is considered a cost-effective prognostic indicator and a useful histological biomarker of HGSOC progression in ovarian tumor tissue.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Yingying Yu, Weiwei Wang, Wenying Lu, Wei Chen, Anquan Shang
Summary: Accumulating evidence suggests that INHBA plays a crucial role in promoting migration and invasion of breast cancer cells by inducing EMT through activating TGF-beta-regulated genes, which potentially make it a diagnostic biomarker and therapeutic target for breast cancer treatment.
Correction
Biochemistry & Molecular Biology
Haihai Liang, Tong Yu, Yue Han, Hua Jiang, Chengyu Wang, Tianyi You, Xiaoguang Zhao, Huitong Shan, Rui Yang, Lida Yang, Hongli Shan, Yunyan Gu
Summary: A correction to this paper has been published and is accessible through the original article.
Article
Medicine, General & Internal
Katelyn F. Handley, Travis T. Sims, Nicholas W. Bateman, Deanna Glassman, Katherine Foster, Sanghoon Lee, Jun Yao, Hui Yao, Bryan M. Fellman, Jinsong Liu, Zhen Lu, Kelly A. Conrads, Brian L. Hood, Waleed Barakat, Li Zhao, Jianhua Zhang, Shannon N. Westin, Joseph Celestino, Kelly M. Rangel, Sunil Badal, Igor Pereira, Prahlad T. Ram, George L. Maxwell, Livia S. Eberlin, P. Andrew Futreal, Robert C. Bast, Nicole D. Fleming, Thomas P. Conrads, Anil K. Sood
Summary: This study identified two novel, gross morphologic subtypes of HGSOC, each with unique clinical features and molecular signatures. These findings may have important implications for triaging patients to surgery or chemotherapy, evaluating outcomes, and developing tailored therapeutic strategies.
Article
Oncology
Chiara Romani, Davide Capoferri, Elisabetta Grillo, Marco Silvestri, Michela Corsini, Laura Zanotti, Paola Todeschini, Antonella Ravaggi, Eliana Bignotti, Franco Odicino, Enrico Sartori, Stefano Calza, Stefania Mitola
Summary: This study identified and characterized a claudin-low molecular profile in high-grade serous ovarian cancer, which shares similarities with the homologous breast cancer subtype. Patients with this molecular profile exhibit poorer overall survival, likely due to the undifferentiated/stem cell component. These findings suggest the potential utility of molecular subtyping for prognostic purposes in managing high-grade serous ovarian cancer.
Article
Oncology
Yicheng Wang, Haoling Xie, Xiaohong Chang, Wenqi Hu, Mengyao Li, Yi Li, Huiping Liu, Hongyan Cheng, Shang Wang, Ling Zhou, Danhua Shen, Sha Dou, Ruiqiong Ma, Yunuo Mao, Honglan Zhu, Xiaobo Zhang, Yuxuan Zheng, Xue Ye, Lu Wen, Kehkooi Kee, Heng Cui, Fuchou Tang
Summary: This study provides insights into the molecular characteristics of high-grade serous ovarian cancer through integrated analysis of multiomic changes and epigenetic regulation. It reveals the upregulation of interferon signaling and metallothioneins, which are influenced by demethylation and hypomethylation. The study also suggests the potential preexistence of metastatic cells in the subclones of primary tumors.
Article
Medicine, Research & Experimental
Yuanzhi Chen, Zhicheng He, Shuting Yang, Cheng Chen, Wenyong Xiong, Yingying He, Shubai Liu
Summary: In this study, it was found that RUNX1 plays a crucial role in the development of high-grade serous ovarian cancer (HGSOC). It regulates apoptosis and EMT function, impacting the physiological function of ovarian cancer cells. Down-regulation of RUNX1 increases sensitivity to drug therapy for ovarian cancer. This research has significant implications for the diagnosis and treatment of HGSOC patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Leticia Aptecar, Carole Puech, Evelyne Lopez-Crapez, Marion Peter, Peter Coopman, Veronique D'Hondt, Gilles Freiss
Summary: The expression level of PTPN13 gene is closely related to the prognosis of HGSOC. Knockout/silencing of PTPN13 increases the migration and invasion ability of KURAMOCHI cells, as well as the expression of mesenchymal phenotype and EMT-related genes. In addition, overexpression of PTPN13 increases the sensitivity of HGSOC cells to platinum-containing drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Aparna Cherukunnath, Ravichandra S. Davargaon, Rahail Ashraf, Urja Kamdar, Amit K. Srivastava, Prem P. Tripathi, Nabanita Chatterjee, Sanjay Kumar
Summary: KLF8 is overexpressed in ovarian cancer and promotes cancer progression. TGF-beta 1 activates KLF8 expression through the Smad2 pathway and regulates epithelial-mesenchymal transition (EMT), contributing to OC progression.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Oncology
Puja Dey, Kentaro Nakayama, Sultana Razia, Masako Ishikawa, Tomoka Ishibashi, Hitomi Yamashita, Kosuke Kanno, Seiya Sato, Tohru Kiyono, Satoru Kyo
Summary: This study successfully developed an in vitro carcinogenic model of LGSOCs and found that the mutations of KRAS and PIK3CA play a causative role in LGSOC tumorigenesis. Simultaneous activation of the KRAS/ERK and PIK3CA/AKT signaling pathways is essential for LGSOC development.
Article
Biochemistry & Molecular Biology
Jiahong Tan, Chunyan Song, Daoqi Wang, Yigang Hu, Dan Liu, Ding Ma, Qinglei Gao
Summary: High-grade serous ovarian cancer (HGSOC) with high expression of hormone receptors, including androgen receptor (AR), estrogen receptor alpha (ER), and progesterone receptor (PR), is associated with longer progression-free survival (PFS), overall survival (OS), and platinum-free interval (PFI). Correlation analysis shows significant positive correlations between hormone receptor expression and survival, indicating that AR, ER, and PR could serve as feasible prognostic biomarkers for HGSOC through immunohistochemical analysis. Co-expression of AR, ER, and PR has an improved predictive performance with an area under the curve (AUC) value of 0.945.
BIOSCIENCE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Xiaolin Luo, Junya Cao, Chuyao Zhang, He Huang, Jihong Liu
Summary: This study investigated the role and mechanism of TRAF4 in high-grade serous ovarian cancer (HGSOC). The results showed that TRAF4 was highly expressed in HGSOC and significantly correlated with shorter overall survival and recurrence-free survival. Knockdown of TRAF4 inhibited the proliferation and tumorigenicity of ovarian cancer cells, while overexpression promoted these abilities.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Ashley Weir, Eun-Young Kang, Nicola S. Meagher, Gregg S. Nelson, Prafull Ghatage, Cheng-Han Lee, Marjorie J. Riggan, Aleksandra Gentry-Maharaj, Andy Ryan, Naveena Singh, Martin Widschwendter, Jennifer Alsop, Michael S. Anglesio, Matthias W. Beckmann, Jessica Berger, Christiani Bisinotto, Jessica Boros, Alison H. Brand, James D. Brenton, Angela Brooks-Wilson, Michael E. Carney, Julie M. Cunningham, Kara L. Cushing-Haugen, Cezary Cybulski, Esther Elishaev, Ramona Erber, Sian Fereday, Anna Fischer, Luis Paz-Ares, Javier Gayarre, Blake C. Gilks, Marcel Grube, Paul R. Harnett, Holly R. Harris, Arndt Hartmann, Alexander Hein, Joy Hendley, Brenda Y. Hernandez, Sabine Heublein, Yajue Huang, Tomasz Huzarski, Anna Jakubowska, Mercedes Jimenez-Linan, Catherine J. Kennedy, Felix K. F. Kommoss, Jennifer M. Koziak, Bernhard Kraemer, Nhu D. Le, Jaime Lesnock, Jenny Lester, Jan Lubinski, Janusz Menkiszak, Britta Ney, Alexander Olawaiye, Sandra Orsulic, Ana Osorio, Luis Robles-Diaz, Matthias Ruebner, Mitul Shah, Raghwa Sharma, Yurii B. Shvetsov, Helen Steed, Aline Talhouk, Sarah E. Taylor, Nadia Traficante, Robert A. Vierkant, Chen Wang, Lynne R. Wilkens, Stacey J. Winham, Javier Benitez, Andrew Berchuck, David D. Bowtell, Francisco J. Candido dos Reis, Linda S. Cook, Anna DeFazio, Jennifer A. Doherty, Peter A. Fasching, Maria J. Garcia, Ellen L. Goode, Marc T. Goodman, Jacek Gronwald, David G. Huntsman, Beth Y. Karlan, Stefan Kommoss, Francesmary Modugno, Joellen M. Schildkraut, Hans-Peter Sinn, Annette Staebler, Linda E. Kelemen, Caroline E. Ford, Usha Menon, Paul D. P. Pharoah, Martin Koebel, Susan J. Ramus, D. Bowtell, A. DeFazio, N. Traficante, S. Fereday, A. Brand, P. Harnett, R. Sharma
Summary: Recently, a study found a positive correlation between protein expression of FOXJ1 and the 5-year survival rate of patients with tubo-ovarian high-grade serous carcinoma (HGSC). However, protein expression of GMNN was not significantly associated with patient survival. This study provides preliminary evidence for the prognostic value of FOXJ1 in HGSC and validates the prior mRNA-based prognostic association through immunohistochemistry.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Kate Millington, Katherine Hayes, Sarah Pilcher, Stephanie Roberts, Sara O. Vargas, Amanda French, Jennifer Veneris, Allison O'Neill
Summary: This case presents a transgender male adolescent diagnosed with an androgen receptor-positive serous borderline ovarian tumour while receiving testosterone treatment for medical gender transition. The report discusses the unique considerations in treating ovarian tumours in transgender males, the unclear role of androgens in the development of ovarian epithelial neoplasia, and the importance of evaluating cancer risk based on patient anatomy in transgender individuals.
BRITISH JOURNAL OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Paula Punzon-Jimenez, Victor Lago, Santiago Domingo, Carlos Simon, Aymara Mas
Summary: High-grade serous ovarian carcinoma (HGSOC) is the most common form of epithelial ovarian carcinoma, and its early diagnosis still relies on traditional methods. Research on its etiopathogenesis provides new insights for finding early detection methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Lanlan Fang, Yanjie Guo, Yiran Li, Qiongqiong Jia, Xiaoyu Han, Boqun Liu, Jiaye Chen, Jung-Chien Cheng, Ying-Pu Sun
Summary: EGCG, the most abundant catechins from green tea, has been studied for its health benefits, including its role in ovarian steroidogenesis. In human granulosa-like tumor cell line KGN, EGCG upregulates StAR expression and enhances P4 production, without affecting other steroidogenesis-related enzymes. The effects of EGCG on steroidogenesis require 67LR-mediated activation of the PKA-CREB signaling pathway.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Qiongqiong Jia, Boqun Liu, Xuan Dang, Yanjie Guo, Xiaoyu Han, Tinglin Song, Jung-Chien Cheng, Lanlan Fang
Summary: GDF-11, a member of the TGF-β superfamily, regulates ovarian steroidogenesis and may have a potential role in PCOS. The study showed that GDF-11 downregulates StAR expression in hGL cells through ALK5-mediated signaling. Unlike GDF-8, GDF-11 expression levels remain consistent between non-PCOS and PCOS patients.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Lanlan Fang, Yang Yan, Yibo Gao, Ze Wu, Zhen Wang, Sizhu Yang, Jung-Chien Cheng, Ying-Pu Sun
Summary: This study found that TGF-beta 1 can upregulate the expression of kisspeptin in human EVT cells through the ALK5 receptor. TGF-beta 1 activates both the SMAD2/3 and the ERK1/2 and PI3K/AKT signaling pathways, with inhibition of ERK1/2 attenuating the stimulatory effect of TGF-beta 1 on kisspeptin expression. Knockdown of kisspeptin attenuates the inhibitory effect of TGF-beta 1 on EVT cell invasion. Serum levels of TGF-beta 1 and kisspeptin are also significantly elevated in patients with PE.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Cell Biology
Ze Wu, Lanlan Fang, Sizhu Yang, Yibo Gao, Zhen Wang, Qingxue Meng, Xuan Dang, Ying-Pu Sun, Jung-Chien Cheng
Summary: This study discovers a new biological function and underlying molecular mechanisms of GDF-11 in the regulation of human extravillous trophoblast cell invasion.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Cell Biology
Jung-Chien Cheng, Xiaoyu Han, Qingxue Meng, Yanjie Guo, Boqun Liu, Tinglin Song, Yuanyuan Jia, Lanlan Fang, Ying-Pu Sun
Summary: This study reveals that HB-EGF can enhance the luteal function in humans by inducing StAR expression and progesterone production through the activation of the ERK1/2 signaling pathway.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Developmental Biology
Jung-Chien Cheng, Yibo Gao, Jiaye Chen, Qingxue Meng, Lanlan Fang
Summary: This study reveals that EGF-induced downregulation of CTGF mediates the EGF-stimulated human trophoblast cell invasion. It provides important insights into the molecular mechanisms mediating EGF-stimulated human trophoblast cell invasion and increases the understanding of the biological functions of CTGF in the human placenta.
Article
Cell Biology
Xuan Dang, Lanlan Fang, Qian Zhang, Boqun Liu, Jung-Chien Cheng, Ying-Pu Sun
Summary: In this study, it was found that AREG upregulated the expression of SPARC in KGN cells via EGFR and activated multiple signaling pathways. It was also discovered that SPARC was a downstream target gene of StAR. Additionally, the study revealed a positive correlation between SPARC protein levels and progesterone levels in follicular fluid. These findings elucidate the regulatory role of AREG on SPARC expression and uncover a novel function of SPARC in progesterone production in granulosa cells.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Cell Biology
Jiaye Chen, Tinglin Song, Sizhu Yang, Qingxue Meng, Xiaoyu Han, Ze Wu, Jung-Chien Cheng, Lanlan Fang
Summary: This study aimed to investigate the effect of GDF-8 on invasion and MMP2 expression in human EVT cells, and found that Snail is a key factor in GDF-8-induced MMP2 expression and cell invasion.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Cell Biology
Xuan Dang, Lanlan Fang, Qiongqiong Jia, Ze Wu, Yanjie Guo, Boqun Liu, Jung-Chien Cheng, Ying-Pu Sun
Summary: This study demonstrated that TGF-beta 1 upregulates SPARC expression in the human ovary and the role of SPARC in the pathogenesis of ovarian hyperstimulation syndrome (OHSS). The activation of Slug transcription factor is required for the TGF-beta 1-induced SPARC expression. SPARC affects the occurrence of OHSS by regulating the expression of VEGF and aromatase. These findings are of great significance for the treatment of clinical infertility and OHSS.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Cell Biology
Yong Shi, Yanjie Guo, Jiayi Zhou, Guanshen Cui, Jung-Chien Cheng, Ying Wu, Yong-Liang Zhao, Lanlan Fang, Xiao Han, Yun-Gui Yang, Yingpu Sun
Summary: We profiled the transcriptomic atlas of developing rat ovaries using scRNA-seq and spatial transcriptomic sequencing, revealing four components of developing granulosa cells and their differential transcriptional regulatory networks. We identified new growth signals from oocytes to cumulus cells and observed three cumulus sequential phases during follicle development. This study provides a new research dimension for temporal and spatial analysis of ovary development and valuable data resources for understanding the mechanisms of mammalian ovary development.
CELL PROLIFERATION
(2023)
Review
Biochemistry & Molecular Biology
Lanlan Fang, Ying-Pu Sun, Jung-Chien Cheng
Summary: Amphiregulin (AREG) is an important growth factor in female reproductive health. It is predominantly induced by luteinizing hormone (LH) and has various roles in the regulation of ovarian functions. Aberrant expression of AREG has been found to contribute to the pathogenesis of ovarian diseases. Understanding the molecular and cellular mechanisms of AREG regulation can lead to innovative approaches for fertility regulation and the prevention and treatment of ovarian diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Endocrinology & Metabolism
Ze Wu, Lanlan Fang, Boqun Liu, Qiongqiong Jia, Jung-Chien Cheng, Ying-Pu Sun
Summary: In this study, metabolomic analysis was conducted to compare the follicular fluid (FF) of patients with OHSS and a control group. The results revealed 59 differentially changed metabolites in the FF of OHSS patients. Among them, 12 metabolites showed potential as valuable biomarkers for OHSS. In addition, certain metabolites were found to positively or negatively correlate with estradiol levels and the number of retrieved oocytes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Ze Wu, Qiongqiong Jia, Boqun Liu, Lanlan Fang, Peter C. K. Leung, Jung-Chien Cheng
Summary: This study reveals that upregulation of NPFFR2 is associated with poor overall survival in epithelial ovarian cancer (EOC). NPFF and NPFFR2 are expressed in human EOC cells, with higher levels in SKOV3 cells compared to CaOV3 and OVCAR3 cells. NPFF treatment stimulates cell invasion by upregulating MMP-9 expression through the NPFFR2-mediated ERK1/2 signaling pathway. Blocking ERK1/2 signaling abolishes the NPFF-induced MMP-9 expression and cell invasion.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Cell Biology
Sizhu Yang, Yuanyuan Jia, Ze Wu, Bingxin Fu, Shenghui Zhou, Leticia Vicosa Pires, Jung-Chien Cheng, Lanlan Fang
Summary: The placenta-secreted hormone hCG plays a critical role in maintaining normal pregnancy. The expression of hCG-beta, which is encoded by the CGB gene, determines the bioavailability of hCG. In this study, it was found that GPER activation upregulates CGB expression through the PKA-CREB signaling pathway, providing important insights into the molecular mechanisms mediating hCG expression and potential therapeutic approaches for placental diseases.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Cell Biology
Jung -Chien Cheng, Qingxue Meng, Qian Zhang, Lingling Zhang, Jiaye Chen, Tinglin Song, Lanlan Fang, Ying-Pu Sun
Summary: This study reveals that Amphiregulin (AREG) induces cell invasion through the activation of the PI3K/AKT pathway, and WNK1 plays an important role in human EVT cells, regulating MMP9 expression and cell invasion.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
