Article
Biochemistry & Molecular Biology
Caroline A. Mcwhorter, Molly J. Mead, Megan D. Rodgers, Myla D. Ebeling, Judy R. Shary, Mathew J. Gregoski, Danforth A. Newton, John E. Baatz, Bruce W. Hollis, Martin Hewison, Carol L. Wagner
Summary: Pregnancy leads to increased synthesis of vitamin D binding protein (DBP) and higher concentrations of total vitamin D and metabolites. The ratio of free 25-hydroxyvitamin D (25(OH)D) to parathyroid hormone (PTH) appears to be a better predictor of pregnancy complications, such as gestational diabetes, compared to total 25(OH)D/PTH. Further research is needed to validate and explore this association.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Nutrition & Dietetics
Gabriele Brosolo, Andrea Da Porto, Luca Bulfone, Laura Scandolin, Antonio Vacca, Nicole Bertin, Cinzia Vivarelli, Leonardo A. Sechi, Cristiana Catena
Summary: Recent evidence suggests that mildly increased fasting and post-oral load blood glucose concentrations are associated with organ damage in nondiabetic patients with hypertension. This study aimed to examine the relationships between serum 25(OH)D levels and glucose tolerance and insulin sensitivity in hypertension.
Article
Medical Laboratory Technology
Fei Ding, Xin Nie, Xiaoling Li, Yong He, Guixing Li
Summary: This study assessed the impact of factors like sex, age, season, temperature, and sunshine hours on plasma PTH, 25-OH-VitD, and Ca levels. Results showed that season may be the main factor affecting the levels, and reference intervals should consider these factors to avoid influencing clinical investigations.
CLINICAL BIOCHEMISTRY
(2021)
Article
Nutrition & Dietetics
Ola Hysaj, Patricia Marques-Gallego, Aline Richard, Magdeldin Elgizouli, Alexandra Nieters, Katharina C. Quack Lotscher, Sabine Rohrmann
Summary: This study assessed parathyroid hormone concentrations in pregnant women during early and late pregnancy, finding an inverse correlation between serum 25(OH)D and PTH levels. Statistically significant determinants of PTH concentrations included 25(OH)D levels, season, parity, and partner's education in early pregnancy, while late pregnancy was affected by 25(OH)D levels and country of origin. These factors seem to primarily impact PTH through 25(OH)D, but may also have other mechanisms of influence.
Article
Veterinary Sciences
Dennis E. Jewell, Kiran S. Panickar
Summary: The optimum concentration of vitamin D for dogs is still debated, but a minimum concentration of 100 ng/mL (250 nM) of circulating vitamin D has been suggested for optimal health. The relationship between dietary intake of vitamin D-3 and circulating 25(OH) D in adult dogs has not been well studied. The safe upper limit of vitamin D in dog foods for adult maintenance is 3,200 IU/kg on a dry matter basis, but this guideline was not based on studies of adult maintenance requirements. Understanding the relationship between dietary vitamin D and circulating vitamin D is important for promoting health in dogs.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Nutrition & Dietetics
Xiaoyun Shan, Yang Cao, Huidi Zhang, Xiayu Zhao, Siran Li, Yichun Hu, Lichen Yang
Summary: The study found that free and bioavailable 25(OH)D correlated well with total 25(OH)D, but only had a threshold effect on P1NP. A total 25(OH)D of < 15.14 ng/mL was marginally associated with a higher risk of reduced HDL-C. Higher levels of free and bioavailable 25(OH)D were associated with a lower risk of reduced HDL-C. PTH and BTMs responded more sensitively to changes in total 25(OH)D than to free or bioavailable 25(OH)D after vitamin D supplementation in Chinese women of childbearing age.
FRONTIERS IN NUTRITION
(2023)
Article
Endocrinology & Metabolism
Hope A. Weiler, Wen Hsuan Fu, Maryam Razaghi, Nathalie Gharibeh, Catherine A. Vanstone
Summary: This study found an association between vitamin D deficiency and elevated parathyroid hormone levels in newborn infants. The global consensus recommendation on vitamin D deficiency (<25 nmol/L) aligns better with the threshold at which parathyroid hormone is elevated compared to the definition set by the National Academy of Medicine (<30 nmol/L).
Article
Medical Laboratory Technology
Ann Vissing Landgrebe, Morten Asp Vonsild Lund, Ulrik Lausten-Thomsen, Christine Frithioff-Bojsoe, Cilius Esmann Fonvig, Johanne Lind Plesner, Louise Aas Holm, Thomas Jespersen, Torben Hansen, Jens Christian Holm
Summary: Concentrations of PTH, vitamin D, calcium, and phosphate in children and adolescents vary with age, sex, and season, which should be taken into consideration when screening for and treating imbalances in bone metabolism.
CLINICA CHIMICA ACTA
(2021)
Article
Nutrition & Dietetics
Bin Wang, Xiaowei Cheng, Shihui Fu, Ding Sun, Weiguang Zhang, Weicen Liu, Xinyu Miao, Qing Luo, Hao Li, Jie Zhang, Xinye Jin, Yali Zhao, Yao Yao, Yizhi Chen
Summary: This longitudinal cohort study examined the relationship between serum levels of 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH), beta-C-terminal telopeptide of type 1 collagen (beta-CTX), and all-cause mortality in centenarians. Lower 25(OH)D levels, higher PTH levels, and higher beta-CTX levels were associated with increased mortality in Chinese community-dwelling centenarians. The association with 25(OH)D was linear, while the associations with PTH and beta-CTX were J-shaped.
Article
Nutrition & Dietetics
Jacklyn N. Hellwege, Xiangzhu Zhu, Xiang Huang, Martha J. Shrubsole, Lei Fan, Bingshan Li, Reid Ness, Douglas L. Seidner, Edward L. Giovannucci, Todd L. Edwards, Qi Dai
Summary: Optimal 25(OH)D levels are associated with a significantly reduced risk of colorectal cancer, particularly among women. Individuals with BPRVID are at higher risks of incident adenoma and colorectal cancer compared to those with HPRVID, especially among women. Treatment strategies should be tailored based on individuals' different response types.
CLINICAL NUTRITION
(2021)
Article
Pharmacology & Pharmacy
Qing Hao, Yun Qin, Wanjun Zhao, Lingyun Zhang, Han Luo
Summary: The study suggests that supplying calcitriol based on a 70% RDP cutoff may be a wise practice in thyroidectomy patients, helping to stratify high-risk patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Nutrition & Dietetics
Rakesh Balachandar, Raghu Pullakhandam, Bharati Kulkarni, Harshpal Singh Sachdev
Summary: This study found that cholecalciferol was more effective than ergocalciferol in improving vitamin D status and regulating PTH levels, regardless of participant demographics, dosage, and vehicle of supplementation.
Article
Orthopedics
Z. Qu, F. Yang, Y. Yan, J. Huang, J. Zhao, J. Hong, S. Li, G. Jiang, W. Wang, S. Yan
Summary: This study indicated an inverse causal relationship between serum PTH concentrations and development of OA, especially knee OA, but no evidence of the causal effect of serum 25(OH)D levels on OA was found. Further investigation is needed to explore potential mechanisms by which serum PTH affects OA.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Multidisciplinary Sciences
Jung Hyun Kwak, Yoon-Hyeong Choi
Summary: The study found an inverse association between vitamin D concentration and the risk of high pulse pressure, especially showing a dose-dependent relationship in females and non-overweight individuals.
SCIENTIFIC REPORTS
(2021)
Article
Dermatology
Mi-Ran Kim, Vinzenz Oji, Frederic Valentin, Heiko Traupe, Jerzy-Roch Nofer, Ingrid Hausser, Hans Christian Hennies, Katja Eckl, Stefan A. Wudy, Alberto Sanchez-Guijo, Laura Kerschke, Judith Fischer, Kira Suessmuth
Summary: Data on vitamin D status of patients with inherited ichthyosis in Europe is limited, with deficiencies found to be more pronounced in specific genetic subtypes. Low 25(OH)D3 levels were associated with severity of scaling, highlighting the importance of screening and substituting for vitamin D deficiency in ichthyosis patients according to recent guidelines.
ACTA DERMATO-VENEREOLOGICA
(2021)
