Article
Dentistry, Oral Surgery & Medicine
Mirja Methuen, Hanna Kangasmaa, Viivi Karoliina Alaraudanjoki, Anna Liisa L. Suominen, Vuokko Anttonen, Hannu Vahanikkila, Panu Karjalainen, Juuso Vaisto, Timo A. Lakka, Marja-Liisa Laitala
Summary: The aim of this study was to investigate the prevalence and severity of erosive tooth wear (ETW) among Finnish adolescents and to evaluate the association between the use of erosive products and ETW. The study found that the prevalence of ETW among Finnish adolescents is comparable to other Nordic and European countries. Boys had a higher frequency of severe ETW compared to girls. Consumption of erosive drinks, fruits, and berries was significantly associated with the severity of ETW.
Article
Dentistry, Oral Surgery & Medicine
Francisca Marro, Saoirse O'Toole, Eduardo Bernabe, David Bartlett, Vicente Aranguiz
Summary: The aim of this study was to determine predictors of erosive tooth wear (ETW) progression using novel primary-care quantitative analysis techniques. The study found that adolescents with higher baseline erosive tooth wear scores, lower parental education, and molar surfaces had greater volume loss. The results are significant for predicting and preventing erosive tooth wear.
JOURNAL OF DENTISTRY
(2022)
Article
Geosciences, Multidisciplinary
Xiaofei Ma, Chengyi Zhao, Jianting Zhu
Summary: Climate warming has a variable impact on global soil erosion, with an overall increase observed primarily in semiarid areas. Different soil erosion models yield significantly different simulation results, with the Revised Universal Soil Loss Equation and Wind Erosion Equation models showing the highest accuracy for water and wind erosion simulations. The driving factors behind soil erosion under climate warming are still uncertain and further research is needed to study the interactions between climate warming and soil erosion, especially in wind erosion models, as well as consider the relationship between the UN Sustainable Development Goals and soil erosion.
Review
Public, Environmental & Occupational Health
Tesfu Zewdu, Duresa Abu, Mulatu Agajie, Tamiru Sahilu
Summary: The prevalence of dental caries in Ethiopia is relatively high, with sweet food consumption being identified as the main risk factor. The Federal Ministry of Health in Ethiopia should focus on strengthening the oral health care system and implementing community-level prevention programs.
ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
(2021)
Review
Public, Environmental & Occupational Health
Amare Teshome, Abebe Muche, Biruk Girma
Summary: The study found that the prevalence of dental caries in East Africa is relatively high, with being female and poor oral health practices identified as independent risk factors.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Health Care Sciences & Services
Kimberley Yip, Phoebe Pui Ying Lam, Cynthia Kar Yung Yiu
Summary: The prevalence of dental erosion among preschool children is around 39.64%, with factors such as frequent intake of fruit juices and soft drinks, being male, and having digestive disorders contributing to a higher likelihood of dental erosion.
Review
Dentistry, Oral Surgery & Medicine
Carla de Souza Oliveira, Tuelita Marques Galdino, Francisco Ivison Rodrigues Limeira, Allyson Nogueira Moreira, Claudia Silami de Magalhaes, Lucas Guimaraes Abreu
Summary: This study found that dental caries may be a relevant issue in individuals pre- and post-liver transplant, with a prevalence of 73.82% in pre-transplant individuals and 72.83% in post-transplant individuals. The main concerns in the included studies were the risk of bias and the very low strength of evidence. Oral health counseling should be included in the care of pre- and/or post-liver transplant individuals.
Review
Public, Environmental & Occupational Health
G. D. Liu, W. J. Ma, H. X. Liu, L. Tang, Y. H. Tan
Summary: By pooling current studies, we found that a history of venous thrombosis, cancer, infection, and multilumina may be risk factors for catheter-related venous thrombosis. These results provide guidance for clinical diagnosis and treatment.
Review
Multidisciplinary Sciences
Fanos Yeshanew Ayele, Aregash Abebayehu Zerga, Fikre Bayu Gebeyehu, Sisay Eshete Tadesse, Segenet Zewude, Yeshi Habteslasie, Zena Befekadu
Summary: This study aimed to estimate the pooled prevalence of good dietary diversity practices and its associated factors among adolescents in Ethiopia. The study found that the pooled prevalence of good dietary diversity practices among adolescents is low. Being urban residents, the medium wealth quintile, mothers' educational status, and fathers' educational status were independent factors of good dietary diversity practice among adolescents. Therefore, focused nutritional interventions should be given to rural residents and adolescents from low economic status.
Review
Multidisciplinary Sciences
Abebaw Gedef Azene, Abiba Mihret Aragaw, Habtamu Tilaye Wubetie, Gizachew Tadesse Wassie, Gebiyaw Wudie Tsegaye, Muluwork Ayele Derebe, Habitamu Dessie Mitiku
Summary: This study revealed a low proportion of pregnant women with adequate dietary diversity in Ethiopia (41%). Maternal education, nutritional information, dietary diversity knowledge, and household wealth index level were significantly associated with pregnant women's dietary diversity practice. Improving awareness about dietary diversity during pregnancy and empowering women economically would greatly improve dietary diversity practice.
Article
Nutrition & Dietetics
Luz Adriana Meneses-Urrea, Manuel Vaquero-Abellan, Dolly Villegas Arenas, Narly Benachi Sandoval, Mauricio Hernandez-Carrillo, Guillermo Molina-Recio
Summary: This study explores the factors associated with dietary patterns in Colombia using secondary data from the National Survey of Nutritional Status of Colombia. The findings indicate that cultural, social, economic, and biological factors influence food choices. Individuals with diabetes and hypertension tend to have traditional and conservative dietary patterns, while women are more likely to follow a conservative pattern and those in the first and second wealth levels are more likely to follow a traditional pattern.
Review
Geriatrics & Gerontology
Mahin Delara, Lauren Murray, Behnaz Jafari, Anees Bahji, Zahra Goodarzi, Julia Kirkham, Zia Chowdhury, Dallas P. Seitz
Summary: This systematic review and meta-analysis estimated the pooled prevalence of polypharmacy and factors associated with polypharmacy. The results showed that polypharmacy is common, especially among older adults and inpatient populations. Clinicians should be aware of the prevalence of polypharmacy and make efforts to minimize inappropriate polypharmacy.
Review
Medicine, General & Internal
Zhenxian Huang, Meixuan Su, Qiaojing Wang, Wenjie Li, Haimin Jiang
Summary: This study utilized meta-analysis to summarize the risk factors of dental caries in Chinese children and adolescents, and explored the characteristics of high-risk groups, providing valuable reference for early detection and prevention.
Review
Multidisciplinary Sciences
Muhammad Riaz, Ghazala Shah, Muhammad Asif, Asma Shah, Kaustubh Adhikari, Amani Abu-Shaheen
Summary: This study identified several socio-demographic, lifestyle, health-related, and psychological factors significantly associated with hypertension in the Pakistani population. Factors such as age, marital status, urban residence, smoking, family history, comorbidities, education level, physical activity, and diet were found to have positive or negative associations with hypertension. The findings may assist healthcare professionals and policymakers in identifying high-risk groups and implementing appropriate prevention strategies. Further research is needed to thoroughly investigate these factors and gather global evidence on the subject.
Article
Dentistry, Oral Surgery & Medicine
Baranya Shrikrishna Suprabha, Ramya Shenoy, Yermunja Mahabala Karuna, Anupama Panakaje Nayak, Arathi Rao, Violet D'Souza
Summary: Parents play a crucial role in their children's dietary habits, but they may struggle to put their knowledge into action due to various influences. Motivational interviewing of parents and governmental and school policies to reduce sugary food consumption may be necessary.
INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yu-Ye Xue, Yun-Yang Lu, Guang-Qiang Sun, Fei Fang, Yu-Qiang Ji, Hai-Feng Tang, Peng-Cheng Qiu, Guang Cheng
Summary: The study found that CN-3 can exhibit cytotoxic effects on TMZ-resistant cells through ROS-mediated apoptosis and autophagy, affecting the expression of multiple cellular factors and reducing the survival rates of SHG44R and U87R cells.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Bao Liu, Qifeng Ji, Ying Cheng, Miao Liu, Bangle Zhang, Qibing Mei, Daozhou Liu, Siyuan Zhou
Summary: The study successfully developed a novel targeted drug delivery system for enhancing immunotherapy of drug-resistant GBM and demonstrated its significant inhibitory effect on tumor growth and prolonged survival time in mice.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Daozhou Liu, Qifeng Ji, Ying Cheng, Miao Liu, Bangle Zhang, Qibing Mei, Menglei Huan, Siyuan Zhou
Summary: CsA@HFn nanoparticles have shown significant therapeutic effects in the treatment of cerebral ischemia/reperfusion injury by alleviating neuron apoptosis, nerve inflammation, and blood-brain barrier damage in the ischemic area. CsA@HFn has great potential in the treatment of ischemic stroke.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Fangyuan Li, Daozhou Liu, Miao Liu, Qifeng Ji, Bangle Zhang, Qibing Mei, Ying Cheng, Siyuan Zhou
Summary: This study explores the application of regulatory T cells (Tregs) biomimetic nanoparticle (CsA@PPTK) in the treatment of myocardial infarction/ischemia-reperfusion injury (MI/RI). The results demonstrate that CsA@PPTK effectively accumulates in ischemic myocardium, scavenges reactive oxygen species (ROS), increases the generation of Tregs, and improves myocardial fibrosis and heart function.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Zhou-Yan Jia, Hao Zhou, Li-Shuang Hou, Fang Kou, Tang-Rui Zhang, Bao-Long Wang, Wei Wang, Si-Yuan Zhou, Bang-Le Zhang
Summary: This study constructed a nanocarrier-mediated cisplatin co-delivery system that can release hyaluronidase to degrade hyaluronan in the tumor stroma, achieving deeper tumor tissue penetration and more effective chemotherapy to pancreatic cancer in vivo. This provides potential clinical application prospects for the treatment of pancreatic cancer.
Article
Nanoscience & Nanotechnology
Yi-Yang Jia, Meng-Lei Huan, Wei Wang, Zhou-Yan Jia, Yu-Hang Wan, Si-Yuan Zhou, Bang-Le Zhang
Summary: This study developed a tumor microenvironment and redox dual stimuli-responsive nano-delivery system PEG-c-(BPEI-SS-Pt), which showed better therapeutic efficacy and minor side effects. The system could release drugs in a sequential pH- and redox-responsive manner under acidic tumor microenvironment.
Article
Biochemistry & Molecular Biology
Yun-Yuan Tian, Yang Liu, Peng-Cheng Qiu, Yao Li, Jin-Ming Hu, Tian-Yi Li, Wen-Wen Chen, Hai-Feng Tang, Yun-Yang Lu
Summary: Phytochemical investigation of Paris fargesii var. petiolata led to the identification of five new steroidal saponins and six known analogs. Compound 1 exhibited inhibitory effects on human cancer cells, potentially by inducing S phase arrest.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Applied
Qing Shao, Tian-Yi Li, Wei Quan, Hui Wang, Ke-Yu Yan, Peng-Cheng Qiu, Hai-Feng Tang, Yun-Yang Lu
Summary: In this study, a new beta-carboline alkaloid was isolated from the root bark of Ailanthus altissima, along with nine known alkaloids. The structure of the new compound was determined using spectroscopic analysis and the absolute configuration of a specific carbon atom was calculated. The isolated compounds were also found to have a neuroprotective effect on PC12 cells.
NATURAL PRODUCT RESEARCH
(2023)
Article
Plant Sciences
Yang Liu, Na Tang, Qian Zhang, Peng-Cheng Qiu, Hai-Feng Tang, Yun-Yang Lu, Bang-Le Zhang
Summary: Two new furostanol saponins, parisverticillatosides A and B (1 and 2), were isolated from the roots of Paris verticillata M.Bieb, along with eleven known steroidal glycosides (3-13). The structures of the new compounds were determined through extensive spectroscopic analysis and chemical evidence. Interestingly, compounds 1 and 2 were identified as epimers with only a difference in the configuration of C-23. The discovery of these new compounds expands the diversity and complexity of saponins in the genus Paris. The cytotoxicity of all saponins against human glioblastoma cell lines U87 and U251 was examined. The results showed that the new furostanol saponins 1 and 2 were inactive, while spirostanol saponins 4 and 5 exhibited significant cytotoxicity against the cell lines with IC50 values of 1.44-3.98 mu M.
PHYTOCHEMISTRY LETTERS
(2023)
Article
Engineering, Biomedical
Wenqiang Qian, Daozhou Liu, Ying Han, Miao Liu, Bao Liu, Qifeng Ji, Bangle Zhang, Qibing Mei, Siyuan Zhou, Ying Cheng
Summary: Simultaneous inhibition of ferroptosis and apoptosis of cardiomyocytes can be a promising strategy to treat myocardial ischemia-reperfusion injury (MI/RI). Taking advantage of the highly expressed transferrin receptor in ischemic myocardium, cyclosporin A (CsA) was wrapped with apoferritin (ApoFn) to actively target and inhibit both ferroptosis and apoptosis in MI/RI mice, resulting in the restoration of cardiac function.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Tian-Yi Li, Yang Du, Min-Chang Wang, Ke Liu, Yang Liu, Yu Cao, Yuan-Yuan Wang, Wen-Wen Chen, Xiao-Ying Qian, Peng-Cheng Qiu, Hai-Feng Tang, Yun-Yang Lu
Summary: A phytochemical investigation of the rhizomes of Paris polyohylla var. latifolia led to the discovery of three new spirostanol saponins, papolatiosides A-C (1-3), and nine known compounds (4-12). Their structures were established using spectroscopic analysis and chemical methods. Compound 1 showed significant cytotoxicity against several human cancer cell lines and induced apoptosis in glioma cells LN229 through the EGFR/PI3K/Akt/mTOR pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Tian-Yan Han, Li-Shuang Hou, Jia-Xin Li, Meng -Lei Huan, Si -Yuan Zhou, Bang-Le Zhang
Summary: Bone metastatic cancer is a common occurrence in breast cancer, but its treatment faces challenges. MicroRNA-34a (miRNA-34a) is a potential anti-cancer miRNA for gene therapy, but its lack of specificity to bone and low accumulation at the site of bone tumor are major challenges. To address this issue, a bone-targeted vector for delivering miR-34a to bone metastatic breast cancer was constructed. The constructed gene delivery system, PCA/miR-34a, effectively prevents miR-34a degradation and enhances bone-specific delivery and distribution. In vitro and in vivo experiments confirm that PCA/miR-34a can enhance anti-tumor efficacy in bone metastatic cancer and provide a potential strategy for gene therapy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Zedong Cai, Meng-Lei Huan, Yao-Wen Zhang, Ting-Ting Zhao, Tian-Yan Han, Wei He, Si-Yuan Zhou, Bang-Le Zhang
Summary: Breast cancer is the most common malignant tumor, particularly drug resistant triple negative breast cancer (TNBC). A combination therapeutic system using dopamine and tumor targeted folic acid modified dopamine as carrier materials was constructed in this study. The optimized nanoparticles exhibited efficient loading of camptothecin and iron, tumor targeted delivery ability, pH-sensitive controlled release, effective photothermal conversion performance, and excellent anti-tumor efficacy in vitro and in vivo. The strategy of CPT/Fe@PDA-FA10 plus laser treatment provided a promising approach for the effective treatment of drug resistant TNBC.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Applied
Yang Liu, Na Tang, Xiao-Ying Qian, Tian-Yi Li, Qian Zhang, Peng-Cheng Qiu, Hai-Feng Tang, Yun-Yang Lu, Bang-Le Zhang
Summary: Four new polyhydroxylated steroidal saponins, parisverticillatosides A-D (1-4), along with four known spirostanol saponins (5-8), were isolated from the roots of Paris verticillata. Their structures were determined through extensive spectroscopic analysis and chemical evidence. The discovery of compounds 1-4 expands the diversity and complexity of this spirostanol saponin family. Saponins 5 and 6 exhibited cytotoxicity against two human glioma cell lines.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ying Han, Daozhou Liu, Ying Cheng, Qifeng Ji, Miao Liu, Bangle Zhang, Siyuan Zhou
Summary: Alzheimer's disease (AD) is a common neurodegenerative disease with a close relationship to mitochondrial energy metabolism. Maintaining mitochondrial homeostasis is important for the energy needs of the brain and is a promising therapeutic target in AD. This review summarizes the mechanisms of mitochondrial homeostasis in AD, its impact on the pathogenesis of early AD, strategies for maintaining mitochondrial homeostasis, and mitochondrial targeting strategies, providing insights for future research and development in this area.
