Article
Virology
Dana May, Anna Bellizzi, Workineh Kassa, John M. Cipriaso, Maurizio Caocci, Hassen S. Wollebo
Summary: The study found that interferons can negatively regulate JC virus transcription and replication by inducing C/EBPβ-LIP.
Article
Oncology
Corinna Haist, Elena Schulte, Nina Bartels, Arthur Bister, Zoe Poschinski, Tabea C. Ibach, Katja Geipel, Constanze Wiek, Martin Wagenmann, Cornelia Monzel, Kathrin Scheckenbach, Helmut Hanenberg
Summary: The study established a highly specific CAR against CD44v6 on HNSCC cells, expressed on normal T-cells, showing high specificity and cytotoxicity against tumor-associated CD44v6.
Article
Endocrinology & Metabolism
Tobias Ackermann, Hidde R. Zuidhof, Christine Mueller, Gertrud Kortman, Martijn G. S. Rutten, Mathilde J. C. Broekhuis, Mohamad Amr Zaini, Gotz Hartleben, Cornelis F. Calkhoven
Summary: Cancer cells rely on glycolysis for energy production and growth. The transcription factor C/EBPλ-LIP promotes glycolysis and mitochondrial respiration in cancer cells. High expression of C/EBPλ-LIP increases vulnerability to glycolysis inhibition.
MOLECULAR METABOLISM
(2023)
Article
Oncology
Andre Franken, Annika Kraemer, Alicia Sicking, Meike Watolla, Mahdi Rivandi, Liwen Yang, Jens Warfsmann, Bernhard M. M. Polzer, Thomas W. P. Friedl, Franziska Meier-Stiegen, Nikolas H. H. Stoecklein, Davut Dayan, Sabine Riethdorf, Volkmar Mueller, Klaus Pantel, Andre Koch, Andreas D. D. Hartkopf, Natalia Krawczyk, Eugen Ruckhaeberle, Dieter Niederacher, Tanja Fehm, Hans Neubauer
Summary: The study found that circulating tumor cells (CTCs) with low expression of EpCAM are difficult to capture using traditional methods. In breast cancer patients, CTCs can be enriched using antibodies against Trop-2 and CD-49f, and it was discovered that EpCAM high-expressing CTCs and low-expressing CTCs have similar chromosomal aberrations and mutations, indicating a close evolutionary relationship.
BRITISH JOURNAL OF CANCER
(2023)
Article
Biology
Laura Mincarelli, Vladimir Uzun, David Wright, Anita Scoones, Stuart A. Rushworth, Wilfried Haerty, Iain C. Macaulay
Summary: Single-cell transcriptomics using long-read sequencing provides novel insights into alternative splicing in cellular differentiation. Over half of the genes detected in standard short-read single-cell analyses are expressed as multiple isoforms, which often have different functions. Ageing has a limited impact on isoform usage, but leads to global and hematopoietic stem cell-specific changes in gene expression. Integrating single-cell and cell-type-specific isoform landscape in hematopoiesis is important for comprehensive molecular profiling and understanding of transcriptional complexity.
COMMUNICATIONS BIOLOGY
(2023)
Article
Hematology
Scarlett Y. Yang, Katharina E. Hayer, Hossein Fazelinia, Lynn A. Spruce, Mukta Asnani, Kathryn L. Black, Ammar S. Naqvi, Vinodh Pillai, Yoseph Barash, Kojo S. J. Elenitoba-Johnson, Andrei Thomas-Tikhonenko
Summary: Noncanonical exon usage plays important roles in cellular phenotypes. In this study, we investigated the contribution of noncanonical exon usage to human B-cell development. We identified genes with local splicing variations and discovered a previously unknown isoform of the FBXW7 gene in normal human pro-B cells. This isoform was also found in samples of pediatric B-cell acute lymphoblastic leukemia (B-ALL). Our findings suggest that this isoform may drive proinflammatory responses and play a role in B-cell development, leukemogenesis, and responses to anticancer therapies.
Article
Biotechnology & Applied Microbiology
Azar Shahpiri, Zahra Majnoun, Akram Kazemi-Nasab, Mohsen Zarei
Summary: This study demonstrated that the co-expression of YieF and OsMT1 effectively enhanced the accumulation of Cr(VI) by E. coli cells, providing new insights into bioremediation strategies.
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alberto Sada Japp, Wenzhao Meng, Aaron M. Rosenfeld, Daniel J. Perry, Puchong Thirawatananond, Rhonda L. Bacher, Chengyang Liu, Jay S. Gardner, Mark A. Atkinson, Klaus H. Kaestner, Todd M. Brusko, Ali Naji, Eline T. Luning Prak, Michael R. Betts
Summary: Researchers were unable to replicate the enrichment of hybrid lymphocytes DE cells and the public B cell clonotype in type 1 diabetes patients as reported by Ahmed and colleagues. These findings suggest that DE cells and their public clonotype are not a prominent feature of T1D.
Article
Cell Biology
Daisuke Harama, Takashi Yahata, Keiko Kagami, Masako Abe, Norie Ando, Shin Kasai, Minori Tamai, Koshi Akahane, Takeshi Inukai, Nobutaka Kiyokawa, Abd Aziz Ibrahim, Kiyoshi Ando, Kanji Sugita
Summary: The study demonstrates that the use of LEN can specifically induce the accumulation of Ik6 in Ph+ALL cells, inhibit their proliferation, induce cell cycle arrest, and promote apoptosis, while synergistically enhancing the efficacy with IM.
CELL DEATH DISCOVERY
(2021)
Article
Cell Biology
Sara Menegatti, Bethany Potts, Eva Garcia-Alegria, Roberto Paredes, Michael Lie-A-Ling, Georges Lacaud, Valerie Kouskoff
Summary: The study reveals the sequential expression of the two RUNX1 isoforms during human blood specification, with RUNX1b marking endothelial cells with hemogenic potential and determining hemogenic competency in a dose-dependent manner. The findings establish RUNX1b isoform as the earliest known marker for hemogenic competency.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Yaprak Dilber Simay Demir, Aysun Ozdemir, Ceren Sucularli, Elifnur Benhur, Mustafa Ark
Summary: The study found that inhibiting the Rho/Rho kinase pathway can reduce the secretory activity of senescent cancer cells, change the composition of SASP, and inhibit the proliferation and migration of non-senescent cancer cells. This suggests that ROCK inhibitors may serve as novel therapeutic drugs targeting senescent cancer cells.
CELLULAR SIGNALLING
(2021)
Article
Multidisciplinary Sciences
Kyra Nicole Laubach, Wensheng Yan, Xiangmudong Kong, Wenqiang Sun, Mingyi Chen, Jin Zhang, Xinbin Chen
Summary: p73 alpha 1 plays a critical role in tumor suppression and the inflammatory response via regulation of Notch1.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Yiyan Ou, Ruiling Chen, Qiwei Qian, Nana Cui, Qi Miao, Ruqi Tang, Zhengrui You, Xiong Ma, Qixia Wang
Summary: TSPAN1 expression is increased and correlated with disease severity in AIH patients. TSPAN1+ B cells secrete inflammatory cytokines and exhibit chemotactic movement towards the liver in AIH. CXCR3 and CXCL10 may contribute to the migration of TSPAN1+ B cells to the liver.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
David Ohayon, Marion Aguirrebengoa, Nathalie Escalas, Thomas Jungas, Cathy Soula
Summary: In this study, a unique subtype of spinal astrocytes known as Olig2-AS was identified, with 245 differentially expressed genes, 135 of which showed higher expression levels compared to other spinal astrocyte populations, serving as a "unique" functional signature of Olig2-AS. Additionally, two genes (inka2 and kcnip3) were identified as specific molecular markers of Olig2-AS in the P7 spinal cord.
Article
Immunology
Luana S. Ortolan, Marion Avril, Jun Xue, Karl B. Seydel, Ying Zheng, Joseph D. Smith
Summary: Cytoadhesion of Plasmodium falciparum-infected red blood cells to microvascular sites in the gastrointestinal tract and kidneys may contribute to organ complications in severe malaria.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)