Article
Medicine, General & Internal
Clare Oliver-Williams, David Stevens, Rupert A. Payne, Ian B. Wilkinson, Gordon C. S. Smith, Angela Wood
Summary: This study compared the risk of cardiovascular disease outcomes for women with and without a history of gestational hypertension and pre-eclampsia using national hospital admissions data in England. The results showed that women with previous gestational hypertension or pre-eclampsia had a greater risk of various cardiovascular outcomes, including stroke, coronary heart disease, cardiomyopathy, and peripheral arterial disease. The associations were consistent across different cardiovascular disease subtypes and increased with the number of affected pregnancies.
Review
Endocrinology & Metabolism
Chiara Cauzzo, Valentina Chiavaroli, Susanna Di Valerio, Francesco Chiarelli
Summary: There is a growing body of evidence showing a strong connection between intrauterine growth and the development of chronic diseases in adults. Birth size and growth pattern have significant effects on cardio-metabolic health in childhood and adulthood. Therefore, it is important to closely monitor the growth pattern of children from the intrauterine period onward to detect potential cardio-metabolic risks and intervene early through lifestyle interventions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Elin Taufer Cederlof, Maria Lundgren, Bertil Lindahl, Christina Christersson
Summary: The aim of this study was to investigate the associations between pregnancy complications and cardiovascular mortality and hospitalizations. The study found that all pregnancy complications were associated with increased risk of all-cause and cardiovascular mortality, as well as hospitalization for cardiovascular disease.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Gastroenterology & Hepatology
Lovisa Rojler, John J. Garber, Agnieszka Butwicka, Bjorn Roelstraete, Jonas F. Ludvigsson
Summary: This study found that individuals with eosinophilic esophagitis (EoE) may be at a higher risk of developing psychiatric disorders compared to the general population and their siblings. This risk should be taken into consideration in clinical care to detect, prevent, and treat comorbidities.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Zahra Pasdar, Neil W. Scott, Lisa Iversen, Philip C. Hannaford, Phyo Kyaw Myint, Sohinee Bhattacharya
Summary: Reproductive factors play an important role in women's future cancer risk, with older age at first pregnancy associated with increased risk of breast and gastrointestinal cancer, and reduced risk of cervical, carcinoma in situ of the cervix, and respiratory cancer.
Article
Multidisciplinary Sciences
Iwona Wronka, Katarzyna Klis
Summary: This study analyzed the association between air pollution levels (suspended particulate matter, sulphur dioxide, benzopyrene) during childhood and adolescence, and age at menarche in women. The results showed that higher levels of suspended particulate matter and nitrogen were associated with younger age at menarche. Girls exposed to high levels of suspended particulate matter had a higher risk of early menarche.
SCIENTIFIC REPORTS
(2022)
Article
Pediatrics
Ann Prybylowski, Julia Howland, Kristin M. Rankin, James W. Collins
Summary: Through a cross-sectional population-based design, it was found that a higher percentage of deaths among term-born infants in the US (compared to foreign-born infants) is caused by paternal nonacknowledgement. The study showed that infants born to US-born women had a prevalence of paternal nonacknowledgement of 11.3%, compared to 7.5% among infants born to foreign-born women. Additionally, the infant mortality rate for term births to US-born women with paternal nonacknowledgement was 5.0/1000, compared to 1.6/1000 for those with paternal acknowledgment.
JOURNAL OF PEDIATRICS
(2023)
Review
Obstetrics & Gynecology
Catherine McNestry, Sarah L. Killeen, Rachel K. Crowley, Fionnuala M. McAuliffe
Summary: There is an increasing recognition of the association between pregnancy complications and the development of chronic diseases later in life. Pregnancy can be seen as a stress test that reveals underlying predispositions to disease. However, healthcare providers lack awareness of these risks. A narrative literature review shows that various pregnancy complications are associated with increased risk of cardiovascular disease, diabetes, venous thromboembolism, chronic kidney disease, postnatal depression, and mental health disorders. It is important to offer counseling and risk reduction advice for women in the postnatal period following a complicated pregnancy. Further research is needed to determine optimal screening intervals for cardiovascular disease and diabetes after a complicated pregnancy.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Pharmacology & Pharmacy
Jessica Gorgui, Odile Sheehy, Jacquetta Trasler, Anick Berard
Summary: This study aimed to evaluate the association between medically assisted reproduction (MAR) and the risk of small for gestational age (SGA) and very small for gestational age (VSGA). The results showed that MAR was associated with an increased risk of SGA among preterm pregnancies.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Snehaa Seal, Jonathan D. Turner
Summary: Glucocorticoids play a critical role in energy metabolism and systemic metabolic dysfunction by activating transcription of genes associated with glucose and lipid regulatory pathways. External environmental factors, particularly early life adversity, can induce lifelong changes in the HPA axis stress response and glucocorticoid levels, impacting long-term health outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Yuanyang Wu, Jiahui Pang, Jiahao Wang, Jing Wu, Shuo Zhang, Siqing Zhang, Yidan Yao, Simeng Cheng, Yiwen Tao, Zheng Shen, Zhi-yun Li, Lin Xie, Hualei Yang
Summary: Based on life course theories, this study examined the association between parity and heart disease among older people in China. The findings showed that having more than three children or more than two boys increased the risk of heart disease. This association was more prominent in rural areas. Early childbearing and late age at first birth were also associated with a higher risk of heart disease. The study suggests the importance of considering the health implications of high parity and providing postpartum support and chronic disease prevention for parents. The elderly in rural areas should also pay attention to heart disease and engage in regular physical exercise and examinations.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Psychiatry
Xuemei Qin, Weiling Zhang, Shuyin Xu, Mohan Ma, Xing Fan, Xueqing Nie, Jin Liu, Yumeng Ju, Li Zhang, Lingjiang Li, Yan Zhang, Bangshan Liu
Summary: This study investigated the prevalence and risk factors of mood symptoms among first-trimester couples during the pandemic in China. The results showed that 17.75% of first-trimester females and 11.83% of partners had depressive symptoms, while 5.92% of females and 9.47% of partners had anxious symptoms. The study found that family functioning, quality of life, and smoking history were closely related to the risk of mood symptoms.
Review
Biochemistry & Molecular Biology
Kuo-Shu Tang, Chun-Yi Ho, Chien-Ning Hsu, You-Lin Tain
Summary: Melatonin, a hormone released by the pineal gland at night, has various functions and plays a crucial role in kidney health and disease. As the prevalence of chronic kidney disease continues to rise, it is important to find a strategy to not only treat but also prevent it. This review examines the effect of melatonin on kidney development, its clinical uses in early life, preventive applications in animal models, and considerations for melatonin supplementation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Alice Maguolo, Francesca Olivieri, Chiara Zusi, Emanuele Miraglia Del Giudice, Anita Morandi, Claudio Maffeis
Summary: The birth weight of overweight and obese children and adolescents is associated with cardiometabolic derangements, with those born SGA at higher risk of prediabetes and high cholesterol.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Endocrinology & Metabolism
Yin Zhang, Mingyang Song, Yin Cao, A. Heather Eliassen, Brian M. Wolpin, Meir J. Stampfer, Walter C. Willett, Kana Wu, Kimmie Ng, Frank B. Hu, Edward L. Giovannucci
Summary: This study prospectively evaluated the association between early-onset and later-onset type 2 diabetes and the risk of early-onset and later-onset cancer. The results showed that early-onset type 2 diabetes was associated with an increased risk of early-onset total cancer, diabetes-related cancer, and obesity-related cancer, particularly among individuals with higher BMI at 18 years of age. Later-onset type 2 diabetes was also associated with a higher risk of later-onset total cancer, diabetes-related cancer, and obesity-related cancer. However, the risk attenuated with aging.
Article
Obstetrics & Gynecology
Linda A. Gallo, Tania F. Gallo, Danielle J. Borg, Karen M. Moritz, Vicki L. Clifton, Sailesh Kumar
Summary: The study found that planned moderate/late preterm births significantly decreased during the COVID-19 lockdown, while there was no impact on extremely or very preterm infants, spontaneous preterm births, or stillbirth rates. A non-significant spike in spontaneous preterm births was observed from late April to early May 2020.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2022)
Article
Nutrition & Dietetics
Yi Ying Ong, Wei Wei Pang, Jonathan Y. Huang, Izzuddin M. Aris, Suresh Anand Sadananthan, Mya-Thway Tint, Wen Lun Yuan, Ling-Wei Chen, Yiong Huak Chan, Neerja Karnani, S. Sendhil Velan, Marielle Fortier, Jonathan Choo, Lieng Hsi Ling, Lynette Shek, Kok Hian Tan, Peter D. Gluckman, Fabian Yap, Yap-Seng Chong, Keith M. Godfrey, Mary F-F Chong, Shiao-Yng Chan, Johan G. Eriksson, Mary E. Wlodek, Yung Seng Lee, Navin Michael
Summary: The study found that with increasing gestational fasting plasma glucose, high/intermediate breastfeeding was associated with lower levels of intramyocellular lipids, liver fat, and triglycerides, indicating that breastfeeding may provide protection against adverse fat partitioning and higher triglyceride concentration in children exposed to increased glycemia in utero.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Developmental Biology
J. F. Briffa, W. Bevens, S. Gravina, J. M. Said, M. E. Wlodek
Summary: This study demonstrates that complete knockout of biglycan is not associated with features of pre-eclampsia.
Article
Obstetrics & Gynecology
Majed A. Suwaydi, Mary E. Wlodek, Ching Tat Lai, Stuart A. Prosser, Donna T. Geddes, Sharon L. Perrella
Summary: This case series investigates early infant feeding practices and milk production in women with gestational diabetes mellitus (GDM). The results indicate that despite early and frequent milk removal, women with GDM still face the risks of delayed secretory activation and insufficient milk supply.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Obstetrics & Gynecology
Vicki L. Clifton, Sailesh Kumar, Danielle Borg, Kym M. Rae, Roslyn N. Boyd, Koa Whittingham, Karen M. Moritz, Hannah E. Carter, Steven M. McPhail, Brenda Gannon, Robert Ware, Barnaby J. W. Dixson, Samudragupta Bora, Cameron Hurst
Summary: This study aimed to examine the impact of COVID-19 lockdown and post lockdown on the mental health of pregnant women and their partners. The results showed a significant decrease in severe anxiety among pregnant and postpartum women during lockdown, and the odds of severe anxiety returned to pre-COVID-19 levels after the lockdown. The lockdown and post-lockdown period did not have a significant effect on the depression, anxiety, and stress levels of the partners.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Nutrition & Dietetics
Yi Ying Ong, Wei Wei Pang, Navin Michael, Izzuddin M. Aris, Suresh Anand Sadananthan, Mya-Thway Tint, Jonathan Tze Liang Choo, Lieng Hsi Ling, Neerja Karnani, S. Sendhil Velan, Marielle V. Fortier, Kok Hian Tan, Peter D. Gluckman, Fabian Yap, Yap-Seng Chong, Keith M. Godfrey, Shiao-Yng Chan, Johan G. Eriksson, Mary F-F Chong, Mary E. Wlodek, Yung Seng Lee
Summary: This study examined the effects of the timing of introduction of complementary foods and the duration of breastfeeding on body fat partitioning and cardiometabolic risk in children. The results showed that shorter breastfeeding duration and earlier introduction of complementary foods were associated with increased child adiposity and cardiometabolic risk. Longer duration of breastfeeding may protect against the cardiometabolic risk associated with early introduction of complementary foods.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Charles S. Urwin, Rodney J. Snow, Dominique Condo, Rhiannon M. J. Snipe, Glenn D. Wadley, Lilia Convit, Amelia J. Carr
Summary: This study compared the recommended doses of sodium citrate and sodium bicarbonate for blood alkalosis and gastrointestinal symptoms. The results showed that both supplements had similar effects, but with different time courses.
INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM
(2023)
Article
Endocrinology & Metabolism
Melanie Tran, Golam Mostofa, Michael Picard, Jianguo Wu, Li Wang, Dong-Ju Shin
Summary: Aberrant hepatic lipid metabolism is the main cause of NAFLD, and SerpinA3N plays a crucial role in regulating NAFLD and glucose homeostasis.
JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Physiology
Emily S. Dorey, John P. Headrick, Tamara M. Paravicini, Mary E. Wlodek, Karen M. Moritz, Melissa E. Reichelt
Summary: The central question of this study is to explore the cardiovascular consequences of periconceptual ethanol on offspring throughout their lifespan. The main finding of the study is that periconceptional alcohol exposure has sex-specific effects on heart growth, with aging female offspring showing decreased cardiac output. This study highlights the importance of understanding the effects of alcohol exposure during pregnancy on cardiac development and function.
EXPERIMENTAL PHYSIOLOGY
(2023)
Review
Neurosciences
Sarah E. Steane, James S. M. Cuffe, Karen M. Moritz
Summary: Prenatal alcohol consumption can have a range of effects on pregnancy outcomes, including miscarriage, fetal growth restriction, and fetal alcohol spectrum disorder. One major mechanism behind these effects is altered DNA methylation and gene expression. Maternal intake of micronutrients like folate and choline can modify the effects of alcohol consumption on development, but more research is needed to fully understand their impact.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Cell Biology
Adam J. Trewin, Kate L. Weeks, Glenn D. Wadley, Severine Lamon
Summary: It has been found that lncRNA Tug1 regulates the expression of MCU by modulating CaMKII, thus regulating calcium signaling in cardiomyocytes. This has important implications for cardiac function.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Nutrition & Dietetics
Majed A. Suwaydi, Ching Tat Lai, Alethea Rea, Zoya Gridneva, Sharon L. Perrella, Mary E. Wlodek, Donna T. Geddes
Summary: There is a lack of understanding about the daily variations in hormones and macronutrients in human milk (HM) and inconsistent sample collection protocols between studies. This study investigated these variations by collecting milk samples from 22 lactating women before and after each breastfeed or expression. The results showed variations in hormone and nutrient concentrations, as well as circadian rhythms in milk volume. Standardized and rigorous sampling procedures considering both within-feed and circadian variations are necessary for a precise understanding of the impacts of these components on infant health, growth, and development.
Article
Nutrition & Dietetics
Linda A. Gallo, Sarah E. Steane, Sophia L. Young, Susan de Jersey, Danielle A. J. M. Schoenaker, Danielle J. Borg, Jack Lockett, Clare E. Collins, Anthony V. Perkins, Sailesh Kumar, Vicki L. Clifton, Shelley A. Wilkinson
Summary: Multiple micronutrient (MMN) supplementation during pregnancy is common in high-income countries, and is associated with private obstetric care, private health insurance, and alignment with meat/vegetarian alternatives recommendations. There is a high reliance on supplements to meet the recommended intake of folate, iodine, and iron, which raises concerns about excessive nutrient intake. Effective strategies for optimizing nutrient intake during pregnancy, including promoting whole food diets and appropriate use of MMN supplements, need to be defined.
MATERNAL AND CHILD NUTRITION
(2023)
Article
Peripheral Vascular Disease
Navin Michael, Suresh Anand Sadananthan, Wen Lun Yuan, Yi Ying Ong, See Ling Loy, Jonathan Y. Huang, Mya-Thway Tint, Natarajan Padmapriya, Jonathan Choo, Lieng Hsi Ling, Michael S. Kramer, Keith M. Godfrey, Peter D. Gluckman, Kok Hian Tan, Johan G. Eriksson, Yap-Seng Chong, Yung Seng Lee, Neerja Karnani, Fabian Yap, Lynette Pei-Chi Shek, Marielle V. Fortier, Karen M. Moritz, Shiao-Yng Chan, S. Sendhil Velan, Mary E. Wlodek
Summary: Characterizing maternal and foetoplacental factors can enable early identification of children at risk of developing prehypertension/hypertension, beyond birthweight. Foetal growth deceleration and high foetoplacental vascular resistance are associated with an increased risk of prehypertension/hypertension at age 6 years.
JOURNAL OF HYPERTENSION
(2022)
Review
Urology & Nephrology
Jenny Kuo, Lisa K. Akison, Mark D. Chatfield, Peter Trnka, Karen M. Moritz
Summary: This study aimed to assess the diagnostic accuracy of urine and serum biomarkers not currently used in routine clinical practice to predict acute kidney injury (AKI) in premature infants. The results showed that uNGAL may be a promising biomarker for the diagnosis of AKI in premature infants.
JOURNAL OF NEPHROLOGY
(2022)