Article
Multidisciplinary Sciences
Hussein Mehidine, Matthieu Refregiers, Frederic Jamme, Pascale Varlet, Marjorie Juchaux, Bertrand Devaux, Darine Abi Haidar
Summary: Meningioma commonly requires total surgical removal to reduce recurrence risk; current surgical tools lack precise real-time histopathological information; thus, developing a multimodal two-photon fluorescence endomicroscope can aid in better delineating tumor boundaries.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Christophe Chevalier, Olivier Leymarie, Laura Sedano, Bruno Da Costa, Charles-Adrien Richard, Pauline Maisonnasse, Matthieu Refregiers, Frederic Jamme, Ronan Le Goffic
Summary: In this study, researchers investigated the correlation between PB1-F2 protein structures and the resulting inflammatory response in influenza A virus-infected mice. The results showed a proinflammatory effect of PB1-F2 fibers compared to other forms of the protein, leading to respiratory distress. This suggests that the virulence mechanisms of PB1-F2 may depend on its sequence and oligomerization status.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Polymer Science
Alessia Melelli, Delphin Pantaloni, Eric Balnois, Olivier Arnould, Frederic Jamme, Christophe Baley, Johnny Beaugrand, Darshil U. Shah, Alain Bourmaud
Summary: PLA-flax non-woven composites show preferential degradation of flax fibres from the edge to the core during garden composting, while erosion of cell walls occurs within the fibres themselves from the central lumen to the periphery primary wall. The ageing process results in a decrease in indentation modulus for fibres in the preserved core of the composite and a change in PLA morphology towards the edge of the sample.
Article
Chemistry, Physical
Dusan K. Bozanic, Radovan Dojcilovic, Jelena D. Pajovic, Dragana Tosic, Dusko Dudic, Matthieu Refregiers, Vladimir Djokovic
Summary: In this study, fluorescent nanocomposite films were prepared by solution mixing of polyvinyl alcohol (PVA) and tryptophan functionalized silver (AgTrp) nanoparticles. The distribution of AgTrp nanoparticles within the polymer matrix was tracked using synchrotron excitation deep-ultraviolet fluorescence imaging. The presence of AgTrp nanoparticles resulted in the pronounced growth of dendrite-like structures, which was confirmed by various imaging techniques. Both tryptophan and AgTrp nanoparticles affected the thermal properties of the matrix, reducing crystallinity and increasing the glass transition temperature of PVA. Furthermore, the films showed a significant increase in conductance under illumination with 250 nm light, with the relative changes reaching almost 200% compared to the dark condition.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Agricultural Engineering
Johnny Beaugrand, Camille Goudenhooft, Camille Alvarado, Marie-Francoise Devaux, Camille Rivard, Sylvie Durand, Hugo Chauvet, Matthieu Refregiers, Frederic Jamme, Fabienne Guillon, Christophe Baley, Alain Bourmaud
Summary: The study focused on the cell wall composition dynamics of flax stems, investigating the fluorescence emission patterns and intensity differences after a 90 degrees tilt. Results showed a significant increase in fluorescence intensity in tilted plants, and differences in stem fluorescence intensity were observed among different developmental stages.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Instruments & Instrumentation
Emmanuel Esteve, David Buob, Frederic Jamme, Chantal Jouanneau, Slavka Kascakova, Jean Philippe Haymann, Emmanuel Letavernier, Louise Galmiche, Pierre Ronco, Michel Daudon, Dominique Bazin, Matthieu Refregiers
Summary: Synchrotron deep ultraviolet fluorescence is a powerful tool for the diagnosis of renal oxalosis, allowing for accurate detection and identification of oxalate crystals and revealing intracellular oxalate accumulation. A nine-point histological score can be used as a diagnostic indicator for renal oxalosis, which is correlated with renal function and urinary oxalate levels.
JOURNAL OF SYNCHROTRON RADIATION
(2022)
Article
Materials Science, Multidisciplinary
Marta Ghirardello, Victor Gonzalez, Letizia Monico, Austin Nevin, Douglas MacLennan, Catherine Schmidt Patterson, Manfred Burghammer, Matthieu Refregiers, Daniela Comelli, Marine Cotte
Summary: The cultural heritage community is increasingly using synchrotron radiation techniques to study art and archaeological objects. This study explores the combination of X-ray techniques and synchrotron-based photoluminescence to analyze two paint samples from a Pablo Picasso painting. The results demonstrate differences in structure, chemical composition, and photoluminescence properties between the two cadmium yellow paints.
MICROSCOPY AND MICROANALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Andras Micsonai, Eva Moussong, Frank Wien, Eszter Boros, Henrietta Vadaszi, Nikoletta Murvai, Young-Ho Lee, Tamas Molnar, Matthieu Refregiers, Yuji Goto, Agnes Tantos, Jozsef Kardos
Summary: The BeStSel method is a powerful tool for analyzing protein secondary structure composition, providing accurate information and predicting protein folding down to the topology/homology level. It also helps distinguish intrinsically disordered proteins and assists in experimental verification and in silico modeling using CD spectroscopy.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Chemistry, Applied
Alessia Melelli, Frederic Jamme, Johnny Beaugrand, Alain Bourmaud
Summary: Flax fibres have been used by humans for thousands of years, evolving from clothing and sails in ancient times to modern applications in automotive and fashion design. This review focuses on the cultural heritage field, discussing the history of flax fibre use in Europe and the Near East, as well as the degradation mechanisms and characterisation techniques. The study highlights the constructive interchange between engineering and cultural heritage through continuous comparison of antiquity and the contemporary era.
CARBOHYDRATE POLYMERS
(2022)
Article
Biology
Julia Vergalli, Hugo Chauvet, Francesco Oliva, Jelena Pajovic, Giuliano Malloci, Attilio Vittorio Vargiu, Matthieu Refregiers, Paolo Ruggerone, Jean-Marie Pages
Summary: This study combines experimental and computational approaches to reveal the interaction and molecular mechanism between quinolone antibiotics and bacterial multidrug efflux pumps. The findings are important for optimizing antibiotics and can be extended to the study of other efflux pumps.
COMMUNICATIONS BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Agnes Banreti, Shayon Bhattacharya, Frank Wien, Koichi Matsuo, Matthieu Refregiers, Cornelia Meinert, Uwe Meierhenrich, Bruno Hudry, Damien Thompson, Stephane Noselli
Summary: Active regulation of chirality is crucial for life, as the preservation of homochirality is essential for maintaining protein function and overall organism health. Accumulation of heterochirality leads to impaired enzyme activity, increased tumor formation, and reduced lifespan.
NATURE COMMUNICATIONS
(2022)
Article
Biophysics
Jelena D. Pajovic, Radovan J. Dojcilovic, Slavka Kascakova, Matthieu Refregiers, Dusan K. Bozanic, Vladimir Djokovic
Summary: Functionalized gold nanoparticles using amino acid tryptophan and vitamin riboflavin showed enhanced resonance energy transfer (RET) efficiency, leading to a different photobleaching dynamics compared to molecules in solution. This effect was utilized for detection of the nanoparticles within autofluorescent biological material.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Hester Colboc, Philippe Moguelet, Emmanuel Letavernier, Vincent Frochot, Jean-Francois Bernaudin, Raphael Weil, Stephan Rouziere, Patricia Senet, Claude Bachmeyer, Naomi Laporte, Ivan Lucas, Vincent Descamps, Reyhan Amode, Florence Brunet-Possenti, Nicolas Kluger, Lydia Deschamps, Arnaud Dubois, Solenn Reguer, Andrea Somogyi, Kadda Medjoubi, Matthieu Refregiers, Michel Daudon, Dominique Bazin
Summary: Characterization of skin deposits associated with various skin diseases using different physico-chemical techniques provides an opportunity to improve diagnosis, understand pathogenesis, and explore therapeutic interventions.
COMPTES RENDUS CHIMIE
(2022)
Article
Plant Sciences
Alessia Melelli, Darshil U. Shah, Gemala Hapsari, Roberta Cortopassi, Sylvie Durand, Olivier Arnould, Vincent Placet, Dominique Benazeth, Johnny Beaugrand, Frederic Jamme, Alain Bourmaud
Summary: Flax, with a long history and cultural significance, has been used for both its seeds and fibres since ancient times. Advances in non-destructive analysis techniques have allowed for a better understanding and preservation of ancient textiles, revealing the technological expertise of civilizations in producing high-quality fibres. This research also demonstrates the potential durability and quality of ancient flax fibres for high-tech applications.
