Article
Pharmacology & Pharmacy
Wenxian Ma, Qiaoyan Jin, Haiqin Guo, Xinpeng Han, Lingbin Xu, Shemin Lu, Changgui Wu
Summary: This study demonstrates that metformin can alleviate airway inflammation and remodeling in an OVA-induced chronic asthmatic model. The protective effects of metformin may be associated with the restoration of AMPKα activity and decreased asthma-related angiogenesis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Mengdi Liu, Ting Wu, Xiaoyu Zhao, Fengyu Zan, Geng Yang, Yuqing Miao
Summary: The study revealed that during cyanobacteria blooms in eutrophic Chaohu Lake, lake water was the primary source of volatile organic compounds (VOCs), with alkanes and aromatics being the most abundantly emitted VOCs, and cyanobacteria acting as an important source of VOCs.
ENVIRONMENTAL RESEARCH
(2021)
Article
Environmental Sciences
Kristin M. Junge, Lisa Buchenauer, Elena Elter, Katja Butter, Tibor Kohajda, Gunda Herberth, Stefan Roeder, Michael Borte, Wieland Kiess, Martin von Bergen, Jan C. Simon, Ulrike E. Rolle-Kampczyk, Irina Lehmann, Richard Gminski, Martin Ohlmeyer, Tobias Polte
Summary: The study shows that emissions from wood do not have significant inflammatory or asthma-promoting effects, even at high VOC levels and long-term exposure. Exposure to wood-related VOCs during pregnancy or the first year of life was not associated with early wheezing or asthma development in children.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Immunology
Diana C. Yanez, Ching-In Lau, Eleftheria Papaioannou, Mira M. Chawda, Jasmine Rowell, Susan Ross, Anna Furmanski, Tessa Crompton
Summary: Foxa2 plays a significant role in lung function regulation and tissue homeostasis. Its absence in the lung epithelium contributes to airway inflammation and goblet cell hyperplasia. Foxa2 expression in T-cells is required to protect against Th2 inflammatory response and maintain the balance of effector cell differentiation and function in the lung.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pediatrics
Sybelle Goedicke-Fritz, Thomas Werner, Hendrik J. Niemarkt, Tim G. A. M. Wolfs, Joerg Ingo Baumbach, Matthew W. Kemp, Alan H. Jobe, Tobias Rogosch, Michelle Bous, Elisabeth Kaiser, Regine Stutz, Sascha Meyer, Rolf Felix Maier, Andreas Rembert Koczulla, Owen Brad Spiller, Boris W. Kramer, Michael Zemlin
Summary: Studying volatile organic compound (VOC) profiles in amniotic fluid may serve as a useful tool to detect and evaluate chorioamnionitis induced by different sources, particularly distinguishing between Up and IL-1α-induced amnionitis. 2-methylpentane could potentially be a volatile biomarker for chorioamnionitis, with its concentration peaking 7 days after intramniotic instillation of Up.
FRONTIERS IN PEDIATRICS
(2021)
Article
Biology
Dong Wang, Entezar Mehrabi Nasab, Seyyed Shamsadin Athari
Summary: The study revealed that loading baicalein in chitosan nanoparticles could serve as an anti-asthma treatment, helping to reduce inflammation and control asthma symptoms. These nanoparticles effectively impacted the immune response and airway sensitivity in asthma mice.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Immunology
Tongqian Wu, Lan Ma, Xiaoqian Jin, Jingjing He, Ke Chen, Dingshan Zhang, Rui Yuan, Jun Yang, Qin Zhong, Haiyan Zhou, Zou Xiang, Yu Fang
Summary: The study demonstrated that S100A4 plays a critical role in regulating mast cell activation and allergic responses. S100A4(-/-) mice showed reduced symptoms in allergic models, indicating that S100A4 is required for mast cell activation and may be involved in the regulation of allergic diseases through this mechanism.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Miroslava Molitorisova, Martina Sutovska, Ivana Kazimierova, Jana Barborikova, Marta Joskova, Elena Novakova, Sona Franova
Summary: Kaempferol, a flavonol, demonstrated potential in modulating allergic airway inflammation and alleviating asthma features, such as airway hyperreactivity and cough reflex, in an experimental guinea pig model.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shanshan Xu, Nan Wang, Dandan Yan, Yingjie Zhong
Summary: The study found that PE can alleviate asthma caused by obesity. In both mouse and cell experiments, PE can reduce airway inflammation and oxidative damage, as well as reduce body weight and inflammation levels in obese asthmatic mice.
MOLECULAR IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Eun-Hwa Jang, Hae-Duck Bae, Yejin Jeon, Dong Hae Shin, Soosung Kang, Kyunglim Lee
Summary: In this study, we investigated nine compounds known to interact with mTCTP for their ability to suppress the activity of extracellular dTCTP. Meclizine, a piperazine-derivative antihistamine, was found to significantly reduce IL-8 release and suppress the NF-kappa B pathway. The direct interaction of meclizine with dTCTP was confirmed by surface plasmon resonance.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Xinxing Zhang, Yu Ma, Yanyu He, Wenjing Gu, Yongdong Yan, Wei Ji, Li Huang, Yuqing Wang, Chuangli Hao, Gang Li, Zhengrong Chen
Summary: The overexpression of Foxp2 gene can attenuate allergic asthma by inhibiting Th9 cell differentiation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Chemistry, Physical
Junxian Gao, Lingling Tang, Zhizhang Shen, Yuming Dong, Zhenyu Wang, Jinze Lyu, Ji Li, Han-Qing Yu
Summary: The coupling of solar energy conversion and catalytic ozonation using a non-noble-metal SiC/CeO2 system was found to effectively eliminate toluene. SiC enhanced the conversion of visible and infrared light to heat, increasing the reaction temperature. SiC also transferred electrons to CeO2, generating more active sites and promoting the reaction efficiency. 25%SiC-CeO2 exhibited outstanding performance in toluene mineralization.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2022)
Review
Biochemistry & Molecular Biology
Efthymia Theofani, Georgina Xanthou
Summary: Autophagy is a crucial self-degradative process in cells that plays a key role in cellular renovation, physiology, and homeostasis. It can be triggered by factors such as starvation, pathogens, and stress, and is important in immune response regulation. Dysregulation of autophagy processes, either impaired or overactive, can contribute to the pathogenesis of various diseases, including infections and cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agronomy
Valter Cruz-Magalhaes, Rafaela A. Guimaraes, Julio C. P. da Silva, Amanda F. de Faria, Marcio P. Pedroso, Vicente P. Campos, Phellippe A. S. Marbach, Flavio H. de Medeiros, Jorge T. De Souza
Summary: Bacillus strains BMH and INV, closely related to Bacillus velezensis, individually reduced the number of galls and eggs of M. incognita by more than 90% in tomato roots. However, when combined (BMH + INV), the suppression of RKN and tomato growth was lower compared to single-strain applications.
PEST MANAGEMENT SCIENCE
(2022)
Article
Engineering, Chemical
Pedro Villarim, Chengmin Gui, Eric Genty, Zhigang Lei, Jaouad Zemmouri, Sophie Fourmentin
Summary: This study evaluates the removal of toluene using a new heat and mass exchanger and elucidates the absorption mechanism at the molecular level. The results show that benzyl alcohol has a higher absorption capacity compared to other solvents, and the addition of water to the solvent mixture also improves absorption. The interaction energy and Gibbs free energy calculations confirm the enhanced absorption of toluene by benzyl alcohol. The results obtained at different scales are in good agreement.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Biotechnology & Applied Microbiology
J. Loske, J. Roehmel, S. Lukassen, S. Stricker, Vg Magalhaes, J. Liebig, Rl Chua, L. Thurmann, M. Messingschlager, A. Seegebarth, B. Timmermann, S. Klages, M. Ralser, B. Sawitzki, Le Sander, Vm Corman, C. Conrad, S. Laudi, M. Binder, S. Trump, R. Eils, M. A. Mall, I Lehmann
Summary: Children exhibit higher basal expression of relevant pattern recognition receptors in airway immune cells, resulting in stronger early innate antiviral responses to SARS-CoV-2 infection compared to adults. Unique immune cell subpopulations, including cytotoxic T cells and memory CD8+ T cells, predominantly occur in children.
NATURE BIOTECHNOLOGY
(2022)
Article
Environmental Sciences
Alexandra Schaffert, Isabel Karkossa, Elke Ueberham, Rita Schlichting, Katharina Walter, Josi Arnold, Matthias Blueher, John T. Heiker, Joerg Lehmann, Martin Wabitsch, Beate I. Escher, Martin von Bergen, Kristin Schubert
Summary: Metabolites of plasticizers such as DINCH, DINP, and DPHP showed high adipogenic potential in human adipocytes and affected the functionality of mature adipocytes.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Microbiology
Christian Jacoby, Christa Ebenau-Jehle, Katharina Saum, Nico Jehmlich, Martin von Bergen, Thomas Bruls, Matthias Boll
Summary: This study investigated the degradation pathway of the quaternary carbon-containing model compound pivalate in the denitrifying bacterium Thauera humireducens strain PIV-1, providing insights into the activation and carbon skeleton rearrangement processes. The results highlight the potential for biodegradation of similar quaternary carbon-containing compounds based on the identified gene clusters and enzymatic activities.
ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Environmental Sciences
Kristin M. Junge, Lisa Buchenauer, Sandra Strunz, Bettina Seiwert, Loreen Thuermann, Ulrike E. Rolle-Kampczyk, Stefan Roeder, Michael Borte, Wieland Kiess, Martin von Bergen, Jan C. Simon, Ana C. Zenclussen, Torsten Schoeneberg, Gabriele I. Stangl, Gunda Herberth, Irina Lehmann, Thorsten Reemtsma, Tobias Polte
Summary: This article explores the importance of parents, especially in the development of a baby. Mothers play a crucial role in meeting the baby's basic needs, such as feeding and diaper changing. Fathers, on the other hand, serve as playmates and educators, engaging with the baby and teaching them new things. The support system provided by both parents is vital to the baby's development.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Multidisciplinary Sciences
Simon A. Schroeter, Damien Eveillard, Samuel Chaffron, Johanna Zoppi, Bernd Kampe, Patrick Lohmann, Nico Jehmlich, Martin von Bergen, Carlos Sanchez-Arcos, Georg Pohnert, Martin Taubert, Kirsten Kuesel, Gerd Gleixner
Summary: The study reveals that functions within decomposer communities are redundantly distributed under different types of litter sources, but their relative expressions are rapidly optimized to address specific litter properties. Furthermore, the decomposer community may be influenced by DOM containing natural antibiotics, leading to specialization towards specific litter sources and decomposition states.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Kristian Jensen Pedersen, Sven-Bastiaan Haange, Katerina Zizalova, Alina Viehof, Thomas Clavel, Martin Lenicek, Beatrice Engelmann, Lukas Y. Wick, Frank G. Schaap, Nico Jehmlich, Ulrike Rolle-Kampczyk, Martin von Bergen
Summary: Bile acids play a crucial role in lipid uptake and gut-microbiome composition. This study reveals the molecular details of the interaction between bile acid modifying bacteria and other strains, highlighting the influence of co-culturing on bacterial functionality.
Article
Allergy
Loreen Thuermann, Matthias Kloes, Sebastian D. Mackowiak, Matthias Bieg, Tobias Bauer, Naveed Ishaque, Marey Messingschlager, Carl Herrmann, Stefan Roeder, Mario Bauer, Sascha Schaeuble, Erik Faessler, Udo Hahn, Dieter Weichenhan, Oliver Muecke, Christoph Plass, Michael Borte, Erika von Mutius, Gabriele I. Stangl, Roger Lauener, Anne M. Karvonen, Amandine Divaret-Chauveau, Josef Riedler, Joachim Heinrich, Marie Standl, Andrea von Berg, Beate Schaaf, Gunda Herberth, Michael Kabesch, Roland Eils, Saskia Trump, Irina Lehmann
Summary: This study used whole genome bisulfite sequencing to identify dysregulation of enhancer regions as a hallmark of childhood asthma. Abnormal DNA methylation was found in key immune genes and was linked to prenatal influences and genetic susceptibility.
Article
Biochemistry & Molecular Biology
Lei Zhang, Marina Toplak, Raspudin Saleem-Batcha, Lars Hoeing, Roman Jakob, Nico Jehmlich, Martin von Bergen, Timm Maier, Robin Teufel
Summary: Antimicrobial resistance is a serious threat to human health, and understanding the underlying mechanisms is crucial. This study discovered and characterized oxidoreductases that inactivate the broad-spectrum antibiotic chloramphenicol through dual oxidation of the C3-hydroxyl group. These enzymes also enable the inactivation of related compounds but not the fluorinated derivative. Phylogenetic analyses suggest that distinct isofunctional enzymes evolved independently in Gram-positive and Gram-negative bacteria. Mechanistic and structural studies provide insights into the catalytic mechanisms of these enzymes, which have both negative and positive impacts on antibiotic resistance and chloramphenicol bioremediation.
Article
Ecology
Nelson Khan, Edward Muge, Francis J. Mulaa, Benson Wamalwa, Martin von Bergen, Nico Jehmlich, Lukas Y. Wick
Summary: Fungi play a crucial role in the biodegradation of soil organochlorine pesticides by facilitating bacterial dispersal and nutrient release. Experimental results indicate that the transfer of nutrients from fungi to bacteria can enhance the degradation of organic pollutants, highlighting the importance of fungal-bacterial interactions.
Article
Biochemistry & Molecular Biology
Ibrahim E. Sallam, Ulrike Rolle-Kampczyk, Stephanie Serena Schaepe, Soumaya S. Zaghloul, Riham S. El-Dine, Ping Shao, Martin von Bergen, Mohamed A. Farag
Summary: This study assessed the effect of gut microbiota on the biotransformation of O. ficus-indica metabolites. The results showed that flavonoid glycosides were converted to two major metabolites, 3-(4-hydroxyphenyl)propanoic acid and phloroglucinol, in vitro at 24 h. In the ex vivo assay, flavonoid glycosides were completely absent in the treated sample, indicating their conversion. The antioxidant potential also declined after biotransformation.
Article
Environmental Sciences
Lisa Buchenauer, Kristin M. Junge, Sven-Bastiaan Haange, Jan C. Simon, Martin von Bergen, Anna-Lena Hoh, Gabriela Aust, Ana C. Zenclussen, Gabriele I. Stangl, Tobias Polte
Summary: Exposure to low-dose glyphosate in mothers has an immunosuppressive effect on their female offspring, which is not observed in the second generation. The altered microbiota composition might mediate this immune response modulation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Medicine, General & Internal
Sebastian Stricker, Niklas Ziegahn, Martin Karsten, Thomas Boeckel, Heike Stich-Boeckel, Jakob Maske, Evelyn Rugo, Anita Balazs, Pamela Millar Buchner, Chantip Dang-Heine, Valentin Schriever, Roland Eils, Irina Lehmann, Leif E. Sander, Markus Ralser, Victor M. Corman, Marcus A. Mall, Birgit Sawitzki, Jobst Roehmel
Summary: This study aims to characterize age-dependent differences in immune responses to respiratory infections, using SARS-CoV-2 as a model virus, and assess age differences in clinical outcomes, including lung function. The study plans to recruit at least 120 children and 60 adults infected with SARS-CoV-2 and collect specimens for multiomics analysis. The data obtained from this study will be correlated with medical history and clinical data.
Article
Peripheral Vascular Disease
Loreen Thuermann, Mario Bauer, Maike Ferland, Marey Messingschlager, Tamara Schikowski, Andrea von Berg, Joachim Heinrich, Gunda Herberth, Irina Lehmann, Marie Standl, Saskia Trump
Summary: This study investigated transcriptional changes of immune modulators associated with hypertension in adolescents, highlighting the importance of early blood pressure monitoring for intervention and prevention of adverse outcomes.
Article
Ecology
Markus Krueger, Narendrakumar Chaudhari, Bo Thamdrup, Will A. Overholt, Laura A. Bristow, Martin Taubert, Kirsten Kuesel, Nico Jehmlich, Martin von Bergen, Martina Herrmann
Summary: The study reveals that complete ammonia-oxidizing bacteria (CMX) of the genus Nitrospira have a competitive advantage over ammonia-oxidizing bacteria (AOB) and archaea (AOA) in oligotrophic carbonate rock aquifers, due to their ecophysiological characteristics and wide occurrence in groundwater. However, their specific contribution to nitrification processes has been unclear. The research aimed to unravel the contribution of CMX, AOA, and AOB to nitrification and identify the environmental drivers of their niche differentiation in oligotrophic carbonate rock aquifers.
Article
Biochemistry & Molecular Biology
Philipp Georg, Rosario Astaburuaga-Garcia, Lorenzo Bonaguro, Sophia Brumhard, Laura Michalick, Lena J. Lippert, Tomislav Kostevc, Christiane Gaebel, Maria Schneider, Mathias Streitz, Vadim Demichev, Ioanna Gemuend, Matthias Barone, Pinkus Tober-Lau, Elisa T. Helbig, David Hillus, Lev Petrov, Julia Stein, Hannah-Philine Dey, Daniela Paclik, Christina Iwert, Michael Muelleder, Simran Kaur Aulakh, Sonja Djudjaj, Roman D. Buelow, Henrik E. Mei, Axel R. Schulz, Andreas Thiel, Stefan Hippenstiel, Antoine-Emmanuel Saliba, Roland Eils, Irina Lehmann, Marcus A. Mall, Sebastian Stricker, Jobst Roehmel, Victor M. Corman, Dieter Beule, Emanuel Wyler, Markus Landthaler, Benedikt Obermayer, Saskia von Stillfried, Peter Boor, Munevver Demir, Hans Wesselmann, Norbert Suttorp, Alexander Uhrig, Holger Mueller-Redetzky, Jacob Nattermann, Wolfgang M. Kuebler, Christian Meisel, Markus Ralser, Joachim L. Schultze, Anna C. Aschenbrenner, Charlotte Thibeault, Florian Kurth, Leif E. Sander, Nils Bluethgen, Birgit Sawitzki
Summary: Severe COVID-19 is associated with highly activated CD16(+) T cells that exhibit cytotoxic functions and contribute to endothelial injury. These CD16(+) T cells can degranulate and induce cytotoxicity through immune-complex-mediated mechanisms independent of the T cell receptor, which is not observed in other diseases. The presence of activated CD16(+) T cells and elevated levels of complement proteins upstream of C3a are associated with a fatal outcome of COVID-19, indicating the pathological role of enhanced cytotoxicity and complement activation in the disease.