Article
Oncology
Betul Oran, Rima M. Saliba, Rohtesh S. Mehta, Amin M. Alousi, David Marin, Ben C. Valdez, Julianne Chen, Qaiser Bashir, Stefan O. Ciurea, Amanda L. Olson, Chitra Hosing, Partow Kebriaei, Katy Rezvani, Elizabeth J. Shpall, Richard E. Champlin, Borje S. Andersson, Uday R. Popat
Summary: Fractionated busulfan treatment in patients with AML or myelodysplastic syndrome improves progression-free survival and overall survival without increasing nonrelapse mortality, compared to nonfractionated lower dose regimens.
Article
Hematology
Harrison K. Tsai, Christopher J. Gibson, H. Moses Murdock, Phani Davineni, Marian H. Harris, Eunice S. Wang, Lukasz P. Gondek, Annette S. Kim, Valentina Nardi, R. Coleman Lindsley
Summary: The study reveals the presence of complex secondary events in patients with KMT2A-PTD, which may be related to the occurrence and relapse of acute myeloid leukemia and myelodysplastic syndrome.
Article
Oncology
Courtney D. DiNardo, Andreas Hochhaus, Mark G. Frattini, Karen Yee, Thomas Zander, Alwin Kraemer, Xueying Chen, Yan Ji, Nehal S. Parikh, Joanne Choi, Andrew H. Wei
Summary: This study aimed to determine the recommended dose for IDH305 in patients with IDH1(R132)-mutant AML and MDS. The results showed acceptable pharmacokinetic characteristics of IDH305 in patients, and demonstrated target engagement. Although adverse events were reported, hepatotoxicity could be managed through dose modification.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Ting Liu, Jianan Rao, Wenting Hu, Bowen Cui, Jiaoyang Cai, Yuhan Liu, Huiying Sun, Xiaoxiao Chen, Yanjing Tang, Jing Chen, Xiang Wang, Han Wang, Wubin Qian, Binchen Mao, Sheng Guo, Ronghua Wang, Yu Liu, Shuhong Shen
Summary: This study identifies potential driver alterations in Chinese pediatric AML, which differ from Western populations, and proposes a prognostic risk classification model.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Yun Wang, Yan-yu Cai, Tobias Herold, Run-cong Nie, Yu Zhang, Robert Peter Gale, Klaus H. Metzeler, Yun Zeng, Shun-qing Wang, Xue-yi Pan, Tong-hua Yang, Yuan-bin Wu, Qing Zhang, Zhi-jun Wuxiao, Xin Du, Zhi-wei Liang, Yong-zhong Su, Jing-bo Xu, Yong-qing Wang, Ze-lin Liu, Jian-wei Wu, Xiong Zhang, Bing-yi Wu, Ruo-zhi Xiao, San-bin Wang, Jin-yuan Li, Pei-dong Chi, Qian-yi Zhang, Si-liang Chen, Zhe-yuan Qin, Xin-mei Zhang, Na Zhong, Wolfgang Hiddemann, Qi-fa Liu, Bei Zhang, Yang Liang
Summary: A novel immune risk score was developed to predict survival in AML patients, utilizing in silico algorithms to evaluate immune composition. The model showed high predictive accuracy in both training and external validation cohorts, with low-risk scores correlating with prolonged survival.
CLINICAL CANCER RESEARCH
(2021)
Article
Hematology
Wan-Hsuan Lee, Chien-Chin Lin, Cheng-Hong Tsai, Feng-Ming Tien, Min-Yen Lo, Sao-Chih Ni, Ming Yao, Mei-Hsuan Tseng, Yuan-Yeh Kuo, Ming-Chih Liu, Jih-Luh Tang, Hsun- Sun, Yi-Kuang Chuang, Wen-Chien Chou, Hsin-An Hou, Hwei-Fang Tien
Summary: The 2022 International Consensus Classification (ICC) has reclassified myeloid neoplasms based on advancements in understanding hematologic malignancies. Notably, MDS with blasts of 10%-19% is now classified as MDS/AML, MDS with mutated SF3B1 as MDS-SF3B1, and MDS with multi-hit TP53 mutations as MDS with mutated TP53. A study analyzing 716 MDS patients found that 75.3% remained in the MDS group according to the ICC, while 24.7% were reclassified to the MDS/AML group. This classification has important implications for treatment choice and risk-stratification.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Oncology
Eileen Wedge, Ulvi Ahmadov, Thomas B. Hansen, Zongliang Gao, Morten Tulstrup, Christophe Come, Sridhar Nonavinkere Srivatsan, Tanzir Ahmed, Jakob S. Jespersen, Balthasar C. Schlotmann, Claudia Schollkopf, Klas Raaschou-Jensen, Niels Odum, Jorgen Kjems, Rasmus O. Bak, Matthew J. Walter, Kirsten Gronbaek, Lasse S. Kristensen
Summary: Mutations in the U2AF1 gene are associated with a higher occurrence of myelodysplastic neoplasms (MDS) and a worse prognosis, but the exact molecular mechanisms are not fully understood. This study found that U2AF1 mutations may impact circRNA production, leading to increased cancer development. Increased circRNA expression levels were observed in cells and patient samples with U2AF1 mutations, suggesting a potential role of circRNA as a biomarker and therapeutic target in MDS.
Review
Oncology
Sargam Kapoor, Grace Champion, Aparna Basu, Anu Mariampillai, Matthew J. Olnes
Summary: Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are hematologic malignancies arising from the bone marrow with poor prognosis. Recent advancements in immune therapies, including immune suppressive therapy and novel treatments like monoclonal antibodies and cellular therapeutics, have shown promise in treating these diseases.
Article
Oncology
Rory M. Shallis, Naval G. Daver, Jessica K. Altman, Robert P. Hasserjian, Hagop M. Kantarjian, Uwe Platzbecker, Valeria Santini, Andrew H. Wei, David A. Sallman, Amer M. Zeidan
Summary: TP53-altered myelodysplastic syndrome with excess blasts and TP53-altered acute myeloid leukemia should be classified under one term for their study in clinical trials, in order to simplify the screening processes and focus on treating patients based on their genetically defined disorders, rather than an arbitrary blast threshold.
Article
Biochemistry & Molecular Biology
Valentina Giudice, Marisa Gorrese, Rosa Vitolo, Angela Bertolini, Rossella Marcucci, Bianca Serio, Roberto Guariglia, Idalucia Ferrara, Rita Pepe, Francesca D'Alto, Barbara Izzo, Antonio Pedicini, Nunzia Montuori, Maddalena Langella, Carmine Selleri
Summary: WT1 expression levels in AML and MDS inversely correlated with normal hematopoiesis and were positively associated with blast counts. Flow cytometry was shown to be more sensitive and specific in distinguishing normal myeloid cells from neoplastic counterpart, even with just linear parameters and CD45 expression. A simple integrated approach combining blast counts by flow cytometry, FLT3 mutational status, and WT1 expression levels may provide a better prognostic definition for both AML and MDS patients.
Review
Immunology
Sarah Weber, Anastasia Parmon, Nina Kurrle, Frank Schnuetgen, Hubert Serve
Summary: MDS and AML patients often experience systemic iron overload issues, iron is closely associated with the pathogenesis and potential treatment strategies of the diseases, imbalances in iron homeostasis may lead to various cell death.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Jiale Ma, Zheng Ge
Summary: A systematic review and network meta-analysis compared the efficacy and safety of DAC and AZA in AML and HR-MDS patients. Both DAC and AZA showed better overall response rate and longer overall survival compared to CCR, but DAC demonstrated higher efficacy in achieving complete remission rate compared to AZA.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Vlad Andrei Cianga, Lydia Campos Catafal, Petru Cianga, Mariana Pavel Tanasa, Mohamad Cherry, Phillipe Collet, Emmanuelle Tavernier, Denis Guyotat, Cristina Rusu, Carmen Mariana Aanei
Summary: The study investigated NK cell maturation in bone marrow under different conditions and found impaired NK cell antitumor response and phenotypic shift in MDS and AML settings. The results suggest immune response failure during myeloid malignancy pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Hassan B. Alkhateeb, Ahmad Nanaa, David Viswanatha, James M. Foran, Talha Badar, Lisa Sproat, Rong He, Phuong Nguyen, Dragan Jevremovic, Mohamad E. Salama, Patricia Greipp, Naseema Gangat, Ayalew Tefferi, Mark R. Litzow, Abhishek A. Mangaonkar, Mithun Vinod Shah, Mrinal Patnaik, Aref Al-Kali
Summary: DDX41 mutations are associated with late onset myelodysplastic syndromes/acute myeloid leukemia. Patients with these mutations often have an indolent course and comparable overall survival to favorable-risk AML patients.
Review
Oncology
Jeffery M. Klco, Charles C. Mullighan
Summary: This review emphasizes the different genetic pathways impacted by germline mutations leading to the development of familial and sporadic haematological malignancies, with a particular focus on recent advances in acute lymphoblastic leukaemia, acute myeloid leukaemia, and myelodysplastic syndromes.
NATURE REVIEWS CANCER
(2021)