期刊
PLOS ONE
卷 7, 期 7, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0040125
关键词
-
资金
- PAPIIT [IN217708, IN205911, IN221909]
- SEP-CoNaCyT [82308, 106598]
- Academia Mexicana de Ciencias
- CONACYT [C01-56431]
- Consejo Nacional de Ciencia y Tecnologia grant [60127-Q]
- Programa de Apoyo a Proyectos de Investigacion e Innovacion Tecnologica
- Universidad Nacional Autonoma de Mexico (PAPIIT) [IN202910]
- Instituto de Ciencia y Tecnologia del Distrito Federal grant [PIFUTP09-279]
Hunter-killer peptides combine two activities in a single polypeptide that work in an independent fashion like many other multi-functional, multi-domain proteins. We hypothesize that emergent functions may result from the combination of two or more activities in a single protein domain and that could be a mechanism selected in nature to form moonlighting proteins. We designed moonlighting peptides using the two mechanisms proposed to be involved in the evolution of such molecules (i.e., to mutate non-functional residues and the use of natively unfolded peptides). We observed that our moonlighting peptides exhibited two activities that together rendered a new function that induces cell death in yeast. Thus, we propose that moonlighting in proteins promotes emergent properties providing a further level of complexity in living organisms so far unappreciated.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据