Article
Veterinary Sciences
Lowell T. Midla, Kevin L. Hill, Nicholas K. Van Engen, Matthew Edmonds, David G. Renter, Marshall N. Streeter, John P. Hutcheson, Philip J. Griebel
Summary: Both commercially available vaccines with a BHV1 component induced immune responses in colostrum-fed calves, including transient increases in interferon concentrations and secretion of IgA antibodies. The two vaccines differed in the magnitude of interferon response and the proportion of calves with detectable interferon concentrations, but both enhanced the IgA response against P. multocida.
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2021)
Article
Medicine, Research & Experimental
Maryam Kateh Shamshiri, Mahmoud Reza Jaafari, Ali Badiee
Summary: The study demonstrated that PEGylated liposomes containing IFN-gamma, LIP-F2, showed significant advantages in tumor treatment, inducing antitumor immune responses and enhancing cargo delivery efficiency.
Article
Agriculture, Dairy & Animal Science
Sherri A. Powledge, Taylor B. McAtee, Amelia R. Woolums, T. Robin Falkner, John T. Groves, Merilee Thoresen, Robert Valeris-Chacin, John T. Richeson
Summary: Vaccination with modified-live virus (MLV) did not have a clear impact on the health or growth of high-risk calves, but intranasal MLV vaccination was associated with increased carriage of Histophilus somni (Hs) in the naris and reduced culture of Mannheimia haemolytica (Mh) from lung tissue samples. This suggests that intranasal MLV vaccination can alter the microbial community in the respiratory tract of cattle.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Virology
Yishu Wang, Yiling Chen, Ying Lin, Yingqin Quan, Xiaoping Xiao, Renli Zhang
Summary: RSV infection is a major cause of lower respiratory tract disease, with no effective treatments found yet. Recent studies have shown that TRIM family member TRIM22 plays a crucial role in resisting RSV infection. RSV infection induces TRIM22 expression through the activation of JAK-STAT1/2 signaling.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Immunology
Teresia W. Maina, Elizabeth A. Grego, Scott Broderick, Randy E. Sacco, Balaji Narasimhan, Jodi L. McGill
Summary: Researchers determined the effectiveness of a nanovaccine based on polyanhydride, encapsulating the BRSV post-fusion F and G glycoproteins and CpG, in the neonatal calf model. The nanovaccine, delivered via heterologous or homologous immunization, demonstrated clinical and virological protection in the calves, comparable to a commercial modified-live vaccine.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Cyril Le Nouen, Christine E. Nelson, Xueqiao Liu, Hong-Su Park, Yumiko Matsuoka, Cindy Luongo, Celia Santos, Lijuan Yang, Richard Herbert, Ashley Castens, Ian N. Moore, Temeri Wilder-Kofie, Rashida Moore, April Walker, Peng Zhang, Paolo Lusso, Reed F. Johnson, Nicole L. Garza, Laura E. Via, Shirin Munir, Daniel L. Barber, Ursula J. Buchholz
Summary: This study generated a pediatric SARS-CoV-2 vaccine candidate using a live-attenuated parainfluenza virus vector, and evaluated its immunogenicity and protective efficacy in rhesus macaques. The vaccine induced strong mucosal and systemic immune responses, including neutralizing antibodies and T cell responses. Immunized macaques showed undetectable viral replication after challenge. The vaccine will be clinically evaluated as an intranasal vaccine for pediatric use.
Article
Immunology
Spyridon Makris, Cecilia Johansson
Summary: Innate immune responses are crucial for protecting the neonatal lung, and neonatal lungs respond differently to various innate immune stimuli compared to adult lungs. Specifically, they show a weaker response to respiratory syncytial virus (RSV) but a stronger response to R848 and influenza virus, possibly due to higher levels of cAMP and enhanced responsiveness to extracellular adenosine. These findings have implications for the development of vaccine adjuvants for neonates.
MUCOSAL IMMUNOLOGY
(2021)
Article
Virology
Barbara N. Porto, Michael L. Litvack, Yuchen Cen, Irene Lok, Sheena Bouch, Michael J. Norris, Wenming Duan, Cameron Ackerley, Martin Post, Theo J. Moraes
Summary: The study demonstrates that ALMs generated from pluripotent stem cells can prevent RSV infection by phagocytosis of virus particles and releasing an antiviral factor. ALMs protect mice from virus-induced weight loss and reduce lung inflammation in experiments, indicating their potential prophylactic role in RSV infection.
Article
Immunology
Xin Wang, Xiaochen Yin, Boya Zhang, Chenfeng Liu, Yahua Lin, Xiaofen Huang, Yufang Li, Chenguang Shen, Weibin Zheng, Guofeng Fu, Junyu Chen, Yanling Wen, Wei Zhang, Bo-Sheng Pan, Mujin Fang, Zizheng Zheng, Zheng Zhang, Quan Yuan, Guo Fu, Shaowei Li, Jun Zhang, Yixin Chen, Ningshao Xia, Qinjian Zhao
Summary: Immunization with an aluminium-zinc hybrid particulate adjuvant (FH-001) alone can quickly induce a broadly protective immune response to resist multiple deadly respiratory viruses. Alveolar macrophages and the type I interferon pathway play essential roles in the prophylactic effect of FH-001.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Multidisciplinary Sciences
Sarhad Alnajjar, Panchan Sitthicharoenchai, Jack Gallup, Mark Ackermann, David Verhoeven
Summary: The study found that dual infection with RSV and Spn can lead to increased disease severity, possibly due to lesion development and altered immune responses rather than bacterial counts. This finding helps to better understand the pathophysiological mechanisms of co-infection of respiratory syncytial virus and Streptococcus pneumoniae.
Review
Immunology
Yuxin Wang, Junwen Zheng, Xia Wang, Pu Yang, Dongchi Zhao
Summary: RSV is a common pathogen causing bronchiolitis and pneumonia in children younger than 2 years old, and is closely associated with recurrent wheezing and airway hyperresponsiveness. Alveolar macrophages (AMs) undergo polarization during RSV infection, resulting in two macrophage phenotypes with pro-inflammatory and anti-inflammatory responses, which play important roles in disease progression and airway hyperresponsiveness.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Felicia Scaggs Huang, David I. Bernstein, Karen S. Slobod, Allen Portner, Toru Takimoto, Charles J. Russell, Michael Meagher, Bart G. Jones, Robert E. Sealy, Christopher Coleclough, Kristen Branum, Michelle Dickey, Kristen Buschle, Monica McNeal, Mat Makowski, Aya Nakamura, Julia L. Hurwitz
Summary: The study demonstrated that SeVRSV vaccine was well-tolerated in healthy adults with only mild to moderate reactions and no severe adverse events. Transient vaccine genome detection was observed due to preexisting immunity towards hPIV-1 and RSV in adults. Minimal antibody responses to SeV and negligible responses to RSV F were observed.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Immunology
Alexandra Correia, Pedro Alves, Ricardo Frois-Martins, Luzia Teixeira, Manuel Vilanova
Summary: Neospora caninum is a protozoan that causes abortion and still-births in cattle. In this study, we extended a mucosal vaccination approach using N. caninum membrane proteins and CpG adjuvant by incorporating the carbomer-based adjuvant Carbigen (TM). Immunized mice showed increased proportions and numbers of memory CD4(+) and CD8(+) T cells. When infected with N. caninum, the immunized mice had lower parasite burdens and produced higher levels of IL-17A.
Article
Immunology
Junjun Ni, Juan Zhao, Xinwen Zhang, Thomas Reinheckel, Vito Turk, Hiroshi Nakanishi
Summary: The study found that Cathepsin H plays a critical role in the proteolytic maturation and stabilization of TLR3, which is necessary for IFN-beta production. CatH deficiency led to impaired TLR3/IFN-beta signaling, resulting in microglial cell death and astrogliosis/glial scar formation in the hippocampus following HI injury, thereby suppressing hippocampal atrophy.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Virology
Hasindu S. Edirisinghe, Anushi E. Rajapaksa, Simon G. Royce, Magdy Sourial, Robert J. Bischof, Jeremy Anderson, Gulcan Sarila, Cattram D. Nguyen, Kim Mulholland, Lien Anh Ha Do, Paul V. Licciardi
Summary: This study evaluated the therapeutic effect of aerosolised palivizumab in neonatal lambs following RSV infection. The results showed that aerosolised palivizumab had a modest effect in reducing inflammatory response, but did not reduce viral loads. Further studies using optimized protocols are needed to validate these findings.
Article
Immunology
Robert N. Abood, Kevin J. McHugh, Helen E. Rich, Marianna A. Ortiz, Joshua M. Tobin, Krishnaveni Ramanan, Keven M. Robinson, Jennifer M. Bomberger, Jay K. Kolls, Michelle L. Manni, Derek A. Pociask, John F. Alcorn
MUCOSAL IMMUNOLOGY
(2019)
Article
Multidisciplinary Sciences
Amanda Ardain, Racquel Domingo-Gonzalez, Shibali Das, Samuel W. Kazer, Nicole C. Howard, Alveera Singh, Mushtaq Ahmed, Shepherd Nhamoyebonde, Javier Rangel-Moreno, Paul Ogongo, Lan Lu, Duran Ramsuran, Maria de la Luz Garcia-Hernandez, Tyler K. Ulland, Matthew Darby, Eugene Park, Farina Karim, Laura Melocchi, Rajhmun Madansein, Kaylesh Jay Dullabh, Micah Dunlap, Nancy Marin-Agudelo, Takashi Ebihara, Thumbi Ndung'u, Deepak Kaushal, Alexander S. Pym, Jay K. Kolls, Adrie Steyn, Joaquin Zuniga, William Horsnell, Wayne M. Yokoyama, Alex K. Shalek, Henrik N. Kloverpris, Marco Colonna, Alasdair Leslie, Shabaana A. Khader
Correction
Multidisciplinary Sciences
Amanda Ardain, Racquel Domingo-Gonzalez, Shibali Das, Samuel W. Kazer, Nicole C. Howard, Alveera Singh, Mushtaq Ahmed, Shepherd Nhamoyebonde, Javier Rangel-Moreno, Paul Ogongo, Lan Lu, Duran Ramsuran, Maria de la Luz Garcia-Hernandez, Tyler K. Ulland, Matthew Darby, Eugene Park, Farina Karim, Laura Melocchi, Rajhmun Madansein, Kaylesh Jay Dullabh, Micah Dunlap, Nancy Marin-Agudelo, Takashi Ebihara, Thumbi Ndung'u, Deepak Kaushal, Alexander S. Pym, Jay K. Kolls, Adrie Steyn, Joaquin Zuniga, William Horsnell, Wayne M. Yokoyama, Alex K. Shalek, Henrik N. Kloverpris, Marco Colonna, Alasdair Leslie, Shabaana A. Khader
Article
Immunology
K. D. Hebert, N. Mclaughlin, M. Galeas-Pena, Z. Zhang, T. Eddens, A. Govero, J. M. Pilewski, J. K. Kolls, D. A. Pociask
MUCOSAL IMMUNOLOGY
(2020)
Article
Pediatrics
Nader Shaikh, Judith M. Martin, Alejandro Hoberman, Megan Skae, Linette Milkovich, Christi McElheny, Robert W. Hickey, Lucine Gabriel, Diana H. Kearney, Massoud Majd, Eglal Shalaby-Rana, George Tseng, Jay Kolls, William Horne, Zhiguang Huo, Timothy R. Shope
PEDIATRIC NEPHROLOGY
(2020)
Article
Critical Care Medicine
Matthew Henkel, Jessica Partyka, Alyssa D. Gregory, Erick Forno, Michael H. Cho, Taylor Eddens, Andrew R. Tout, Nathan Salamacha, William Horne, Krithika S. Rao, Yijen Wu, John F. Alcorn, Dennis Kostka, Raphael Hirsch, Juan C. Celedon, Steven D. Shapiro, Jay K. Kolls, Brian T. Campfield
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Medicine, Research & Experimental
Naoki Iwanaga, Ivy Sandquist, Alanna Wanek, Janet McCombs, Kejing Song, Jay K. Kolls
Article
Virology
Joshua M. Currey, Felix Rabito, Nicholas J. Maness, Robert Blair, Jay Rappaport, Xuebin Qin, Jay K. Kolls, Akhilesh K. Srivastava
Summary: The study shows that the Beta and Gamma variants of SARS-CoV-2 have a poor ability to replicate in C57BL/6 mice, with no significant pathological or clinical changes observed.
Article
Biochemistry & Molecular Biology
Berengere Villeret, Reem Ghinnagow, Saade Kheir, Maelys Born-Bony, Jay K. Kolls, Ignacio Garcia-Verdugo, Jean-Michel Sallenave
Summary: This study reveals the importance of lymphocytes in fighting against Pseudomonas aeruginosa infection. The bacterium down-regulates IL-23 and IL-22 protein accumulation in the lungs, but up-regulates their RNA production. Adenovirus-mediated over-expression of IL-1, IL-23, and IL-7 can rescue mice from Pseudomonas aeruginosa-induced lethality, suggesting its potential value in locally immunosuppressed individuals like cystic fibrosis patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Narayanappa Amruta, Saifudeen Ismael, Sarah R. Leist, Timothy E. Gressett, Akhilesh Srivastava, Kenneth H. Dinnon III, Elizabeth B. Engler-Chiurazzi, Nicholas J. Maness, Xuebin Qin, Jay K. Kolls, Ralph S. Baric, Gregory Bix
Summary: Increasing evidence suggests that SARS-CoV-2 infection affects neurological function, and developing laboratory mouse models is important for studying the underlying mechanisms. Our study demonstrates that SARS-CoV-2 (MA10) infection induces neuroinflammation in laboratory mice and could be used as a novel model to study SARS-CoV-2-mediated cerebrovascular pathology.
Meeting Abstract
Cardiac & Cardiovascular Systems
T. Watanabe, Z. Guan, M. Horie, B. Joe, M. U. Juan, H. Buhari, D. Hwang, J. K. Kolls, M. Liu, S. Keshavjee, S. Juvet, T. Martinu
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2020)
Meeting Abstract
Immunology
Yasuka Matsunaga, Alanna Wanek, Kejin Song, Cathy Flemington, Trevon Clark, Jacob Bitoun, Jay Kolls
JOURNAL OF IMMUNOLOGY
(2019)
Meeting Abstract
Immunology
Shiping Lu, Kejing Song, Jennifer Bomberger, Jay K. Kolls
JOURNAL OF IMMUNOLOGY
(2019)
Meeting Abstract
Immunology
Naoki Iwanaga, Ivy Sandquist, Kong Chen, Elizabeth B. Norton, Javier Rangel Moreno, Jay K. Kolls
JOURNAL OF IMMUNOLOGY
(2019)
Meeting Abstract
Immunology
Naoki Iwanaga, Ivy Sandquist, Kong Chen, Elizabeth B. Norton, Javier Rangel Moreno, Jay K. Kolls
JOURNAL OF IMMUNOLOGY
(2019)