Review
Pharmacology & Pharmacy
Qihang Kong, Yue Quan, Geer Tian, Junteng Zhou, Xiaojing Liu
Summary: Mechanosensing and mechanotransduction are crucial processes in mechanobiology, with purinergic P2 receptors playing a key role in cellular mechanotransduction. Understanding the specific mechanism of P2 receptor-mediated mechanotransduction is valuable, as interactions between P2 receptors and other mechanosensitive molecules affect physiological processes in cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Marta Boccazzi, Stefano Raffaele, Thomas Zanettin, Maria P. Abbracchio, Marta Fumagalli
Summary: Neurodevelopmental disorders (NDDs) encompass a range of congenital pathological conditions that affect cognitive, social behavior, and sensory/motor functioning. Recent research has linked genetic disorders involving purine metabolism to autism-like behaviors in humans. Dysregulated purine and pyrimidine levels have also been found in biofluids of individuals with other NDDs. Blocking specific purinergic pathways has been shown to reverse cognitive and behavioral defects in rodent models of NDDs. These findings suggest that targeting P2 receptor signaling could lead to the development of more specific treatments and early detection markers for NDDs.
Article
Neurosciences
Shilin Jia, JinYue Liu, Yanhao Chu, Qing Liu, Lijia Mai, Wenguo Fan
Summary: The trigeminal ganglion is responsible for processing orofacial sensory information, and the communication between trigeminal ganglion neurons and other cells plays a crucial role in this process. Purinergic signaling, a widespread pathway in intercellular communication, contributes to neuromodulation and orofacial sensation. In this study, single-cell RNA sequencing was performed to identify different cell populations in the trigeminal ganglion and explore the expression patterns of genes associated with purinergic signaling.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Julian Lommen, Julika Detken, Katharina Harr, Charlotte von Gall, Amira A. H. Ali
Summary: This study provides a detailed systematic analysis on the spatial and temporal distribution of P2 in the mouse hippocampus, revealing distinct spatial and temporal distribution patterns of P2 receptors in different hippocampal layers. The temporal distribution of P2 receptors can be segregated into two large time domains, the early to mid-day and the mid to late night.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Paula Mut-Arbona, Beata Sperlagh
Summary: The purinergic pathway is involved in both pro-inflammatory and anti-inflammatory responses, and the breakdown of ATP is essential in maintaining its balance. ATP is considered a clear indicator of cell damage and pathological conditions when released during tissue damage, inflammation, or hypoxia. This review focuses on the role of P2 receptor-mediated purinergic signaling in normal and pathological brain development, particularly in neurodevelopmental psychiatric disorders. The review emphasizes the timedependent dynamic changes in the purinome and its involvement in shaping the normal and aberrant patterns of central nervous system development and diseases over one's lifespan.
Article
Neurosciences
Rachel Feldman-Goriachnik, Menachem Hanani
Summary: Neuronal excitation leads to NO release, inducing SGCs activation, with ATP potentially playing a role in NO's action.
Article
Multidisciplinary Sciences
Roberta de Ceglia, Ada Ledonne, David Gregory Litvin, Barbara Lykke Lind, Giovanni Carriero, Emanuele Claudio Latagliata, Erika Bindocci, Maria Amalia Di Castro, Iaroslav Savtchouk, Ilaria Vitali, Anurag Ranjak, Mauro Congiu, Tara Canonica, William Wisden, Kenneth Harris, Manuel Mameli, Nicola Mercuri, Ludovic Telley, Andrea Volterra
Summary: A subpopulation of astrocytes selectively expresses synaptic-like glutamate-release machinery, actively secretes the transmitter, and is localized to discrete sites in the hippocampus. These specialized astrocytes play important roles in central nervous system physiology and diseases, and may serve as a potential therapeutic target.
Review
Immunology
Edward S. Schulman, Haruhisa Nishi, Amir Pelleg
Summary: Since the late 1970s, there has been a significant increase in the incidence and mortality of asthma. This review focuses on the role of endogenous purine nucleotide ATP in mast cells' physiology, particularly in allergic reactions. ATP activates P2 purinergic cell-surface receptors to trigger heightened inflammatory responses. It is the most potent enhancer of IgE-mediated mast cell degranulation described to date. The reviewed studies provide insights into the unpredictability and intensity of clinical reactions to minimal allergen exposures and potential therapeutic approaches targeting ATP-related enhancement of allergic reactions are discussed.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Qian Yu, Soma Biswas, Gang Ma, Peiquan Zhao, Baojie Li, Jing Li
Summary: This study elucidates the major mechanisms governing corneal maintenance, regeneration, and aging, including the role of the Rela gene, the synthesis of Retinoic acid, and the impact of angiogenesis. Interventions targeting these pathways could effectively improve corneal regeneration and aging processes.
Article
Cell Biology
Kristen L. Segars, Nicholas A. Azzari, Stephanie Gomez, Cody Machen, Celeste B. Rich, Vickery Trinkaus-Randall
Summary: Research has shown that changes in corneal stiffness and signaling contribute to decreased wound healing efficacy in older mice. As mice age, the stiffness of the cornea changes, leading to longer healing times. Additionally, there is reduced calcium signaling at the wound site in older mice, resulting in lower cell activity compared to younger mice.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
David A. Bereiter, Mostafeezur Rahman, Fabeeha Ahmed, Randall Thompson, Nhungoc Luong, Julie K. Olson
Summary: Dry eye disease (DED) is a chronic inflammatory condition characterized by an increase in tear osmolarity and loss of tear film integrity. This study found that activation of the purinergic receptor subtype 7 (P2X7R) in both peripheral and central trigeminal pain pathways contributes to ocular hyperalgesia and microglia activation in DED patients. The use of estrogen treatment further amplifies these effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Yan-Jia Luo, Jing Ge, Ze-Ka Chen, Zi-Long Liu, Michael Lazarus, Wei-Min Qu, Zhi-Li Hang, Ya-Dong Li
Summary: This study reveals that glutamatergic VP neurons control wakefulness and depressive-like behaviors through separated projections. Activation of VPVglut2 neurons increases wakefulness and induces anxiety/depressive-like behaviors, while inhibition attenuates these behaviors. Separate projections of VPVglut2 neurons to the lateral hypothalamus and lateral habenula promote arousal and depressive-like behaviors, respectively.
Article
Biochemistry & Molecular Biology
Vincent Yeung, Tancy C. Zhang, Ling Yuan, Mohit Parekh, John A. Cortinas, Eleni Delavogia, Audrey E. K. Hutcheon, Xiaoqing Guo, Joseph B. Ciolino
Summary: This study investigates the bidirectional communication between corneal epithelial cells and corneal stromal cells through extracellular vesicles (EVs). The researchers found that EVs released by corneal myofibroblasts can enhance corneal epithelial cell migration and proliferation. These findings may offer a novel therapeutic approach for corneal wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Mauricio Reyna-Jeldes, Erwin De la Fuente-Ortega, Daniela Cerda, Erandi Velazquez-Miranda, Katherine Pinto, Francisco G. Vazquez-Cuevas, Claudio Coddou
Summary: The study investigated the role of purinergic signaling in gastric cancer, revealing that the expression patterns of P2Y2R and P2X4R in GC cells are associated with cell proliferation, migration, and epithelial-mesenchymal transition (EMT).
Review
Biochemistry & Molecular Biology
Janielle P. Maynard, Karen S. Sfanos
Summary: P2 purinergic receptors play a crucial role in the normal function of the kidney, bladder, and prostate, as well as in various urologic disorders. Dysregulation of these receptors is associated with disease initiation and progression. Additionally, these receptors are overexpressed in urologic cancers and have potential as therapeutic targets. Exploring the role of P2 purinergic receptors in urologic diseases can provide new mechanistic insights and potential treatment options.
PURINERGIC SIGNALLING
(2022)
Article
Biotechnology & Applied Microbiology
Nima Saeidi, Xiaoqing Guo, Audrey E. K. Hutcheon, Edward A. Sander, Shyam Sundar Bale, Suzanna A. Melotti, James D. Zieske, Vickery Trinkaus-Randall, Jeffrey W. Ruberti
BIOTECHNOLOGY AND BIOENGINEERING
(2012)
Review
Ophthalmology
Mary Ann Stepp, James D. Zieske, Vickery Trinkaus-Randall, Briana M. Kyne, Sonali Pal-Ghosh, Gauri Tadvalkar, Ahdeah Pajoohesh-Ganji
EXPERIMENTAL EYE RESEARCH
(2014)
Review
Cell Biology
Cheryl Chi, Vickery Trinkaus-Randall
JOURNAL OF CELLULAR PHYSIOLOGY
(2013)
Article
Multidisciplinary Sciences
Courtney Mankus, Celeste Rich, Martin Minns, Vickery Trinkaus-Randall
Article
Anatomy & Morphology
Obianamma E. Onochie, Anwuli J. Onyejose, Celeste B. Rich, Vickery Trinkaus-Randall
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Yoonjoo Lee, Min Tae Kim, Garrett Rhodes, Kelsey Sack, Sung Jun Son, Celeste B. Rich, Vijaya B. Kolachalama, Christopher Gabel, Vickery Trinkaus-Randall
Article
Oncology
Garrett Rhodes, Kristen L. Segars, Yoonjoo K. Lee, Audrey E. K. Hutcheon, Celeste B. Rich, Vickery Trinkaus-Randall
Summary: The study showed that the interaction between pannexin1 and P2X7 is altered in pretype 2 diabetic tissue, and pannexin1 plays a role in the healing response. The irregular cell morphology and reduced cell-cell communication in DiO tissue suggest the importance of pannexin1 in the coordinated movement of epithelial sheets during wound healing.
ANALYTICAL CELLULAR PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ruiyi Ren, Anne A. Humphrey, David L. Swain, Haiyan Gong
Summary: This study investigated the relationship between intraocular pressure (IOP) and effective filtration area (EFA) in a mouse model of steroid-induced ocular hypertension. The researchers found that a reduction in EFA correlated with an increase in IOP, suggesting that morphological changes in the trabecular meshwork contribute to elevated IOP in this model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Biochemistry & Molecular Biology
Lijuan Xu, Xinyao Zhang, Yang Cao, Yin Zhao, Juan Gu, Wenqing Ye, Xiaojie Wang, Jinxin Li, Ruiyi Ren, Yuanbo Liang
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2023)
Article
Ophthalmology
Ruiyi Ren, Guorong Li, Thuy Duong Le, Casey Kopczynski, W. Daniel Stamer, Haiyan Gong
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2016)
Article
Ophthalmology
Chen-Yuan Charlie Yang, Ye Liu, Zhaozeng Lu, Ruiyi Ren, Haiyan Gong
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2013)
Article
Ophthalmology
Dimitrios Karamichos, Celeste B. Rich, Ramin Zareian, Audrey E. K. Hutcheon, Jeffrey W. Ruberti, Vickery Trinkaus-Randall, James D. Zieske
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2013)
Article
Biochemistry & Molecular Biology
Courtney Mankus, Cheryl Chi, Celeste Rich, Ruiyi Ren, Vickery Trinkaus-Randall