Editorial Material
Neurosciences
Jeffrey F. DiBerto, Bryan L. Roth
Summary: Psilocybin has been shown to have potentially rapid and enduring antidepressant effects. A study in Neuron demonstrates that psilocybin quickly induces dendritic spine formation in cortical layer V pyramidal neurons, providing a potential cellular mechanism for its therapeutic actions.
Article
Clinical Neurology
Xin Ding, Hai-Bo Zhang, Hui Qiu, Xin Wen, Long-zhen Zhang
Summary: Young rats showed cognitive deficits and morphological changes in dendritic spines at both 1 and 3 months postirradiation. Significant reductions in spine density were observed in the DG at both time points, as well as a decrease in spine density in the basal dendrites of CA1 neurons only at 1 month postirradiation. Dynamic changes in spine morphology were found to persist 3 months following cranial irradiation.
CHILDS NERVOUS SYSTEM
(2022)
Article
Biochemistry & Molecular Biology
Ju Hwan Kim, Kyung Hwun Chung, Yeong Ran Hwang, Hye Ran Park, Hee Jung Kim, Hyung-Gun Kim, Hak Rim Kim
Summary: Exposure to radiofrequency electromagnetic fields (RF-EMFs) may lead to a reduction in dendritic spine number in hippocampal neurons, decreased expression of glutamate receptors in mushroom-type dendritic spines, and lower BDNF expression. RF-EMF exposure during early developmental stages in mice may decrease overall synaptic density and affect memory function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Shou-Zen Fan, Chih-Wei Sung, Yi-Hsuan Tsai, Sheng-Rong Yeh, Wei-Sheng Lin, Pei-Yu Wang
Summary: The reduced expression of the Indy gene has been shown to extend lifespan in Caenorhabditis elegans and Drosophila melanogaster, as well as improve the metabolic health of Mus musculus by inducing a physiological status similar to dietary restriction. The deletion of the mammalian Indy gene (mIndy, SLC13A5) in mice significantly enhances memory performance and motor coordination, similar to what is observed in animals under dietary restriction. Tissue-specific deletion of mIndy in the nervous system is sufficient to improve memory performance, indicating a critical role for brain-derived mIndy expression in regulating memory function.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Cell Biology
Shou-Zen Fan, Cheng-Sheng Lin, Yu-Wen Wei, Sheng-Rong Yeh, Yi-Hsuan Tsai, Andrew Chengyu Lee, Wei-Sheng Lin, Pei-Yu Wang
Summary: The study shows that dietary supplementation with citrate can reduce energy status and extend lifespan in fruit flies, with implications on AMPK, TOR, and ketogenesis at the molecular level. Additionally, mice fed a high-fat diet supplemented with citrate or β-OHB demonstrate improved metabolic health and memory. These findings suggest that dietary citrate supplementation may be a beneficial intervention for age-related dysfunction in the future.
Review
Biochemistry & Molecular Biology
Ewa Baczynska, Katarzyna Karolina Pels, Subhadip Basu, Jakub Wlodarczyk, Blazej Ruszczycki
Summary: This article reviews experimental approaches designed to assess quantitative features of dendritic spines under physiological stimuli and in pathological conditions. By comparing various methodological pipelines and systematically summarizing the methodology and results of relevant experiments, the focus is on quantitative data regarding the number of animals, cells, dendritic spines, types of studied parameters, size of observed changes, and their statistical significance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Parisa Yarmohammadi-Samani, Hamid Taghipourbibalan, Jafar Vatanparast
Summary: The study found that prolonged sensory deprivation led to significant differences in behavior and spatial memory in female SD rats, while working memory errors increased in both sexes of SD rats. Additionally, there were sex-dependent variations in neuronal structure and synapse numbers in SD rats.
Article
Neurosciences
Audrey J. Weber, Ashley B. Adamson, Kelsey M. Greathouse, Julia P. Andrade, Cameron D. Freeman, Jung Vin Seo, Rosaria J. Rae, Courtney K. Walker, Jeremy H. Herskowitz
Summary: The researchers generated ROCK2(fl/fl) mice and found that Cre/ROCK2(fl/fl) mice exhibited anxiety-like behaviors. Different spine density and morphology were observed in CA1 hippocampus, mPFC, and BLA among the mice.
Article
Engineering, Multidisciplinary
YuWei Cao, Chun Shen, Hu Qiu, WanLin Guo
Summary: Dendritic spines receive synaptic inputs and play a crucial role in initiating dendritic NMDA spikes and action potentials. The number and morphology of spines constantly change during learning and memory processes. This study investigates the influence of spine number and morphology on dendritic NMDA spikes and reveals that the threshold number of spines differs between distal and proximal dendrites due to differences in impedance. Additionally, the presence of more AMPA receptors on spines leads to larger NMDA spikes. The findings highlight the importance of the dynamic distribution of spine number and morphology in neurodegenerative diseases.
SCIENCE CHINA-TECHNOLOGICAL SCIENCES
(2023)
Article
Virology
Wei Yao, Ping Zhou, Qiujin Yan, Xiulin Wu, Yaru Xia, Wenshi Li, Xuhang Li, Fan Zhu
Summary: Human endogenous retroviruses (HERVs) are remnants of ancestral germline infections by exogenous retroviruses. In this study, ERVWE1 was found to change the density and morphology of dendritic spines in schizophrenia through inhibiting the Wnt/c-Jun N-terminal kinases non-canonical pathway via miR-141-3p. miR-141-3p, Wnt5a, and Arp2 may serve as potential clinical blood-based biomarkers or therapeutic targets for schizophrenia.
Article
Neurosciences
Li Cheng, Yanfang Su, Kaining Zhi, Yaru Xie, Chun Zhang, Xianfang Meng
Summary: This study reveals the essential role of MAD2B in regulating learning and memory. Conditional knockout of MAD2B improves the learning and memory abilities in mice and increases the number of neurons in the hippocampus and cerebral cortex.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Jan A. Knobloch, Gilles Laurent, Marcel A. Lauterbach
Summary: This study used superresolution STED microscopy to explore the shape and distribution characteristics of dendritic spines in the turtle cortex. The results showed that dendritic spines can be classified into several distinguishable shape categories, and spines of a given category are not randomly distributed, but rather appear more frequently on certain dendrites. Additionally, significant inter-dendrite differences in parameters such as spine density and length were observed.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jing Dong, Hui Fu, Yuanyuan Fu, Mingdan You, Xudong Li, Chaonan Wang, Kunkun Leng, Yuan Wang, Jie Chen
Summary: Exposure to DEHP during pregnancy can impair hippocampal synaptic plasticity in male offspring, affecting synaptic structure and dendritic spine development, possibly through the downregulation of the Rac1/PAK/LIMK1/cofilin signaling pathway. Female offspring did not show these alterations in hippocampal structure.
ACS CHEMICAL NEUROSCIENCE
(2021)
Review
Neurosciences
Akiko Tabuchi, Daisuke Ihara
Summary: Accumulating evidence suggests that MKL/MRTF plays critical roles in various physiological and pathological processes in different cell types. These molecules translocate from the cytoplasm to the nucleus in association with actin rearrangement, regulating gene expression and cell motility. In the nervous system, MKL/MRTF is highly expressed in the brain, especially at synapses, influencing dendritic complexity and spine maturation.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Courtney K. Walker, Kelsey M. Greathouse, Benjamin D. Boros, Emily H. Poovey, Kelsey R. Clearman, Raksha Ramdas, Hamad M. Muhammad, Jeremy H. Herskowitz
Summary: This study combined cell and biochemical analyses of the Tau P301S mouse line (PS19) and observed changes in synaptic tau protein levels and dendritic spine morphology in response to age and hyperphosphorylated tau accumulation. The research revealed brain region-specific alterations in dendritic spine density and morphology in PS19 mice, indicating a possible spine remodeling in response to tau accumulation and age.
Article
Pharmacology & Pharmacy
Kavita Gulati, Ayanabha Chakraborti, Arunabha Ray
CURRENT PHARMACEUTICAL DESIGN
(2015)
Article
Biology
Antino R. Allen, Jacob Raber, Ayanabha Chakraborti, Sourabh Sharma, John R. Fike
RADIATION RESEARCH
(2015)
Article
Behavioral Sciences
Jacob Raber, Antino R. Allen, Sydney Weber, Ayanabha Chakraborti, Sourabh Sharma, John R. Fike
BEHAVIOURAL BRAIN RESEARCH
(2016)
Article
Behavioral Sciences
Ayanabha Chakraborti, Kavita Gulati, Arunabha Ray
BEHAVIOURAL BRAIN RESEARCH
(2008)
Article
Pharmacology & Pharmacy
Ayanabha Chakraborti, Kavita Gulati, Arunabha Ray
EUROPEAN JOURNAL OF PHARMACOLOGY
(2011)
Article
Biology
Antino R. Allen, Kirsten Eilertson, Ayanabha Chakraborti, Sourabh Sharma, Jennifer Baure, Julian Habdank-Kolaczkowski, Barrett Allen, Susanna Rosi, Jacob Raber, John R. Fike
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Tanzeel Ahmed, Ashok K. Tripathi, Rafat S. Ahmed, Shukla Das, Sanvidhan G. Suke, Rahul Pathak, Ayanabha Chakraboti, Basu Dev Banerjee
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2008)
Article
Biochemistry & Molecular Biology
Ayanabha Chakraborti, Kavita Gulati, Arunabha Ray
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2014)
Article
Behavioral Sciences
Kavita Gulati, Ayanabha Chakraborti, Arunabha Ray
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2009)
Article
Chemistry, Medicinal
Rafat S. Ahmed, Sanvidhan G. Suke, Vandana Seth, Ayanahha Chakrahorti, Ashok K. Tripathi, Basu D. Banerjee
PHYTOTHERAPY RESEARCH
(2008)
Article
Multidisciplinary Sciences
Yani Zou, Rikki Corniola, David Leu, Aslam Khan, Peyman Sahbaie, Ayanabha Chakraborti, David J. Clark, John R. Fike, Ting-Ting Huang
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2012)
Article
Biology
Jacob Raber, Susanna Rosi, Ayanabha Chakraborti, Kelly Fishman, Catherine Dayger, Matthew J. Davis, Laura Villasana, John R. Fike
RADIATION RESEARCH
(2011)
Review
Biochemistry & Molecular Biology
Basu Dev Banerjee, Ayanabha Chakraborti, Sanvidhan G. Suke, Rafat S. Ahmed, A. K. Tripathi
INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS
(2008)
Article
Behavioral Sciences
Ayanabha Chakraborti, Kavita Gulati, Basu Dev Banerjee, Arunabha Ray
BEHAVIOURAL BRAIN RESEARCH
(2007)