Article
Biochemistry & Molecular Biology
Celine Baron-Menguy, Arnaud Bocquet, Alexis Richard, Anne-Laure Guihot, Bertrand Toutain, Pierre Pacaud, Celine Fassot, Gervaise Loirand, Daniel Henrion, Laurent Loufrani
Summary: The study found that sildenafil can enhance revascularization after ischemia, improve tissue blood flow and promote arteriogenesis. These effects are associated with the activation of PI3K, Akt, and eNOS, but not with VEGF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Ziyi Chen, Meng Zhang, Yufeng Liu, Zhe Chen, Ling Wang, Wenjuan Wang, Jincheng Wang, Mingqian He, Bingyin Shi, Yue Wang
Summary: In this study, it was found that VEGF-A enhances the cytotoxicity of CD4 CTLs through the VEGF-R1/VEGF-R2/AKT/mTOR pathway. These findings provide insights for the development of novel treatments for disorders associated with CD4 CTLs.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Elle Koivunotko, Jasmi Snirvi, Arto Merivaara, Riina Harjumaki, Swarna Rautiainen, Minna Kelloniemi, Kirsi Kuismanen, Susanna Miettinen, Marjo Yliperttula, Raili Koivuniemi
Summary: Adipose-derived mesenchymal stromal cells (ASCs) hold great potential for cellular therapies and can differentiate into endothelial cells (ECs) and other angiogenic cell types. Nanofibrillated cellulose (NFC) hydrogel is a suitable matrix for 3D cell culture of ASCs and can stimulate angiogenesis. This study recommends the use of NFC hydrogel as an animal-free biomaterial scaffold for therapeutic angiogenesis and other cell therapy purposes.
Article
Biochemistry & Molecular Biology
Ning Wang, Cheng Zhang, Yu Xu, Hor-Yue Tan, Haiyong Chen, Yibin Feng
Summary: The study demonstrated that berberine can decelerate the progression of diabetic retinopathy by inhibiting insulin-induced neovascularization of retinal endothelial cells. In both experimental type I and type II diabetic mice, berberine effectively suppressed the expression of HIF-1 alpha and VEGF, improving diabetic retinopathy under insulin treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Polymer Science
Ana C. Manjua, Joaquim M. S. Cabral, Frederico Castelo Ferreira, Carla A. M. Portugal
Summary: This work demonstrates the ability to remotely control the paracrine performance of MSCs in secreting VEGF-A by modulation of an external magnetic field. Higher magnetic field intensity is associated with increased cell death and poor angiogenic effect. Dynamic magnetic field and higher frequency stimulation improve the angiogenic performance of endothelial cells.
Article
Multidisciplinary Sciences
S. T. Tsikis, S. C. Fligor, T. I. Hirsch, A. Pan, L. J. Yu, H. Kishikawa, M. M. Joiner, P. D. Mitchell, M. Puder
Summary: This study using an LPS-induced disease model reveals the long-term pulmonary functional outcomes of acute lung injury (ALI) and identifies angiogenic proteins as potential therapeutic targets following lung injury.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Shuang Song, Guanhua Zhang, Xutao Chen, Jian Zheng, Xiangdong Liu, Yiqing Wang, Zijun Chen, Yuxi Wang, Yingliang Song, Qin Zhou
Summary: This study demonstrates that overexpression of HIF-1a in adipose-derived stem cells (ADSCs) promotes their biological functions and enhances the angiogenic ability of human umbilical vein endothelial cells (HUVECs). Additionally, HIF-1a overexpression in ADSCs improves bone remodeling and osseointegration around titanium implants. It was also confirmed that HIF-1a promotes osteogenic differentiation and biological functions in ADSCs through the VEGF/AKT/mTOR pathway.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Ana C. Manjua, Joaquim M. S. Cabral, Carla A. M. Portugal, Frederico Castelo Ferreira
Summary: This study demonstrates the use of external magnetic fields to stimulate mesenchymal stromal cells (MSCs) and increase the production of vascular endothelial growth factor-A (VEGF-A). The magnetic stimulation significantly enhances MSCs angiogenic potential and guides their morphology and alignment, leading to an increase in new vessel formation in both in vitro and in vivo models. Ultimately, this research reveals the potential to manipulate cellular processes through short-term magnetic stimulation.
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
(2021)
Article
Immunology
Shimaa Khaled, Rania R. Abdelaziz, Ghada M. Suddek, Sally L. Elshaer
Summary: This study evaluates the angiogenic potential of candesartan, an angiotensin-II receptor blocker, in an experimental model of vascular complications associated with type-2 diabetes. The results demonstrate that candesartan is able to reverse ischemic insult and induce reparative angiogenesis in diabetic rats with peripheral arterial diseases. This finding could pave the way for the therapeutic use of candesartan in diabetic patients experiencing vascular complications in clinical settings.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mingming Yan, Lei Cai, Xin Duan, Muhammad Farooq Rai
Summary: Evidence suggests that KIF26B regulates the differentiation of stromal cells into adipocytes and plays a role in the development of obesity. Loss of KIF26B leads to reduced adipogenic differentiation and altered cell cycle progression, potentially through PPARg and AKT/mTOR signaling pathways.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Nutrition & Dietetics
Minseo Kwon, Yerin Kim, Jihye Lee, John A. Manthey, Yang Kim, Yuri Kim
Summary: Neohesperidin dihydrochalcone (NHDC) and its derivative NHDC-O-glycoside (GNHDC) can inhibit obesity and lipid accumulation through regulating multiple pathways.
Article
Biochemistry & Molecular Biology
Nicolo Costantino Brembilla, Ali Modarressi, Dominik Andre-Levigne, Estelle Brioudes, Florian Lanza, Hubert Vuagnat, Stephane Durual, Laurine Marger, Wolf-Henning Boehncke, Karl-Heinz Krause, Olivier Preynat-Seauve
Summary: This study evaluates the influence of a gelatin sponge on adipose-derived stromal cells (ASC). The results show that the gelatin sponge strongly influences the transcriptome of ASC and acted as a concentrator and reservoir of the regenerative ASC secretome. The gelatin sponge also increased angiogenesis in vivo and promoted wound healing.
Article
Oncology
Michael Doyle, Noor Kwami, Jaitri Joshi, Lisa M. Arendt, Jessica Mccready
Summary: Breast cancer diagnosed during pregnancy and lactation (pregnancy-associated breast cancer, PABC) is more aggressive and has a decreased survival rate compared to breast cancers diagnosed at other stages in life. Previous research indicates that developmental changes to the fat cells in the mammary gland in lactation increase blood vessel growth within tumors. This study aimed to determine if other cells within the tumor contribute to PABC aggressiveness. The findings indicate that tumor cells transplanted with fat cells isolated during lactation increase inflammatory cells called macrophages and promote tumor cell growth in the mammary glands of mice.
Article
Immunology
Xinsheng Xu, Lihua Cui, Lanqiu Zhang, Lei Yang, Yuzhen Zhuo, Caixia Li
Summary: The study found that Saikosaponin d (SSd) can inhibit the tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC), especially by suppressing macrophage polarization. SSd can regulate immune cells, reduce the degree of M2 macrophage polarization, and reactivate the local immune response by downregulating phosphorylated STAT6 levels and the PI3K/AKT/mTOR signaling pathway. The results suggest that SSd may be a potential therapeutic agent for PDAC.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Swarna Rautiainen, Timo Laaksonen, Raili Koivuniemi
Summary: Adipose-derived mesenchymal stem/stromal cells (ASCs) are a promising option for therapeutic angiogenesis, as they can promote blood vessel formation. Co-culturing ASCs with ECs can improve the formation of functional vessels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Qiaojun Qu, Huilong Nie, Shuang Hou, Feng Wang, Kunshan He, Panxia Deng, Shangqiu Chen, Zeyu Zhang, Chongwei Chi, Zhenhua Hu, Hong Shan, Jie Tian
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Biochemical Research Methods
Lishuang Guo, Meishan Cai, Xiaoning Zhang, Zeyu Zhang, Xiaojing Shi, Xiaojun Zhang, Jiangang Liu, Zhenhua Hu, Jie Tian
Summary: This study explored a novel weighted auxiliary set matching pursuit (WASMP) method to enhance the accuracy of CLT reconstruction. The experiments showed that the WASMP method achieved superior performance in terms of positional accuracy and shape recovery.
JOURNAL OF BIOPHOTONICS
(2022)
Article
Computer Science, Interdisciplinary Applications
Yaxin Shang, Zechen Wei, Hui Hui, Xiaohu Li, Liang Li, Yongqiang Yu, Ligong Lu, Li Li, Hongjun Li, Qi Yang, Meiyun Wang, Meixiao Zhan, Wei Wang, Guanghao Zhang, Xiangjun Wu, Li Wang, Jie Liu, Jie Tian, Yunfei Zha
Summary: Automatic segmentation of infected regions is essential for the diagnosis and assessment of COVID-19 pneumonia. In this study, a two-stage hybrid UNet method is proposed, which achieves accurate segmentation of infected regions. Furthermore, a 3D-ResNet model is trained for COVID-19 pneumonia screening. The results show that the proposed approach performs well in various evaluation metrics and can serve as an efficient assisting tool for radiologists in COVID-19 diagnosis from CT images.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2022)
Article
Computer Science, Artificial Intelligence
Liwen Zhang, Lianzhen Zhong, Cong Li, Wenjuan Zhang, Chaoen Hu, Di Dong, Zaiyi Liu, Junlin Zhou, Jie Tian
Summary: This study proposes a novel approach for predicting the overall survival risk of human cancer patients based on CT images. By using a multi-task network with tailored attention modules, the method improves the accuracy of OS risk prediction and achieves good results in clinical stage prediction.
Article
Oncology
Xiaojun Zeng, Wen Zhu, Wenjun Lin, Jie Tian, Jian Yang, Chihua Fang
Summary: This article introduces the feasibility of laparoscopic extended right posterior sectionectomy and related methods, and demonstrates that virtual liver segment projection and ICG fluorescence imaging can improve the accuracy of the surgery.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Xiaojun Zeng, Wen Zhu, Wenjun Lin, Jie Tian, Jian Yang, Chihua Fang
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Jingbo Wang, Siyi Li, Kun Wang, Ling Zhu, Lin Yang, Yunjing Zhu, Zhen Zhang, Longwei Hu, Yuan Yuan, Qi Fan, Jiliang Ren, Gongxin Yang, Weilong Ding, Xiaoyu Zhou, Junqi Cui, Chunye Zhang, Ying Yuan, Ruimin Huang, Jie Tian, Xiaofeng Tao
Summary: Real-time fluorescence imaging can improve the detection rate of tumor margins in oral squamous cell carcinoma (SCC) patients. The feasibility of using c-MET-binding peptide-indocyanine green (cMBP-ICG) for intraoperative detection of tumor margins was evaluated in a clinical trial. The application of cMBP-ICG showed high sensitivity and moderate specificity in detecting tumor margins in oral SCC patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Changjian Li, Jiahui Mi, Yueqi Wang, Zeyu Zhang, Xiaoyong Guo, Jian Zhou, Zhenhua Hu, Jie Tian
Summary: Fast identification of tumor area is crucial during lung cancer surgery. This study developed a new technology using fluorescent probes to define tumor boundaries and distinguish metastatic lymph nodes, thus improving surgical accuracy.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiangjun Wu, Bingxi He, Pengli Gao, Peng Zhang, Yaxin Shang, Liwen Zhang, Jing Zhong, Jingying Jiang, Hui Hui, Jie Tian
Summary: This article proposes a deep learning method to address the sparse-view reconstruction problem in projection MPI. By constructing a simulated data set and using novel projections generated by a projection generative network (PGNet), the temporal resolution of 3D imaging in projection MPI is improved while suppressing streaking artifacts.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yueqi Wang, Changjian Li, Jiaming Zhuo, Hui Hui, Bing Zhou, Jie Tian
Summary: This study presents a dual-reaction fluorescent probe named DR-1, which visualizes Fe(II) and ROS simultaneously, offering great potential to explore the mechanism of ferroptosis both in vitro and in vivo.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Review
Chemistry, Analytical
Xiaohua Jia, Guodong Shen, Jia Jia, Yan Zhang, Dan Zhang, Wanjun Li, Jianjun Zhang, Xinglu Huang, Jie Tian
Summary: This article introduces the importance of cancer stem cells and the method of lineage tracing, as well as the application of molecular imaging in the dynamic detection of cancer stem cells. The article analyzes the current situation and looks forward to the future development of cancer stem cell detection.
Article
Oncology
Bao Li, Fengling Li, Zhenyu Liu, FangPing Xu, Guolin Ye, Wei Li, Yimin Zhang, Teng Zhu, Lizhi Shao, Chi Chen, Caixia Sun, Bensheng Qiu, Hong Bu, Kun Wang, Jie Tian
Summary: This study aimed to explore the predictive information for pCR from WSIs in breast cancer patients. The study found that the WSI feature-based DLPM showed good predictive performance and combining it with clinical characteristics improved the prediction performance. The study also found that DLPM performed best in predicting the TNBC subtype and achieved the highest prediction performance when combined with clinical characteristics and stromal TILs in the primary and validation cohorts.
Article
Oncology
Zeyu Zhang, Cheng Fang, Yang Zhang, Song Su, Bo Li, Gang Liu, Zhenhua Hu, Jie Tian
Summary: The application of the nano-scale probe IgG-IRDye800CW allows for precise resection of hepatic carcinoma in patients with cirrhosis. Near-infrared window II (NIR-II) fluorescence imaging can detect HCC lesions and provide clear surgical margins, improving surgical precision.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Chemistry, Analytical
Chen Wei, Shenghan Ren, Kaitai Guo, Haihong Hu, Jimin Liang
Summary: In this study, a high-resolution Swin Transformer network (HRSTNet) is proposed for medical image segmentation. The HRSTNet replaces convolutional layers with Transformer blocks and continuously exchanges feature map information with different resolutions. Experimental results demonstrate that the HRSTNet achieves comparable performance with the state-of-the-art Transformer-based U-Net-like architecture on multiple medical image datasets.
Article
Computer Science, Artificial Intelligence
Chen Wei, Chuang Niu, Yiping Tang, Yue Wang, Haihong Hu, Jimin Liang
Summary: This article introduces a neural predictor guided evolutionary algorithm to enhance the exploration ability of neural architecture search (NAS) and designs two types of neural predictors. Experimental results indicate that this method achieves good performance in NAS tasks.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)