Article
Mathematics
Svetoslav G. Nikolov, Olaf Wolkenhauer, Momchil Nenov, Julio Vera
Summary: In this paper, a four-dimensional ordinary differential equation (ODE) model representing the main interactions between Sox9, Sox10, Olig2 and several miRNAs in the process of oligodendrocyte differentiation is derived. The dynamical properties of the model are analyzed using the Lyapunov-Andronov theory.
Article
Biochemistry & Molecular Biology
Yilin Han, Marianne King, Evgenii Tikhomirov, Povilas Barasa, Cleide Dos Santos Souza, Jonas Lindh, Daiva Baltriukiene, Laura Ferraiuolo, Mimoun Azzouz, Maurizio R. Gullo, Elena N. Kozlova
Summary: The study aims to determine the survival and differentiation of boundary cap neural crest stem cells (BC) in gelatin-based 3D bioprinted bioink scaffolds for the fabrication of spinal cord organoids on a chip. The gelatin-based and enzymatically cross-linked hydrogel was found to be a suitable bioink for building a multicellular, bioprinted spinal cord organoid, but further measures are needed to achieve uniform neural differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Yangyang Cao, Le Li, Zhipeng Fan
Summary: This review summarizes the important role of Polycomb repressive complex 2 (PRC2) in the differentiation of stem cells into osteoblasts or neurocytes, revealing its core subunits, variants, potential functions, and interaction mechanisms with other molecules.
CELL PROLIFERATION
(2021)
Review
Cell & Tissue Engineering
Cong Zhao, Wen Xie, Hecheng Zhu, Ming Zhao, Weidong Liu, Zhaoping Wu, Lei Wang, Bin Zhu, Shasha Li, Yao Zhou, Xingjun Jiang, Qiang Xu, Caiping Ren
Summary: Stem cells are unique cells with the ability to self-renew and differentiate into various functional cells. Recent studies have revealed the crucial roles of long non-coding RNAs (lncRNAs) and RNA-binding proteins (RBPs) in the self-renewal and differentiation of stem cells. This review summarizes the functions of lncRNAs and their RBPs in determining the fate of stem cells, focusing on their involvement in epigenetic regulation, signaling pathway regulation, splicing, mRNA stability, and subcellular localization. Understanding the regulatory mechanisms of lncRNAs and RBPs will contribute to the development of clinical regenerative medicine.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Chemistry, Multidisciplinary
Krishna Deo Sharma, Karrer M. Alghazali, Rabab N. Hamzah, Sahitya Chetan Pandanaboina, Zeid A. Nima Alsudani, Malek Muhi, Fumiya Watanabe, Guo-Lei Zhou, Alexandru S. Biris, Jennifer Yanhua Xie
Summary: This study found that functionalized gold nanorods (AuNRs) can promote the differentiation of rat fetal neural stem cells (NSCs) into oligodendrocytes (ODCs), and showed better results compared to poly-D-lysine (PDL) coated surface.
Article
Biochemistry & Molecular Biology
Sarbani Saha, Rumela Bose, Shreeta Chakraborty, Rupasri Ain
Summary: This study reveals the essential role of Cox6B2 in maintaining the stemness of trophoblast stem cells and its regulation by various factors including other genes and microRNAs. These findings have important implications for understanding stem cell biology and placental growth.
Article
Cell Biology
Ki-Youb Park, Sekyung Kim, Man Su Kim
Summary: Taxol has a significant impact on neural stem cells from the mouse neurogenic region, leading to decreased proliferation and neuronal differentiation, while not affecting astrocyte differentiation. It may interfere with neurogenesis through disturbance in the cell cycle and eliminate differentiated oligodendrocytes.
Article
Multidisciplinary Sciences
Joachim Hanna, Flavio Beke, Louise M. O'Brien, Chrysa Kapeni, Hung-Chang Chen, Valentina Carbonaro, Alexander B. Kim, Kamal Kishore, Timon E. Adolph, Mikkel-Ole Skjoedt, Karsten Skjoedt, Marc de la Roche, Maike de la Roche
Summary: The study implicates Hedgehog signaling in Th17 polarization and intestinal immunopathology, suggesting the potential therapeutic use of Hedgehog inhibitors in the treatment of inflammatory bowel disease.
NATURE COMMUNICATIONS
(2022)
Review
Cell Biology
Robin J. M. Franklina, Jonas Frisen, David A. Lyons
Summary: The biology of CNS remyelination has attracted interest due to its potential for regenerative therapies. Recent studies have identified two modes of remyelination, raising questions for future research.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Xueyue Wang, Yan Ruan, Junlei Zhang, Yanping Tian, Lianlian Liu, JiaLi Wang, Gaoke Liu, Yuda Cheng, Yixiao Xu, Yi Yang, Meng Yu, Binyu Zhao, Yue Zhang, Jiaqi Wang, Jiangjun Wang, Wei Wu, Ping He, Lan Xiao, Jiaxiang Xiong, Rui Jian
Summary: The study identifies two Yap splicing isoforms in ESCs with different distributions and effects on self-renewal and differentiation potential, with Yap472 playing a more essential role in neuroectoderm differentiation.
Article
Biochemistry & Molecular Biology
Xiang Zhao, Bethany N. Radford, Mark Ungrin, Wendy Dean, Myriam Hemberger
Summary: Normal developmental progression relies on close interactions between the embryonic and extraembryonic lineages in the pre- and peri-gastrulation stage conceptus. Trophoblast cells of the extraembryonic ectoderm play a role in delaying cardiomyocyte differentiation dynamics and prolonging pluripotency in embryonic stem cells (ESCs). These findings provide insights into the intricate crosstalk between different compartments of the early conceptus and have implications for synthetic embryo research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Fabian L. Cardenas-Diaz, Derek C. Liberti, John P. Leach, Apoorva Babu, Jonathan Barasch, Tian Shen, Maria A. Diaz-Miranda, Su Zhou, Yun Ying, Danielle A. Callaway, Michael P. Morley, Edward E. Morrisey
Summary: By using single-cell transcriptomics, tissue damage segmentation, and mouse lineage tracing, we found that Tfcp2l1 is a regulator of lung alveolus regeneration. Loss of Tfcp2l1 inhibits self-renewal and enhances AT2-AT1 differentiation in adult AT2 cells. Tfcp2l1 temporally regulates AT2 self-renewal and differentiation in alveolar regions undergoing active regeneration.
Article
Cell & Tissue Engineering
Kee-Pyo Kim, Cui Li, Daria Bunina, Hyun-Woo Jeong, Julia Ghelman, Juyong Yoon, Borami Shin, Hongryeol Park, Dong Wook Han, Judith B. Zaugg, Johnny Kim, Tanja Kuhlmann, Ralf H. Adams, Kyung-Min Noh, Steven A. Goldman, Hans R. Schoeler
Summary: By transducing an optimized transcription factor combination into a permissive donor phenotype, pericyte-derived iOPCs (PC-iOPCs) can overcome the limitations of inefficient generation and limited expansion and differentiation competence. PC-iOPCs are stably expandable and functionally myelinogenic with high differentiation competence.
Article
Endocrinology & Metabolism
Yotam Harnik, Lisa Buchauer, Shani Ben-Moshe, Inna Averbukh, Yishai Levin, Alon Savidor, Raya Eilam, Andreas E. Moor, Shalev Itzkovitz
Summary: The study identified spatial discrepancies between enterocyte mRNA and protein levels in the intestinal epithelium, providing a spatial blueprint of proteins along the villi. Through spatial sorting and Bayesian methods, it was found that while many genes exhibit zonated proteins towards the villus tip, mRNA is zonated towards the villus bottom. Independent protein synthesis delays in space were shown to explain many mRNA-protein discordances.
Article
Chemistry, Multidisciplinary
Min Hao, Zixian Zhang, Chao Liu, Yue Tian, Jiazhi Duan, Jianlong He, Zhaoyang Sun, He Xia, Shan Zhang, Shuhua Wang, Yuanhua Sang, Guogang Xing, Hong Liu
Summary: In this study, it is demonstrated that hydroxyapatite (HAp) nanorods can regulate the neural differentiation of NSCs and lead to the differentiation of NSCs into mature neurons exhibiting well-defined electrophysiological behavior within 5 days. RNA-sequencing data also reveal that the neuroactive ligand-receptor interaction pathway is dominant in the enriched differentiated neuronal population.
ADVANCED MATERIALS
(2021)
Article
Multidisciplinary Sciences
Matthew C. Canver, Elenoe C. Smith, Falak Sher, Luca Pinello, Neville E. Sanjana, Ophir Shalem, Diane D. Chen, Patrick G. Schupp, Divya S. Vinjamur, Sara P. Garcia, Sidinh Luc, Ryo Kurita, Yukio Nakamura, Yuko Fujiwara, Takahiro Maeda, Guo-Cheng Yuan, Feng Zhang, Stuart H. Orkin, Daniel E. Bauer
Article
Hematology
Elenoe C. Smith, Sidinh Luc, Donyell M. Croney, Mollie B. Woodworth, Luciano C. Greig, Yuko Fujiwara, Minh Nguyen, Falak Sher, Jeffrey D. Macklis, Daniel E. Bauer, Stuart H. Orkin
Article
Multidisciplinary Sciences
Takeshi Masuda, Xin Wang, Manami Maeda, Matthew C. Canver, Falak Sher, Alister P. W. Funnell, Chris Fisher, Maria Suciu, Gabriella E. Martyn, Laura J. Norton, Catherine Zhu, Ryo Kurita, Yukio Nakamura, Jian Xu, Douglas R. Higgs, Merlin Crossley, Daniel E. Bauer, Stuart H. Orkin, Peter V. Kharchenko, Takahiro Maeda
Article
Medicine, Research & Experimental
Samuel Lessard, Emily Stern Gatof, Melissa Beaudoin, Patrick G. Schupp, Falak Sher, Adnan Ali, Sukhpal Prehar, Ryo Kurita, Yukio Nakamura, Esther Baena, Jonathan Ledoux, Delvac Oceandy, Daniel E. Bauer, Guillaume Lettre
JOURNAL OF CLINICAL INVESTIGATION
(2017)
Article
Biochemistry & Molecular Biology
Nan Liu, Victoria V. Hargreaves, Qian Zhu, Jesse V. Kurland, Jiyoung Hong, Woojin Kim, Falak Sher, Claudio Macias-Trevino, Julia M. Rogers, Ryo Kurita, Yukio Nakamura, Guo-Cheng Yuan, Daniel E. Bauer, Jian Xu, Martha L. Bulyk, Stuart H. Orkin
Article
Cell & Tissue Engineering
Falak Sher, Sandra Amor, Wouter Gerritsen, David Baker, Samuel L. Jackson, Erik Boddeke, Sjef Copray
CELL TRANSPLANTATION
(2012)
Article
Cell & Tissue Engineering
Falak Sher, Erik Boddeke, Sjef Copray
CELLULAR REPROGRAMMING
(2011)
Article
Clinical Neurology
Falak Sher, Veerakumar Balasubramaniyan, Erik Boddeke, Sjef Copray
CURRENT OPINION IN NEUROLOGY
(2008)
Review
Neurosciences
Sjef Copray, Jimmy Long Huynh, Falak Sher, Patrizia Casaccia-Bonnefil, Erik Boddeke
Article
Cell & Tissue Engineering
Falak Sher, Reinhard Rossler, Nieske Brouwer, Veerakumar Balasubramaniyan, Erik Boddeke, Sjef Copray
Article
Cell & Tissue Engineering
Falak Sher, Go van Dam, Erik Boddeke, Sjef Copray
Letter
Biochemical Research Methods
Jonathan Y. Hsu, Charles P. Fulco, Mitchel A. Cole, Matthew C. Canver, Danilo Pellin, Falak Sher, Rick Farouni, Kendell Clement, Jimmy A. Guo, Luca Biasco, Stuart H. Orkin, Jesse M. Engreitz, Eric S. Lander, J. Keith Joung, Daniel E. Bauer, Luca Pinello
Article
Genetics & Heredity
Falak Sher, Mir Hossain, Davide Seruggia, Vivien A. C. Schoonenberg, Qiuming Yao, Paolo Cifani, Laura M. K. Dassama, Mitchel A. Cole, Chunyan Ren, Divya S. Vinjamur, Claudio Macias-Trevino, Kevin Luk, Connor McGuckin, Patrick G. Schupp, Matthew C. Canver, Ryo Kurita, Yukio Nakamura, Yuko Fujiwara, Scot A. Wolfe, Luca Pinello, Takahiro Maeda, Alex Kentsis, Stuart H. Orkin, Daniel E. Bauer
Article
Biotechnology & Applied Microbiology
Vivien A. C. Schoonenberg, Mitchel A. Cole, Qiuming Yao, Claudio Macias-Trevino, Falak Sher, Patrick G. Schupp, Matthew C. Canver, Takahiro Maeda, Luca Pinello, Daniel E. Bauer