Article
Infectious Diseases
Noha M. M. Gamaleldin, Hebatallah S. S. Bahr, Yaser A. A. Mostafa, Bryant F. F. McAllister, Amr El Zawily, Che J. J. Ngwa, Gabriele Pradel, Hossam M. M. Hassan, Usama Ramadan Abdelmohsen, Dalal Hussien M. Alkhalifah, Wael N. N. Hozzein
Summary: This study described the actinomycetes associated with Red Sea soft coral and their potential as antimalarial agents. The extract derived from the ISP2 media showed the best antimalarial activity, while LC-HRMS metabolomics identified a range of alkaloids from the genus Rhodococcus. The docking analysis predicted the potential compounds that could be the source of the antimalarial potential.
Article
Chemistry, Organic
Saibin Zhu, Yeji Wang, Zhongqing Wen, Yanwen Duan, Yong Huang
Summary: The study revealed that Huanglongmycin congener 14 exhibited stronger cytotoxicity against tested cancer cells, and highlighted the critical role of the C-7 ethyl group of 14 in its binding to the DNA-topoisomerase I complex.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Imen Weslati, Luara Simoes, Ana Teixeira, Pier Parpot, Aly Raies, Rui Oliveira
Summary: Actinomycetes are capable of producing secondary metabolites with antimicrobial and antioxidant activities. Streptomyces sp. strain FR7 isolated from Raf Raf forest in Tunisia displayed high antimicrobial activity and strong DPPH radical scavenging activity. This strain has great potential as a source of antibacterial and antioxidant metabolites.
LETTERS IN APPLIED MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jing Liu, Fei Xia, Han Ouyang, Wei Wang, Te Li, Yutong Shi, Xiaojun Yan, Xia Yan, Shan He
Summary: Ten nardosinane-related terpenoids were isolated from the Xisha soft coral Lemnalia sp., including five new compounds and two unusual condensed nardosinanes. These compounds exhibited antimicrobial activity.
Article
Microbiology
Achiraya Somphong, Vasun Poengsungnoen, Kawinnat Buaruang, Chanwit Suriyachadkun, Paranee Sripreechasak, Somboon Tanasupawat, Wongsakorn Phongsopitanun
Summary: A total of 37 actinobacteria were isolated from lichen samples collected in Thailand, including a new species of the genus Streptomyces. The classification status of these strains was determined based on their cell composition and gene sequences.
ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY
(2022)
Article
Chemistry, Medicinal
Xia Yan, Han Ouyang, Wei Wang, Jing Liu, Te Li, Bin Wu, Xiaojun Yan, Shan He
Summary: Chemical investigation of the South China Sea soft coral Lemnalia sp. yielded 13 structurally diverse terpenoids, including some new compounds with antimicrobial and antiviral activities, as well as cytotoxic effects against cancer cells.
Article
Chemistry, Organic
Mingyu Liu, Pinglin Li, Xuli Tang, Xiangchao Luo, Kechun Liu, Yun Zhang, Qi Wang, Guoqiang Li
Summary: New rearranged nardosinane sesquiterpenoids with unique carbon skeletons were isolated from the soft coral Lemnalia sp. collected from Xisha Islands of the South China Sea. Compound 1 and 10 exhibited in vivo angiogenesis promoting activity, while compounds 3 and 4 showed antiviral activity against the H1N1 virus.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Omnia Hesham Abdelhafez, John Refaat Fahim, Ramy R. El Masri, M. Alaraby Salem, Samar Yehia Desoukey, Safwat Ahmed, Mohamed Salah Kamel, Sheila Marie Pimentel-Elardo, Justin R. Nodwell, Usama Ramadan Abdelmohsen
Summary: The study demonstrated the potential of Nephthea sp. as a source of anticancer compounds, with the n-butanol fraction showing strong inhibitory activities against breast and lung cancer cells, and biogenic AgNPs of the soft coral extract enhancing its anti-proliferative effects against lung and breast cancer cells. Metabolic profiling revealed structurally diverse terpenoids with binding affinities to target proteins, suggesting their contribution to the anti-proliferative properties of Nephthea sp. through tyrosine kinase inhibition.
Article
Chemistry, Applied
Mingyu Liu, Pinglin Li, Xiangchao Luo, Leen van Ofwegen, Xuli Tang, Guoqiang Li
Summary: Two new neolemnane-type sesquiterpenoids, lemnolins A and B, along with a known tricyclic sesquiterpenoid, were isolated from the South China Sea soft coral Lemnalia sp. Compound 1 exhibited antiviral activity against influenza A (H1N1) virus in vitro.
NATURAL PRODUCT RESEARCH
(2021)
Article
Computer Science, Information Systems
Sijia Jiang, Zijing Tan, Jiawei Wang, Zhikang Wang, Shuai Ma
Summary: Conditional functional dependencies (CFDs) generalize functional dependencies and have wide applicability. We propose an approach to discover CFDs that can detect errors in data, guided by a small set of erroneous attribute values labeled by users. The approach consists of data sampling, CFD discovery, refinement, and iteration, with novel efficient techniques to reduce user interactions. Extensive experimental evaluations are conducted to verify the approach.
INFORMATION SYSTEMS
(2023)
Article
Biochemistry & Molecular Biology
Kui Wang, Jing Liu, Jian Huang, Xue Leng, Te Li, Ouyang Han, Wenhan Lin, Xia Yan, Shan He
Summary: New sesquiterpenoids, sinulalides A and B, along with known terpenoids, were isolated from the soft coral Sinularia scabra in the South China Sea. The structures and stereochemistry of these compounds were determined through spectroscopic data analysis and computer-assisted methods. Sinulatones A and B exhibited inhibitory activity against osteoclast precursor cells in bioassays.
Article
Chemistry, Medicinal
You-Cheng Lin, Chi-Chien Lin, Yi-Chia Chu, Chung-Wei Fu, Jyh-Horng Sheu
Summary: Chemical investigation of the soft coral Cespitularia sp. led to the discovery of twelve new verticillane-type diterpenes and norditerpenes, as well as some sesquiterpenes, with promising anti-inflammatory activities. The structures of these metabolites were established by extensive spectroscopic analyses, including 2D NMR experiments.
Article
Biochemistry & Molecular Biology
Lan-Fang Li, Qing-Xuan Wu, Hao Wu, Yao Li, Qian Peng, Ren-Hao Han, Da-Hu Zhang, Wei-Dong Yu, Rui Xu, Juan Wang, Zhaobin Fan, Shao-Yang Hou
Summary: Streptomyces sp. HP-A2021, isolated from rhizosphere soil of Ginkgobiloba L., was found to harbor a wealth of cryptic secondary metabolite biosynthetic gene clusters. Genome sequencing and bioinformatics analysis revealed the presence of 33 secondary metabolite biosynthetic gene clusters, including the putative thiotetroamide, alkylresorcinol, coelichelin, and geosmin. Antibacterial activity assays confirmed that HP-A2021 showed potent antimicrobial activity against human pathogenic bacteria.
BIOCHEMICAL GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Xue Leng, Jing Liu, Xiao Han, Te Li, Han Ouyang, Xia Yan, Shan He
Summary: Chemical investigation of the Xisha soft coral Sarcophyton sp. has resulted in the discovery of eight cembrane-type diterpenoids, including three new compounds (sarcophynoids A-C) and five known analog compounds. Their structures were identified using spectroscopic analysis and computer-assisted methods. All compounds were tested for antibacterial activities, and compounds 4-7 and 8 showed antibacterial activity against S. aureus, B. subtilis, and P. aeruginosa, with MIC of 4-64 μg/mL.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Genetics & Heredity
Sam E. Williams, Catherine R. Back, Eleanor Best, Judith Mantell, James E. M. Stach, Tom A. Williams, Paul R. Race, Paul Curnow
Summary: A new strain of Streptomyces, designated A15ISP2-DRY2T, was isolated from the tissue of the deep-sea sponge Polymastia corticata collected at a depth of 1869 m from the Gramberg Seamount in the Atlantic Ocean. This strain has a considerable biosynthetic potential and showed antibacterial activity against drug-resistant human pathogens.
MICROBIAL GENOMICS
(2023)