Article
Biochemistry & Molecular Biology
Arkadiusz Borek, Robert Ekiert, Artur Osyczka
Summary: Cytochrome bc1 is a homodimer with both structural and functional similarity. Experiments based on cross-dimer mutated derivatives have implicated the role of inter-monomer electron transfer in catalysis. This study confirms the enzymatic origin of observed activities and their relevance in exploring conditions for inter-monomer electron transfer. However, the mechanistic and physiological significance of this equilibration is still unknown.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2023)
Article
Cell Biology
David Sherlock, Paul C. M. Fogg
Summary: GafA, a transcriptional regulator, controls gene expression of gene transfer agents (GTAs) by interacting with RNA polymerase omega subunit (Rpo-omega). It also autoregulates its own expression through a mechanism that is independent of Rpo-omega. This study provides a comprehensive regulatory model for GTAs and suggests an atypical mechanism for RNA polymerase recruitment and specific transcriptional activation in Alphaproteobacteria.
Article
Chemistry, Analytical
Yize Zhang, Yingyong Ni, Xuan Zhao, Ting Wang, Xiaojiao Zhu, Xianshun Sun, Sen Wang, Dandan Li, Junjun Wang, Hongping Zhou
Summary: This study presents a general design of tumor stimulus-activatable pretheranostic agents and successfully constructs a system for multimodal diagnostic and treatment of tumors. By targeting the overexpression of hypochlorite in tumors, three mechanisms including fluorescence, photothermal, and photoacoustic signals are activated, improving the accuracy and efficiency of treatment and diagnosis.
ANALYTICAL CHEMISTRY
(2023)
Article
Obstetrics & Gynecology
Lan N. Vuong
Summary: Freeze-all strategy has emerged as an alternative approach in in vitro fertilization (IVF) to reduce the negative effects of controlled ovarian stimulation. However, current studies have inconsistent results and a personalized approach should be taken based on individual patient characteristics and preference.
HUMAN REPRODUCTION
(2022)
Article
Computer Science, Interdisciplinary Applications
Pedro Gamito, Teresa Souto, Ana Rita Conde, Agata Salvador, Maria Jose Ferreira, Joao Alves de Sousa, Marco Ferreira, Fabio Dias, Shivani Atul, Rita Pereira, Edna Tavora, Ines Maia, Jorge Oliveira
Summary: This study investigates the role of unfamiliar synthetic agents (SyA) in promoting relaxation in a virtual environment. The results suggest that the presence of a non-familiar humanoid character in the virtual setting did not negatively influence the relaxation outcome, indicating that virtual-based relaxation interventions can be effective.
Article
Genetics & Heredity
Nawshin T. B. Alim, Sonja Koppenhofer, Andrew S. Lang, J. Thomas Beatty
Summary: This study investigated why Rhodobacter capsulatus strain 37b4 lacks recipient capability and found that it is because 37b4 strain is unable to bind with RcGTA. The reason for the inability to bind is that it lacks Capsular Polysaccharide (CPS), which is due to the absence of genes previously shown to be necessary for CPS production in another strain.
Article
Chemistry, Physical
Heqi Gao, Xinwen Qi, Jingtian Zhang, Nan Wang, Jingrui Xin, Di Jiao, Kaining Liu, Ji Qi, Yong Guan, Dan Ding
Summary: This study develops a smart one-for-all nanoagent that can optimize photophysical energy transformation and related phototheranostic properties through light-driven structure switch, holding great potential for multifunctional biomedical applications.
Article
Nanoscience & Nanotechnology
Su Gao, Shuangshuang Chen, Yangyang Liu, Hailei Mao, Qinghua Lu
Summary: The CIAH interface is a multifunctional platform that can capture CTCs, analyze cell subpopulations, and test drug responses, making it a promising tool for studying single-cell profiling and personalized anticancer therapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Physical
Jun Hee Jang, Insoo Ro, Phillip Christopher, Mahdi M. Abu-Omar
Summary: A bifunctional Pt-ReOx/C heterogeneous catalyst was used to achieve the one-step conversion of mucic acid to adipates with high yield using isopropanol as solvent and reductant. The catalyst is reusable and demonstrated a broad substrate scope for various diols, showcasing its potential for multifunctional catalysis in biomass-derived molecule valorization.
Article
Chemistry, Multidisciplinary
Lohith Kotte, Vinusha Pendota, Bojja Sreedhar, Jagadeesh Babu Nanubolu
Summary: The design and development of multicomponent systems in the salt-cocrystal continuum zone offer opportunities for selecting the right crystal form with desirable properties. A new multicomponent system between famciclovir and fumaric acid was investigated, resulting in the identification of three crystalline forms. The crystal structure analysis provided important insights into the ionization state of the complexes.
Article
Engineering, Electrical & Electronic
Christopher A. A. Bower, Brook Raymond, Christopher Verreen, Carl Prevatte, Salvatore Bonafede, Andrew Pearson, Nathan Rivers, Benjamin Keller, Tiffany Weeks, Brandon Trinh, Erik Vick, Erich Radauscher, Nikhil Jain, Miroslav Samarskiy, Matthew A. Meitl
Summary: This paper reviews the application of transfer printing in the development of microLED displays and describes a pixel-driver microIC with vertically integrated microLEDs, which enables assembly onto passive wiring panels to realize displays.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2023)
Article
Astronomy & Astrophysics
V Witzke, A. Shapiro, M. Cernetic, R. Tagirov, N. M. Kostogryz, L. S. Anusha, Y. C. Unruh, S. K. Solanki, R. L. Kurucz
Summary: Researchers have developed an efficient code that combines opacity distribution functions, stellar atmospheres, and spectral synthesis, providing more numerical functionality and being substantially faster compared to other available codes. This all-in-one code has been validated against previous calculations and observations.
ASTRONOMY & ASTROPHYSICS
(2021)
Article
Engineering, Environmental
Jiaoyan Huang, Caicheng Long, Lei Zhang, Taiping Qing, Peng Zhang, Zhihe Qing, Bo Feng
Summary: This study reports a dual-functional platform based on the photoinduced electron transfer process for detection and degradation of tetracycline. Carbon dots serve as fluorescence probes for tetracycline detection and demonstrate excellent photodegradation ability without the need for external photosensitizers or cocatalysts.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Computer Science, Artificial Intelligence
Shantian Yang, Bo Yang, Zhongfeng Kang, Lihui Deng
Summary: In multi-intersection traffic signal control, current MDRL algorithms have drawbacks in terms of transferability and flexibility in handling time-varying number of vehicles.
Article
Chemistry, Inorganic & Nuclear
Yun Luo, Jia-Pei Liu, Lin-Ke Li, Shuang-Quan Zang
Summary: Due to the favorable stimuli-responsive chromic properties of the viologen unit, compound 1 shows reversible photochromism, thermochromism, electrochromism, and naked-eye-detectable differentiable vapochromic response to different volatile amines.
INORGANIC CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Paul C. M. Fogg, Joshua A. Haley, W. Marshall Stark, Margaret C. M. Smith
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2017)
Article
Microbiology
Kevin S. Kuchinski, Cedric A. Brimacombe, Alexander B. Westbye, Hao Ding, J. Thomas Beatty
JOURNAL OF BACTERIOLOGY
(2016)
Article
Microbiology
Alexander B. Westbye, Zoe O'Neill, Tegan Schellenberg-Beaver, J. Thomas Beatty
Article
Biochemistry & Molecular Biology
Paul C. M. Fogg, Ellen Younger, Booshini D. Fernando, Thanafez Khaleel, W. Marshall Stark, Margaret C. M. Smith
NUCLEIC ACIDS RESEARCH
(2018)
Article
Multidisciplinary Sciences
Paul C. M. Fogg
NATURE COMMUNICATIONS
(2019)
Article
Virology
D. Sherlock, J. X. Leong, P. C. M. Fogg
JOURNAL OF VIROLOGY
(2019)
Article
Ecology
Laura Villanueva, F. A. Bastiaan von Meijenfeldt, Alexander B. Westbye, Subhash Yadav, Ellen C. Hopmans, Bas E. Dutilh, Jaap S. Sinninghe Damste
Summary: The study has shown the existence of a putative archaeal pathway for membrane lipid synthesis in bacteria of the Fibrobacteres-Chlorobi-Bacteroidetes group, indicating the possibility of "mixed membranes" in natural environments and potentially bridging the once-thought fundamental divide in biology.
Article
Microbiology
Reynold G. Farrera-Calderon, Purvikalyan Pallegar, Alexander B. Westbye, Christina Wiesmann, Andrew S. Lang, J. Thomas Beatty
Summary: Protein phosphorylation is a universal mechanism for cellular signal transduction. The CckA, ChpT, and CtrA proteins form a key phosphorelay pathway in Rhodobacter capsulatus, with cyclic-di-GMP reversing the phosphotransfer flow. Further research on representatives of this pathway is important for understanding bacterial regulatory networks.
JOURNAL OF BACTERIOLOGY
(2021)
Article
Cell Biology
David Sherlock, Paul C. M. Fogg
Summary: GafA, a transcriptional regulator, controls gene expression of gene transfer agents (GTAs) by interacting with RNA polymerase omega subunit (Rpo-omega). It also autoregulates its own expression through a mechanism that is independent of Rpo-omega. This study provides a comprehensive regulatory model for GTAs and suggests an atypical mechanism for RNA polymerase recruitment and specific transcriptional activation in Alphaproteobacteria.
Article
Biotechnology & Applied Microbiology
David Sherlock, Paul C. M. Fogg
Summary: Biofilms are structures that allow bacteria to survive adverse conditions and potentially increase gene transfer between bacteria. This study identified a gene called cysE1 that is involved in optimal receipt of GTA DNA, accumulation of extracellular polysaccharide, and biofilm formation in Rhodobacter capsulatus. The findings suggest that GTA production and biofilm formation are coregulated, which has implications for understanding bacterial evolution and the impact of GTAs in the environment.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Medical Laboratory Technology
Alexander Bauer Westbye, Finn Erik Aas, Sandra R. Dahl, Svetlana N. Zykova, Oskar Kelp, Louise K. Dahll, Per M. Thorsby
Summary: Free thyroid hormone concentrations are method-dependent, especially at high concentrations. Current clinical guidelines do not address the impact of method differences on treatment recommendations for hyperthyroidism.
CLINICAL BIOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Pavol Bardy, Conor I. W. MacDonald, Roman Pantucek, Alfred A. Antson, Paul C. M. Fogg
Summary: A new type of membrane-containing bacteriophage called Jorvik has been identified and characterized, which infects freshwater bacteria and exhibits high virulence. This provides important experimental insights into phage diversity and interactions in microbial communities.
Article
Endocrinology & Metabolism
Louise Koren Dahll, Alexander Bauer Westbye, Kristin Vinorum, Yngve Sejersted, Tuva Baroy, Per Medboe Thorsby, Sara Salehi Hammerstad
Summary: This study investigated 4 previously untreated adult patients with THRA pathogenic variants. The results showed that these patients exhibited more pronounced phenotype features and hypothyroid symptoms than previously described in patients treated with levothyroxine from childhood or adolescence.
JOURNAL OF THE ENDOCRINE SOCIETY
(2023)
Article
Biotechnology & Applied Microbiology
Hong Ga, Gabrielle Taylor, Stephanie K. Evans, Paul C. M. Fogg, Margaret C. M. Smith
SYNTHETIC AND SYSTEMS BIOTECHNOLOGY
(2020)
Review
Microbiology
Alexander B. Westbye, J. Thomas Beatty, Andrew S. Lang
CURRENT OPINION IN MICROBIOLOGY
(2017)