Article
Plant Sciences
Caixia Zang, Hui Liu, Junmei Shang, Hanyu Yang, Lu Wang, Chanjuan Sheng, Zihong Zhang, Xiuqi Bao, Yang Yu, Xinsheng Yao, Dan Zhang
Summary: The study demonstrates that GJ-4 improves cognitive deficits in APP/PS1 transgenic mice by reducing A beta levels, inhibiting tau protein phosphorylation, and suppressing neuroinflammatory responses. These findings provide a basis for further development of GJ-4 as a potential treatment for AD.
Article
Biochemistry & Molecular Biology
Oksana Fihurka, Yuzhu Hong, Jiyu Yan, Breanna Brown, Xiaoyang Lin, Ning Shen, Yanhong Wang, Haohan Zhao, Marcia N. Gordon, David Morgan, Qingyu Zhou, Ping Chang, Chuanhai Cao
Summary: The research found that low-dose THC treatment through intranasal delivery significantly slows memory decline, decreases the levels of Alzheimer's disease-related peptides, and promotes reductions in tau protein levels and changes in mitochondrial function markers. Blood biochemical parameters showed insignificant changes during treatment. Intranasal delivery is a non-invasive and convenient method that targets therapeutics to the brain, minimizing systemic exposure to avoid adverse effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Othman Othman, Hayley Marshall, Mitchell Masterson, Poppy Winlow, Graham Gibson, Yuchun Ding, Marie-Christine Pardon
Summary: This study found that T beta 4 can alleviate the inflammatory response caused by lipopolysaccharide (LPS) in the gut, and reduce sickness symptoms in a mouse model of Alzheimer's disease. The treatment prevented amyloid burden in Alzheimer's mice and induced reactive microgliosis in aging wildtype mice.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Hector M. Estevez-Silva, German Cuesto, Ninovska Romero, Jose Miguel Brito-Armas, Abraham Acevedo-Arozena, Angel Acebes, Daniel J. Marcellino
Summary: Sigma-1 receptor agonists ACR16 and PRE-084 have been shown to promote the formation of new synapses and dendritic spines in vitro, while also exhibiting neuroprotective effects against oxidative stress and excitotoxicity. In an APP/PS1 mouse model, ACR16 improved spatial learning and memory deficits through activation of the PI3K/Akt pathway.
Article
Biochemistry & Molecular Biology
Xue Wang, Huiling Gao, Xiaoyu Zhang, Shengxu Qian, Cunli Wang, Lijing Deng, Manli Zhong, Guangyan Qing
Summary: This study reports a potential therapeutic approach for Alzheimer's disease using chiral liposomes. These liposomes can reduce the aggregation and deposition of amyloid-beta and improve cognitive deficits. This study opens new horizons for the use of liposomes in drug development.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Biology
Andrea Stojakovic, Sergey Trushin, Anthony Sheu, Layla Khalili, Su-Youne Chang, Xing Li, Trace Christensen, Jeffrey L. Salisbury, Rachel E. Geroux, Benjamin Gateno, Padraig J. Flannery, Mrunal Dehankar, Cory C. Funk, Jordan Wilkins, Anna Stepanova, Tara O'Hagan, Alexander Galkin, Jarred Nesbitt, Xiujuan Zhu, Utkarsh Tripathi, Slobodan Macura, Tamar Tchkonia, Tamar Pirtskhalava, James L. Kirkland, Rachel A. Kudgus, Renee A. Schoon, Joel M. Reid, Yu Yamazaki, Takahisa Kanekiyo, Song Zhang, Emirhan Nemutlu, Petras Dzeja, Adam Jaspersen, Ye In Christopher Kwon, Michael K. Lee, Eugenia Trushina
Summary: Partial inhibition of mitochondrial complex I can reduce neurodegeneration and improve key disease phenotypes in a symptomatic mouse model of Alzheimer's disease, including enhancing cognitive function and reducing oxidative stress and inflammation.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lara Ordonez-Gutierrez, Gemma Fabrias, Josefina Casas, Francisco Wandosell
Summary: Modification of the omega-6/omega-3 ratio in diets can affect Aβ production and senile plaque formation in mice. Higher omega-6/omega-3 ratios in the diet lead to increased amyloid burden in the hippocampus of male TG mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Diana J. Zajac, Benjamin C. Shaw, David J. Braun, Stefan J. Green, Joshua M. Morganti, Steven Estus
Summary: Short chain fatty acid (SCFA) treatment was found to modify the gut microbiome profile, but it did not significantly affect behavior, astrocyte activation or amyloid neuropathology.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
John Bosco Ruganzu, Quzhao Zheng, Xiangyuan Wu, Yingying He, Xiaoqian Peng, Hui Jin, Jinsong Zhou, Ruiyang Ma, Shengfeng Ji, Yanbing Ma, Yihua Qian, Yang Wang, Weina Yang
Summary: The overexpression of TREM2 was found to rescue cognitive deficits, reduce Aβ plaque deposition, decrease synaptic and neuronal loss, as well as ameliorate neuroinflammation, likely through the inhibition of neuroinflammatory responses via the JAK/STAT/SOCS signaling pathway and promotion of M2 microglia activation. This study highlights TREM2 as a potential target against AD by shifting microglia from an M1 to M2 phenotype.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Plant Sciences
Gao-Shang Chai, Juan Gong, Jia-Jun Wu, Rui-Kun Ma, Jun Zhu, Dong-Dong Jia, Yu-Qi Zhang, Xiao-Run Zhai, Hong-Xu Sun, Yun Juan Nie, Peng Zhao, Yi-Liang Xu, Hai Tao Yu
Summary: This study aims to investigate the protective role of Danggui Buxue decoction (DBD) in the cognitive deficits and pathology process of Alzheimer's disease (AD). The results showed that DBD could effectively attenuate memory impairments, decrease A beta accumulation, restore mitochondrial biogenesis deficits and mitochondrial dysfunction, and improve H4K12 acetylation, suggesting that DBD might be a promising complementary drug candidate for AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Cell Biology
Jia-Jun Wu, Haitao Yu, Shu-Guang Bi, Zhong-Xuan Wang, Juan Gong, Yu-Ming Mao, Fang-Zhou Wang, Yu-Qi Zhang, Yun-Juan Nie, Gao-Shang Chai
Summary: Growing evidence suggests that aerobic exercise can reverse autophagy-lysosomal deficits and attenuate amyloid-beta pathology in Alzheimer's disease. The molecular mechanism involves the activation of ADRB2/beta 2-adrenergic receptor and upregulation of AMPK-MTOR signaling pathway. AE can also enhance V-ATPase function by upregulating VMA21 levels. The inhibition of ADRB2 blocks the beneficial effects of AE on A beta pathology and cognitive deficits.
Article
Cell Biology
Ning Bai, Na Li, Rong Cheng, Yi Guan, Xiong Zhao, Zhijie Song, Hongde Xu, Fei Yi, Bo Jiang, Xiaoman Li, Xuan Wu, Cui Jiang, Tingting Zhou, Qiqiang Guo, Wendong Guo, Yanling Feng, Zhuo Wang, Mengtao Ma, Yang Yu, Zhanyou Wang, Shengping Zhang, Chuangui Wang, Weidong Zhao, Shihui Liu, Xiaoyu Song, Hua Liu, Liu Cao
Summary: Aging is a primary risk factor for neurodegenerative diseases, and inhibiting SIRT2 has been found to improve cognitive impairment in an Alzheimer's disease model. This improvement is attributed to the enhanced acetylation of APP, leading to non-amyloidogenic processing and increased soluble APP-alpha.
Article
Neurosciences
Biao Luo, Jian Chen, Gui-Feng Zhou, Xiao-Yong Xie, Jing Tang, Qi-Xin Wen, Li Song, Shi-Qi Xie, Yan Long, Guo-Jun Chen, Xiao-Tong Hu
Summary: Apicidin improves AD symptoms in APP/PS1 mice by regulating the expression of ADAM10, leading to a decrease in A beta levels rather than phosphorylation of tau.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Yang Zhu, Hao Huang, Zhi Chen, Yong Tao, Ling-Yi Liao, Shi-Hao Gao, Yan-Jiang Wang, Chang-Yue Gao
Summary: This study uncovers a novel mechanism by which intermittent theta burst stimulation (iTBS) improves cognitive function in Alzheimer's disease (AD) patients by modulating mitochondrial respiration and function through ISCA1-mediated iron-sulfur cluster assembly. This provides a mechanistic target for iTBS therapy in AD.
NEUROSCIENCE BULLETIN
(2023)
Article
Neurosciences
Kelly H. Forest, Ruth Taketa, Komal Arora, Cedomir Todorovic, Robert A. Nichols
Summary: The N-Aβ core can reverse impaired synaptic plasticity in hippocampal slices from 5xFAD APP/PS1 model mice, including effects on LTP and LTD, correlating with alleviation of downregulation of hippocampal AMPA-type glutamate receptors in preparations from 5xFAD mice. The action of the N-Aβ core depends on a critical di-histidine sequence and involves the phosphoinositide-3 (PI3) kinase pathway via mTOR (mammalian target of rapamycin).
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
