Article
Cell Biology
Luis Arpa, Carlos Batlle, Peijin Jiang, Carme Caelles, Jorge Lloberas, Antonio Celada
Summary: IL-4 is a key activator of macrophage alternative activation and induces an anti-inflammatory phenotype. The IL-4 signaling pathway involves STAT-6 and MAPK family members. We found that JNK-1 activation regulates the expression of genes involved in alternative activation in response to IL-4.
Article
Immunology
Yuan Zhang, Jonathan Aldridge, Georgios K. Vasileiadis, Helena Edebo, Anna-Karin H. Ekwall, Anna-Carin Lundell, Anna Rudin, Cristina Maglio
Summary: Adiponectin can induce the production of various pro-inflammatory chemokines and cytokines in PBMCs and FLS from non-inflamed subjects, supporting the hypothesis that adiponectin is involved in the early phases of RA pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Monika Okuliarova, Nikoleta Mazgutova, Miroslava Majzunova, Valentina Sophia Rumanova, Michal Zeman
Summary: Research on the effects of exposure to dim light at night on immune cells and renal immune-related markers in rats reveals that dLAN disrupts the daily variations of circulating immune cells and disturbs renal immune and redox balance. These findings suggest a weakened circadian control and highlight the need for further studies on the impact of dLAN-disturbed immune balance on the immune system's response to other challenges.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Bishnu Prasad Sinha, Priyanka Mehta, Md Asmaul Hoque, Purbita Bandopadhyay, Ayandip Nandi, Ipsita Saha, Anita Nandi Mitra, Asish Mondal, Boudhayan Bhattacharjee, Georgios Chamilos, Rajesh Pandey, Kaushik Basu, Dipyaman Ganguly
Summary: Cases of rhino-orbital mucormycosis in COVID-19 patients have been reported, but the specific immune mechanisms underlying susceptibility to this infection remain unexplored. This study aimed to investigate the regulation of circulating cytokines in COVID-19-associated mucormycosis (CAM) patients and its potential pathogenic links with myeloid phagocyte function and susceptibility to mucormycosis.
Article
Cardiac & Cardiovascular Systems
Eula G. A. Neves, Carolina C. Koh, Thaiany G. Souza-Silva, Livia Silva Araujo Passos, Ana Carolina C. Silva, Teresiama Velikkakam, Fernanda Villani, Janete Soares Coelho, Claudia Ida Brodskyn, Andrea Teixeira, Kenneth J. Gollob, Maria do Carmo P. Nunes, Walderez O. Dutra
Summary: This study investigates the characteristics and functions of T-cell subpopulations in patients with chronic Chagas cardiomyopathy (CCC) and idiopathic dilated cardiomyopathy (IDC), and finds that the inflammatory response differs significantly at the systemic and local cellular levels in these two cardiomyopathies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Immunology
Nathella Pavan Kumar, V. V. Banurekha, Girish C. P. Kumar, Arul Nancy, C. Padmapriyadarsini, A. Stella Mary, K. R. Uma Devi, Manoj Murhekar, Subash Babu
Summary: Covaxin vaccination induces enhanced cytokine and chemokine responses as early as month 1, following prime-boost vaccination, indicating robust activation of innate and adaptive immune responses in vaccine recipients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jurij Kiefer, Johannes Zeller, Balazs Bogner, Isabel A. Hoerbrand, Friederike Lang, Emil Deiss, Oscar Winninger, Mark Fricke, Sheena Kreuzaler, Eva Smudde, Markus Huber-Lang, Karlheinz Peter, Kevin J. Woollard, Steffen U. Eisenhardt
Summary: This paper presents a flow cytometry-based protocol for evaluating subset-specific activation and cytokine expression of circulating blood monocytes in humans and rats, offering an unbiased functional endpoint analysis for studying the differential regulation of monocytes in inflammatory and allogeneic immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Patricia Urban, Paola Italiani, Diana Boraschi, Sabrina Gioria
Summary: The study investigates the interaction of SARS-CoV-2 with the human immune system, finding that monocytes pre-exposed to the N protein exhibit a milder response to subsequent viral or bacterial challenges, potentially leading to a mild response to new infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Veterinary Sciences
Garrett J. Mullenix, Elizabeth S. Greene, Nima K. Emami, Guillermo Tellez-Isaias, Walter G. Bottje, Gisela F. Erf, Michael T. Kidd, Sami Dridi
Summary: The study demonstrates that the inclusion of Spirulina can reduce systemic inflammation and bacterial translocation induced by a low protein diet, making it a promising alternative protein source in poultry diets.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Medicine, General & Internal
Federica Angiulli, Elisa Conti, Chiara Paola Zoia, Fulvio Da Re, Ildebrando Appollonio, Carlo Ferrarese, Lucio Tremolizzo
Summary: Neuroinflammation is a key feature in the development of Alzheimer's disease, involving both resident innate immune cells in the brain and the peripheral immune system due to dysfunction in the blood-brain barrier. Peripheral biomarkers in the blood can reflect pathological changes in the AD brain, highlighting their potential for early diagnosis and monitoring of disease progression and treatment effectiveness.
Article
Immunology
Elisabet Van Loon, Baptiste Lamarthee, Thomas Barba, Sandra Claes, Maarten Coemans, Henriette de Loor, Marie-Paule Emonds, Priyanka Koshy, Dirk Kuypers, Paul Proost, Aleksandar Senev, Ben Sprangers, Claire Tinel, Olivier Thaunat, Amaryllis H. Van Craenenbroeck, Dominique Schols, Maarten Naesens
Summary: Through multiplex assay, we found that kidney transplant patients with donor-specific anti-human leukocyte antigen antibodies and histological rejection have increased levels of pro-inflammatory cytokines in blood. Even in patients without histological rejection, elevated pro-inflammatory cytokine levels can be observed. These findings challenge the concept of histology as the gold standard for identifying ongoing allo-immune activation after transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Li-Li Lu, Shu-xiu Xiao, Zhi-yuan Lin, Jin-jin Bai, Wei Li, Zheng-qing Song, Yu-hong Zhou, Bin Lu, Wei-Zhong Wu
Summary: This study investigated the clinical utility and antitumor effects of novel GPC3-7-19-CAR-T cells in advanced hepatocellular carcinoma. The results showed that GPC3-7-19-CAR-T cells had higher killing efficiency than conventional GPC3-CAR-T cells and could reverse the immunosuppressive tumor microenvironment. Furthermore, treatment with GPC3-7-19-CAR-T cells resulted in tumor reduction in one advanced hepatocellular carcinoma patient.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Benedikt Hermann Siegler, Marc Altvater, Jan Niklas Thon, Christopher Neuhaus, Christoph Arens, Florian Uhle, Christoph Lichtenstern, Markus Alexander Weigand, Sebastian Weiterer
Summary: Postoperative abdominal infections are common triggers of sepsis and septic shock in intensive care units worldwide. This study found that sepsis-induced differential occupancy of CTCF within the MHC-II region in patients with postoperative sepsis leads to altered monocytic transcriptional response, suggesting an important role of CTCF in modulating the transcriptional response of immunocompromised human monocytes during critical illness.
Article
Endocrinology & Metabolism
Xiaoli Zhang, Jing Yuan, Shan Zhang, Wendong Li, Yiran Xu, Hongwei Li, Lingling Zhang, Xi Chen, Wenjun Ding, Jinjin Zhu, Juan Song, Xiaoyang Wang, Changlian Zhu
Summary: This study used a rat model of germinal matrix hemorrhage (GMH) to explore immune response, brain injury, and neurobehavioral changes after hemorrhagic injury. The results showed an increase in immune cells, chemokines/cytokines, and inflammatory mediators after GMH. The animal model partially reproduced the brain injury and motor dysfunction seen in human neonates with GMH.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Oncology
Emilio Esteban, Francisco Exposito, Guillermo Crespo, Julio Lambea, Alvaro Pinto, Javier Puente, Jose A. Arranz, Miriam Redrado, Cristina Rodriguez-Antona, Carlos de Andrea, Marta Lopez-Brea, Esther Redin, Angel Rodriguez, Diego Serrano, Jorge Garcia, Enrique Grande, Daniel Castellano, Alfonso Calvo
Summary: High levels of CXCL10, CXCL11, HGF, and IL-6 before treatment were found to be associated with poor prognosis in metastatic renal cell carcinoma patients treated with sunitinib or pazopanib. These factors may constitute a secretory cluster that acts coordinately to promote tumor growth and resistance to antiangiogenic therapy. A prognostic index incorporating these biomarkers can predict higher risk of relapse in mRCC patients.