Article
Immunology
Fangfang Bai, Zi Chen, Shuanglan Xu, Lu Han, Xiaoning Zeng, Shouxiong Huang, Zhou Zhu, Linfu Zhou
Summary: The study found that wogonin alleviates airway neutrophilia in severe neutrophilic asthma by inducing neutrophil apoptosis and inhibiting HMGB1-mediated ASMCs activation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ying Cheng, Ning Wang, Long Zhao, Cuicui Liu, Jing Wang, Cailing Ma, Xiaolan Shi
Summary: The study investigated the role of NOVA1 in childhood asthma, with findings suggesting that inhibition of NOVA1 may alleviate TGF-131-induced inflammation and migration through the PTBP1/PTEN/AKT pathway. This indicates that targeting NOVA1 could be useful in preventing or treating asthma airway remodeling.
MOLECULAR IMMUNOLOGY
(2021)
Article
Allergy
Ruyi Li, Feiyun Wang, Jianghong Wei, Yun Lin, Guofang Tang, Lizong Rao, Libing Ma, Qing Xu, Jingjie Wu, Qian Lv, Rui Zhou, Huiren Lei, Xueqiang Zhao, Dong Yao, Bo Xiao, Haiming Huang, Jiange Zhang, Biwen Mo
Summary: Recent studies have shown that macrophage migration inhibitory factor (MIF) plays a significant role in asthmatic inflammation. This study demonstrated that MIF promotes airway remodeling by enhancing ASMC autophagy. Inhibiting MIF reduced airway remodeling in mouse models, highlighting the potential therapeutic target for asthma treatment.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2021)
Article
Cell Biology
Ieva Janulaityte, Andrius Januskevicius, Virginija Kalinauskaite-Zukauske, Jolita Palacionyte, Kestutis Malakauskas
Summary: The study showed that asthmatic eosinophils can significantly increase contractility and migration of ASMC and PF, as well as upregulate the expression of contractile apparatus proteins in these cells. Eosinophils from asthma patients have a greater effect on ASMC and PF compared to healthy subjects' eosinophils.
Article
Oncology
Qin Yang, Qing Miao, Hui Chen, Duo Li, Yongfeng Luo, Joanne Chiu, Hong-Jun Wang, Michael Chuvanjyan, Michael S. Parmacek, Wei Shi
Summary: Abnormal growth of airway smooth muscle cells is a key feature in asthmatic airway remodeling. The role of Myocd, a transcriptional coactivator, in this process has been investigated in a mouse model of chronic asthma. Deletion of Myocd mitigated airway smooth muscle cell hypertrophy and hyperplasia, reduced inflammation and collagen deposition, and attenuated abnormal mucin production. Myocd could be a potential therapeutic target for treating severe and persistent asthma.
JOURNAL OF PATHOLOGY
(2023)
Review
Biology
Harshita Shailesh, Ibrahim A. Janahi
Summary: Obesity is a significant risk factor for asthma and has a detrimental effect on the severity of the disease. It impairs lung airway function and leads to increased inflammation and severe remodeling of the bronchus. This review discusses the current research on the role of obesity in modulating airway cell functions and explores different therapeutic approaches for treating obese asthmatic individuals.
Article
Cell Biology
Alen Faiz, Louise M. Harkness, Gavin Tjin, Victor Bernal, Peter Horvatovich, Alan James, John G. Elliot, Janette K. Burgess, Anthony W. Ashton
Summary: The study found that the ECM deposited by asthmatic and non-asthmatic ASM cells under non-stimulated conditions had similar composition and angiogenic potential, both capable of regulating the behavior of endothelial cells. This suggests that the dysregulation of airway ECM in asthma is driven by even low levels of inflammation, emphasizing the need for more effective anti-inflammatory therapies to maintain airway ECM and regulate aberrant angiogenesis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Physiology
Amanda L. Tatler, Christopher J. Philp, Michael R. Hill, Sam Cox, Andrew M. Bullock, Anthony Habgood, Alison John, Robert Middlewick, Katherine E. Stephenson, Amanda T. Goodwin, Charlotte K. Billington, Reuben D. O. ' Dea, Simon R. Johnson, Bindi S. Brook
Summary: Airway remodeling in chronic asthma involves increased ASM and ECM. A new method reveals that ASM and ECM changes are more pronounced in small and large airways compared to intermediate airways. Changes in ASM resolve over 7 days, while ECM and epithelial changes persist. The method highlights important spatial differences in remodeling and could set new analysis standards for murine asthma models.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Cell Biology
Ruping Wang, Sakeeb Khan, Guoning Liao, Yidi Wu, Dale D. Tang
Summary: This study found that nestin promotes the migration of smooth muscle cells by regulating Plk1 phosphorylation, which in turn regulates vimentin phosphorylation, the connection of vimentin filaments with paxillin, and focal adhesion assembly.
Review
Physiology
Dora (Jun Ping) Xiong, James G. Martin, Anne-Marie Lauzon
Summary: Asthma is a common chronic inflammatory disease of the airways that varies in its presentation and severity. Airway smooth muscle is the major contributor to airway narrowing and asthma symptoms. Various factors can contribute to the dysfunction of airway smooth muscle. Methodological limitations in studying the airways have hindered our understanding of asthma mechanisms.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Ling Ding, Guang-Ling Liu, Lu Lu, Lei Ge, Jin-Ya Wang
Summary: This study revealed the up-regulation of circ_CSNK1E in asthma samples and PDGF-BB induced ASMCs. Inhibition of circRNA_CSNK1E suppressed proliferation and migration of ASMCs. CircRNA_CSNK1E acted as a sponge for miR-34a-5p, which in turn inhibited the proliferation and migration of ASMCs. VAMP2 was identified as a direct target of miR-34a-5p. Inhibition of circRNA_CSNK1E suppressed proliferation and migration of PDGF-BB induced ASMCs through the miR-34a-5p/VAMP2 axis.
CELLULAR SIGNALLING
(2022)
Article
Immunology
Jyun-Yi Du, Hong-Yue Lai, Yu-Wei Hsiao, Jhih-Ying Chi, Ju-Ming Wang
Summary: This study reveals the role of Pentraxin 3 (PTX3) in shrimp allergy and demonstrates that PTX3 can facilitate mast cell activation and immune inflammatory responses. The findings also suggest that RI37 can serve as a therapeutic agent for shrimp allergy.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Miroslava Molitorisova, Martina Sutovska, Ivana Kazimierova, Jana Barborikova, Marta Joskova, Elena Novakova, Sona Franova
Summary: Kaempferol, a flavonol, demonstrated potential in modulating allergic airway inflammation and alleviating asthma features, such as airway hyperreactivity and cough reflex, in an experimental guinea pig model.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Suhayla H. Shareef, Kawa Amin, Christer Janson
Summary: In individuals with allergic asthma, there is an increased expression of beta-dystroglycan in airway smooth muscle and a higher number of eosinophils compared to healthy individuals. This suggests a potential role for eosinophils in airway remodeling in allergic asthma.
Article
Allergy
Haruka Miki, William B. Kiosses, Mario C. Manresa, Rinkesh K. Gupta, Gurupreet S. Sethi, Rana Herro, Ricardo Da Silva Antunes, Paramita Dutta, Marina Miller, Kai Fung, Ashu Chawla, Katarzyna Dobaczewska, Ferhat Ay, David H. Broide, Alexei V. Tumanov, Michael Croft
Summary: This study found that signaling through lymphotoxin beta receptor and herpesvirus entry mediator from LIGHT directly controls the dysregulation of airway smooth muscle cells in asthma. By using animal models and in vitro experiments, it was discovered that these receptors play a crucial role in airway smooth muscle hyperresponsiveness and remodeling.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Pengcheng Liu, Peng Xiao, Ming Lu, Hui Wang, Na Jin, Zifeng Lin
Summary: Ti3C2Tx MXene with -F, -Cl, and -Br terminations were synthesized, and their effects on lithium storage properties were studied. Ti3C2Brx MXene exhibited the highest lithium storage capacity of 189 mAh/g, followed by Ti3C2Clx with 138 mAh/g and Ti3C2Fx with 123 mAh/g. Theoretical calculations revealed that the adsorption formation energy of halogen atoms on Ti atoms followed the trend of Ti-F > Ti-Cl > Ti-Br, which correlated with the surface terminations on MXenes. The exposure of MXene to oxygen resulted in a competition between halogen and oxygen, and Ti3C2Brx MXene showed the highest Ti to O ratio and the lowest Ti to Br ratio, explaining its superior lithium storage capacity. This work provides insights into improving the lithium storage properties of MXene electrodes through surface chemistry regulation.
CHINESE CHEMICAL LETTERS
(2023)
Article
Materials Science, Multidisciplinary
Zhaoyang Wang, Xiaobin Liao, Min Zhou, Fuzhi Huang, Kwadwo Asare Owusu, Jiantao Li, Zifeng Lin, Qi Sun, Xufeng Hong, Congli Sun, Yi-Bing Cheng, Yan Zhao, Liqiang Mai
Summary: In this study, a bifunctional electrocatalyst with abundant heterointerfaces and sulfur vacancies on graphene (Cu1Ni2-S/G) was prepared for oxygen reduction and alcohols oxidation reactions (ORR, AOR). The Cu1Ni2-S/G catalyst showed significantly enhanced ORR activity with long term stability and achieved a high Faradaic efficiency for ethyl acetate production during AOR. The study highlights the synergistic effects of interfacial coupling and vacancies engineering in tailoring catalytic activity and opens up new avenues for self-driven biomass electrocatalysis systems.
ENERGY & ENVIRONMENTAL MATERIALS
(2023)
Article
Engineering, Multidisciplinary
Xiaohua Feng, Kui Liu, Yuxuan Chen, Haobo Zhang, Zongyang Li, Fenglei Zhang, Zehuang Lu, Jie Zhang
Summary: Passive resonant gyroscopes (PRGs) utilizing the Pound-Drever-Hall (PDH) method have a lower shot-noise limit, but technical obstacles hinder reaching the intrinsic noise floor. This article shows that the residual amplitude modulation (RAM) effect in the phase locking process hampers accuracy and stability of PRGs' output signals, especially at low frequencies. To overcome this, the Pearson correlation coefficient is proposed to evaluate the correlation between the RAM signal and PDH signal, achieving better performance in rotational sensitivity and resolution.
MEASUREMENT SCIENCE AND TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Mojdeh Matloubi, Latifa Koussih, Lianyu Shan, Chelsea Lukawy, Abdelilah S. Gounni
Summary: Asthma is a heterogeneous airway disease characterized by airway inflammation and remodeling, affecting more than 300 million people worldwide and posing a significant burden on society. Semaphorin3E, a critical molecule in lung pathophysiology, plays a role in both lung development and homeostasis. Recent studies have demonstrated that the Semaphorin3E-plexinD1 axis is implicated in asthma, impacting inflammatory and structural cells associated with airway inflammation, tissue remodeling, and airway hyperresponsiveness. This review highlights the potential role of the Semaphorin3E-plexinD1 axis as a therapeutic target in airway allergic diseases.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Physics, Applied
Cen Liang, Changyuan Wang, Wenjun Cao, Hanyu Zhao, Feng Li, Chunchang Wang
Summary: In this work, (1-x)(0.92NaNbO(3)-0.08BaTiO(3))-xCa(0.7)La(0.2)TiO(3) (NNBT -xCIT) ceramics were successfully designed and prepared by the solid-state reaction method. Investigations on the structure, dielectric, and energy storage properties were performed. The NNBT -0.25CLT ceramic with orthorhombic phase at room temperature was found to exhibit extremely small grain size and compacted microstructure. A large W-rec of 3.1 J/cm(3) and a high eta of 91.5% under the electric field of 360 kV/cm were achieved simultaneously in the sample. In addition, the energy storage performance of the sample exhibits thermal stability over the temperature range of 25-140 degrees C and the frequency range of 5-500 Hz. The charge and discharge tests reveal that the ceramic shows a large current density C-D of 965 A/cm(2) and power density P-D of 154 MW/cm(3). This work demonstrates that the NNBT-0.25CLT ceramic is a prospective energy storage material for potential application in the field of pulsed power devices.
JOURNAL OF ADVANCED DIELECTRICS
(2023)
Article
Chemistry, Multidisciplinary
Ni Zhang, Tinghao Li, Can Wang, Qiu Xiong, Feng Li, Zilong Zhang, Chunyan Deng, Chongzhu Hu, Naoyuki Shibayama, Jihuai Wu, Peng Gao
Summary: Recent research shows that by using a host-guest strategy with 4-tert-Butyl-1-(ethoxycarbonyl-methoxy) thiacalix[4]arene (tBuTCA) to complex with the cations and Lead(II) iodide (PbI2), the formation of Pb-Pb dimers can be prevented, thus significantly suppressing non-radiative recombination. This study highlights the importance of supramolecular engineering in constructing high-quality perovskites for efficient and stable solar cells.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Lu-Kang Zhao, Xuan-Wen Gao, Jianjia Mu, Wen-Bin Luo, Zhaomeng Liu, Zhenhua Sun, Qin-Fen Gu, Feng Li
Summary: K-metal batteries, using potassium as the primary resource, are promising candidates for large-scale energy storage. However, uneven potassium deposition and dendrite growth on the anode limit their application. By constructing an integrated anode with cold-rolled potassium metal and a potassium-affine porous interconnected mediator, the transportation of potassium ions is enhanced, leading to a dendrite-free and durable anode with excellent cycling ability.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Editorial Material
Critical Care Medicine
Bouchaib Lamkioued, Abdelilah S. Gounni
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Materials Science, Multidisciplinary
Yuqiong Li, Bing Lan, Chunlong Dai, Siwei Li, Fan Zhang, Zifeng Lin
Summary: A Lewis acid molten salt method is used to synthesize the lamellar structured Mo2AlB2 by selectively etching a layer of aluminium atoms from the MoAlB precursor. The synthesized Mo2AlB2 exhibits excellent catalytic activity for hydrogen evolution reaction under alkaline conditions, with long-term stability, and low overpotential (145 mV) and Tafel slope (76 mV dec-1) at 10 mA cm-2.
MATERIALS RESEARCH LETTERS
(2023)
Article
Chemistry, Physical
Yongqiu Xian, Bin Wang, Zifeng Lin
Summary: In this study, Ti3C2Tx MXene is shown to operate at a wide potential range in a mild AlCl3 aqueous electrolyte and retain high pseudocapacitive activity, achieving a capacity of up to 85 mAh g(-1), surpassing its performance in H2SO4 electrolyte of 78 mAh g(-1). In situ electrochemical quartz crystal microbalance results suggest that the high capacity originates from the pseudocapacitive intercalation/deintercalation of H+ instead of Al3+, providing the possibility of coupling MXene anodes with proton redox active cathodes to achieve high-energy and high-power devices.
Review
Electrochemistry
Huifa Shi, Jiakai Cao, Zhenhua Sun, Zahid Ali Ghazi, Xiaoyang Zhu, Sa Han, Danyang Ren, Guixia Lu, Hongbo Lan, Feng Li
Summary: 3D printing, as a new technology, brings great freedom in the design and manufacturing of batteries. It offers unique advantages by producing more advanced batteries with specific properties. In this review, an overview of 3D printing technologies in the field of customizable batteries is provided, including the fundamental concepts, distinct advantages, operating mechanisms, printing materials requirements, manufacturing accuracy, and technical features of five representative 3D printing techniques. The state-of-the-art developments, current challenges, and potential research areas for practical applications of 3D printed customizable batteries are summarized and discussed.
BATTERIES & SUPERCAPS
(2023)
Article
Chemistry, Multidisciplinary
Ru Xiao, Tong Yu, Shan Yang, Xiaoyin Zhang, Tianzhao Hu, Ruogu Xu, Zhuoyan Qu, Guangjian Hu, Zhenhua Sun, Feng Li
Summary: This study reports a new non-carbon-dominated catalytic system using macroporous nickel/cobalt phosphide (NiCoP) as the sulfur host for lithium-sulfur (Li-S) batteries. The catalytic system exhibits high tap density and mechanical hardness, improving the electrochemical reaction kinetics and showing excellent electrochemical performance under high sulfur loading and lean electrolyte conditions.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Haorui Shen, Tong Yu, Pei Tang, Huicong Yang, Jun Tan, Shuo Bai, Feng Li
Summary: In this study, the stability of the electrolyte-anode interface is improved and the interfacial transfer dynamics are accelerated by preparing micro-arrays of nano-hydroxyapatite (nHA) on the Cu foil. The formation of aggregates of anions is promoted, leading to improved decomposition efficiency and the formation of a more protective solid electrolyte interface (SEI) film. This approach effectively suppresses the formation of lithium dendrites and enhances the lifespan and efficiency of the anode.
ADVANCED MATERIALS
(2023)
Review
Materials Science, Multidisciplinary
Feng Li, Zhen-xin Zhao, Xu Chen, Wen-yi Li, Xiao-min Wang
Summary: This review summarizes the synthesis methods and applications of MXenes as host materials for lithium metal anodes, focusing on their advantages in mitigating volume changes and inhibiting lithium dendrite growth. Potential research directions are also discussed.
NEW CARBON MATERIALS
(2023)
Article
Chemistry, Physical
Ruogu Xu, Shengjun Xu, Fei Wang, Ru Xiao, Pei Tang, Xiaoyin Zhang, Shuo Bai, Zhenhua Sun, Feng Li
Summary: Poly(ethylene oxide) (PEO) based electrolytes play a critical role in solid-state lithium metal batteries. In this study, a double-crosslinked PEO-based electrolyte with C-S-C groups and functionalized metal-organic frameworks (MOFs) is proposed to enhance the ionic conductivity and stability of the battery. The results demonstrate a promising strategy to develop advanced electrolytes for potential solid-state lithium-metal batteries.
