SPARC Overexpression Inhibits Cell Proliferation in Neuroblastoma and Is Partly Mediated by Tumor Suppressor Protein PTEN and AKT

MicroRNA-34a is a potent tumor suppressor molecule in vivo in neuroblastoma

(2011) Amanda Tivnan et al.   BMC CANCER

Knockdown of Secreted Protein Acidic and Rich in Cysteine (SPARC) Expression Diminishes Radiosensitivity of Glioma Cells

(2011) Haiyan Liu et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

SPARC Stimulates Neuronal Differentiation of Medulloblastoma Cells via the Notch1/STAT3 Pathway

(2011) P. Bhoopathi et al.   CANCER RESEARCH

Enhancing radiosensitivity: Targeting the DNA repair pathways

(2010) Timothy J. Jorgensen   CANCER BIOLOGY & THERAPY

Cathepsin B facilitates autophagy-mediated apoptosis in SPARC overexpressed primitive neuroectodermal tumor cells

(2010) P Bhoopathi et al.   CELL DEATH AND DIFFERENTIATION

Akt Activation Emulates Chk1 Inhibition and Bcl2 Overexpression and Abrogates G2 Cell Cycle Checkpoint by Inhibiting BRCA1 Foci

(2010) Ivana Tonic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PTEN augments SPARC suppression of proliferation and inhibits SPARC-induced migration by suppressing SHC-RAF-ERK and AKT signaling

(2010) Stacey L. Thomas et al.   NEURO-ONCOLOGY

Protein phosphatase 2A has an essential role in the activation of γ-irradiation-induced G2/M checkpoint response

(2010) Y Yan et al.   ONCOGENE

Induction of Akt Activity by Chemotherapy Confers Acquired Resistance

(2009) Wei-Chien Huang et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Modulation of matrix remodeling by SPARC in neoplastic progression

(2009) Alexandre Chlenski et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The hard life of soft cells

(2009) Paul A. Janmey et al.   CELL MOTILITY AND THE CYTOSKELETON

SPARC functions as an inhibitor of adipogenesis

(2009) Jing Nie et al.   Journal of Cell Communication and Signaling

The role of the matricellular protein SPARC in the dynamic interaction between the tumor and the host

(2008) Osvaldo L. Podhajcer et al.   CANCER AND METASTASIS REVIEWS

Tissue Inhibitor of Metalloproteinase 3 Suppresses Tumor Angiogenesis in Matrix Metalloproteinase 2-Down-regulated Lung Cancer

(2008) C. Chetty et al.   CANCER RESEARCH

SPARC in cancer biology: Its role in cancer progression and potential for therapy

(2008) Isabella T. Tai et al.   DRUG RESISTANCE UPDATES

Inhibition of matrix metalloproteinase-2 enhances radiosensitivity by abrogating radiation-induced FoxM1-mediated G2/M arrest in A549 lung cancer cells

(2008) Chandramu Chetty et al.   INTERNATIONAL JOURNAL OF CANCER

A prototypic matricellular protein in the tumor microenvironment—Where there's SPARC, there's fire

(2008) Clancy J. Clark et al.   JOURNAL OF CELLULAR BIOCHEMISTRY